- The study analyzed cancer registry data from Malawi between 1996-2005 to describe the age at cancer diagnosis.
- The median ages at diagnosis were lower for AIDS-defining cancers (most 42 years) than non-AIDS defining cancers (at least 46 years).
- Childhood and adult cancer ages followed lognormal distributions. The overall age distribution was best modeled as a finite mixture of two lognormal distributions, with means of 5.1 and 45.1 years, reflecting a bimodal distribution with peaks in childhood and mid-adulthood.
- The study analyzed age at cancer diagnosis data from Malawi's National Cancer Registry from 1996-2005.
- The median ages at diagnosis were lower for AIDS-defining cancers (most 42 years) than non-AIDS defining cancers (at least 46 years).
- Childhood and adult cancer ages followed lognormal distributions. The overall age distribution was best fit by a finite mixture of two lognormal distributions, with means of 5.1 and 45.1 years, suggesting a bimodal distribution with peaks in childhood and mid-adulthood.
Indo-American Journal of Agricultural and Veterinary Sciences". It appears to be an international online journal that publishes research and review articles in English on topics related to agriculture and veterinary sciences of the journals in research .
Contextual Factors Associated with Health-Related Quality of Life in Older Ad...JohnJulie1
The purpose of this study was to examine contextual factors associated with physical and mental health-related quality of life (HRQOL) in older adult cancer survivors.
Contextual Factors Associated with Health-Related Quality of Life in Older Ad...EditorSara
The purpose of this study was to examine contextual factors associated with physical and mental health-related quality of life (HRQOL) in older adult cancer survivors.
Contextual Factors Associated with Health-Related Quality of Life in Older Ad...EditorSara
This study is a secondary data analysis of the 2014 Behavioral Risk Factor Surveillance System. Only adults age 65 and older who had a cancer history in the Cancer Survivorship module were included (n=3,846).
Contextual Factors Associated with Health-Related Quality of Life in Older Ad...semualkaira
The purpose of this study was to examine contextual factors associated with physical and mental health-related quality of life (HRQOL) in older adult cancer survivors.
Contextual Factors Associated with Health-Related Quality of Life in Older Ad...semualkaira
This study is a secondary data analysis of the 2014 Behavioral Risk Factor Surveillance System. Only adults age 65 and older who had a cancer history in the Cancer Survivorship module were included (n=3,846).
- The study analyzed cancer registry data from Malawi between 1996-2005 to describe the age at cancer diagnosis.
- The median ages at diagnosis were lower for AIDS-defining cancers (most 42 years) than non-AIDS defining cancers (at least 46 years).
- Childhood and adult cancer ages followed lognormal distributions. The overall age distribution was best modeled as a finite mixture of two lognormal distributions, with means of 5.1 and 45.1 years, reflecting a bimodal distribution with peaks in childhood and mid-adulthood.
- The study analyzed age at cancer diagnosis data from Malawi's National Cancer Registry from 1996-2005.
- The median ages at diagnosis were lower for AIDS-defining cancers (most 42 years) than non-AIDS defining cancers (at least 46 years).
- Childhood and adult cancer ages followed lognormal distributions. The overall age distribution was best fit by a finite mixture of two lognormal distributions, with means of 5.1 and 45.1 years, suggesting a bimodal distribution with peaks in childhood and mid-adulthood.
Indo-American Journal of Agricultural and Veterinary Sciences". It appears to be an international online journal that publishes research and review articles in English on topics related to agriculture and veterinary sciences of the journals in research .
Contextual Factors Associated with Health-Related Quality of Life in Older Ad...JohnJulie1
The purpose of this study was to examine contextual factors associated with physical and mental health-related quality of life (HRQOL) in older adult cancer survivors.
Contextual Factors Associated with Health-Related Quality of Life in Older Ad...EditorSara
The purpose of this study was to examine contextual factors associated with physical and mental health-related quality of life (HRQOL) in older adult cancer survivors.
Contextual Factors Associated with Health-Related Quality of Life in Older Ad...EditorSara
This study is a secondary data analysis of the 2014 Behavioral Risk Factor Surveillance System. Only adults age 65 and older who had a cancer history in the Cancer Survivorship module were included (n=3,846).
Contextual Factors Associated with Health-Related Quality of Life in Older Ad...semualkaira
The purpose of this study was to examine contextual factors associated with physical and mental health-related quality of life (HRQOL) in older adult cancer survivors.
Contextual Factors Associated with Health-Related Quality of Life in Older Ad...semualkaira
This study is a secondary data analysis of the 2014 Behavioral Risk Factor Surveillance System. Only adults age 65 and older who had a cancer history in the Cancer Survivorship module were included (n=3,846).
Contextual Factors Associated with Health-Related Quality of Life in Older Ad...semualkaira
The purpose of this study was to examine contextual
factors associated with physical and mental health-related quality
of life (HRQOL) in older adult cancer survivors.
It's great to hear that presumably the Asian Journal of Agricultural Sciences and Veterinary Medicine hopes to facilitate research and development in the fields of Agricultural Sciences and Veterinary Medicine through its journal publications of the scopus database journal.
Indo-American Journal of Agricultural and Veterinary Sciences". It appears to be an international online journal that publishes research and review articles in English on topics related to agriculture and veterinary sciences is the journal of the journal papers
1. The document discusses several cases involving the use of demographic indices and statistical methods to analyze mortality data. These include calculating standardized mortality ratios to compare mortality rates between populations while adjusting for differences in age structure.
2. Indirect standardization is used in one case to compare the mortality of the Colombian department of Vichada to the overall mortality in Colombia using age-specific mortality rates.
