A recent study found that people with cannabis dependence have changes in neural circuitry in brain regions related to habit formation, reward, and psychopathology.
For more information, please visit the NIDA Notes website:
https://www.drugabuse.gov/news-events/nida-notes
You can view NIDA's Comment Policy here:
https://www.drugabuse.gov/comment-policy
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The world is watching as Canada becomes one of the first countries to legalize recreational cannabis, and there's still much we don't know about how this huge social change will affect our lives.
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Watch the full webinar recording at https://go.ucalgary.ca/2018-07-11URNAP-WhatdoeslegalizedcannabismeanforCanadians_LPRegistration.html
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The world is watching as Canada becomes one of the first countries to legalize recreational cannabis, and there's still much we don't know about how this huge social change will affect our lives.
In this webinar, Dr. Chris Wilkes, MD, from UCalgary's Cumming School of Medicine reviews what the research to date tells us about the impact of cannabis on the brain, and what needs further study. Dr. Fiona Clement, PhD, whose team compiled the Cannabis evidence series for the Alberta provincial government, looks at the factors informing government policy, including evidence from other jurisdictions that have legalized marijuana.
Watch the full webinar recording at https://go.ucalgary.ca/2018-07-11URNAP-WhatdoeslegalizedcannabismeanforCanadians_LPRegistration.html
How Genes Change When Alcohol, Drugs Rewire Brain.pdfGoogle
Alcohol and drugs have a profound effect on the brain, changing how genes work according to recent research. The science behind addiction is complex, and understanding how these substances rewire the brain is crucial in developing effective prevention and treatment options for addiction. In this article, we will explore the fascinating ways in which alcohol and drugs can alter the functioning of our genes, leading to addiction and other long-term effects on brain plasticity.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
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Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
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https://www.etran.rs/2024/en/home-english/
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Slides from:
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Track: Artificial Intelligence
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Cannabis Dependence Is Associated With Changes in Neural Circuitry That May Contribute to Psychopathology
1. DRUGABUSE.GOV
A study found:
• People with cannabis dependence have
changes in neural circuitry in brain
regions related to reward processing,
habit formation, and psychopathology.
• These changes in neural circuitry may
provide a useful marker for tracking
psychopathology associated with
cannabis misuse.
Cannabis Dependence Is Associated With Changes in
Neural Circuitry That May Contribute to Psychopathology
2. DRUGABUSE.GOV
People with cannabis use often
show psychiatric symptoms, such as:
• Lack of motivation
• Negative thoughts or feelings
• Increased risk of psychosis
(e.g., schizophrenia)
Cannabis Use Can Lead to Psychiatric Symptoms
3. DRUGABUSE.GOV
Dr. Peter Manza of the National Institute on Alcohol Abuse and
Alcoholism (NIAAA) and colleagues from NIDA suspected that
cannabis exposure gives rise to psychological problems by
disrupting normal functioning in brain regions that use the
neurotransmitter dopamine.
The researchers hypothesized that the drug alters local functional
connectivity (LFC) in dopamine-using brain regions.
LFC quantifies the extent to which neurons in a region activate in
concert.
Functional Connectivity Maps Coordination Among Neurons
Adapted from Manza et al. 2018. Permission
for use of data provided by Dr. P. Manza.
4. DRUGABUSE.GOV
The researchers used fMRI to
compare LFC in the subcortex of
30 cannabis-dependent and
30 nondependent people.
The image shows LFC as revealed in
(from top) horizontal, sagittal, and
coronal cross-sections of the brain.
Hot colors (red, yellow) indicate
regions with high LFC.
LFC Is Assessed With Functional Magnetic Resonance Imaging (fMRI)
Adapted from Manza et al. 2018. Permission for use of data provided by Dr. P. Manza.
5. DRUGABUSE.GOV
Dr. Manza and colleagues found:
• Study participants with a history of cannabis
dependence had higher LFC in several brain
regions.
• Affected regions included the midbrain (including
the ventral tegmental area and substantia nigra),
ventral striatum, thalamus, and brainstem.
• The ventral tegmental area and substantia nigra
contain dopamine-producing neurons, and the
ventral striatum contains abundant receptors for
dopamine.
Cannabis Dependence Was Associated With Increased LFC
in Dopamine-Using Brain Regions
Adapted from Manza et al. 2018. Permission for use of data provided by Dr. P. Manza.
6. DRUGABUSE.GOV
The dopamine-using regions in the midbrain and
ventral striatum where cannabis use was associated
with increased LFC participate in networks that have
been implicated in drug use (e.g., reward learning and
habit formation) and/or psychiatric problems (e.g.,
schizophrenia).
Roles of Brain Regions With Increased LFC
Ventral striatum
Thalamus
Substantia
nigra
Ventral
tegmental
area
Brainstem
7. DRUGABUSE.GOV
The study also found:
• People who began using cannabis
at a younger age had higher LFC
throughout the subcortex,
compared with those who
started later.
• People with higher subcortical
LFC showed a greater sense of
alienation—an indicator of
negative emotions.
Adapted from Manza et al. 2018. Permission for use of data provided by Dr. P. Manza.
Earlier Age of Onset of Cannabis Use Was Associated With Greater LFC and
Negative Emotions
8. DRUGABUSE.GOV
The researchers concluded that:
• Cannabis dependence is associated with altered local functional
connectivity in key signaling pathways.
• Earlier onset of cannabis use is associated with greater changes in
connectivity.
• Altered functional connectivity in these regions may provide a useful
marker for tracking psychopathology associated with cannabis dependence.
Dr. Manza cautions that the data cannot determine if these brain changes
preceded cannabis use, possibly increasing the risk for cannabis dependence,
or if they resulted from cannabis dependence. Longitudinal studies such as the
Adolescent Brain and Cognitive Development (ABCD) Study have potential to
shed more light on these relationships.
Conclusions
Source: Manza, P., Tomasi, D., and Volkow, N.D. Subcortical local functional hyperconnectivity in cannabis dependence. Biological Psychiatry 3(3):285-293, 2018.