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Bristol-Myers Squibb Continues Excellent Financial Performance
            Led By Double-Digit Global Net Sales Growth and Strong Earnings Results
       •   Reports Broad-Based Net Sales Growth of 14% from Continuing Operations

       •   Records Growth in GAAP Diluted EPS of $1.29 Compared to $0.43 in 2007; Includes
           After-Tax Gain of $0.99 Per Share From Sale of ConvaTec

       •   Posts 2008 GAAP Diluted EPS from Continuing Operations of $0.30 Compared to
           $0.38 in 2007

       •   Posts Non-GAAP Diluted EPS Growth from Continuing Operations of $0.46 Compared
           to $0.33 in 2007

       •   Raises 2008 GAAP EPS Guidance to $1.61 to $1.66, Subject to Receipt of Cash for
           ImClone Shares, and Refines 2008 Non-GAAP EPS Guidance to $1.65 to $1.70,
           Representing Upper Range of Previous Guidance

       •   Strengthens Cash Position to $7.2 Billion From $4.0 Billion on June 30, 2008
       (NEW YORK, October 23, 2008) -- Consistent with recent performance, Bristol-Myers Squibb
Company (NYSE:BMY) today reported strong sales growth and earnings performance for the third
quarter 2008.
       “Bristol-Myers Squibb continues to deliver excellent operating results. With double-digit sales
growth in the third quarter and with strong financial results for the first nine months of 2008, we are
refining our 2008 non-GAAP earnings-per-share guidance to between $1.65 to $1.70, which is the upper
range of our prior guidance,” said James M. Cornelius, chairman and chief executive officer.
       “Our recent success gives us confidence that our BioPharma strategy is the right one to help us
fulfill our commitments to patients and shareholders,” Cornelius added. “As we continue to demonstrate
strong performance in the marketplace, we’re moving forward to attain our goals, both commercially
and with the advancement of our new product pipeline. The strength of our balance sheet and cash
position enables us to execute our strategy, including our ongoing business development activity.”
                                                  Third Quarter 2008
                                                              2008          2007            Change
       Net Sales                                              $5,254        $4,601            14%
       Net Earnings                                           $2,578        $ 858            200%
       Net Earnings From Continuing Operations                $ 588         $ 753            (22%)

       Net Earnings Per Common Share                            1.29          0.43           200%
       GAAP Diluted EPS From Continuing Operations              0.30          0.38           (21%)
       Non-GAAP Diluted EPS From Continuing Operations          0.46          0.33            39%
       ($ amounts in millions, except per share amounts)

                                                      1
THIRD QUARTER RESULTS
•   Bristol-Myers Squibb posted third quarter 2008 net sales from continuing operations of $5.3 billion,
    an increase of 14%, including a 3% favorable foreign exchange impact, compared to the same period
    in 2007. Pharmaceutical net sales totaled $4.5 billion and sales of Nutritionals totaled $744 million
    in the third quarter of 2008, representing increases of 15% and 10%, respectively, compared to 2007.


•   U.S. pharmaceutical net sales increased 18% to $2.7 billion in the third quarter of 2008 compared to
    the same period in 2007, primarily due to strong performance from PLAVIX® and ABILIFY® , and
    strong results from the HIV and hepatitis portfolio as well as ORENCIA®.


•   International pharmaceutical net sales increased 11%, including a 7% favorable foreign exchange
    impact, to $1.8 billion in the third quarter of 2008 compared to the same period in 2007. The
    increase was primarily due to the strong performance of BARACLUDE®, ABILIFY®, SPRYCEL™
    and the HIV portfolio.


•   Gross profit as a percentage of net sales improved to 68.9% in the third quarter 2008 compared to
    67.9% in 2007. This increase of 1.0% was driven by favorable product mix, cost improvement from
    productivity initiatives and favorable foreign exchange, partially offset by higher manufacturing
    rationalization charges in 2008, which accounted for a 0.7% decrease.


•   Marketing, selling and administrative expenses increased by 9%, including an unfavorable 3%
    foreign exchange impact, to $1.2 billion in the third quarter of 2008 compared to the same period in
    2007.

•   Advertising and product promotion spending increased by 7%, including an unfavorable 2% foreign
    exchange impact, to $362 million in the third quarter of 2008 compared to the same period in 2007.

•   Research and development expenses increased 4%, including an unfavorable 1% foreign exchange
    impact, to $834 million in the third quarter of 2008 compared to the same period in 2007.

•   The effective tax rate on earnings from continuing operations before minority interest and income
    taxes was 26.7% for the third quarter of 2008, compared with 23.2% in the third quarter of 2007.
    The company expects the full year 2008 non-GAAP effective tax rate from continuing operations to
    be in line with the previously issued guidance of approximately 24%.

                                                    2
•   The company reported third quarter net earnings of $2.6 billion or $1.29 per diluted share, compared
    to net earnings of $858 million or $0.43 per diluted share for the same period in 2007. The third
    quarter 2008 net earnings includes a $2.0 billion after-tax gain, or $0.99 per share, attributed to the
    sale of the company’s ConvaTec business which is recorded in discontinued operations. In addition,
    the third quarter of 2008 and 2007 net earnings include the impact of specified items as discussed
    under “Use of Non-GAAP Financial Information.”


•   The company reported earnings from continuing operations of $588 million or $0.30 per diluted
    share which represented a 21% decrease from prior year primarily due to the impact of specified
    items.


•   Non-GAAP earnings from continuing operations excluding specified items amounted to $910
    million, or $0.46 per diluted share, which represents a 39% increase from the prior year. This
    increase is driven by higher sales growth, improved gross margins and execution of cost-
    containment measures.


SELECTED BALANCE SHEET AND CASH UPDATES
•   The company's financial condition improved significantly during the quarter as a result of $1.4
    billion of cash generated from operating activities as well as $4.1 billion in proceeds from the sale of
    ConvaTec. Cash and cash equivalents were $7.2 billion as of September 30, 2008 of which a
    significant majority was invested in U.S. Treasury Bills and Treasury-backed securities, consistent
    with the more conservative approach the company announced it would take earlier in 2008.


•   Net debt, which is defined as short-term borrowings and long-term debt less cash and cash
    equivalents and marketable securities, was reduced by $4.6 billion to a net cash position of $1.2
    billion.


•   An impairment charge of $224 million, $184 million net of tax, related to certain auction rate
    securities (ARS) was recognized during the three months ended September 30, 2008. The charge
    was required after an analysis of other-than-temporary impairment factors, including the severity of
    decline in the securities and current financial market conditions. The carrying value of the $811
    million of principal invested in ARS as of December 31, 2007 has been reduced to a remaining
    amount of $213 million as of September 30, 2008.
                                                      3
BUSINESS DEVELOPMENT UPDATE
       Eli Lilly commenced a tender offer to acquire ImClone on October 14, 2008. Based on Bristol-
Myers Squibb’s ownership of 14.4 million shares of ImClone, the company expects to receive
approximately $1.0 billion in cash upon the closing of the transaction. Bristol-Myers Squibb continues
to have long-term marketing rights to ERBITUX in the U.S. and Canada and believes it has rights to
ImClone’s investigational compound IMC-11F8.
       The company is executing on its strategic priorities for its healthcare group. On August 1, the
company announced that it had completed the divestiture of the ConvaTec business unit to Nordic
Capital Fund VII and Avista Capital Partners. On September 25, the company announced that Mead
Johnson Nutrition Company had filed a registration statement with the U.S. Securities and Exchange
Commission for an initial public offering of its Class A common stock.
       Bristol-Myers Squibb is focusing on supplementing its internal research and development
portfolio with strategic partnerships and acquisitions. In August, the company announced a global
alliance with PDL BioPharma to develop and commercialize elotuzumab, an anti-CS1 antibody
currently in Phase I development for multiple myeloma.