3. Another case examines mortality trends among foundry workers using standardized mortality ratios and discusses methods to address potential biases from issues like loss to follow up.
This document summarizes key points from a workshop on cancers that commonly affect adolescents and young adults (AYA).
1) Outcomes for AYA patients with acute lymphoblastic leukemia, breast cancer, and colon cancer have improved less than for pediatric or older adult patients. One reason may be that the biology of these cancers differs between AYA and other age groups.
2) For AYA acute lymphoblastic leukemia, outcomes are poorer than in children and the disease appears to be biologically distinct, with differences in genetic abnormalities. New research is identifying additional high-risk subtypes in this population.
3) Studies of AYA breast and colon cancers are also finding these diseases to be more aggressive and
This document describes a study that uses a Markov chain Monte Carlo simulation to model the rising incidence of Type II diabetes in youth ages 15-20 in the United States. The study aims to identify risk factors contributing to the rise and understand the impact on dependency ratios. Aggregate data from various sources was used to simulate disease progression and estimate covariates. The model is expected to help reformulate dependency ratios by accounting for the effects of morbidity on labor participation.
Objective: The prognostic indictors of age-related poor outcomes in patients with acute myeloid leukemia (AML) are still controversial. The aim of this work was to provide comprehensive insights into the effect of different hemocytes and to investigate the association between age and clinical features in adult patients with AML.
Study Design: A retrospective study was performed to determine the role of age in the therapeutic outcomes of AML. A total of 166 newly diagnosed adult patients’ data from January 2015 to November 2019 in Zhongshan Hospital of Xiamen University were collected and analyzed.
Results: Older patients presented a poorer prognosis (p=0.001) with shorter overall survival, which is served as age-related outcomes. Binary logistic regression demonstrated that cytogenetic risk (OR=4.508, 95% CI 2.733–7.435), leukocyte (OR=7.410, 95% CI 1.139–5.910), and bone marrow blast cells (OR=3.261, 95% CI 1.075–5.615) were independent indictors for age-related prognosis. In addition, Kaplan-Meier curve also revealed that the above factors were associated with overall survival (all p values <0.001).
Conclusion: Cytogenetic risk, leukocyte, and bone marrow blast cells are dominant factors which account for the age-related poor outcomes and shorter overall survival in AML.
Keywords: acute myeloid leukemia, adult, cytogenetic risk, hemocyte, leukemia, overall survival
Sex- and Age-specific Increases in Suicide Attempts by Self-Poisoning in the ...Δρ. Γιώργος K. Κασάπης
There was a more than twofold increase in the rate of suspected self-poisoning suicide cases between 2011 and 2018, according to a new study that looked at more than 1.6 million such cases.
Here’s what else you need to know:
•Overall trends: Cases of suicide attempts by self-poisoning doubled in those aged 10-18 between 2011 and 2018, rising from around 39,000 to more than 78,000.
•Gender: More girls than boys attempted suicide by self-poisoning. The rate of intentional attempts among girls 10-18 also steadily increased from 2011-2018.
•Outcomes: The number of serious outcomes — including death and hospitalizations — as a result of the poisoning increased 235% between 2000 and 2018, and more than 1,400 children died.
Cancer and other noncommunicable diseases (NCDs) arenowwidely recognized as a threat to global development.The latest United Nations high-level meeting on NCDs reaffirmed thisc observation and also highlighted the slow progress in meeting the 2011 Political Declarationon the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting,and budgeting have been identified as major obstacles in achieving these goals. All of these have incommon that they require information on the local cancer epidemiology.
The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Seroprevalence among blood donors is a major public health problem, both in
developed and developing countries, in its magnitude. The aim of this study
was to determine the seroprevalence of hepatitis B in blood donors. This is a
descriptive study carried out in the city of Mbuji-Mayi at the General Hospital
of Dipumba in blood donors (family, volunteer and remunerated) recorded
from 01/to31/December 2016; the data were collected in a transverse fashion.
The following observations were made: During the study period, 1584 blood
donors were registered. After analyzing the data, the seroprevalence of hepatitis
B in blood donors was 2.2%, 77.8% were male (sex ratio M/F 3.5 and voluntary
donors were 50.4%.
This document discusses cancers in Barnet and the UK. It covers several key points:
1) Cancer is the second leading cause of death in Barnet and the UK. There are many types of cancer that impact different organs. Lung, colon/rectum, breast and prostate cancers cause the most deaths in Barnet based on 2004-2007 data.
2) Risk factors for cancer include tobacco use, alcohol intake, diet, obesity and family history. Screening programs have helped reduce cancer mortality through earlier detection.
3) The document examines relationships between cancer rates and socioeconomic factors like deprivation. Lung cancer deaths are higher in more deprived areas while trends for breast and colorectal cancers are less
Stm functional showdeck mockup v2 w refsmonkmartinez
1. The study examined rates of hematopoietic stem cell transplantation (HCT) for leukemia, lymphoma, and multiple myeloma between 1997-2002 using data from the Center for International Blood and Marrow Transplant Registry and SEER cancer registry.
2. It found that Caucasians were more likely than African Americans to receive HCT, including autologous, HLA identical sibling, and unrelated donor HCT.
3. Men were slightly more likely than women to receive HCT overall, but this difference was only significant for autologous HCT.
Cancer Incidence and Survival By Major Ethnic GroupThink Ethnic
This report analyzes cancer incidence and survival rates in England between 2002-2006 by major ethnic group using data from the National Cancer Data Repository, which links cancer registry and hospital data. Some key findings:
1) Overall, non-White ethnic groups had lower cancer incidence than Whites, except for certain cancer sites in specific groups. Asians had higher rates of liver, mouth, and cervical cancers. Black males had higher prostate cancer rates.
