This document is a thesis that examines using multi-agent and CFD simulations to model human behavior and combustion in road tunnel fire scenarios. It presents a case study of the St. Demetrio tunnel in Italy, where FDS+Evac software is used to simulate egress times and conditions under different fire and ventilation scenarios. The results show that for a 6 MW car fire scenario, evacuation is completed within 15-20 minutes without issues with visibility or intoxication, though backlayering did occur for a bus fire scenario when one jet fan was off.