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Medical emergency
1www.medicinemcq.com
 Dysfunction of
 Either cerebral hemispheres or
 Midbrain tegmentum
▪ Reticular activating system
2www.medicinemcq.com
 Function
 Maintains the cerebral cortex in a state of
wakeful consciousness
www.medicinemcq.com
3
 Upper brainstem
 Medial thalamus
 Very close to area concerned with pupillary
function and eye movements
 Pupillary enlargement
 Loss of movements of the eyes
4www.medicinemcq.com
 Reticular activating system
 Ascending projections to the cortex
 Cortex
 Corticothalamic connections
5www.medicinemcq.com
 75 mL per 100 g/min in gray matter
 30 mL per 100 g/min in white matter
 Mean
 55 mL per 100 g/min
www.medicinemcq.com
6
 120 seconds
 Glucose utilization
 5 mg per 100 g/min
7www.medicinemcq.com
 Last 10 s after the cessation of blood flow
 Oxygen consumption
 3.5 mL per 100 g/min
8www.medicinemcq.com
 120 seconds
www.medicinemcq.com
9
 Acute confusion with agitation
 Hallucinations
 Perception without a stimuli
▪ Sight, sound, touch, smell or taste
 Illusions
 Misperceptions of stimuli
10www.medicinemcq.com
11www.medicinemcq.com
12www.medicinemcq.com
13www.medicinemcq.com
14www.medicinemcq.com
1. Metabolic
2. Damage to RAS
3. Damage of large portions of cerebral
hemispheres
 Small focal lesions of one or both cerebral
hemispheres
 Do not cause coma
15www.medicinemcq.com
Suppression of thalamo-cerebral function
 Drugs
 Toxins
 Hypoglycemia
 Anoxia
 Azotemia
 Hepatic failure
16www.medicinemcq.com
 What is the date, day, month and year?
 Where are you now?
 Which is the state capital?
 Why are you in the hospital now?
www.medicinemcq.com
17
 Immediate memory
 Repeat 3 to 5 numbers
 Show the patient 3 to 5 objects (e.g., pen,
key) to remember
 10 minutes later ask him which objects
were shown
18www.medicinemcq.com
 Evaluated while the history is being taken
 Serial subtraction of 3 from 30 or 7 from 100
 Can detect even mild confusional states
19www.medicinemcq.com
 Normal light reflex
 Normal LP
 Normal CT
 Bilateral asterixis
For rest of the slides, visit www.medicinemcq.com > Neurology
20

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Coma - Part 1

  • 2.  Dysfunction of  Either cerebral hemispheres or  Midbrain tegmentum ▪ Reticular activating system 2www.medicinemcq.com
  • 3.  Function  Maintains the cerebral cortex in a state of wakeful consciousness www.medicinemcq.com 3
  • 4.  Upper brainstem  Medial thalamus  Very close to area concerned with pupillary function and eye movements  Pupillary enlargement  Loss of movements of the eyes 4www.medicinemcq.com
  • 5.  Reticular activating system  Ascending projections to the cortex  Cortex  Corticothalamic connections 5www.medicinemcq.com
  • 6.  75 mL per 100 g/min in gray matter  30 mL per 100 g/min in white matter  Mean  55 mL per 100 g/min www.medicinemcq.com 6
  • 7.  120 seconds  Glucose utilization  5 mg per 100 g/min 7www.medicinemcq.com
  • 8.  Last 10 s after the cessation of blood flow  Oxygen consumption  3.5 mL per 100 g/min 8www.medicinemcq.com
  • 10.  Acute confusion with agitation  Hallucinations  Perception without a stimuli ▪ Sight, sound, touch, smell or taste  Illusions  Misperceptions of stimuli 10www.medicinemcq.com
  • 15. 1. Metabolic 2. Damage to RAS 3. Damage of large portions of cerebral hemispheres  Small focal lesions of one or both cerebral hemispheres  Do not cause coma 15www.medicinemcq.com
  • 16. Suppression of thalamo-cerebral function  Drugs  Toxins  Hypoglycemia  Anoxia  Azotemia  Hepatic failure 16www.medicinemcq.com
  • 17.  What is the date, day, month and year?  Where are you now?  Which is the state capital?  Why are you in the hospital now? www.medicinemcq.com 17
  • 18.  Immediate memory  Repeat 3 to 5 numbers  Show the patient 3 to 5 objects (e.g., pen, key) to remember  10 minutes later ask him which objects were shown 18www.medicinemcq.com
  • 19.  Evaluated while the history is being taken  Serial subtraction of 3 from 30 or 7 from 100  Can detect even mild confusional states 19www.medicinemcq.com
  • 20.  Normal light reflex  Normal LP  Normal CT  Bilateral asterixis For rest of the slides, visit www.medicinemcq.com > Neurology 20