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This certificate was awarded to Soham Pal for completing the Common Purpose Global Leader Experience program in Bristol, England in April 2015. The certificate recognizes Soham Pal's participation in and completion of the Common Purpose Global Leader Experience program held in Bristol, England.
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Natural compounds from the bark of the cinchona tree, most notably quinine was observed to exhibit antimalarial activity.
Until the development of synthetic derivatives (ie. 4-aminoquinoline antimalarials), quinine continued to be the first choice to treat malaria.
Quinine is associated with side effects such as diarrhœa.
4-aminoquinoline antimalarials such as amodiaquine and chloroquine largely replaced quinine because of reduced unpleasant side effects.
The life cycle of the parasite and the immunological defence mechanisms against the parasite are complex.
Part of the parasite’s life cycle involves invasion of red blood cells (erythrocytes).
The haemoglobin within the red blood cell is broken down by the parasite and is used as a source of amino acids.
The 4-aminoquinolines act at the erythrocytic stage of the parasite.
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common purpose
- 1. / '~Q...I.-l- ccrnmonpurpo / This certificate is awarded to: Soham Pal on completion of the Common Purpose Global Leader Experience, Bristol April ~015