NEW PRODUCT PIPELINE UPDATE
       Bristol-Myers Squibb and its partner AstraZeneca announced on July 23 that the regulatory
submissions for ONGLYZA (saxagliptin) were made in both the United States and in Europe on June 30
and July 1, respectively. On September 2, the U.S. Food and Drug Administration (FDA) announced it
had accepted the filing.
       The following regulatory and data milestones occurred in the third quarter or in October:


   • On October 1, the FDA approved the use of REYATAZ® (atazanavir sulfate) 300 milligram
       once-daily boosted with ritonavir 100 milligram as part of combination therapy in previously
       untreated (treatment-naïve) HIV-1 infected patients. This use of once-daily REYATAZ/ritonavir
       in HIV-1 infected treatment-naïve adult patients is based upon 48-week results from the
       CASTLE study, which demonstrated similar antiviral efficacy of REYATAZ/ritonavir to twice-
       daily lopinavir/ritonavir, each as part of HIV combination therapy in treatment-naïve HIV-1
       infected adult patients. Data from the CASTLE study were published in the August 23 issue of
       The Lancet.



                                                   4
• Bristol-Myers Squibb and its development partner Pfizer announced in August that the primary
    endpoint was not met in a Phase III study of apixaban – a novel anticoagulant – for prevention of
    venous thromboembolism (VTE) in patients undergoing total knee replacement. The rate of the
    primary efficacy endpoint on apixaban was numerically similar to that observed with enoxaparin,
    but did not meet the pre-specified statistical criteria for non-inferiority compared to enoxaparin.
    The results of the trial do not necessitate any changes in protocols of any other ongoing apixaban
    studies. The companies are considering further studies in preventing VTE in knee surgery and
    will not submit the U.S. filing for VTE prevention in the second half of 2009, as had been
    previously communicated. Programs directed toward prevention of VTE including EMEA
    registrational studies, treatment of VTE, and in the prevention of stroke in atrial fibrillation
    continue as planned.
•   A Phase II study of apixaban (APPRAISE-1) provided encouraging trends suggesting that
    anticoagulation with apixaban on top of current standards of care and continued beyond the
    initial hospitalization for acute coronary syndrome may reduce the risk of a second heart attack,
    stroke or death.
• The company and its development partner AstraZeneca announced results of phase III studies of
    ONGLYZA™ (saxagliptin), a potential treatment for type 2 diabetes, in September at the
    European Association for the Study of Diabetes. Data showed ONGLYZA, used in combination
    with metformin as initial therapy, when added to a sulfonylurea or thiazolidinedione in patients
    with inadequately controlled type 2 diabetes significantly lowered A1C and demonstrated
    significant improvements across key measures of glucose control.
• Bristol-Myers Squibb and its development partner ImClone Systems announced ERBITUX®
    five-year data showing significant improvement in overall survival for patients with locally or
    regionally advanced head and neck cancer. In the September 10 issue of the New England
    Journal of Medicine, the EXTREME study was published and it showed that ERBITUX
    improved survival in first-line recurrent and/or metastatic head and neck cancer.
• Bristol-Myers Squibb and its development partner Medarex, Inc. announced in September
    updated survival data from three phase 2 studies of ipilimumab in patients with advanced
    metastatic melanoma (stage III or IV) who had been previously treated. Study results showed
    that approximately half of patients who received ipilimumab (10 mg/kg) remained alive beyond
    one year.



                                                  5
2008 GUIDANCE
        Bristol-Myers Squibb is raising its 2008 earnings guidance for fully diluted earnings per share
from continuing operations on a GAAP basis to between $1.61 and $1.66, reflecting an estimated $900
million pre-tax gain ($0.29 per share after tax) from Eli Lilly’s acceptance of the company’s tender of its
ImClone shares. If the company does not receive such cash from the tender, the company expects to
lower 2008 guidance on a GAAP basis to between $1.32 to $1.37 per share. The company is also
refining its 2008 fully diluted earnings per share from continuing operations guidance on a non-GAAP
basis to be between $1.65 and $1.70, which is the upper end of its previous guidance. The non-GAAP
guidance excludes specified items as discussed under “Use of Non-GAAP Financial Information.”
Details reconciling the GAAP and non-GAAP bases are provided in supplemental materials available on
the company’s website.
        The company reaffirms guidance that it expects non-GAAP earnings per share from continuing
operations to grow at a minimum of 15 percent compounded annual growth rate, from the 2007 base
through 2010 without rebasing for the agreement to sell the ConvaTec business, excluding costs
associated with the Productivity Transformation Initiative and other specified items that have not yet
been identified and quantified.
        The non-GAAP 2008 guidance and the three-year compound annual growth rate exclude other
specified items such as gains or losses from sale of businesses and product lines; from sale of equity
investments and from discontinuations of operations; restructuring and other exit costs; accelerated
depreciation charges; asset impairments; charges and recoveries relating to significant legal proceedings;
upfront and milestone payments for licensing arrangements; payments for in-process research and
development; debt retirement costs; impairments to investments; and significant tax events.
        The financial guidance for 2008 and the three-year compound annual growth rate exclude the
impact of any potential strategic acquisitions and divestitures and further assume that the company and
its product partner, sanofi-aventis, maintain U.S. exclusivity for the PLAVIX® patent through at least
2010.


Use of Non-GAAP Financial Information

        This press release contains non-GAAP financial measures, including non-GAAP earnings and
earnings per share information, adjusted to exclude certain costs, expenses, gains and losses and other
specified items. Among the items in GAAP measures but excluded for purposes of determining adjusted
earnings and other adjusted measures are: charges related to implementation of the Productivity
Transformation Initiative and the company’s strategy for Mead Johnson Nutritionals; gains or losses
from sale and leaseback of properties and from discontinuations of operations; restructuring and other
exit costs; accelerated depreciation charges; asset impairments; charges relating to significant legal
                                                     6
proceedings; upfront and milestone payments for in-licensing of products that have not achieved
regulatory approval that are immediately expensed; payments for in-process research and development;
impairments to investments; and significant tax events. This information is intended to enhance an
investor’s overall understanding of the company’s past financial performance and prospects for the
future. For example, non-GAAP earnings and earnings per share information is an indication of the
company’s baseline performance before items that are considered by the company to be not reflective of
the company’s ongoing results. In addition, this information is among the primary indicators the
company uses as a basis for evaluating company performance, allocating resources, setting incentive
compensation targets, and planning and forecasting of future periods. This information is not intended
to be considered in isolation or as a substitute for net earnings or diluted earnings per share prepared in
accordance with GAAP.

Statement on Cautionary Factors

         This press release contains certain forward-looking statements within the meaning of the Private
Securities Litigation Reform Act of 1995 regarding, among other things, statements relating to goals,
plans and projections regarding the company’s financial position, results of operations, market position,
product development and business strategy. These statements may be identified by the fact that they use
words such as quot;anticipatequot;, quot;estimatesquot;, quot;shouldquot;, quot;expectquot;, quot;guidancequot;, quot;projectquot;, quot;intendquot;, quot;planquot;,
quot;believequot; and other words and terms of similar meaning in connection with any discussion of future
operating or financial performance. Such forward-looking statements are based on current expectations
and involve inherent risks and uncertainties, including factors that could delay, divert or change any of
them, and could cause actual outcomes and results to differ materially from current expectations. These
factors include, among other things, market factors (including whether uncertainties in the credit and
capital markets or a further deterioration of these markets will lead to future impairments to the
company’s investment portfolio), competitive product development and approvals, pricing controls and
pressures (including changes in rules and practices of managed care groups and institutional and
governmental purchasers), economic conditions such as interest rate and currency exchange rate
fluctuations, judicial decisions and governmental laws and regulations related to Medicare, Medicaid
and healthcare reform, pharmaceutical rebates and reimbursement, claims and concerns that may arise
regarding the safety and efficacy of in-line products and product candidates, changes to wholesaler
inventory levels, variability in data provided by third parties, changes in, and interpretation of,
governmental regulations and legislation affecting domestic or foreign operations, including tax
obligations, difficulties and delays in product development, manufacturing or sales, patent positions and
the ultimate outcome of any litigation matter, including whether Apotex will prevail in its appeal of the
District court’s decision in the PLAVIX® patent litigation. These factors also include the company’s
ability to execute successfully its strategic plans, including its Productivity Transformation Initiative, the
expiration of patents or data protection on certain products (including the expiration of data protection
for PLAVIX® in the European Union), and the impact and result of governmental investigations. There
can be no guarantees with respect to pipeline products that future clinical studies will support the data
described in this release, that the products will receive necessary regulatory approvals, or that they will
prove to be commercially successful; nor are there guarantees that regulatory approvals will be sought,
or sought within currently expected timeframes, or that contractual milestones will be achieved. For
further details and a discussion of these and other risks and uncertainties, see the company's periodic
reports, including the annual report on Form 10-K, quarterly reports on Form 10-Q and current reports
on Form 8-K, filed with or furnished to the Securities and Exchange Commission. The company
undertakes no obligation to publicly update any forward-looking statement, whether as a result of new
information, future events or otherwise.

