call girls in Kamla Market (DELHI) 🔝 >༒9953330565🔝 genuine Escort Service 🔝✔️✔️
BP_Control.ppt physology1.ppt
1. Control of blood pressure
Outline
• Short term control (baroreceptors)
– Location
– Types of baroreceptor
– Baroreceptor reflex
• Other stretch receptors
• Long-term control
– Renin/ angiotensin/ aldosterone system
– Vasopressin
– Atrial natiuretic peptide
• Response to blood loss (shock)
2. Control of blood pressure
• Mean blood pressure is controlled by changing
total peripheral resistance and or cardiac output.
P = CO x TPR (compare Ohm’s law)
– Cardiac output is controlled by sympathetic and para
sympathetic nerves which effect:
• heart rate
• force of contraction
– TPR controlled by nervous and chemical means to
effect constriction/dilatation of
• arterioles and venules
3. Regulation of blood pressure
How is pressure “measured”?
• Short term
– Baroreceptors
• Long term
– Kidney via renin angiotensin system
4. http://www.cvphysiology.com/Blood Pressure/bp012 baroreceptor anat.gif
Location of
baroreceptors
• Baroreceptors sense stretch and
rate of stretch by generating
action potentials (voltage spikes)
• Located in highly distensible
regions of the circulation to
maximise sensitivity
5. Baroreceptor output
(from single fibres)
Rapid decrease in mean pressure
From: Introduction to Cardiovascular physiology. J.R. Levick. Arnold 4th edition (2003)
Rapid increase in mean pressure
Response to pulse pressure
6. Two types of baroreceptor
• Type A
– High sensitivity
– High firing rate
• Type C
– Lower sensitivity
– Lower firing rate
– Higher threshold (before firing starts)
• Therefore can deal with higher pressures than
type A which become “saturated”
From “An Introduction to Cardiovascular Physiology”
J.R. Levick
7. Response of single baroreceptor
fibre to change in pressure
From “An Introduction to Cardiovascular Physiology” J.R. Levick
9. Baroreceptor reflex is a
feedback loop
Read
temperature
Is temperature
too high?
No
Yes
Boiler on
Negative feedback
Example: central heating system
Set temperature
10. Baroreceptor reflex is a
feedback loop
“Read”
pressure
Is pressure
too high?
Two way negative feedback
Yes
Increase CO
Increase TPR
No
Reduce CO
Reduce TPR
12. Other stretch receptors
• Coronary artery baroreceptors
– Respond to arterial pressure but more sensitive than
carotid and aortic ones
• Veno-atrial mechanoreceptors
– Respond to changes in central blood volume
• Lie down, lift your legs and cause peripheral vasodilatation
• Unmyelinated mechanoreceptors
– Respond to distension of heart
• Ventricular ones during systole; atrial ones during inspiration
13. Location of receptors in and near the heart
From “An Introduction to Cardiovascular Physiology” J.R. Levick
Spinal cord
Baroreceptors in
coronary arteries and
aortic arch
Sympathetic afferents &
unmyelinated nociceptors
Cardiac pain
Nucleus tractus solitarius
Cardiac vagal afferents
unmyelinated
myelinated
14. Other receptors
• Heart chemosensors
– Cause pain in response to ischaemia
• K+, lactic acid, bradykinin, prostaglandins
• Arterial chemosensors
– Stimulated in response to
• Hypoxaemia, hypercapnia*, acidosis,
hyperkalaemia**
• Regulate breathing
• Lung stretch receptors
– Cause tachycardia during inspiration
*too much CO2
**too much K+
15. Overview of short-term control mechanisms
From: Introduction to Cardiovascular physiology. J.R. Levick. Arnold 4th edition (2003)
16. Long term control of blood pressure
• Involves control of blood volume/sodium
balance by the kidneys
– Hormonal control
• Renin-angiotensin-aldosterone system
• Antidiuretic hormone (vasopressin)
• Atrial natiuretic peptide
– Pressure natriuresis
18. Vasopressin
• Enhances water retention
• Causes vasoconstriction
• Secretion increased by unloading of
aortic Baroreceptors and atrial sensors
http://www.cvphysiology.com/Blood%20Pressure/BP016.htm
19. Atrial natiuretic peptide
• Increases salt excretion via kidneys
– By reducing water reabsorption in the
collecting ducts
– relaxes renal arterioles
– inhibits sodium reabsorption in the
distal tubule
• Released in response to stimulation of
atrial receptors
20. Summary of long term BP control
• Cardiac output and BP depend on renal control of
extra-cellular fluid volume via:
– Pressure natriuresis, (increased renal filtration)
– Changes in:
• Vasopressin
• Aldosterone
• Atrial natiuretic peptide
All under the control of altered cardiovascular
receptor signaling
21. Shock
Definition:
A pathophysiological disorder characterised by acute
failure of the cardiovascular system to perfuse the
tissues of the body adequately.
Levick J.R. “An Introduction to Cardiovascular Physiology”
Symptoms
– Cold, clammy skin
– Muscular weakness
– Rapid and shallow breathing
– Rapid and weak pulse
– Low pulse pressure (and sometimes mean pressure)
– Reduced urine output
– Confusion
22. Types of shock
– Hypovolaemia
• Caused by drop in blood (plasma) volume
– e.g. haemorrhage, diarrhoea, vomiting, injury
– Septic
• Caused by bacterial endotoxins
– e.g. salmonella
– Cardiogenic
• An acute interruption of of cardiac function
– e.g. myocarditis (inflammation of the heart muscle) or
myocardial infarction
– Anaphylactic
• Caused by allergic reaction
23. Effect of blood loss
• less than 10%, no serious symptoms
– e.g. blood transfusion
• 20 - 30% blood loss not usually life
threatening
• greater than 30%, severe drop in BP
and, often, death due to impaired
cerebral and coronary perfusion
24. Response to moderate blood loss
(compensated haemorrhage)
• Blood volume falls therefore pulse pressure
and stroke volume fall. (Frank-Starling
mechanism: reduced LV contractile force)
• Cardiopulmonary stretch receptor and
baroreceptor activity falls
• Arterial chemoreceptor activity increases, due
to hypoxia and acidosis
rapid breathing
release of vasoconstrictors
Vasopressin, angiotensin etc.
25. Response to moderate blood loss
More serious blood loss
can be treated by
transfusion to lessen the
effects shown here