Driving Behavioral Change for Information Management through Data-Driven Gree...
Blockchain in Bioinformatics
1.
2. Trends: Past 5 years
An investment of $100 in Bitcoin in 2011 is now worth $482,666.67
3. Overview of Blockchain.
A Transaction in Blockchain.
High affinity of Blockchain- why?
Blockchain in Bioinformatics.
Use cases.
Structure of the session
4. Blockchain
Distributed digital ledger or database.
● Record of transactions and it can be money, good or secure data.
● Designed in a way the makes it impossible to alter.
● Every node contains a copy of all the blocks.
6. High affinity of Blockchain- why?
Trust
Distributed
Traceability
Transparency
7. Transparency
Permissioned and permissionless blockchains.
● Permissioned Blockchain
○ Authorized access.
○ BigchainDB, Corda.
● Permissionless Blockchain
○ Open access.
○ Bitcoin and Ethereum blockchains.
8. Distributed
● Network operates on a peer-to-peer basis.
● Avoids vulnerability of centralized computers hackers can exploit.
● Provides key players to follow better governance and compliance
regulations.
9. Trust
● Consensus algorithm provides a secure way updating the state
according to some specific transition rules.
● Popular consensus mechanisms:
○ Proof of Work (PoW)
■ Eg: Bitcoin, Ethereum
○ Proof of Stake (PoS)
■ Eg: Tezos
10. Traceability
● Blocks are added in a linear and chronological order.
● Key to a blockchain's security- Hash.
○ Hash is a unique string of characters.
○ A Hash function creates a Hash taking the block’s information.
○ Hash from one block is added to the data in the next block.
○ Creating the next block, a trace of it is woven into the new hash and
throughout the chain.
11. Blockchain in Bioinformatics
Secure and controlled access to your genomic data.
Data security is a particular challenge.
Genomic and health information is increasingly captured, stored made
available and commoditized.
12. How to share without sacrificing accessibility, control and security?
Blockchain can be used to manage genomic data which is very large.
However, blocks can only be upto 1 MB.
What can be done?
Divide personal genomic data files into Sub Units.
Encrypt and hash the Sub Units uniquely.
Store personal genome file metadata on a Blockchain.
Restore file by retrieving file metadata and decrypt to get the Sub Unit
locations.
The lack of trust inherent in the blockchain system is particularly noteworthy to our topic of ‘consensus’. Because any entity, individual, or party can submit information to the blockchain (that is to say, try to add information to the database), it is necessary for the distributed operators of the blockchain to evaluate and agree on all addenda before they are permanently incorporated into the blockchain (the database). Because we cannot be sure of the author’s trustworthiness, it is vital that all new information must be reviewed and confirmed before being accepted. This review results in the ‘consensus’ I am examining here.
HOW TO SHARE ?
Without sacrificing accessibility and control.
With better security.