                                                      7
Statement on Mead Johnson Nutrition Company Registration Statement

        A registration statement relating to the securities of Mead Johnson Nutrition Company has been
filed with the U.S. Securities and Exchange Commission but has not yet become effective. These
securities may not be sold nor may offers to buy these securities be accepted before the time the
registration statement becomes effective. This press release shall not constitute an offer to sell or a
solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in
which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the
securities laws of any such state or jurisdiction.

Company and Conference Call Information

        Bristol-Myers Squibb is a global biopharmaceutical and company whose mission is to extend
and enhance human life.
        There will be a conference call on October 23, 2008 at 10:30 a.m. (EDT) during which company
executives will address inquiries from investors and analysts. Investors and the general public are
invited to listen to a live web cast of the call at www.bms.com/ir or by dialing 913-312-9330,
confirmation code 7242577. Materials related to the call will be available at the same website prior to
the call.
        For more information, contact: Brian Henry, 609-252-3337, Communications, Tracy Furey, 609-
252-3208, Communications, John Elicker, 212-546-3775, Investor Relations, or Suketu Desai, 609-252-
5796, Investor Relations.

ABILIFY® is the trademark of Otsuka Pharmaceutical Co., Ltd.
ATRIPLA™ is a trademark of both Bristol-Myers Squibb Co. and Gilead Sciences, Inc.
AVAPRO®, AVALIDE® and PLAVIX® are trademarks of sanofi-aventis
ERBITUX® is a trademark of ImClone Systems Incorporated




                                                       8
BRISTOL-MYERS SQUIBB COMPANY
                                 NET SALES BY OPERATING SEGMENTS
                  FOR THE THREE AND NINE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007
                                      (Unaudited, dollars in millions)



                                                       Three Months                 Nine Months
                                                    Ended September 30,          Ended September 30,
                                                   2008           2007          2008           2007

Pharmaceuticals                                $       4,510   $    3,926   $    13,173     $   11,234

Nutritionals                                            744           675         2,175          1,901

Net Sales                                      $       5,254   $    4,601   $    15,348     $   13,135




                                                   9
BRISTOL-MYERS SQUIBB COMPANY
                                          SELECTED PRODUCTS
                    FOR THE THREE AND NINE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007
                                        (Unaudited, dollars in millions)

        The following table sets forth worldwide and U.S. reported net sales for selected products for the three and nine
        months ended September 30, 2008 compared to the three and nine months ended September 30, 2007. In addition,
        the table includes, where applicable, the estimated total U.S. prescription change for the retail and mail-order
        channels for the comparative periods presented for certain of the company's U.S. pharmaceutical products based on
        third-party data. A significant portion of the company's U.S. pharmaceutical sales is made to wholesalers. Where
        changes in reported net sales differ from prescription growth, this change in net sales may not reflect underlying
        prescriber demand.


                                          Worldwide Net Sales                U.S. Net Sales
                                                            %                            % Change    % Change in U.S. Total
                                        2008    2007     Change         2008    2007                 Prescriptions vs. 2007

Three Months Ended September 30,

Pharmaceuticals
Cardiovascular
   Plavix                              $ 1,439   $ 1,254 15%           $1,263   $ 1,080     17%              7%
   Avapro/Avalide                         334      309     8%             189       176      7%             (7)%
   Pravachol                                34      86   (60)%           (18)        17     *              (52)%
Virology
   Reyataz                                342     273     25%            176       141      25%             18%
   Sustiva Franchise (total revenue)      294     237     24%            185       151      23%             15%
   Baraclude                              144      72    100%             36        22      64%             59%
Oncology
   Erbitux                                184     185     (1)%           182       183       (1)%           N/A
   Taxol                                   91     102    (11)%            (1)        1    (200)%            N/A
   Sprycel                                 82      46     78%              21       17       24%            29%
   Ixempra                                 25      ---      ---            24       ---        ---          N/A
Affective (Psychiatric) Disorders
   Abilify                                564     420    34%             435       329      32%             26%
Immunoscience
   Orencia                                119      60    98%              97        57      70%             N/A
Nutritionals
   Enfamil                                295     281     5%             178       195      (9)%            N/A



* In excess of +/- 200%




                                                                  10
(Continued)

                                         Worldwide Net Sales       U.S. Net Sales
                                                          %                            %        % Change in U.S. Total
                                       2008    2007     Change     2008     2007     Change     Prescriptions vs. 2007

Nine Months Ended September 30,

Pharmaceuticals
Cardiovascular
   Plavix                              $4,134   $3,381             $3,609   $2,882      25%              26%
                                                           22%
   Avapro/Avalide                         974      876     11%        547      509       7%              (7)%
   Pravachol                              176      353   (50)%          7      121    (94)%             (78)%
Virology
   Reyataz                               963      790     22%        495      422      17%              15%
   Sustiva Franchise (total revenue)     849      696     22%        531      442      20%              14%
   Baraclude                             388      176    120%        100       59      69%              60%
Oncology
   Erbitux                               567      507     12%        560      501       12%             N/A
   Taxol                                 286      308     (7)%         2        9     (78)%             N/A
   Sprycel                               224      102    120%         62       41       51%             42%
                                                                               ---
   Ixempra                                76       ---       ---      75                  ---           N/A
Affective (Psychiatric) Disorders
   Abilify                              1,547    1,198    29%       1,186     944      26%              20%
Immunoscience
   Orencia                               312      156    100%        257      150      71%               N/A
Nutritionals
   Enfamil                               872      802      9%        536      543      (1)%              N/A




                                                              11
BRISTOL-MYERS SQUIBB COMPANY
                                CONSOLIDATED STATEMENTS OF EARNINGS
                    FOR THE THREE AND NINE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007
                               (Unaudited, amounts in millions except per share data)

                                                                 Three Months              Nine Months
                                                              Ended September 30,       Ended September 30,
                                                              2008         2007         2008         2007


Net Sales                                                 $ 5,254       $ 4,601     $15,348       $13,135
Cost of products sold                                       1,634         1,478       4,874         4,152
Marketing, selling and administrative                       1,208         1,105       3,507         3,260
Advertising and product promotion                             362           338       1,101           950
Research and development                                      834           802       2,442         2,338
Acquired in-process research and development                   —             —           32            —
Provision for restructuring, net                               26            —           67            44
Litigation expense, net                                        30            —           32            14
Gain on sale of product assets                                 —           (247)         —           (273)
Equity in net income of affiliates                           (164)         (139)       (478)         (393)
Other expense, net (a)                                        169             8         188            29
Total expenses                                              4,099         3,345      11,765        10,121
Earnings from Continuing Operations
                                                              1,155         1,256       3,583         3,014
Before Minority Interest and Income Taxes
Provision for income taxes                                      308           292         896           535
Minority interest, net of taxes                                 259           211         730           546
Net Earnings from Continuing Operations                        588           753        1,957         1,933


Discontinued Operations:
Earnings, net of taxes                                          8            105        107           321
Gain on Disposal, net of taxes                              1,982             —       1,939            —
                                                            1,990            105      2,046           321
Net Earnings                                              $ 2,578       $    858    $ 4,003       $ 2,254
Earnings per Common Share
Basic:
   Net Earnings from Continuing Operations                $ 0.30        $ 0.38      $ 0.99        $ 0.98
   Discontinued Operations:
     Earnings, net of taxes                                   —           0.05        0.06          0.17
     Gain on Disposal, net of taxes                         1.00           —          0.98           —
   Net Earnings per Common Share                          $ 1.30        $ 0.43      $ 2.03        $ 1.15
Diluted:
   Net Earnings from Continuing Operations                $ 0.30        $ 0.38      $ 0.98        $ 0.98
   Discontinued Operations:
     Earnings, net of taxes                                   —           0.05        0.05          0.16
     Gain on Disposal, net of taxes                         0.99            —         0.97           —
   Net Earnings per Common Share                          $ 1.29        $ 0.43      $ 2.00        $ 1.14

