The document provides an overview of the Comprehensive Safety Analysis 2010 (CSA 2010) program from the U.S. Department of Transportation Federal Motor Carrier Safety Administration. It describes limitations of the current enforcement model, and introduces the new CSA 2010 approach which includes a new Safety Measurement System to assess carrier safety, a new intervention process, and changes to the Safety Fitness Determination. It also discusses preliminary results from the CSA 2010 operational test, the national rollout plan, and implications for commercial drivers.