Vascular Endothelial Growth Factor Interferes with angiogenesis, the process by which tumours develop their own blood supply Was just given a brand name - Recentin
Based on a quinazoline structure Telescoped process Dropwise addition of bromo-chloro-propane to form free base, pH-controlled wash, addition of salt source and cooled
Method 2 litre vessel Largely successful, in fact greater yield - 65% to over 70%, purity 99% by GC Greatest issue was heat generated from exothermic reaction
Even while adding dropwise
Optimise the work-up step
Current process just water – most environmentally-friendly option Reduced volume of water – two thirds of original amount sufficient for <5% LTL
Different anti-solvents change the impurity profile of product Choose anti-solvent, temperature and length of hold to achieve specified impurity levels – robust process This work may be used for next AZD2171 process description later this year
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