You will hear about an LLNL developed high-efficiency filter made from ceramic materials in a metal housing. The filters are scalable and can be engineered for myriad commercial applications.
Demands on a drug’s synthetic process naturally evolve during its life cycle. Scouting alternate routes early in process development offers significant benefits.
You will hear about an LLNL developed high-efficiency filter made from ceramic materials in a metal housing. The filters are scalable and can be engineered for myriad commercial applications.
Demands on a drug’s synthetic process naturally evolve during its life cycle. Scouting alternate routes early in process development offers significant benefits.
The development of insect resistance to the key fumigant phosphine is driving renewed interest in the development of alternatives. One such alternative is the use of low oxygen atmospheres that are usually created through the generation of nitrogen. However, the costs of nitrogen generation have
been a longstanding barrier to the adoption of the low oxygen atmospheres in agricultural storages such as grains.
The research team has taken advantage of recent advances in the cost of nitrogen generation (membrane technology) to assist industry overcome operational barriers to uptake of the
technology.
VMN (vibrating mesh nebulization).
History
Irish company,
founded in Galway, started in 1997
CEO John Power
2015- AARC Zenith Award- 3 million patient world wide
Particles smaller than one micron are most important to eliminate because they make up 99% of the number of particles in your air and can be breathed deep into the lungs and AEROCIDE can do that
National Renewable Energy Laboratory – July 1998
Self Cleaning Catalyst: Mineralization of E. Coli to Water Vapor and CO2
State of Wisconsin Hygiene Laboratory – August 2002
Performance of AiroCide® in Controlling Bacterial Spores (Anthrax-like spores)
Food & Drug Administration (FDA) – November 2002
Verification of Technology and Class II Medical Device Listing
Texas Tech University – June 2003
AiroCide® Destroys Mycotoxins from Mold Spores
Texas A&M University – June 2004
Peer Reviewed and Published Paper on AiroCide® Performance in a
Hospital Operating Room
Air Quality Sciences, Inc. – 2005 to date
Independent Air Quality Testing Lab, conducting multiple efficacy tests on
AiroCide® and RevolutionAir prototypes
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As people encounter more chemicals at home, at school and at work, it is critical we use New Science to understand potential hazards and minimize adverse health effects.
Inside this journal:
Air Quality Databases, Paint and VOCs, Semi-VOCs, Environmental Chamber To Go
About New Science Journals:
This journal is part of New Science, dedicated to showcasing how UL is advancing and innovating safety in our fast changing world through the demonstration of fundamental discovery, testing methodologies and equipment, procedures, software and standards.
Directed at: Manufacturers, retailers, built environment professionals, policy and other influencers, service professionals, press/media
Should we be testing endoscopes? One life - Central Sterilising Club (csc) ...OneLife SA
The use of contaminated endoscopes can lead to patient-to-patient transmission of pathogens and infections. Studies evaluated cleanliness of patient-ready scopes after reprocessing and revealed between 10% and 30% of residual contamination.
Should therefore surveillance be standardized?
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With applied Genomics expertise, global co-location with Central Labs and solutions from biomarker discovery to CDx, our genomics solutions will help make your Precision Medicine drug development a reality.
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The development of insect resistance to the key fumigant phosphine is driving renewed interest in the development of alternatives. One such alternative is the use of low oxygen atmospheres that are usually created through the generation of nitrogen. However, the costs of nitrogen generation have
been a longstanding barrier to the adoption of the low oxygen atmospheres in agricultural storages such as grains.
The research team has taken advantage of recent advances in the cost of nitrogen generation (membrane technology) to assist industry overcome operational barriers to uptake of the
technology.
VMN (vibrating mesh nebulization).
History
Irish company,
founded in Galway, started in 1997
CEO John Power
2015- AARC Zenith Award- 3 million patient world wide
Particles smaller than one micron are most important to eliminate because they make up 99% of the number of particles in your air and can be breathed deep into the lungs and AEROCIDE can do that
National Renewable Energy Laboratory – July 1998
Self Cleaning Catalyst: Mineralization of E. Coli to Water Vapor and CO2
State of Wisconsin Hygiene Laboratory – August 2002
Performance of AiroCide® in Controlling Bacterial Spores (Anthrax-like spores)
Food & Drug Administration (FDA) – November 2002
Verification of Technology and Class II Medical Device Listing
Texas Tech University – June 2003
AiroCide® Destroys Mycotoxins from Mold Spores
Texas A&M University – June 2004
Peer Reviewed and Published Paper on AiroCide® Performance in a
Hospital Operating Room
Air Quality Sciences, Inc. – 2005 to date
Independent Air Quality Testing Lab, conducting multiple efficacy tests on
AiroCide® and RevolutionAir prototypes
Indoor Air Quality
As people encounter more chemicals at home, at school and at work, it is critical we use New Science to understand potential hazards and minimize adverse health effects.