Average Common Shares Outstanding:
Basic                                                         1,977         1,974       1,976         1,968
Diluted                                                       2,004         2,012       2,006         2,005
(a)
      Other expense, net
       Interest expense                                   $     84      $    109    $  237        $  325
       Interest income                                         (37)          (69)     (111)         (184)
       Impairment charge of marketable securities               224           —        247            —
       Foreign exchange transaction (gains)/losses             (51)           21       (34)           24
       Other, net                                              (51)          (53)     (151)         (136)
                                                          $    169      $      8    $ 188         $   29

                                                     12
BRISTOL-MYERS SQUIBB COMPANY
                                             SPECIFIED ITEMS
                          FOR THE THREE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007
                                         (Unaudited, dollars in millions)

Three months ended September 30, 2008

                                                                                                                                 Other
                                             Cost of    Marketing,              Research                                       (income)/
                                                                                              Provision for Litigation expense expense,
                                            products    selling and               and
                                                                                            restructuring, net       net          net               Total
                                              sold     administrative         development
Productivity Transformation
Initiative:
Downsizing and streamlining of
                                                 -          -                      -        $    26           $     -          $        -          $ 26
 worldwide operations                   $              $                     $
Accelerated depreciation and other
                                              53               -                   -               -                -                   -            53
 shutdown costs
Process standardization
                                               -            28                     -               -                -                   -            28
 implementation costs
                                                                                   -
                                              53            28                                    26                -                   -           107

Litigation Matters:
Litigation settlement                          -               -                   -               -               30                   -            30

Other:
Mead Johnson Nutritionals charges             -             9                      -              -                 -              -                 9
Product liability                             -             -                      -              -                 -              2                 2
Upfront and milestone payments                -             -                     37              -                 -              -                 37
Auction rate securities impairment            -             -                      -              -                 -            224                224
                                             $53           $37                   $37             $26               $30         $ 226                409
Income taxes on items above                                                                                                                         (87)
(Increase)/Decrease to Net Earnings from Continuing Operations                                                                                      $322

Three months ended September 30, 2007


                                                            Cost of                             Gain
                                                           products          Research and     on sale of     Other (income)/
                                                             sold            development    product assets    expense, net             Total
 Litigation Matters:
 Insurance recovery                                        $       -         $         -    $          -      $     (11)           $    (11)
 Product liability                                                 -                   -               -               5                   5
                                                                    -                  -               -              (6)                (6)

 Other:
 Upfront and milestone payments                                     -              60               -                 -                   60
 Accelerated depreciation and asset impairment                     17                               -                 -                   17
 Gain on sale of product assets                                     -               -            (247)                -                 (247)
                                                           $       17        $     60        $   (247)        $      (6)                (176)
 Income taxes on items above                                                                                                              82
 (Increase)/Decrease to Net Earnings from Continuing Operations                                                                    $        (94)




                                                                        13
BRISTOL-MYERS SQUIBB COMPANY
                                                SPECIFIED ITEMS
                             FOR THE NINE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007
                                            (Unaudited, dollars in millions)
Nine months ended September 30, 2008
                                                       Marketing,                          Provision                                   Other
                                                         selling                               for                                   (income)/
                                                                         Research                                  Litigation
                                     Cost of products     and              and           restructuring,             expense,          expense,
                                           sold       administrative   development             net                     net              net             Total
Productivity Transformation
Initiative:
Downsizing and streamlining of
                                                   -        -                -                                         -
                                                                                         $ 67                                        $    -           $ 67
 worldwide operations                     $            $               $                                       $
Accelerated depreciation and other
                                              207           -                -                 -                       -                  -             207
 shutdown costs
Process standardization
                                                   -       64                -                 -                       -                  -                 64
 implementation costs
Gain on sale and leaseback of
                                                -           -                -                 -                       -                 (9)             (9)
 properties
                                                                             -                                         -
                                              207          64                                 67                                         (9)            329

Litigation Matters:
Litigation settlement                              -        -                -                 -                     32                   -                 32

Other:
Mead Johnson Nutritionals charges                  -       10                -                 -                       -                  -                 10
Product liability                                  -        -                -                 -                       -                 18                 18
Upfront and milestone payments                     -        -               88                 -                       -                  -                 88
Acquired in-process research &
 development                                  -           -               32                -                     -                      -               32
Auction rate securities impairment            -           -                -                -                     -                    247              247
                                          $ 207        $ 74            $ 120             $ 67                  $ 32                  $ 256              756
Income taxes on items above                                                                                                                            (154)
(Increase)/Decrease to Net Earnings from Continuing Operations                                                                                        $ 602

Nine months ended September 30, 2007
                                                                                                                                                  Gain on
                                                                                                                                                  sale of
                                          Cost of        Research       Provision for
                                         products          and          restructuring,         Litigation            Other (income)/              product
                                                                                              expense, net
                                           sold        development            net                                     expense, net                 assets            Total
Litigation Matters:
Litigation settlement                $        -        $        -      $         -        $           14             $           -            $        -         $     14

Insurance recovery                            -                 -                -                         -                    (11)                    -             (11)

Product liability                             -                 -                -                         -                     5                          -           5
                                               -                -                -                        14                    (6)                         -           8

Other:
Upfront and milestone
 payments                                     -            157                   -                         -                     -                     -              157
Downsizing and streamlining of
 worldwide operations                         -                 -           44                             -                     -                     -               44
Accelerated depreciation and
 asset impairment                          46                   -                -                         -                     -                     -               46

Gain on sale of product assets                -                 -                -                         -                                       (273)
                                                                                                                                 -                                   (273)

                                    $ 46            $ 157              $    44            $           14             $          (6)           $    (273)              (18)
Income taxes on items above                                                                                                                                            37
Change in estimate for taxes on prior year items                                                                                                                     (39)
(Increase)/Decrease to Net Earnings from Continuing Operations                                                                                                   $   (20)



                                                                       14
BRISTOL-MYERS SQUIBB COMPANY
                                         RECONCILIATION OF GAAP RESULTS OF CONTINUING OPERATIONS
                                              TO NON-GAAP RESULTS OF CONTINUING OPERATIONS
                                          FOR THE THREE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007
                                                             (Unaudited, amounts in millions except per share data)

                                                                                        Q3 2008                                    Q3 2007
                                                                                        Specified                                  Specified
                                                                                                           Non                                       Non
                                                                             GAAP        Items*                           GAAP      Items*
                                                                                                          GAAP                                      GAAP


           Net Sales                                                     $ 5,254                                      $ 4,601
                                                                                                      $ 5,254                                   $ 4,601
           Cost of Products Sold                                             1,634          (53)                          1,478       (17)
                                                                                                          1,581                                     1,461
               Gross Profit                                                  3,620          53                            3,123        17
                                                                                                          3,673                                     3,140
                                                                                           1.0%                                       0.3%
                    Gross Margin as% of Sales                                68.9%                        69.9%           67.9%                     68.2%


           Marketing Selling and Admin                                       1,208          (37)                          1,105
                                                                                                          1,171                                     1,105
           Advertising and Product Promotion                                  362                                          338
                                                                                                           362                                       338
               Total SGA                                                     1,570          (37)                          1,443
                                                                                                          1,533                                     1,443
                                                                                           (0.7%)
                    SG&A as % of Sales                                       29.9%                        29.2%           31.4%                     31.4%


           R&D                                                                834           (37)                           802        (60)
                                                                                                           797                                       742
                                                                                           (0.7%)                                    (1.3%)
                    R&D as % of Sales                                        15.9%                        15.2%           17.4%                     16.1%


           Provision for restructuring, net                                    26          (26)                               -             -
                                                                                                              -                                         -
           Litigation expense, net                                             30           (30)                              -             -
                                                                                                              -                                         -
           Gain on sale of Product Assets                                        -            -                           (247)       247
                                                                                                              -                                         -
           Equity in Net Income of Affiliates                                (164)            -                           (139)         -
                                                                                                          (164)                                     (139)
           Other expense/(income), net                                        169          (226)                             8          6
                                                                                                            (57)                                      14

           Earnings from Continuing Operations Before Minority
           Interest & Taxes                                               $1,155           409                        $1,256        (176)
                                                                                                      $ 1,564                                   $1,080


           Provision for income taxes                                         308           87                             292        (82)
                                                                                                           395                                       210

           Minority Interest, net of taxes                                    259                                          211
                                                                                                           259                                       211

           Net Earnings - Continuing Operations                               588          322                             753        (94)
                                                                                                           910                                       659


               Net Earnings – Discontinued Ops                               1,990                                         105
                                                                                                          1,990                                      105
           Net Earnings                                                  $ 2,578           322                        $    858        (94)
                                                                                                      $ 2,900                                   $    764

              Interest Exp on Conv. Of Conv Debt Bonds                          4                             4             10                        10
           Net Earnings used for Diluted EPS Calc - Continuing
                                                                         $    592          322        $    914        $    763        (94)      $    669
           Operations.