2) Black and Asian women had poorer breast cancer survival rates at some ages compared to Whites. Asians had better lung cancer survival. There were no significant differences in colorectal cancer survival.
3) Data limitations included 24% of patients lacking ethnicity data and small
Anemia is a common condition of cancer patients. This is because cancers cause inflammation that decrease red blood cell production. In addition, many chemotherapies are myelosuppressive, meaning they slow down the production of new blood cells by the bone marrow.
Drug Repurposing: Recent Advancements, Challenges, and Future Therapeutics fo...JohnJulie1
Cancer is a prime public health burden that accounts for approximately 9.9 million deaths worldwide. Despite recent advances in treatment regimen and huge capital investment in the pharmaceutical sector, there has been little success in improving the chances of survival of cancer patients.
Abnormal Sodium and Chlorine Level Is Associated With Prognosis of Lung Cance...JohnJulie1
The imbalance of sodium and chloride ions occurs frequently in patients with lung cancer. However, the correlation between ion concentration change and patients prognosis have not been studied thoroughly. Our research will fill the gap, especially for high ion concentration.
Diagnostic Accuracy of Raised Platelet to Lymphocyte Ratio in Predicting Heli...JohnJulie1
Helicobacter Pylori (HP) infection is prevalent among patients with dyspepsia in developing countries with low socioeconomic status. The gold standard investigation is invasive method gastric biopsy through upper GI endoscopy, however non-invasive methods (stool for HP antigen) are not reliable up to the mark also need to wait for two weeks without symptomatic treatment. It is important to have a reliable, cost effective and easily accessible non-invasive marker to diagnose patients with H. pylori infection. Several non-invasive laboratory have been predicted in having the role in diagnosis of H.pylori infection. Therefore, the aim of our study was to determine the diagnostic accuracy of platelet to lymphocyte ratio in predicting H.Pylori infection in patients with dyspepsia.
IRF5 Promotes the Progression of Hepatocellular Carcinoma and is Regulated by...JohnJulie1
The IRF family of proteins involves in the tumor progression. However, but the functions of IRF5 in the tumorigenesis are largely unknown. Here, IRF5 was found to be up-regulated in hepatocellular carcinoma (HCC). Interfering with IRF5 inhibited the growth and tumorigenic ability of HCC cells.
•
Fibrous
•
Fibro glandular
•
Adipose (Fatty)
What is Tomosynthesis?
•
Is a 3 dimensional projection
•
Reduces overlapping tissue seen with 2D only
•
15 projections are taken with each combo exposure (7.5) (-7.5)
•
With an average breast (18*24) 3D dose is 1.34, combo is 2.56 Milligrey. (3 Milligrey FDA) (2D is 1.2
Alterations of Gut Microbiota From Colorectal Adenoma to CarcinomaJohnJulie1
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers.
Contextual Factors Associated with Health-Related Quality of Life in Older Ad...semualkaira
The purpose of this study was to examine contextual
factors associated with physical and mental health-related quality
of life (HRQOL) in older adult cancer survivors.
It's great to hear that presumably the Asian Journal of Agricultural Sciences and Veterinary Medicine hopes to facilitate research and development in the fields of Agricultural Sciences and Veterinary Medicine through its journal publications of the scopus database journal.
Indo-American Journal of Agricultural and Veterinary Sciences". It appears to be an international online journal that publishes research and review articles in English on topics related to agriculture and veterinary sciences is the journal of the journal papers
1. The document discusses several cases involving the use of demographic indices and statistical methods to analyze mortality data. These include calculating standardized mortality ratios to compare mortality rates between populations while adjusting for differences in age structure.
2. Indirect standardization is used in one case to compare the mortality of the Colombian department of Vichada to the overall mortality in Colombia using age-specific mortality rates.
3. Another case examines mortality trends among foundry workers using standardized mortality ratios and discusses methods to address potential biases from issues like loss to follow up.
This document summarizes key points from a workshop on cancers that commonly affect adolescents and young adults (AYA).
1) Outcomes for AYA patients with acute lymphoblastic leukemia, breast cancer, and colon cancer have improved less than for pediatric or older adult patients. One reason may be that the biology of these cancers differs between AYA and other age groups.
2) For AYA acute lymphoblastic leukemia, outcomes are poorer than in children and the disease appears to be biologically distinct, with differences in genetic abnormalities. New research is identifying additional high-risk subtypes in this population.
3) Studies of AYA breast and colon cancers are also finding these diseases to be more aggressive and
This document describes a study that uses a Markov chain Monte Carlo simulation to model the rising incidence of Type II diabetes in youth ages 15-20 in the United States. The study aims to identify risk factors contributing to the rise and understand the impact on dependency ratios. Aggregate data from various sources was used to simulate disease progression and estimate covariates. The model is expected to help reformulate dependency ratios by accounting for the effects of morbidity on labor participation.
Objective: The prognostic indictors of age-related poor outcomes in patients with acute myeloid leukemia (AML) are still controversial. The aim of this work was to provide comprehensive insights into the effect of different hemocytes and to investigate the association between age and clinical features in adult patients with AML.
Study Design: A retrospective study was performed to determine the role of age in the therapeutic outcomes of AML. A total of 166 newly diagnosed adult patients’ data from January 2015 to November 2019 in Zhongshan Hospital of Xiamen University were collected and analyzed.
Results: Older patients presented a poorer prognosis (p=0.001) with shorter overall survival, which is served as age-related outcomes. Binary logistic regression demonstrated that cytogenetic risk (OR=4.508, 95% CI 2.733–7.435), leukocyte (OR=7.410, 95% CI 1.139–5.910), and bone marrow blast cells (OR=3.261, 95% CI 1.075–5.615) were independent indictors for age-related prognosis. In addition, Kaplan-Meier curve also revealed that the above factors were associated with overall survival (all p values <0.001).
