This document summarizes information about Clostridium difficile (C. difficile) infection, including: - C. difficile affects 40% of patients in hospital settings and surpasses MRSA infections. - It is transmitted through the fecal-oral route and can spread through contaminated objects. - Risk factors include antibiotic use, advanced age, surgery, chemotherapy, and severe illness. - Signs and symptoms range from mild to severe and can include systemic complications.