           Avg Shares (Diluted)                                              2,004                                        2,012
                                                                                                          2,004                                     2,012

           Diluted EPS - Continuing Operations                           $ 0.30            0.16                       $ 0.38         (0.05)
                                                                                                      $ 0.46                                    $ 0.33

                   Net Earnings - Continuing Operations as a %
                                                                              11.2%        6.1%                            16.4%      (2.1%)
                                                                                                          17.3%                                     14.3%
                   of sales


                                                                             26.7%         (1.4%)                         23.2%       (3.8%)
                    Effective Tax Rate                                                                    25.3%                                     19.4%


* Please refer to the Specified Items schedules for further details.




                                                                                      15
BRISTOL-MYERS SQUIBB COMPANY
                                         NET DEBT CALCULATION
                                AS OF SEPTEMBER 30, 2008 AND JUNE 30, 2008
                                        (Unaudited, dollars in millions)



                                                              September 30, 2008     June 30, 2008
Cash and cash equivalents                                    $       7,173         $       4,047
Marketable securities-current                                          258                   355
Short-term borrowings                                                 (135)               (1,799)
Long-term debt                                                      (6,120)               (6,021)
Net cash / (debt)                                            $       1,176         $      (3,418)




                                                    16

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bristol myerd squibb Bristol-Myers Squibb Company Reports Third Quarter 2008 Financial Results

