This document compares three Microsoft web development frameworks: ASP.NET, .NET Core, and Blazor, highlighting their unique features and ideal use cases. ASP.NET is best for enterprise-grade applications, .NET Core offers cross-platform compatibility and high performance for modern applications, while Blazor allows for interactive web UIs using C#. The conclusion encourages choosing the appropriate framework based on project requirements and offers assistance from Intellisource Technologies in making this decision.