Conclusion: Cytogenetic risk, leukocyte, and bone marrow blast cells are dominant factors which account for the age-related poor outcomes and shorter overall survival in AML.
Keywords: acute myeloid leukemia, adult, cytogenetic risk, hemocyte, leukemia, overall survival
Sex- and Age-specific Increases in Suicide Attempts by Self-Poisoning in the ...Δρ. Γιώργος K. Κασάπης
There was a more than twofold increase in the rate of suspected self-poisoning suicide cases between 2011 and 2018, according to a new study that looked at more than 1.6 million such cases.
Here’s what else you need to know:
•Overall trends: Cases of suicide attempts by self-poisoning doubled in those aged 10-18 between 2011 and 2018, rising from around 39,000 to more than 78,000.
•Gender: More girls than boys attempted suicide by self-poisoning. The rate of intentional attempts among girls 10-18 also steadily increased from 2011-2018.
•Outcomes: The number of serious outcomes — including death and hospitalizations — as a result of the poisoning increased 235% between 2000 and 2018, and more than 1,400 children died.
Cancer and other noncommunicable diseases (NCDs) arenowwidely recognized as a threat to global development.The latest United Nations high-level meeting on NCDs reaffirmed thisc observation and also highlighted the slow progress in meeting the 2011 Political Declarationon the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting,and budgeting have been identified as major obstacles in achieving these goals. All of these have incommon that they require information on the local cancer epidemiology.
The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Seroprevalence among blood donors is a major public health problem, both in
developed and developing countries, in its magnitude. The aim of this study
was to determine the seroprevalence of hepatitis B in blood donors. This is a
descriptive study carried out in the city of Mbuji-Mayi at the General Hospital
of Dipumba in blood donors (family, volunteer and remunerated) recorded
from 01/to31/December 2016; the data were collected in a transverse fashion.
The following observations were made: During the study period, 1584 blood
donors were registered. After analyzing the data, the seroprevalence of hepatitis
B in blood donors was 2.2%, 77.8% were male (sex ratio M/F 3.5 and voluntary
donors were 50.4%.
This document discusses cancers in Barnet and the UK. It covers several key points:
1) Cancer is the second leading cause of death in Barnet and the UK. There are many types of cancer that impact different organs. Lung, colon/rectum, breast and prostate cancers cause the most deaths in Barnet based on 2004-2007 data.
2) Risk factors for cancer include tobacco use, alcohol intake, diet, obesity and family history. Screening programs have helped reduce cancer mortality through earlier detection.
3) The document examines relationships between cancer rates and socioeconomic factors like deprivation. Lung cancer deaths are higher in more deprived areas while trends for breast and colorectal cancers are less
Stm functional showdeck mockup v2 w refsmonkmartinez
1. The study examined rates of hematopoietic stem cell transplantation (HCT) for leukemia, lymphoma, and multiple myeloma between 1997-2002 using data from the Center for International Blood and Marrow Transplant Registry and SEER cancer registry.
2. It found that Caucasians were more likely than African Americans to receive HCT, including autologous, HLA identical sibling, and unrelated donor HCT.
3. Men were slightly more likely than women to receive HCT overall, but this difference was only significant for autologous HCT.
Cancer Incidence and Survival By Major Ethnic GroupThink Ethnic
This report analyzes cancer incidence and survival rates in England between 2002-2006 by major ethnic group using data from the National Cancer Data Repository, which links cancer registry and hospital data. Some key findings:
1) Overall, non-White ethnic groups had lower cancer incidence than Whites, except for certain cancer sites in specific groups. Asians had higher rates of liver, mouth, and cervical cancers. Black males had higher prostate cancer rates.
2) Black and Asian women had poorer breast cancer survival rates at some ages compared to Whites. Asians had better lung cancer survival. There were no significant differences in colorectal cancer survival.
3) Data limitations included 24% of patients lacking ethnicity data and small
Anemia is a common condition of cancer patients. This is because cancers cause inflammation that decrease red blood cell production. In addition, many chemotherapies are myelosuppressive, meaning they slow down the production of new blood cells by the bone marrow.
Drug Repurposing: Recent Advancements, Challenges, and Future Therapeutics fo...JohnJulie1
Cancer is a prime public health burden that accounts for approximately 9.9 million deaths worldwide. Despite recent advances in treatment regimen and huge capital investment in the pharmaceutical sector, there has been little success in improving the chances of survival of cancer patients.
Abnormal Sodium and Chlorine Level Is Associated With Prognosis of Lung Cance...JohnJulie1
The imbalance of sodium and chloride ions occurs frequently in patients with lung cancer. However, the correlation between ion concentration change and patients prognosis have not been studied thoroughly. Our research will fill the gap, especially for high ion concentration.
Diagnostic Accuracy of Raised Platelet to Lymphocyte Ratio in Predicting Heli...JohnJulie1
Helicobacter Pylori (HP) infection is prevalent among patients with dyspepsia in developing countries with low socioeconomic status. The gold standard investigation is invasive method gastric biopsy through upper GI endoscopy, however non-invasive methods (stool for HP antigen) are not reliable up to the mark also need to wait for two weeks without symptomatic treatment. It is important to have a reliable, cost effective and easily accessible non-invasive marker to diagnose patients with H. pylori infection. Several non-invasive laboratory have been predicted in having the role in diagnosis of H.pylori infection. Therefore, the aim of our study was to determine the diagnostic accuracy of platelet to lymphocyte ratio in predicting H.Pylori infection in patients with dyspepsia.
