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El documento describe la historia de ARPANET y el desarrollo de Internet. ARPANET comenzó en la década de 1960 como una red militar financiada por DARPA para conectar computadoras de forma remota. Más adelante, se desarrollaron protocolos como TCP/IP y HTTP que permitieron el crecimiento de ARPANET en Internet. La World Wide Web popularizó Internet al hacer que la información fuera accesible a través de navegadores web y URLs.
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Este documento fornece informações sobre uma música chamada "Around The World" e inclui imagens do Google para ilustrá-la. A autoria da música é desconhecida e a formatação foi feita por Stela Lecocq.
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This Christmas song reflects on the passing of another year and the beginning of a new one. It expresses the hope that this Christmas is enjoyable for people of all backgrounds, and that the new year will be good without any fear, wars, or fights. The song wishes everyone a merry Christmas and a happy new year.
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Paginas Web
El documento describe la historia de ARPANET y el desarrollo de Internet. ARPANET comenzó en la década de 1960 como una red militar financiada por DARPA para conectar computadoras de forma remota. Más adelante, se desarrollaron protocolos como TCP/IP y HTTP que permitieron el crecimiento de ARPANET en Internet. La World Wide Web popularizó Internet al hacer que la información fuera accesible a través de navegadores web y URLs.
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Este documento fornece informações sobre uma música chamada "Around The World" e inclui imagens do Google para ilustrá-la. A autoria da música é desconhecida e a formatação foi feita por Stela Lecocq.
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El documento narra la excursión de un grupo de amigos en motocicleta a Catoira. Se reunieron en un bar con sus motos preparadas y emprendieron el viaje. Una vez allí, se vistieron como romanos y comenzaron a explorar los montes en moto. Hubo varias paradas técnicas para reparar las motos. Exploraron diversos caminos y senderos, disfrutando de la naturaleza. Para comer, aprovecharon para descansar y recuperar fuerzas. Luego de comer continuaron el recorrido
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El documento propone reformas constitucionales para establecer un Estado de Derecho en Guatemala mediante el fortalecimiento del sistema judicial y la separación de poderes. Plantea crear un Senado encargado de legislar sobre derecho privado y leyes electorales, mientras una Cámara de Diputados se enfocaría en legislación ordinaria. Las reformas buscan reducir la violencia, corrupción y pobreza al garantizar los derechos individuales como la vida, propiedad y certeza contractual.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
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En el siglo XV, los hermanos Alberto Dürer y su hermano querían estudiar arte pero su padre no podía pagarlo. Lanzaron una moneda para decidir quién estudiaría, y Alberto ganó. Su hermano trabajó 4 años en minas de carbón para pagar sus estudios. Años después, cuando Alberto se había convertido en un exitoso artista, quiso pagar los estudios de su hermano pero sus manos estaban dañadas por el trabajo en las minas y ya no podía pintar.
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Este documento presenta una teoría inquietante en la que el comportamiento de la especie humana se asemeja al de un patógeno que consume sin límites los recursos de su anfitrión, la Tierra, dañándola. Al igual que el cuerpo humano eleva su temperatura para combatir una infección, el calentamiento global podría ser la forma en que la Tierra induce una "fiebre" para contrarrestar la contaminación humana. Desde la década de 1950, la evidencia muestra que los seres humanos están ejerciendo un efecto pat
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This letter from the National Affordable Housing Management Association thanks Jim Kosiara for his company AIMCO's participation in the National Communities of Quality Recognition Program. It congratulates him on meeting the criteria to earn the distinction of becoming a nationally recognized Community of Quality Corporate Partner. The letter encourages promoting this new designation locally to highlight well-managed, affordable multifamily housing. Contact information is provided for any questions regarding the Community of Quality Corporate Partner program.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
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Avartana Sneha is a unique method of Preparation of Sneha Kalpana in Ayurveda, mainly it is indicated for the Vataja rogas.
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Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
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There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
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