Inside this journal:
Air Quality Databases, Paint and VOCs, Semi-VOCs, Environmental Chamber To Go
About New Science Journals:
This journal is part of New Science, dedicated to showcasing how UL is advancing and innovating safety in our fast changing world through the demonstration of fundamental discovery, testing methodologies and equipment, procedures, software and standards.
Directed at: Manufacturers, retailers, built environment professionals, policy and other influencers, service professionals, press/media
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The use of contaminated endoscopes can lead to patient-to-patient transmission of pathogens and infections. Studies evaluated cleanliness of patient-ready scopes after reprocessing and revealed between 10% and 30% of residual contamination.
Should therefore surveillance be standardized?
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II Subalternation and Theology
III Theology and Dogmatic Declarations
IV The Mixed Principles of Theology
V Virtual Revelation: The Unity of Theology
VI Theology as a Natural Science
VII Theology’s Certitude
VIII Conclusion
Notes
Bibliography
All the contents are fully attributable to the author, Doctor Victor Salas. Should you wish to get this text republished, get in touch with the author or the editorial committee of the Studia Poinsotiana. Insofar as possible, we will be happy to broker your contact.
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2. 02
INHALATION STUDY 01
INHALATION
CASE STUDY 01
Covance problem solving
saved a client over $5 million
in test article during a chronic
inhalation toxicity study
in primates.
BACKGROUND
A primary objective of the Covance inhalation studies group
is to conduct all studies using the most efficient test article
delivery methods available in order to contain and minimize
the cost of preclinical product testing to our customers. While
aerosol production in the preclinical setting is typically more
efficient than can be achieved in the clinic, animal exposure
systems are at the same time highly wasteful of test article.
Large animal (dog, minipig or primate) facemask exposure
systems highlight this contradiction in that the initially
efficient test article generation is offset by combined losses
within the delivery system, as a result most of the test article
is not usually presented to the animals.
These losses are associated with high aerosol concentrations,
airflows that must exceed the minute volume of the species
used, dynamic (continuous) aerosol production throughout
the respiratory cycle and losses within the delivery piping due
to delivery system complexity.
This combination of factors means that a significant
proportion of the test article generated does not reach the
facemask position or is taken directly to the system exhaust
filters. This compares unfavorably with the relatively
high proportion of drug substance that is delivered to the
respiratory tract by the demand systems that are commonly
used by patients in clinical practice.
3. 03
INHALATION STUDY 01
THE CHALLENGE
The client approached Covance for a chronic
toxicity study in a large animal species with
a biopharmaceutical that was to be presented
clinically as a dry powder generated from
capsules using a commercially available inhaler.
Test article consumption in this early work had
been significantly greater than had been estimated
pre-study, with much of the excess passing directly
to exhaust filters.
As the projected cost of continuing the program
using facemask methods for the preclinical work
was threatening to become the rate limiting factor,
the client approached Covance with the challenge
of bringing product development back within the
available budget.
THE SOLUTION
The Covance aerosol technology and inhalation
engineering services groups designed and
manufactured a unique, micro-processor controlled
oro-pharyngeal delivery system employing powder
ejection directly from the client’s clinical capsules.
Initial trials confirmed the potential of the concept
and subsequent aerosol sampling from the prototype
device and mass balance work in vivo showed that
upwards of 40% of the test article dispensed from
each capsule was delivered. Although satisfactory
in terms of the overall percentage delivery, the first
prototype was labor intensive to operate, requiring two
technicians to dose each animal.
As a consequence the system was further refined
and optimized to provide automated sequencing of
capsules from a magazine such that the main study
exposures could be performed by a single operator
thus reducing the cost of the study.
Aerosol delivery efficiency with the final system was
greater than 50% of the material dispensed and the
preclinical delivery system employed methods that
directly mimicked test article delivery in the clinic.
CUSTOMER BENEFITS
The predicted overall test article consumption for
delivery using the conventional facemask exposure
system was 1.75 kg for the study. Using the Covance
designed and built methods the test material
requirement was only 0.74 kg. The saving achieved
by placing the chronic toxicity study with Covance
was 1.01 kg of test article at a manufacturing cost of
$5000 per g.
By using Covance designed equipment and methods
the client saved an estimated $5,050,000 in test
article for a single 12 month chronic toxicity study in
primates – savings that were substantially greater than
the price of the study!
Covance
0.74kg
Covance
$3,700,000
Use of
conventional
facemask
exposure
1.75kg
Use of
conventional
facemask
exposure
$8,750,000
Test Material
Usage
Cost of
Manufactured
Material
Cost saving to customer - $5,050,000