  • 1. Bristol-Myers Squibb Continues Excellent Financial Performance Led By Double-Digit Global Net Sales Growth and Strong Earnings Results • Reports Broad-Based Net Sales Growth of 14% from Continuing Operations • Records Growth in GAAP Diluted EPS of $1.29 Compared to $0.43 in 2007; Includes After-Tax Gain of $0.99 Per Share From Sale of ConvaTec • Posts 2008 GAAP Diluted EPS from Continuing Operations of $0.30 Compared to $0.38 in 2007 • Posts Non-GAAP Diluted EPS Growth from Continuing Operations of $0.46 Compared to $0.33 in 2007 • Raises 2008 GAAP EPS Guidance to $1.61 to $1.66, Subject to Receipt of Cash for ImClone Shares, and Refines 2008 Non-GAAP EPS Guidance to $1.65 to $1.70, Representing Upper Range of Previous Guidance • Strengthens Cash Position to $7.2 Billion From $4.0 Billion on June 30, 2008 (NEW YORK, October 23, 2008) -- Consistent with recent performance, Bristol-Myers Squibb Company (NYSE:BMY) today reported strong sales growth and earnings performance for the third quarter 2008. “Bristol-Myers Squibb continues to deliver excellent operating results. With double-digit sales growth in the third quarter and with strong financial results for the first nine months of 2008, we are refining our 2008 non-GAAP earnings-per-share guidance to between $1.65 to $1.70, which is the upper range of our prior guidance,” said James M. Cornelius, chairman and chief executive officer. “Our recent success gives us confidence that our BioPharma strategy is the right one to help us fulfill our commitments to patients and shareholders,” Cornelius added. “As we continue to demonstrate strong performance in the marketplace, we’re moving forward to attain our goals, both commercially and with the advancement of our new product pipeline. The strength of our balance sheet and cash position enables us to execute our strategy, including our ongoing business development activity.” Third Quarter 2008 2008 2007 Change Net Sales $5,254 $4,601 14% Net Earnings $2,578 $ 858 200% Net Earnings From Continuing Operations $ 588 $ 753 (22%) Net Earnings Per Common Share 1.29 0.43 200% GAAP Diluted EPS From Continuing Operations 0.30 0.38 (21%) Non-GAAP Diluted EPS From Continuing Operations 0.46 0.33 39% ($ amounts in millions, except per share amounts) 1
  • 2. THIRD QUARTER RESULTS • Bristol-Myers Squibb posted third quarter 2008 net sales from continuing operations of $5.3 billion, an increase of 14%, including a 3% favorable foreign exchange impact, compared to the same period in 2007. Pharmaceutical net sales totaled $4.5 billion and sales of Nutritionals totaled $744 million in the third quarter of 2008, representing increases of 15% and 10%, respectively, compared to 2007. • U.S. pharmaceutical net sales increased 18% to $2.7 billion in the third quarter of 2008 compared to the same period in 2007, primarily due to strong performance from PLAVIX® and ABILIFY® , and strong results from the HIV and hepatitis portfolio as well as ORENCIA®. • International pharmaceutical net sales increased 11%, including a 7% favorable foreign exchange impact, to $1.8 billion in the third quarter of 2008 compared to the same period in 2007. The increase was primarily due to the strong performance of BARACLUDE®, ABILIFY®, SPRYCEL™ and the HIV portfolio. • Gross profit as a percentage of net sales improved to 68.9% in the third quarter 2008 compared to 67.9% in 2007. This increase of 1.0% was driven by favorable product mix, cost improvement from productivity initiatives and favorable foreign exchange, partially offset by higher manufacturing rationalization charges in 2008, which accounted for a 0.7% decrease. • Marketing, selling and administrative expenses increased by 9%, including an unfavorable 3% foreign exchange impact, to $1.2 billion in the third quarter of 2008 compared to the same period in 2007. • Advertising and product promotion spending increased by 7%, including an unfavorable 2% foreign exchange impact, to $362 million in the third quarter of 2008 compared to the same period in 2007. • Research and development expenses increased 4%, including an unfavorable 1% foreign exchange impact, to $834 million in the third quarter of 2008 compared to the same period in 2007. • The effective tax rate on earnings from continuing operations before minority interest and income taxes was 26.7% for the third quarter of 2008, compared with 23.2% in the third quarter of 2007. The company expects the full year 2008 non-GAAP effective tax rate from continuing operations to be in line with the previously issued guidance of approximately 24%. 2
  • 3. The company reported third quarter net earnings of $2.6 billion or $1.29 per diluted share, compared to net earnings of $858 million or $0.43 per diluted share for the same period in 2007. The third quarter 2008 net earnings includes a $2.0 billion after-tax gain, or $0.99 per share, attributed to the sale of the company’s ConvaTec business which is recorded in discontinued operations. In addition, the third quarter of 2008 and 2007 net earnings include the impact of specified items as discussed under “Use of Non-GAAP Financial Information.” • The company reported earnings from continuing operations of $588 million or $0.30 per diluted share which represented a 21% decrease from prior year primarily due to the impact of specified items. • Non-GAAP earnings from continuing operations excluding specified items amounted to $910 million, or $0.46 per diluted share, which represents a 39% increase from the prior year. This increase is driven by higher sales growth, improved gross margins and execution of cost- containment measures. SELECTED BALANCE SHEET AND CASH UPDATES • The company's financial condition improved significantly during the quarter as a result of $1.4 billion of cash generated from operating activities as well as $4.1 billion in proceeds from the sale of ConvaTec. Cash and cash equivalents were $7.2 billion as of September 30, 2008 of which a significant majority was invested in U.S. Treasury Bills and Treasury-backed securities, consistent with the more conservative approach the company announced it would take earlier in 2008. • Net debt, which is defined as short-term borrowings and long-term debt less cash and cash equivalents and marketable securities, was reduced by $4.6 billion to a net cash position of $1.2 billion. • An impairment charge of $224 million, $184 million net of tax, related to certain auction rate securities (ARS) was recognized during the three months ended September 30, 2008. The charge was required after an analysis of other-than-temporary impairment factors, including the severity of decline in the securities and current financial market conditions. The carrying value of the $811 million of principal invested in ARS as of December 31, 2007 has been reduced to a remaining amount of $213 million as of September 30, 2008. 3
  • 4. BUSINESS DEVELOPMENT UPDATE Eli Lilly commenced a tender offer to acquire ImClone on October 14, 2008. Based on Bristol- Myers Squibb’s ownership of 14.4 million shares of ImClone, the company expects to receive approximately $1.0 billion in cash upon the closing of the transaction. Bristol-Myers Squibb continues to have long-term marketing rights to ERBITUX in the U.S. and Canada and believes it has rights to ImClone’s investigational compound IMC-11F8. The company is executing on its strategic priorities for its healthcare group. On August 1, the company announced that it had completed the divestiture of the ConvaTec business unit to Nordic Capital Fund VII and Avista Capital Partners. On September 25, the company announced that Mead Johnson Nutrition Company had filed a registration statement with the U.S. Securities and Exchange Commission for an initial public offering of its Class A common stock. Bristol-Myers Squibb is focusing on supplementing its internal research and development portfolio with strategic partnerships and acquisitions. In August, the company announced a global alliance with PDL BioPharma to develop and commercialize elotuzumab, an anti-CS1 antibody currently in Phase I development for multiple myeloma. NEW PRODUCT PIPELINE UPDATE Bristol-Myers Squibb and its partner AstraZeneca announced on July 23 that the regulatory submissions for ONGLYZA (saxagliptin) were made in both the United States and in Europe on June 30 and July 1, respectively. On September 2, the U.S. Food and Drug Administration (FDA) announced it had accepted the filing. The following regulatory and data milestones occurred in the third quarter or in October: • On October 1, the FDA approved the use of REYATAZ® (atazanavir sulfate) 300 milligram once-daily boosted with ritonavir 100 milligram as part of combination therapy in previously untreated (treatment-naïve) HIV-1 infected patients. This use of once-daily REYATAZ/ritonavir in HIV-1 infected treatment-naïve adult patients is based upon 48-week results from the CASTLE study, which demonstrated similar antiviral efficacy of REYATAZ/ritonavir to twice- daily lopinavir/ritonavir, each as part of HIV combination therapy in treatment-naïve HIV-1 infected adult patients. Data from the CASTLE study were published in the August 23 issue of The Lancet. 4
