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Calcium Channel Blockers (ZEM)
Pharmacodynamics:
 ↓ contractility force => ↓ BP
 ↓ electrical contractility => ↓ heart
rate
Indications:
 Angina Pectoris
 Hypertension
 Dysrhythmias
Common brands:
 NP: Verapamil
 NP: Diltiazem
 Istin (amlodipine)
 Dilzem (diltiazem)
 Adizem (diltiazem)
 Zemtard (diltiazem)
 Cardene (nicardipine hydrochloride)
 Adalat (nifedipine)
S/Es:
 N&V
 Facial flushing
 Headaches
 Ankle oedema
 Constipation
Cardiac Glycosides (OXIN)
Pharmacodynamics:
 ↓ conductivity in AV node
 ↑ myocardial contractility
Indications:
 CCF
 SVT
 A Fib
Common brands:
 NP: Digoxin
 NP: Digitoxin
 Lanoxin (digoxin)
S/Es:
 N&V; Diarrhoea
 Abdo pain
 Headache
 Fatigue, drowsiness
 Confusion
 Dysrhythmias
Beta Blockers (LOL)
Pharmacodynamics:
 Block β-adrenoreceptors => ↓ heart
rate, ↓ BP
Indications:
 Hypertension
 Angina Pectoris
 Post-MI
Common Brands:
 NP: Propanolol
 NP: Atenolol
 NP: Sotalol
 Inderal: (propanolol)
 Emcor (bisoprolol)
 Eucardic (carvedilol)
 Nebilet (nebivolol)
 Beta-Cardone (sotalol)
S/Es:
 Breathlessness, wheeze
 Cold extremities
 Ankle oedema
 Tiredness, dizziness
C/I: Asthma
Loop Diuretics (IDE)
Pharmacodynamics:
 ↓ reabsorption from ascending limb
of Loop of Henle
Indications:
 CCF
 Left ventricular failure
 Pulmonary Oedema
Common brands:
 NP: Furosemide
 Lasix (furosemide)
 Burinex (bumetanide)
S/Es:
 Hypotension
 N&V, GIT disturbance
 Hyponatraemia
 Hypokalemia
 Hypomagnesemia
Thrombolytics (PLASE)
Pharmacodynamics:
 ↑ plasmin
 ↓ fibrin
Indications:
 MI (esp. ST segment ↑)
 DVT
 Pulmonary embolism
Common brands:
 NP: rt-PA (alteplase)
 NP: streptokinase
 Rapilysin (reteplase)
 Streptase (streptokinase)
 Metalyse (tenecteplase)
S/Es:
 N&V
 Bleeding
 Dysrhythmias
 Hypotension
 Rash, flushing
Anti-arrhythmics (ARONE)
Pharmacodynamics:
 ↓ conductivity in AV node
 ↑ myocardial contractility
Indications:
 Supraventricular and ventricular
arrhythmias
 Cardiac arrest (VF/VT)
Common brands:
 NP: Amiodarone
 Cordarone X
S/Es:
 Peripheral neuropathy
 Bradycardia
 N&V (rare)
 Metallic taste
 Hot flushes, dizziness
C/Is:
 Pregnancy
 Hypotension
 Breastfeeding
Nitrates (NITRATE)
Pharmacodynamics:
 Coronary vasodilation
 Reduction in venous return to heart
Indications:
 Angina Pectoris
 LVF
Common brands:
 NP: Glyceryl Trinitrate
 Glytrin (Glyceryl Trinitrate)
 Angitak (Isosorbide Trinitrate)
 Nitrocine (Glyceryl Trinitrate)
 TransidermNitro (Glyceryl Trinitrate)
S/Es:
 Hot flushes, dizziness
 Tachycardia
 Hypotension
 Headache
C/Is: hypotension, cardiac tamponade,
anaemia
Antiplatelet Drugs
Pharmacodynamics:
 decrease platelet aggregation
 inhibit thrombus formation
Indications:
 prevention of ischaemic events
 prophylaxis of thromboembolism
Common brands:
 NP: Aspirin
 NP: Clopidogrel
 Nu-Seals 75 (aspirin)
 Caprin (aspirin)
 Plavix (clopidogrel)
S/Es:
 Aspirin: bronchospasm, GI bleeding
 Clopidogrel: dyspepsia, abdo pain,
N&V, constipation, gastritis,
diarrhoea, GI bleeding
C/Is:
 Aspirin: U-16, breastfeeding, GI
ulceration, haemophilia
 Clopidogrel: Active bleeding,
breastfeeding
ACE Inhibitors (PRIL)
Pharmacodynamics:
 inhibit angiotensin I > II conversion
 antihypertensive
Indications:
 Heart failure
 Hypertension
Common brands:
 NP: captopril
 Zestril (lisinopril)
 Coversyl (perindopril)
 Tritzce (ramipril)
S/Es:
 Arrhythmias, angina, chest pain,
syncope, CVA, MI, hypotension
 Dry mouth, loss of appetite, skin
reactions, confusion, depression
 Anxiety, impotence, flushing, N&V
C/Is:
 Renal impairment
 Pregnancy
Alpha adrenoreceptor blockers (SIN)
Pharmacodynamics:
 Block α-adrenoreceptors => ↓ heart
rate, ↓ BP
Indications:
 hypertension
 angina pectoris, post-MI
Common brands:
 Cardura, Cardura XL (doxazosin)
 Hypovase (prazosin)
S/Es:
 Flushes
 N&V, tiredness
 Hypotension
 Dizziness, breathlessness
Proton Pump Inhibitors (ZOLE)
Pharmacodynamics:
 inhibit gastric acid
 block H-K ATP enzyme system
Indications:
 Gastric & duodenal ulcers
 GORD; oesophagitis
 NSAID assoc ulcers
 Dyspepsia
Common brands:
 Nexium (esomeprazole)
 Zoton (lansoprazole)
 NP: Omeprazole
 Losec (omeprazole)
 Protium (pantoprazole)
S/Es:
 N&V, diarrhoea, constipation
 Abdo pain, flatulence, dry mouth
 Dizziness, drowsiness, headache
 Sweating, rash, fever, insomnia

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Common Medications

  • 1. Calcium Channel Blockers (ZEM) Pharmacodynamics:  ↓ contractility force => ↓ BP  ↓ electrical contractility => ↓ heart rate Indications:  Angina Pectoris  Hypertension  Dysrhythmias Common brands:  NP: Verapamil  NP: Diltiazem  Istin (amlodipine)  Dilzem (diltiazem)  Adizem (diltiazem)  Zemtard (diltiazem)  Cardene (nicardipine hydrochloride)  Adalat (nifedipine) S/Es:  N&V  Facial flushing  Headaches  Ankle oedema  Constipation Cardiac Glycosides (OXIN) Pharmacodynamics:  ↓ conductivity in AV node  ↑ myocardial contractility Indications:  CCF  SVT  A Fib Common brands:  NP: Digoxin  NP: Digitoxin  Lanoxin (digoxin) S/Es:  N&V; Diarrhoea  Abdo pain  Headache  Fatigue, drowsiness  Confusion  Dysrhythmias Beta Blockers (LOL) Pharmacodynamics:  Block β-adrenoreceptors => ↓ heart rate, ↓ BP Indications:  Hypertension  Angina Pectoris  Post-MI Common Brands:  NP: Propanolol  NP: Atenolol  NP: Sotalol  Inderal: (propanolol)  Emcor (bisoprolol)  Eucardic (carvedilol)  Nebilet (nebivolol)  Beta-Cardone (sotalol) S/Es:  Breathlessness, wheeze  Cold extremities  Ankle oedema  Tiredness, dizziness C/I: Asthma Loop Diuretics (IDE) Pharmacodynamics:  ↓ reabsorption from ascending limb of Loop of Henle Indications:  CCF  Left ventricular failure  Pulmonary Oedema Common brands:  NP: Furosemide  Lasix (furosemide)  Burinex (bumetanide) S/Es:  Hypotension  N&V, GIT disturbance  Hyponatraemia  Hypokalemia  Hypomagnesemia