IRF5 Promotes the Progression of Hepatocellular Carcinoma and is Regulated by...JohnJulie1
The IRF family of proteins involves in the tumor progression. However, but the functions of IRF5 in the tumorigenesis are largely unknown. Here, IRF5 was found to be up-regulated in hepatocellular carcinoma (HCC). Interfering with IRF5 inhibited the growth and tumorigenic ability of HCC cells.
•
Fibrous
•
Fibro glandular
•
Adipose (Fatty)
What is Tomosynthesis?
•
Is a 3 dimensional projection
•
Reduces overlapping tissue seen with 2D only
•
15 projections are taken with each combo exposure (7.5) (-7.5)
•
With an average breast (18*24) 3D dose is 1.34, combo is 2.56 Milligrey. (3 Milligrey FDA) (2D is 1.2
Alterations of Gut Microbiota From Colorectal Adenoma to CarcinomaJohnJulie1
Gut microbiota has been implicated as a critical role in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). However, few basic research has revealed the association between gut microbiota and the development of CRA and CRC. We aim to compare the diversity and composition of intestinal flora in CRA and CRC patients, to reveal the changes of intestinal microorganism in the evolution of normal intestinal mucosa-CRA-CRC axis, and to explore potential biomarkers.
Prognosis of Invasive Micropapillary Carcinoma of the Breast Analyzed by Usin...JohnJulie1
Invasive micropapillary carcinoma (IMPC) is a rare type of breast cancer with high frequency of regional lymph node metastasis. However, the prognosis of IMPC has remained controversial for decades. We aimed to compare the differences of prognosis between IMPC and Invasive ductal carcinoma(IDC) of the breast by utilizing Surveillance, Epidemiology, and End Results (SEER) database.
Uretero-Enteric Anastomosis Stricture after Urinary Diversion; Detailed Analy...JohnJulie1
To report the lessons we have learned in the management of uretero-enteric anastomosis stricture (UEAS) in a tertiary urology center over a decade of experience.
Clinic Correlation and Prognostic Value of P4HB and GRP78 Expression in Gastr...JohnJulie1
Prolyl 4-hydroxylase, beta polypeptide (P4HB) and Glucose‑regulated protein 78 (GRP78) represent for poor prognosis of various cancers, while rare research investigate correlation of them. This study aimed to explore correlation and prognostic value of them in gastric cancer (GC).
Combined Analysis of Micro RNA and Proteomic Profiles and Interactions in Pat...JohnJulie1
Liquid Chromatography Tandem Mass Spectrometry
The Liquid Mass System(LMS) includes an Easy nLC1000 (Thermo Fisher) coupled ultra-high resolution mass spectrometer Orbitrap Fusion Lumos (Thermo Fisher) with a Thermo Fisher electrospray source. Each injection is sent to a preset column (Acclaim PepMap C18, 100 μm x 2 cm, Thermo Scientific) for adsorption at a flow rate of 3 L/min. The sample is then sent to the analyzer column (Acclaim PepMap C18, 75 μm x 15 cm, Thermo Scientific) for separation.
Skeletal muscle channelopathy are rare heterogeneous episodic disorders with marked genotypic and phenotypic variability resulting in periodic paralysis, and falls in young people which often misdiagnosed or undiagnosed due to its rarity, often the symptoms are miscommunicated to the treating phycision due to its episodic nature and not uncommonly physical examination by the time patient attend the clinic or hospital will be unremarkable apart from periodic muscle paralysis where patient will presented to ED with flaccid weakness,
The Use of the Infrared Laser Therapy of 890-910 NM for the Treatment Breast ...JohnJulie1
The document summarizes experimental and clinical research on using infrared laser therapy between 890-910 nm to treat breast cancer. Experimental studies showed that lower doses of laser therapy (0.46 J/cm2) inhibited tumor growth more than higher doses. Laser therapy combined with chemotherapy was also effective, particularly with vincristin. Clinical studies on 136 breast cancer patients found that laser therapy before or after surgery, or alone, reduced complications, improved immune function and quality of life, and increased survival time. Histological analysis found over 50% tumor tissue disappeared after effective laser treatment.
Prevalence of Hpv Infection in the Lekoumou and Niari Departments (Congo Braz...JohnJulie1
This study aimed to determine the prevalence of HPV infection in women in the Lekoumou and Niari departments of Congo Brazzaville. The researchers collected samples from 100 women aged 16-73 and tested them for HPV. They found an overall HPV prevalence of 29%. Certain demographic factors like age, education level, marital status, age of first intercourse, number of sexual partners and parity did not show statistically significant associations with HPV infection status. The study provides baseline data on HPV prevalence in the region that can inform future cervical cancer prevention efforts.
Upper Rectal Cancer: Benefit After Preoperative Chemoradiation Versus Upfront...JohnJulie1
Upper rectal cancer management is controversial. The present series reports the outcomes of treatment comparing neoadjuvant chemoradiation (NCRT) versus upfront surgery.
Follow-Up Strategies in Focal Liver Lesions And Treatment MethodsJohnJulie1
Today, advances in cross-sectional imaging have led to the detection and early recognition of incidental/focal liver lesions (FCL). In approximately 17,000 cases of chest CT, incidental liver lesions were found in 6% [1]. In general, FCL consists of hepatocytes, biliary epithelium, mesenchymal tissue, connective tissue, or metastasized cells from distant sites. Most incidental lesions are benign, some may require careful management and treatment.