  • 5. • Bristol-Myers Squibb and its development partner Pfizer announced in August that the primary endpoint was not met in a Phase III study of apixaban – a novel anticoagulant – for prevention of venous thromboembolism (VTE) in patients undergoing total knee replacement. The rate of the primary efficacy endpoint on apixaban was numerically similar to that observed with enoxaparin, but did not meet the pre-specified statistical criteria for non-inferiority compared to enoxaparin. The results of the trial do not necessitate any changes in protocols of any other ongoing apixaban studies. The companies are considering further studies in preventing VTE in knee surgery and will not submit the U.S. filing for VTE prevention in the second half of 2009, as had been previously communicated. Programs directed toward prevention of VTE including EMEA registrational studies, treatment of VTE, and in the prevention of stroke in atrial fibrillation continue as planned. • A Phase II study of apixaban (APPRAISE-1) provided encouraging trends suggesting that anticoagulation with apixaban on top of current standards of care and continued beyond the initial hospitalization for acute coronary syndrome may reduce the risk of a second heart attack, stroke or death. • The company and its development partner AstraZeneca announced results of phase III studies of ONGLYZA™ (saxagliptin), a potential treatment for type 2 diabetes, in September at the European Association for the Study of Diabetes. Data showed ONGLYZA, used in combination with metformin as initial therapy, when added to a sulfonylurea or thiazolidinedione in patients with inadequately controlled type 2 diabetes significantly lowered A1C and demonstrated significant improvements across key measures of glucose control. • Bristol-Myers Squibb and its development partner ImClone Systems announced ERBITUX® five-year data showing significant improvement in overall survival for patients with locally or regionally advanced head and neck cancer. In the September 10 issue of the New England Journal of Medicine, the EXTREME study was published and it showed that ERBITUX improved survival in first-line recurrent and/or metastatic head and neck cancer. • Bristol-Myers Squibb and its development partner Medarex, Inc. announced in September updated survival data from three phase 2 studies of ipilimumab in patients with advanced metastatic melanoma (stage III or IV) who had been previously treated. Study results showed that approximately half of patients who received ipilimumab (10 mg/kg) remained alive beyond one year. 5
  • 6. 2008 GUIDANCE Bristol-Myers Squibb is raising its 2008 earnings guidance for fully diluted earnings per share from continuing operations on a GAAP basis to between $1.61 and $1.66, reflecting an estimated $900 million pre-tax gain ($0.29 per share after tax) from Eli Lilly’s acceptance of the company’s tender of its ImClone shares. If the company does not receive such cash from the tender, the company expects to lower 2008 guidance on a GAAP basis to between $1.32 to $1.37 per share. The company is also refining its 2008 fully diluted earnings per share from continuing operations guidance on a non-GAAP basis to be between $1.65 and $1.70, which is the upper end of its previous guidance. The non-GAAP guidance excludes specified items as discussed under “Use of Non-GAAP Financial Information.” Details reconciling the GAAP and non-GAAP bases are provided in supplemental materials available on the company’s website. The company reaffirms guidance that it expects non-GAAP earnings per share from continuing operations to grow at a minimum of 15 percent compounded annual growth rate, from the 2007 base through 2010 without rebasing for the agreement to sell the ConvaTec business, excluding costs associated with the Productivity Transformation Initiative and other specified items that have not yet been identified and quantified. The non-GAAP 2008 guidance and the three-year compound annual growth rate exclude other specified items such as gains or losses from sale of businesses and product lines; from sale of equity investments and from discontinuations of operations; restructuring and other exit costs; accelerated depreciation charges; asset impairments; charges and recoveries relating to significant legal proceedings; upfront and milestone payments for licensing arrangements; payments for in-process research and development; debt retirement costs; impairments to investments; and significant tax events. The financial guidance for 2008 and the three-year compound annual growth rate exclude the impact of any potential strategic acquisitions and divestitures and further assume that the company and its product partner, sanofi-aventis, maintain U.S. exclusivity for the PLAVIX® patent through at least 2010. Use of Non-GAAP Financial Information This press release contains non-GAAP financial measures, including non-GAAP earnings and earnings per share information, adjusted to exclude certain costs, expenses, gains and losses and other specified items. Among the items in GAAP measures but excluded for purposes of determining adjusted earnings and other adjusted measures are: charges related to implementation of the Productivity Transformation Initiative and the company’s strategy for Mead Johnson Nutritionals; gains or losses from sale and leaseback of properties and from discontinuations of operations; restructuring and other exit costs; accelerated depreciation charges; asset impairments; charges relating to significant legal 6
  • 7. proceedings; upfront and milestone payments for in-licensing of products that have not achieved regulatory approval that are immediately expensed; payments for in-process research and development; impairments to investments; and significant tax events. This information is intended to enhance an investor’s overall understanding of the company’s past financial performance and prospects for the future. For example, non-GAAP earnings and earnings per share information is an indication of the company’s baseline performance before items that are considered by the company to be not reflective of the company’s ongoing results. In addition, this information is among the primary indicators the company uses as a basis for evaluating company performance, allocating resources, setting incentive compensation targets, and planning and forecasting of future periods. This information is not intended to be considered in isolation or as a substitute for net earnings or diluted earnings per share prepared in accordance with GAAP. Statement on Cautionary Factors This press release contains certain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 regarding, among other things, statements relating to goals, plans and projections regarding the company’s financial position, results of operations, market position, product development and business strategy. These statements may be identified by the fact that they use words such as quot;anticipatequot;, quot;estimatesquot;, quot;shouldquot;, quot;expectquot;, quot;guidancequot;, quot;projectquot;, quot;intendquot;, quot;planquot;, quot;believequot; and other words and terms of similar meaning in connection with any discussion of future operating or financial performance. Such forward-looking statements are based on current expectations and involve inherent risks and uncertainties, including factors that could delay, divert or change any of them, and could cause actual outcomes and results to differ materially from current expectations. These factors include, among other things, market factors (including whether uncertainties in the credit and capital markets or a further deterioration of these markets will lead to future impairments to the company’s investment portfolio), competitive product development and approvals, pricing controls and pressures (including changes in rules and practices of managed care groups and institutional and governmental purchasers), economic conditions such as interest rate and currency exchange rate fluctuations, judicial decisions and governmental laws and regulations related to Medicare, Medicaid and healthcare reform, pharmaceutical rebates and reimbursement, claims and concerns that may arise regarding the safety and efficacy of in-line products and product candidates, changes to wholesaler inventory levels, variability in data provided by third parties, changes in, and interpretation of, governmental regulations and legislation affecting domestic or foreign operations, including tax obligations, difficulties and delays in product development, manufacturing or sales, patent positions and the ultimate outcome of any litigation matter, including whether Apotex will prevail in its appeal of the District court’s decision in the PLAVIX® patent litigation. These factors also include the company’s ability to execute successfully its strategic plans, including its Productivity Transformation Initiative, the expiration of patents or data protection on certain products (including the expiration of data protection for PLAVIX® in the European Union), and the impact and result of governmental investigations. There can be no guarantees with respect to pipeline products that future clinical studies will support the data described in this release, that the products will receive necessary regulatory approvals, or that they will prove to be commercially successful; nor are there guarantees that regulatory approvals will be sought, or sought within currently expected timeframes, or that contractual milestones will be achieved. For further details and a discussion of these and other risks and uncertainties, see the company's periodic reports, including the annual report on Form 10-K, quarterly reports on Form 10-Q and current reports on Form 8-K, filed with or furnished to the Securities and Exchange Commission. The company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. 7
  • 8. Statement on Mead Johnson Nutrition Company Registration Statement A registration statement relating to the securities of Mead Johnson Nutrition Company has been filed with the U.S. Securities and Exchange Commission but has not yet become effective. These securities may not be sold nor may offers to buy these securities be accepted before the time the registration statement becomes effective. This press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. Company and Conference Call Information Bristol-Myers Squibb is a global biopharmaceutical and company whose mission is to extend and enhance human life. There will be a conference call on October 23, 2008 at 10:30 a.m. (EDT) during which company executives will address inquiries from investors and analysts. Investors and the general public are invited to listen to a live web cast of the call at www.bms.com/ir or by dialing 913-312-9330, confirmation code 7242577. Materials related to the call will be available at the same website prior to the call. For more information, contact: Brian Henry, 609-252-3337, Communications, Tracy Furey, 609- 252-3208, Communications, John Elicker, 212-546-3775, Investor Relations, or Suketu Desai, 609-252- 5796, Investor Relations. ABILIFY® is the trademark of Otsuka Pharmaceutical Co., Ltd. ATRIPLA™ is a trademark of both Bristol-Myers Squibb Co. and Gilead Sciences, Inc. AVAPRO®, AVALIDE® and PLAVIX® are trademarks of sanofi-aventis ERBITUX® is a trademark of ImClone Systems Incorporated 8
  • 9. BRISTOL-MYERS SQUIBB COMPANY NET SALES BY OPERATING SEGMENTS FOR THE THREE AND NINE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007 (Unaudited, dollars in millions) Three Months Nine Months Ended September 30, Ended September 30, 2008 2007 2008 2007 Pharmaceuticals $ 4,510 $ 3,926 $ 13,173 $ 11,234 Nutritionals 744 675 2,175 1,901 Net Sales $ 5,254 $ 4,601 $ 15,348 $ 13,135 9
