International Store VM Ideas for electronics , technologyPESHWA ACHARYA
Who says technology , electronics retail you cannot create great store design & Retail VM …..Here are some of examples, ideas of great store design , retail VM for the electronics , technology , IT , Telecom retail sector
International Store VM Ideas for electronics , technologyPESHWA ACHARYA
Who says technology , electronics retail you cannot create great store design & Retail VM …..Here are some of examples, ideas of great store design , retail VM for the electronics , technology , IT , Telecom retail sector
"PHİLOSOPHER EFRUZHU ORİGİNAL THE FİRST TİME DECLARATİON PUBLİCATİONS ALL OF THE WORLD "
A. " ALİMHU AHADHU UNİVERSAL SYSTEM 99 THEORİES AND LAWS " NORTH CYPRUS
B. "EFRUZHU HABİRHU GLOBAL PHİLOSOPHİCAL 99 HYPOTHESES AND LEGİSLATİONS "
C. "ALLAMHU ALEMHU ĞAYBİ,EFRUZHU SCİENTİFİC 99 PREVİSİONS AND POİNTERS "
E. "EFRUZHU ANTİCANCER DRUG HU NORTH CYPRUS
33 CORRECTİONS AND THERAPY REGİMENS
EFRUZHU FOCUSHU 99 NEW SCİENCES NORTH CYPRUS TURKİSH CYPRİOT
1.NEW SCİENCE "HUCENTROLOGY" NORTH CYPRUS TURKİSH CYPRİOT
2.NEW SCİENCE "METAPOSİHUOLOGY" NORTH CYPRUS TURKİSH CYPRİOT
3.NEW SCİENCE "UNİQUEHUUNOLOGY" NORTH CYPRUS TURKİSH CYPRİOT
4.NEW SCİENCE "MİDHUBALANCOLOGY" NORTH CYPRUS TURKİSH CYPRİOT
5.NEW SCİENCE "HUDUOCONTROLOGY" NORTH CYPRUS TURKİSH CYPRİOT
6.NEW SCİENCE "HUNEUOFEMOMASOLOGY" NORTH CYPRUS TURKİSH CYPRİOT
7.NEW SCİENCE "HUMAGNİTUDOLOGY" NORTH CYPRUS TURKİSH CYPRİOT
99 NEW SCİENCES NEW THEOREMS ...
"PHİLOSOPHER EFRUZHU ORİGİNAL ALL OF THE WORLD THE FİRST TİME DECLARATİON "
A. " ALİMHU AHADHU UNİVERSAL SYSTEM 99 THEORİES AND LAWS " NORTH CYPRUS
B. "EFRUZHU HABİRHU GLOBAL PHİLOSOPHİCAL 99 HYPOTHESES AND LEGİSLATİONS "
C. "ALLAMHU ALEMHU ĞAYBİ,EFRUZHU SCİENTİFİC 99 PREVİSİONS AND POİNTERS "
E. "EFRUZHU ANTİCANCER DRUG HU NORTH CYPRUS
99 NEW SCİENCES
1.NEW SCİENCE "METAPOSİHUOLOGY" NCY. 2.NEW SCİENCE "HUCENTROLOGY" NCY.
3.NEW SCİENCE "UNİQUEHUUNOLOGY" NCY. 4.NEW SCİENCE "MİDHUBALANCOLOGY" NCY.
5.NEW SCİENCE "HUDUOCONTROLOGY" NCY. 6.NEW SCİENCE "HUNEUOFEMOMASOLOGY" NCY.
7.NEW SCİENCE "HUMAGNİTUDOLOGY" NCY.