Pancreatic Adenocarcinoma with Isolated Venous Involvement: Is Neoadjuvant Tr...JohnJulie1
Neoadjuvant Treatment (NAT) is indicated in locally advanced tumors and improves the results of subsequent surgery. In borderline tumors, the place of this preoperative treatment is more controversial, probably because borderline tumors are a heterogeneous group. We focused on the tumors with venous involvement without any arterial involvement and studied the results of neoadjuvant treatment in this particular group.
Predictive Value of Biomarkers Fibrinogen Like Protein-2 and A-Fetoprotein fo...JohnJulie1
Data concerning the utility of biomarkers for accurate early HCC detection in cirrhotic patients are lacking. 1.2. Methods: We evaluated 112 consecutive Caucasian cirrhotic patients with (n=28) or without (n=84) concomitant HCC at baseline for serum AFP and plasma fibrinogen like protein-2 (FGL-2) levels. Patients without confirmed HCC at baseline were further followed up every six months with ultrasound and serum AFP levels, according to HCC surveillance program. Imaging as well as histological confirmation of HCC was established in patients with new lesions.
The Black Fungus is One of the Bad Consequences of COVID 19JohnJulie1
This document discusses the black fungus (mucormycosis) infection that has emerged as a consequence of the COVID-19 pandemic. It describes how steroid treatments for COVID-19 can weaken the immune system and allow mucormycosis to take hold, especially in diabetic or immunocompromised patients. The main types and symptoms of mucormycosis are outlined. Diagnosis involves microscopy and imaging exams, while treatment requires antifungal drugs and sometimes surgical removal of infected tissues to prevent spread. A relationship between COVID-19, diabetes, and the increased risk of contracting mucormycosis is presented.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
Hiranandani Hospital in Powai, Mumbai, is a premier healthcare institution that has been serving the community with exceptional medical care since its establishment. As a part of the renowned Hiranandani Group, the hospital is committed to delivering world-class healthcare services across a wide range of specialties, including kidney transplantation. With its state-of-the-art facilities, advanced medical technology, and a team of highly skilled healthcare professionals, Hiranandani Hospital has earned a reputation as a trusted name in the healthcare industry. The hospital's patient-centric approach, coupled with its focus on innovation and excellence, ensures that patients receive the highest standard of care in a compassionate and supportive environment.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
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1. Clinics of Oncology
ISSN: 2640-1037
Research Article
Marital Status and Survival in Patients with Multiple Myeloma:
The Role of Marriage in the Management of Multiple Myeloma
Islam MS1*
, Lee C2
, Kim J3
, Enright R4
and Kotoucek P5
1
Department of Hematology, Queen Elizabeth Hospital and Guy’s Hospital, London, SE18 4QH, UK
2
Examinations, National Council of State Boards of Nursing, 111 E Upper Wacker Dr Suite 2900, Chicago, IL 60601, USA
3
Department of Psychology, Liberty University, Lynchburg, VA 24515, USA
4
University of Wisconsin-Madison and International Forgiveness Institute, Inc., Madison, WI
5
Department of Hematology, Broomfield Hospital, Court Road, Chelmsford, CM1 7LE, UK
Volume 2 Issue 3- 2019
Received Date: 30 Nov 2019
Accepted Date: 16 Dec 2019
Published Date: 26 Dec 2019
2. Keywords
Myeloma, Marriage, Survival,
Psychosocial
1. Abstract
Despite better understanding of Multiple Myeloma (MM) and the development of novel therapeutic
strategies which improved overall survival, MM still remain largely incurable. This warrants a
better understanding of socio-demographic factors that may influence disease course and outcomes
across MM patient. Positive influence of marital status is well established for many solid and liquid
cancers. However, limited literature is available showing its influence on MM patients. Surveillance,
EpidemiologyandEndResultsprogramme(SEER)datawasusedtoidentifytotal29,507MMpatients
diagnosed in 2011 through 2015 and 16,519 patients who had symptomatic MM and their clinical
and follow-up information available were analysed. The outcome variable was the survival time from
diagnosis to death due to myeloma. On mixed effects Cox regression for myeloma-specific mortality,
there was a significant interaction between marital status and sex at the nominal significance level
(α) of 0.01. Holding demographic covariates age, income, education, race, and residence at a fixed
value, the hazard ratio (HR) of myeloma-specific mortality for married male patients over the HR
for married female patients was about 18% lower. In addition, younger age, high income, African-
American patients were less likely to die of myeloma. Further analysis indicated that patients
who were unmarried, widowed or divorced, were at significantly greater risk of myeloma-specific
mortality after being adjusted for the demographic covariates (p< 0.01). Our analysis supports the
positive effect of marriage on the outcome of MM patients. The effect of strengthening psychosocial
support should be investigated as supplementary treatment for MM patients.
*Corresponding Author (s): Md Serajul Islam, Department of Hematology, Queen Eliz-
abeth Hospital and Guy’s Hospital, London SE18 4QH, UK, E-mail: serajul@doctors.
org.uk
clinicsofoncology.com
Citation: Islam MS, Marital Status and Survival in Patients with Multiple Myeloma: The Role of Marriage
in the Management of Multiple Myeloma. Clinics of Oncology. 2019; 2(3): 1-8
3. Introduction
Multiple myeloma (MM) accounts for 1% and 10% of all cancers
and of all hematologic malignancies respectively [1]. Each year
over 30,000 new MM cases are diagnosed in the United States,
and over 12,000 patient’s die of the disease [2]. The median age
of diagnosis is about 65 years [3]. MM is currently an incurable
condition. Introduction of several novel anti-myeloma drugs over
the last decade has improved the survival of MM patients; however,
MM still remains largely incurable. Survival estimates in MM
vary based on the source of the data. Data from trials using novel
therapies show that the median survival in MM is approximately
6years [4]. In the subset of patients eligible for autologous stem
cell transplant (ASCT), the median overall survival (OS) is
approximately 8 years [5]. Among elderly patients (age >75years),
median OS is lower, and is approximately 5 years [6].Evidence also
suggests greater improvements in OS among white individuals
3. income, education, and survival months, than unmarried patients.
