This document summarizes information from two clinical trials and an FDA guidance document on antimicrobial medical devices. The first clinical trial evaluated Procellera, an antimicrobial wound dressing, compared to Mepilex for acute wounds. The second clinical trial evaluated Normlgel Ag, an antimicrobial hydrogel, for treating chronic wounds with localized infection. The FDA guidance provides recommendations for 510(k) submissions for devices containing antimicrobial agents.