99 NEW THEOREMS
1.NONENTİTY 2.MATURENESS 3.ENDLESSNESS 4.SİNGLE1 MULTİPLE SİNGLE1 UNİVERSE 5.PROBLEM SOLUBİLİTY 6.PLANES AND LAYERS 7.LİVELİNESS AND LİFELESSNESS 8.MULTİPLİCİTY 9.OJECTİVİTY AND SUBJECTİVİTY 10.ALLİHU1=HALİKHU1=GODHU1 ONENESS 11.AFTER DEATH,LİVİNG FOREVER 12.RELATİONSHİP OF SİNGLENESS AND PLURALİTY
"PHİLOSOPHER EFRUZHU ORİGİNAL THE FİRST TİME DECLARATİON PUBLİCATİONS ALL OF THE WORLD "
A. " ALİMHU AHADHU UNİVERSAL SYSTEM 99 THEORİES AND LAWS " NORTH CYPRUS
B. "EFRUZHU HABİRHU GLOBAL PHİLOSOPHİCAL 99 HYPOTHESES AND LEGİSLATİONS "
C. "ALLAMHU ALEMHU ĞAYBİ,EFRUZHU SCİENTİFİC 99 PREVİSİONS AND POİNTERS "
E. "EFRUZHU ANTİCANCER DRUG HU NORTH CYPRUS
33 CORRECTİONS AND THERAPY REGİMENS
EFRUZHU FOCUSHU 99 NEW SCİENCES NORTH CYPRUS TURKİSH CYPRİOT
1.NEW SCİENCE "HUCENTROLOGY" NORTH CYPRUS TURKİSH CYPRİOT
2.NEW SCİENCE "METAPOSİHUOLOGY" NORTH CYPRUS TURKİSH CYPRİOT
3.NEW SCİENCE "UNİQUEHUUNOLOGY" NORTH CYPRUS TURKİSH CYPRİOT
4.NEW SCİENCE "MİDHUBALANCOLOGY" NORTH CYPRUS TURKİSH CYPRİOT
5.NEW SCİENCE "HUDUOCONTROLOGY" NORTH CYPRUS TURKİSH CYPRİOT
6.NEW SCİENCE "HUNEUOFEMOMASOLOGY" NORTH CYPRUS TURKİSH CYPRİOT
7.NEW SCİENCE "HUMAGNİTUDOLOGY" NORTH CYPRUS TURKİSH CYPRİOT
99 NEW SCİENCES NEW THEOREMS ...
"PHİLOSOPHER EFRUZHU ORİGİNAL ALL OF THE WORLD THE FİRST TİME DECLARATİON "
A. " ALİMHU AHADHU UNİVERSAL SYSTEM 99 THEORİES AND LAWS " NORTH CYPRUS
B. "EFRUZHU HABİRHU GLOBAL PHİLOSOPHİCAL 99 HYPOTHESES AND LEGİSLATİONS "
C. "ALLAMHU ALEMHU ĞAYBİ,EFRUZHU SCİENTİFİC 99 PREVİSİONS AND POİNTERS "
E. "EFRUZHU ANTİCANCER DRUG HU NORTH CYPRUS
99 NEW SCİENCES
1.NEW SCİENCE "METAPOSİHUOLOGY" NCY. 2.NEW SCİENCE "HUCENTROLOGY" NCY.
3.NEW SCİENCE "UNİQUEHUUNOLOGY" NCY. 4.NEW SCİENCE "MİDHUBALANCOLOGY" NCY.
5.NEW SCİENCE "HUDUOCONTROLOGY" NCY. 6.NEW SCİENCE "HUNEUOFEMOMASOLOGY" NCY.
7.NEW SCİENCE "HUMAGNİTUDOLOGY" NCY.
99 NEW THEOREMS
1.NONENTİTY 2.MATURENESS 3.ENDLESSNESS 4.SİNGLE1 MULTİPLE SİNGLE1 UNİVERSE 5.PROBLEM SOLUBİLİTY 6.PLANES AND LAYERS 7.LİVELİNESS AND LİFELESSNESS 8.MULTİPLİCİTY 9.OJECTİVİTY AND SUBJECTİVİTY 10.ALLİHU1=HALİKHU1=GODHU1 ONENESS 11.AFTER DEATH,LİVİNG FOREVER 12.RELATİONSHİP OF SİNGLENESS AND PLURALİTY
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