As shown in (Table 2), all the mean differences of age, income,
education, and survival months between married and unmarried
patients were statistically significant. However, their effect sizes
were small according to the criteria suggested by Cohen [20]. For
the marital status, a plot of survival curves using Kaplan-Meier
method [21] is in (Figure 1a). The dark grey curve is for married
patients and the light grey curve is for unmarried patients. The
dotted line represents the median survival probability (0.5). The
survival curves indicated that the married patients had higher
survival probability than the unmarried patients. The survival
probability of 0.5 for the unmarried patients reached at about 53rd
month. Married patients were more likely to be male or white. Most
of patients in the data were urban situated. During five years from
2011 to 2015, the percentages of patients diagnosed with myeloma
between married and unmarried patients were quite similar
one another. Married patients were more likely to be alive than
unmarried patients. The χ2
test showed that sex, race, and mortality
had a strong relationship with marital status while residence and
year of diagnosis did not (Table 2).
On mixed effects Cox regression for MM mortality, there was
a significant interaction between marital status and sex at the
nominal significance level (α) of 0.01. Holding the other covariates,
such as age, income, education, race, and residence at a fixed value,
the hazard ratio of MM mortality for married female patients over
the hazard ratio for married male was about 18% higher. In other
words, male patients benefitted more from marriage than did
female patients. In contrast, female patients who were not married
benefitted more than male patients who were not married. In
addition to the male married patients, younger patients, or patients
who had a higher income or were African American were less
likely to die of MM. The output of the mixed effects Cox regression
is described in (Table 3a).
The associations between subgroups of unmarried patients and the
myeloma mortality were also investigated. (Table 3b) summarizes
the adjusted hazard ratio, the 95% confidence interval (CI), and the
p value, for each subgroup of unmarried patients after adjusting
for demographics. All the subgroups of unmarried patents,
except separated patients, were at significantly greater risk of MM
mortality. For example, patients who were never married showed
the highest hazard ratio, about 52% higher, than patients who were
married, followed by patients who were widowed and divorced,
with 46% and 39% higher, respectively. (Figure 1b) depicted the
density of married patients and three subgroup unmarried patients
over predicted probability of myeloma mortality. The distribution
of married patients lied in the lowest probability while the widowed
patients lied in the highest probability.
7. Discussion
Adhering to the vow, “Til death do us part,” may be health
promoting. Among individuals who are well and among patients
who are suffering a wide array of illnesses, marriage is often
Figure 1a: Survival curves (Kaplan-Meier curves) for Marital Status
clinicsofoncology.com 3
Figure 1b: Density plots of Predicted Probability of Myeloma Mortality
Volume 2 Issue 3 -2019 Research Article
4. associated with longer life and better quality of life [22]. The
aim of this study was to investigate the impact of marital status
on the survival of MM patients. Our results demonstrated that
married patients had better survival compared with unmarried
patients. These findings remained significant after controlling for
demographic variables.
Studies assessing the impact of marital status on disease specific
survival among cancer patients showed conflicting results, with
protective [23,24], mixed, [25] and non-significant, [26] effects.
Very little literature is available about the effect on marriage on
the survival of MM. None of these above studies has examined
the effect of marriage on the outcome of MM treatment and its
survival. National Institutes of Health/National Cancer Institute
spends approximately $5 billion per annum [27]on cancer research
focused mainly on biologic investigations. However, our study
suggests that targeted psychosocial support interventions could
prove to be a cost-effective method of improving survival among
patients with myeloma.
Previous studies among cancer patients showed associations
between marital status and improved outcomes [15,28] An
explanation for the relationship is that marriage is a source of
social support. Spouses may encourage their partners to take
cancer screening, support to complete recommended treatment,
and receive more intensive therapy. Numerous published studies
have observed that unmarried patients are at significantly higher
risk of late stage diagnosis, suboptimal treatment, and cancer death
[15]. We found that unmarried patients, including those who are
never married, are at significantly greater risk of death resulting
from MM than patients who are married. It may be because
married people seek medical attention earlier due the possible
clinicsofoncology.com 4
Characteristic
Unmarried Married
(n = 6,443) (n = 10,076)
No. % No. %
Age, years
Mean 67.1 65.8
SD 13.1 11.3
Income, USD*
Mean 58,519.8 60,227.7
SD 15,185.2 15,439.8
Percent that completed high school*
Mean 85.0 85.4
SD 6.0 6.1
Survival months
Mean 19.2 21.7
SD 16.6 16.7
Sex
Male 2,694 41.8 6,375 63.3
Female 3,749 58.2 3,701 36.7
Race
White 3,357 52.1 6,545 65
African American 1,921 29.8 1,451 14.4
Native American 40 0.6 48 0.5
Asian 285 4.4 738 7.3
Hispanic 840 13.1 1,294 12.8
Residence*
Rural 72 1.1 138 1.4
Urban 6,371 98.9 9,938 98.6
Year diagnosis
2011 1,147 17.8 1,732 17.2
2012 1,241 19.3 1,935 19.2
2013 1,295 20.1 2,021 20.1
2014 1,310 20.3 2,121 21.1
2015 1,450 22.5 2,267 22.5
Mortality
Alive (Censored) 4,316 67.0 7,585 75.3
Dead (Myeloma) 2,127 33.0 2,491 24.7
* County-level data
Table 1: Demographic Statistics
t-test
Mean
Difference
95% CI of the
Difference
Pr
(2-tailed)
Effect
Size*
Age, years 1.371 0.981 to 1.760 < 0.001 0.114
Income, USD -1,707.83
-2,185.751 to
-1,229.911
< 0.001 0.112
Percent that completed high
school
-0.460 -0.650 to -0.270 < 0.001 0.076
Survival months -2.451 -2.972 to -1.930 < 0.001 0.147
Chi-squared (χ2) test χ2 Statistics df Pr
Sex 729.900 1 < 0.001
Race 620.800 4 < 0.001
Residence 1.794 1 0.180
Year diagnosis 1.832 4 0.767
Mortality 133.700 1 < 0.001
Table 2: Comparison between the married and unmarried patients
Volume 2 Issue 3 -2019 Research Article
5. encouragement by their spouses and have an early diagnosis
and early appropriate treatment. Spouses also may encourage
patients to undergo definitive versus expectant management [29],
potentially accounting for the discrepancies in the survival. There
are many explanations for the vital question of why marriage is
associated with improved cancer-specific survival after adjustment
for demographics, stage, and treatment, but the most likely reason
is that married patients have better adherence with prescribed
treatments than unmarried patients [30].