  • 2. Thrombolytics (PLASE) Pharmacodynamics:  ↑ plasmin  ↓ fibrin Indications:  MI (esp. ST segment ↑)  DVT  Pulmonary embolism Common brands:  NP: rt-PA (alteplase)  NP: streptokinase  Rapilysin (reteplase)  Streptase (streptokinase)  Metalyse (tenecteplase) S/Es:  N&V  Bleeding  Dysrhythmias  Hypotension  Rash, flushing Anti-arrhythmics (ARONE) Pharmacodynamics:  ↓ conductivity in AV node  ↑ myocardial contractility Indications:  Supraventricular and ventricular arrhythmias  Cardiac arrest (VF/VT) Common brands:  NP: Amiodarone  Cordarone X S/Es:  Peripheral neuropathy  Bradycardia  N&V (rare)  Metallic taste  Hot flushes, dizziness C/Is:  Pregnancy  Hypotension  Breastfeeding Nitrates (NITRATE) Pharmacodynamics:  Coronary vasodilation  Reduction in venous return to heart Indications:  Angina Pectoris  LVF Common brands:  NP: Glyceryl Trinitrate  Glytrin (Glyceryl Trinitrate)  Angitak (Isosorbide Trinitrate)  Nitrocine (Glyceryl Trinitrate)  TransidermNitro (Glyceryl Trinitrate) S/Es:  Hot flushes, dizziness  Tachycardia  Hypotension  Headache C/Is: hypotension, cardiac tamponade, anaemia Antiplatelet Drugs Pharmacodynamics:  decrease platelet aggregation  inhibit thrombus formation Indications:  prevention of ischaemic events  prophylaxis of thromboembolism Common brands:  NP: Aspirin  NP: Clopidogrel  Nu-Seals 75 (aspirin)  Caprin (aspirin)  Plavix (clopidogrel) S/Es:  Aspirin: bronchospasm, GI bleeding  Clopidogrel: dyspepsia, abdo pain, N&V, constipation, gastritis, diarrhoea, GI bleeding C/Is:  Aspirin: U-16, breastfeeding, GI ulceration, haemophilia  Clopidogrel: Active bleeding, breastfeeding
  • 3. ACE Inhibitors (PRIL) Pharmacodynamics:  inhibit angiotensin I > II conversion  antihypertensive Indications:  Heart failure  Hypertension Common brands:  NP: captopril  Zestril (lisinopril)  Coversyl (perindopril)  Tritzce (ramipril) S/Es:  Arrhythmias, angina, chest pain, syncope, CVA, MI, hypotension  Dry mouth, loss of appetite, skin reactions, confusion, depression  Anxiety, impotence, flushing, N&V C/Is:  Renal impairment  Pregnancy Alpha adrenoreceptor blockers (SIN) Pharmacodynamics:  Block α-adrenoreceptors => ↓ heart rate, ↓ BP Indications:  hypertension  angina pectoris, post-MI Common brands:  Cardura, Cardura XL (doxazosin)  Hypovase (prazosin) S/Es:  Flushes  N&V, tiredness  Hypotension  Dizziness, breathlessness Proton Pump Inhibitors (ZOLE) Pharmacodynamics:  inhibit gastric acid  block H-K ATP enzyme system Indications:  Gastric & duodenal ulcers  GORD; oesophagitis  NSAID assoc ulcers  Dyspepsia Common brands:  Nexium (esomeprazole)  Zoton (lansoprazole)  NP: Omeprazole  Losec (omeprazole)  Protium (pantoprazole) S/Es:  N&V, diarrhoea, constipation  Abdo pain, flatulence, dry mouth  Dizziness, drowsiness, headache  Sweating, rash, fever, insomnia