  • 10. BRISTOL-MYERS SQUIBB COMPANY SELECTED PRODUCTS FOR THE THREE AND NINE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007 (Unaudited, dollars in millions) The following table sets forth worldwide and U.S. reported net sales for selected products for the three and nine months ended September 30, 2008 compared to the three and nine months ended September 30, 2007. In addition, the table includes, where applicable, the estimated total U.S. prescription change for the retail and mail-order channels for the comparative periods presented for certain of the company's U.S. pharmaceutical products based on third-party data. A significant portion of the company's U.S. pharmaceutical sales is made to wholesalers. Where changes in reported net sales differ from prescription growth, this change in net sales may not reflect underlying prescriber demand. Worldwide Net Sales U.S. Net Sales % % Change % Change in U.S. Total 2008 2007 Change 2008 2007 Prescriptions vs. 2007 Three Months Ended September 30, Pharmaceuticals Cardiovascular Plavix $ 1,439 $ 1,254 15% $1,263 $ 1,080 17% 7% Avapro/Avalide 334 309 8% 189 176 7% (7)% Pravachol 34 86 (60)% (18) 17 * (52)% Virology Reyataz 342 273 25% 176 141 25% 18% Sustiva Franchise (total revenue) 294 237 24% 185 151 23% 15% Baraclude 144 72 100% 36 22 64% 59% Oncology Erbitux 184 185 (1)% 182 183 (1)% N/A Taxol 91 102 (11)% (1) 1 (200)% N/A Sprycel 82 46 78% 21 17 24% 29% Ixempra 25 --- --- 24 --- --- N/A Affective (Psychiatric) Disorders Abilify 564 420 34% 435 329 32% 26% Immunoscience Orencia 119 60 98% 97 57 70% N/A Nutritionals Enfamil 295 281 5% 178 195 (9)% N/A * In excess of +/- 200% 10
  • 11. (Continued) Worldwide Net Sales U.S. Net Sales % % % Change in U.S. Total 2008 2007 Change 2008 2007 Change Prescriptions vs. 2007 Nine Months Ended September 30, Pharmaceuticals Cardiovascular Plavix $4,134 $3,381 $3,609 $2,882 25% 26% 22% Avapro/Avalide 974 876 11% 547 509 7% (7)% Pravachol 176 353 (50)% 7 121 (94)% (78)% Virology Reyataz 963 790 22% 495 422 17% 15% Sustiva Franchise (total revenue) 849 696 22% 531 442 20% 14% Baraclude 388 176 120% 100 59 69% 60% Oncology Erbitux 567 507 12% 560 501 12% N/A Taxol 286 308 (7)% 2 9 (78)% N/A Sprycel 224 102 120% 62 41 51% 42% --- Ixempra 76 --- --- 75 --- N/A Affective (Psychiatric) Disorders Abilify 1,547 1,198 29% 1,186 944 26% 20% Immunoscience Orencia 312 156 100% 257 150 71% N/A Nutritionals Enfamil 872 802 9% 536 543 (1)% N/A 11
  • 12. BRISTOL-MYERS SQUIBB COMPANY CONSOLIDATED STATEMENTS OF EARNINGS FOR THE THREE AND NINE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007 (Unaudited, amounts in millions except per share data) Three Months Nine Months Ended September 30, Ended September 30, 2008 2007 2008 2007 Net Sales $ 5,254 $ 4,601 $15,348 $13,135 Cost of products sold 1,634 1,478 4,874 4,152 Marketing, selling and administrative 1,208 1,105 3,507 3,260 Advertising and product promotion 362 338 1,101 950 Research and development 834 802 2,442 2,338 Acquired in-process research and development — — 32 — Provision for restructuring, net 26 — 67 44 Litigation expense, net 30 — 32 14 Gain on sale of product assets — (247) — (273) Equity in net income of affiliates (164) (139) (478) (393) Other expense, net (a) 169 8 188 29 Total expenses 4,099 3,345 11,765 10,121 Earnings from Continuing Operations 1,155 1,256 3,583 3,014 Before Minority Interest and Income Taxes Provision for income taxes 308 292 896 535 Minority interest, net of taxes 259 211 730 546 Net Earnings from Continuing Operations 588 753 1,957 1,933 Discontinued Operations: Earnings, net of taxes 8 105 107 321 Gain on Disposal, net of taxes 1,982 — 1,939 — 1,990 105 2,046 321 Net Earnings $ 2,578 $ 858 $ 4,003 $ 2,254 Earnings per Common Share Basic: Net Earnings from Continuing Operations $ 0.30 $ 0.38 $ 0.99 $ 0.98 Discontinued Operations: Earnings, net of taxes — 0.05 0.06 0.17 Gain on Disposal, net of taxes 1.00 — 0.98 — Net Earnings per Common Share $ 1.30 $ 0.43 $ 2.03 $ 1.15 Diluted: Net Earnings from Continuing Operations $ 0.30 $ 0.38 $ 0.98 $ 0.98 Discontinued Operations: Earnings, net of taxes — 0.05 0.05 0.16 Gain on Disposal, net of taxes 0.99 — 0.97 — Net Earnings per Common Share $ 1.29 $ 0.43 $ 2.00 $ 1.14 Average Common Shares Outstanding: Basic 1,977 1,974 1,976 1,968 Diluted 2,004 2,012 2,006 2,005 (a) Other expense, net Interest expense $ 84 $ 109 $ 237 $ 325 Interest income (37) (69) (111) (184) Impairment charge of marketable securities 224 — 247 — Foreign exchange transaction (gains)/losses (51) 21 (34) 24 Other, net (51) (53) (151) (136) $ 169 $ 8 $ 188 $ 29 12
  • 13. BRISTOL-MYERS SQUIBB COMPANY SPECIFIED ITEMS FOR THE THREE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007 (Unaudited, dollars in millions) Three months ended September 30, 2008 Other Cost of Marketing, Research (income)/ Provision for Litigation expense expense, products selling and and restructuring, net net net Total sold administrative development Productivity Transformation Initiative: Downsizing and streamlining of - - - $ 26 $ - $ - $ 26 worldwide operations $ $ $ Accelerated depreciation and other 53 - - - - - 53 shutdown costs Process standardization - 28 - - - - 28 implementation costs - 53 28 26 - - 107 Litigation Matters: Litigation settlement - - - - 30 - 30 Other: Mead Johnson Nutritionals charges - 9 - - - - 9 Product liability - - - - - 2 2 Upfront and milestone payments - - 37 - - - 37 Auction rate securities impairment - - - - - 224 224 $53 $37 $37 $26 $30 $ 226 409 Income taxes on items above (87) (Increase)/Decrease to Net Earnings from Continuing Operations $322 Three months ended September 30, 2007 Cost of Gain products Research and on sale of Other (income)/ sold development product assets expense, net Total Litigation Matters: Insurance recovery $ - $ - $ - $ (11) $ (11) Product liability - - - 5 5 - - - (6) (6) Other: Upfront and milestone payments - 60 - - 60 Accelerated depreciation and asset impairment 17 - - 17 Gain on sale of product assets - - (247) - (247) $ 17 $ 60 $ (247) $ (6) (176) Income taxes on items above 82 (Increase)/Decrease to Net Earnings from Continuing Operations $ (94) 13
  • 14. BRISTOL-MYERS SQUIBB COMPANY SPECIFIED ITEMS FOR THE NINE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007 (Unaudited, dollars in millions) Nine months ended September 30, 2008 Marketing, Provision Other selling for (income)/ Research Litigation Cost of products and and restructuring, expense, expense, sold administrative development net net net Total Productivity Transformation Initiative: Downsizing and streamlining of - - - - $ 67 $ - $ 67 worldwide operations $ $ $ $ Accelerated depreciation and other 207 - - - - - 207 shutdown costs Process standardization - 64 - - - - 64 implementation costs Gain on sale and leaseback of - - - - - (9) (9) properties - - 207 64 67 (9) 329 Litigation Matters: Litigation settlement - - - - 32 - 32 Other: Mead Johnson Nutritionals charges - 10 - - - - 10 Product liability - - - - - 18 18 Upfront and milestone payments - - 88 - - - 88 Acquired in-process research & development - - 32 - - - 32 Auction rate securities impairment - - - - - 247 247 $ 207 $ 74 $ 120 $ 67 $ 32 $ 256 756 Income taxes on items above (154) (Increase)/Decrease to Net Earnings from Continuing Operations $ 602 Nine months ended September 30, 2007 Gain on sale of Cost of Research Provision for products and restructuring, Litigation Other (income)/ product expense, net sold development net expense, net assets Total Litigation Matters: Litigation settlement $ - $ - $ - $ 14 $ - $ - $ 14 Insurance recovery - - - - (11) - (11) Product liability - - - - 5 - 5 - - - 14 (6) - 8 Other: Upfront and milestone payments - 157 - - - - 157 Downsizing and streamlining of worldwide operations - - 44 - - - 44 Accelerated depreciation and asset impairment 46 - - - - - 46 Gain on sale of product assets - - - - (273) - (273) $ 46 $ 157 $ 44 $ 14 $ (6) $ (273) (18) Income taxes on items above 37 Change in estimate for taxes on prior year items (39) (Increase)/Decrease to Net Earnings from Continuing Operations $ (20) 14
  • 15. BRISTOL-MYERS SQUIBB COMPANY RECONCILIATION OF GAAP RESULTS OF CONTINUING OPERATIONS TO NON-GAAP RESULTS OF CONTINUING OPERATIONS FOR THE THREE MONTHS ENDED SEPTEMBER 30, 2008 AND 2007 (Unaudited, amounts in millions except per share data) Q3 2008 Q3 2007 Specified Specified Non Non GAAP Items* GAAP Items* GAAP GAAP Net Sales $ 5,254 $ 4,601 $ 5,254 $ 4,601 Cost of Products Sold 1,634 (53) 1,478 (17) 1,581 1,461 Gross Profit 3,620 53 3,123 17 3,673 3,140 1.0% 0.3% Gross Margin as% of Sales 68.9% 69.9% 67.9% 68.2% Marketing Selling and Admin 1,208 (37) 1,105 1,171 1,105 Advertising and Product Promotion 362 338 362 338 Total SGA 1,570 (37) 1,443 1,533 1,443 (0.7%) SG&A as % of Sales 29.9% 29.2% 31.4% 31.4% R&D 834 (37) 802 (60) 797 742 (0.7%) (1.3%) R&D as % of Sales 15.9% 15.2% 17.4% 16.1% Provision for restructuring, net 26 (26) - - - - Litigation expense, net 30 (30) - - - - Gain on sale of Product Assets - - (247) 247 - - Equity in Net Income of Affiliates (164) - (139) - (164) (139) Other expense/(income), net 169 (226) 8 6 (57) 14 Earnings from Continuing Operations Before Minority Interest & Taxes $1,155 409 $1,256 (176) $ 1,564 $1,080 Provision for income taxes 308 87 292 (82) 395 210 Minority Interest, net of taxes 259 211 259 211 Net Earnings - Continuing Operations 588 322 753 (94) 910 659 Net Earnings – Discontinued Ops 1,990 105 1,990 105 Net Earnings $ 2,578 322 $ 858 (94) $ 2,900 $ 764 Interest Exp on Conv. Of Conv Debt Bonds 4 4 10 10 Net Earnings used for Diluted EPS Calc - Continuing $ 592 322 $ 914 $ 763 (94) $ 669 Operations. Avg Shares (Diluted) 2,004 2,012 2,004 2,012 Diluted EPS - Continuing Operations $ 0.30 0.16 $ 0.38 (0.05) $ 0.46 $ 0.33 Net Earnings - Continuing Operations as a % 11.2% 6.1% 16.4% (2.1%) 17.3% 14.3% of sales 26.7% (1.4%) 23.2% (3.8%) Effective Tax Rate 25.3% 19.4% * Please refer to the Specified Items schedules for further details. 15
  • 16. BRISTOL-MYERS SQUIBB COMPANY NET DEBT CALCULATION AS OF SEPTEMBER 30, 2008 AND JUNE 30, 2008 (Unaudited, dollars in millions) September 30, 2008 June 30, 2008 Cash and cash equivalents $ 7,173 $ 4,047 Marketable securities-current 258 355 Short-term borrowings (135) (1,799) Long-term debt (6,120) (6,021) Net cash / (debt) $ 1,176 $ (3,418) 16