Psychologically, cancer diagnosis usually results in more distress
than other diagnoses [31]. Married patients display less distress,
depression, and anxiety than their unmarried counterparts
after cancer diagnosis, this may be because a partner shares the
emotional burden and provide appropriate psychological support
[32]. Labile psychological state can lead to poor adherence to
treatment and as a consequence poor outcome. A study showed
that women with depression who are diagnosed with breast cancer
undergo definitive treatment less often, hence poorer survival [33].
Treating healthcare professionals should consider screening for
psychological health among unmarried patients with MM and refer
patients to mental health specialists if symptoms are identified.
In addition, physicians should consider closer observation of
unmarried patients with MM to maximize adherence.
One study has shown that cortisol levels to be lower in patients
with cancer who have adequate support networks. A diurnal
cortisol patterns have been linked with natural-killer cell count
and survival in cancer patients [34], providing a physiological
basis for the psychologically data. Hence the married MM patient
may have shown survival advantage in our study. If the benefits
of marriage on MM survival are mediated through spousal
psychosocial support, then the most effective way to combat the
increased risks associated with unmarried MM patients would
be to aggressively promote support mechanisms. A randomized
controlled trial revealed that a psychosocial support-based
intervention was associated with a near doubling of overall survival
among advanced metastatic breast cancer patients [35]. Similar
effect was shown among metastatic non–small-cell lung cancer
that early implementation of supportive measures/palliative care
along with standard oncologic care improved the median survival
of patients relative to standard oncologic care alone [36].This may
again explain why married MM patient has better survival in our
study in compare to their unmarried counterpart as the married
patients had better support system.
Our study shows a clear protective effect of marriage among
myeloma patients. Interestingly, the impact of marriage specific
mortality seemed to be greater in men than in women in our study.
The exact reasons for this will need to be explored further, but it
could, for example, reflect that unmarried women receive greater
psychosocial support from their relatives (e.g. their own children),
clinicsofoncology.com 5
Random effects
Group Variable Std Dev Variance
County Intercept 0.055126838 0.003038968
Estimate HR
Std.
Error
z value Pr ( >|z|)
Married -0.448 0.639 0.042 -10.690 0.00E+00 ***
Age 0.047 1.048 0.001 34.290 0.00E+00 ***
Income 0.000 1.000 0.000 -5.640 1.70E-08 ***
Education -0.002 0.998 0.003 -0.530 0.590000
Female -0.225 0.798 0.044 -5.070 4.10E-07 ***
African
American
-0.138 0.871 0.041 -3.390 0.000710 ***
Native
American
-0.106 0.899 0.202 -0.530 0.600000
Asian 0.010 1.01 0.067 0.150 0.880000
Hispanic 0.048 1.049 0.049 0.980 0.330000
Rural -0.071 0.931 0.125 -0.570 0.570000
Married x
Female
0.163 1.177 0.061 2.650 0.008000 **
Signif. Codes: 0 ‘***’ 0.001 ‘**’ 0.01
Table 3a: Estimate and Hazard Ratio from the Mixed Effects Cox Regression
Note. HR refers to Hazard Ratio.
HR 95% CI Pr (>|z|)
Married Reference Group -
Never Married 1.517 1.392 to 1.654 0.00E++ ***
Separated 1.071 0.791 to 1.450 0.66
Divorced 1.386 1.250 to 1.537 5.30E-10 ***
Widowed 1.464 1.346 to 1.592 0.00E++ ***
Table 3b: Association between subgroups of unmarried patients and the myeloma
mortality
Volume 2 Issue 3 -2019 Research Article
6. should be considered for better outcomes for unmarried MM
patients, who are at greater risk. Some roles of marriage in the
management of multiple myeloma are not included in statistics like
the story of a lawyer who was the wife and caregiver of her husband
a consultant cardiologist who was a patient with myeloma. She
convinced scientists in Harvard University and the clinician in
UAMS hospital to use Thalidomide in treatment of myeloma [39].
In her desperate effort she inspired an international research on
immunomodulatory drugs in myeloma, nowadays a back bone of
any treatment regimes.
8. Conclusion
Findings from our analysis support the positive effect of marriage
on the survival of multiple myeloma patients. Psychological distress
among cancer patients is enormous. Unmarried MM patients (i.e.
divorced, widowed and never married) often lack adequate support
network to cope with such distress. Given the potential benefits
of psychological and social support via marriage linked to the
greater survival of MM patients, the effects of adding empirically
supported interventions such as Forgiveness Therapy [40] to the
regular treatment regimen should be further investigated.
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