The document discusses biodisponibility (bioavailability), defined as the amount of a drug that reaches systemic circulation in an active form and the speed at which it accesses circulation. It notes that the fraction of a drug capable of reaching the site of action depends on the physicochemical properties of the active ingredient, excipients, manufacturing process, and formulation storage conditions, as well as individual characteristics like intestinal motility or gastric pH. Any changes to these factors can alter both the total amount of active ingredient absorbed and the rate of absorption. Factors influencing bioavailability include those inherent to the drug, biological factors, formulation, and concurrent administration of other medications.
The document contains templates for PowerPoint presentations with different styles like infographic, timeline, our team, etc. It provides instructions and placeholders to customize the templates by adding text, photos, colors. The templates are designed to be visually appealing and help impress audiences. They can be easily modified for different presentation needs and content.
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This document contains a template for creating presentations with various styles like infographic, timeline, our team, etc. It includes placeholder text and sections for adding titles, images, and content. The template comes with instructions to simply change the colors, photos and text to create customized presentations.
The document discusses the development of a soccer learning media based on the Lectora Inspire platform. It presents the research methodology, which involved developing the media at SMK Negeri 1 Laguboti high school in Toba Regency, North Sumatra. It covers theoretical studies on the topic as well as chapters on the introduction and research methodology.
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The document discusses the concept of K3LH, which stands for health, work safety, and the environment. K3LH refers to efforts to protect human workers to ensure they remain healthy and safe while working. It discusses that K3LH is important to protect every worker's safety in carrying out their work for livelihood and national productivity and production. Workers and others in the workplace need to be ensured safety, and every source of production needs to be used and utilized safely and efficiently. K3LH provides guidelines for identifying and assessing risks and hazards to safety and health in the workplace.
This document discusses maintaining immunity and faith. It covers personal immunization, COVID vaccination, and social immunity. It emphasizes the importance of a healthy lifestyle like nutrition, exercise, and rest for boosting immunity. Maintaining faith involves enjoining good and forbidding evil. The document presents Islamic principles on these topics and includes several Quranic verses.
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Hand sanitizers are portable heroes, eliminating germs on the go. With alcohol-based formulas or gentler options, they keep hands clean, preventing illnesses. Their convenience and effectiveness make them a staple for health-conscious individuals, ensuring cleanliness anytime, anywhere.
The document contains templates for PowerPoint presentations with different styles like infographic, timeline, our team, etc. It provides instructions and placeholders to customize the templates by adding text, photos, colors. The templates are designed to be visually appealing and help impress audiences. They can be easily modified for different presentation needs and content.
The document contains templates for PowerPoint presentations on various topics like oncology, medical treatment, and portfolios. The templates include layouts like timelines, teams, infographics, and clean text. They are designed to be easily customizable by changing colors, photos, and text. The templates aim to help users create professionally designed presentations that stand out and impress audiences.
This document contains a template for creating presentations with various styles like infographic, timeline, our team, etc. It includes placeholder text and sections for adding titles, images, and content. The template comes with instructions to simply change the colors, photos and text to create customized presentations.
The document discusses the development of a soccer learning media based on the Lectora Inspire platform. It presents the research methodology, which involved developing the media at SMK Negeri 1 Laguboti high school in Toba Regency, North Sumatra. It covers theoretical studies on the topic as well as chapters on the introduction and research methodology.
This document appears to be a template for a PowerPoint presentation. It includes numerous slides with generic text and placeholders for customization. The slides cover a variety of styles and types of content including infographics, timelines, charts, portraits, and more. Repeated messages in the template emphasize that it allows creating a modern, beautifully designed presentation that is easy to customize.
The document discusses the concept of K3LH, which stands for health, work safety, and the environment. K3LH refers to efforts to protect human workers to ensure they remain healthy and safe while working. It discusses that K3LH is important to protect every worker's safety in carrying out their work for livelihood and national productivity and production. Workers and others in the workplace need to be ensured safety, and every source of production needs to be used and utilized safely and efficiently. K3LH provides guidelines for identifying and assessing risks and hazards to safety and health in the workplace.
This document discusses maintaining immunity and faith. It covers personal immunization, COVID vaccination, and social immunity. It emphasizes the importance of a healthy lifestyle like nutrition, exercise, and rest for boosting immunity. Maintaining faith involves enjoining good and forbidding evil. The document presents Islamic principles on these topics and includes several Quranic verses.
Hand Sanitizers and how to help others in caringamer7vill
Hand sanitizers are portable heroes, eliminating germs on the go. With alcohol-based formulas or gentler options, they keep hands clean, preventing illnesses. Their convenience and effectiveness make them a staple for health-conscious individuals, ensuring cleanliness anytime, anywhere.
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The document contains templates for creating presentations using PowerPoint. It includes templates with different styles like agenda, timeline, teams, and infographics. The templates can be customized by changing colors, photos, and text. They are meant to help users create professionally designed presentations that will impress audiences.
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The document provides examples of different styles and templates for PowerPoint presentations, including agenda, timeline, profile, infographic, and portfolio styles. The templates are designed to be easily customizable by changing colors, photos, and text. They can be used to create modern, professionally designed presentations that impress audiences.
The document appears to be a template for a PowerPoint presentation. It includes multiple slides with templates for different styles like timeline, infographic, portfolio. The slides can be customized with colors, photos, text. The overall message is that this template provides a modern, customizable presentation design to save time and impress audiences.
The document contains examples of different styles - including timeline, team, infographic, and arrow styles - that can be used for PowerPoint presentations. The styles demonstrate variations in layouts, formatting, and elements like progress bars, titles, text boxes, and examples of how customization of colors, photos and text is supported. The overall document serves as a reference guide for the different presentation styles available.
The document discusses having humility in service. It introduces the topics of having one love, one spirit, and one purpose in order to achieve unity in service. It provides examples of how to impress an audience and add uniqueness to presentations by using a modern, beautifully designed PowerPoint template that is easy to customize. The template includes various slide styles like infographics, timelines, teams, and portfolios that can simply presentations.
This document contains information about a group project. It includes:
1. The names of 5 group members: Alvin, Galang, Nisa, Ritha, and Linda.
2. Chapters that will be included in the project such as the introduction, literature review, implementation, results and discussion, and conclusion.
3. Key topics that will be discussed including entrepreneurship, hydroponics, and terrariums.
The document appears to be a template for creating PowerPoint presentations. It includes various slide layouts like agenda, infographic, timeline and team member slides. The slides can be customized with colors, photos and text. The template aims to help users create professionally designed presentations and impress audiences. It states the slides are easily customizable and can add uniqueness to presentations.
The document contains templates for infographic style PowerPoint presentations. The templates include slides with layouts for including text, images, and charts. The templates emphasize including modern designs, being easy to customize colors and content, and impressing audiences. The templates can be used to create presentations for topics like business, food, restaurants, and more.
The document contains templates for infographic style PowerPoint presentations. The templates allow users to easily design modern presentations by changing colors, photos and text. The templates are meant to impress audiences and add unique appeal to presentations. The document provides numerous templates with different layouts that can be customized.
This document discusses various psychiatric conditions and their treatment with antipsychotics. Psychiatric conditions are divided into three main categories: psychosis, neurosis, and affective disorders. Neurosis includes conditions like anxiety, phobias, obsessive-compulsive disorder, hysteria, and reactive depression. Affective disorders, also called mood disorders, include endogenous depression, mania, bipolar disorder, and unipolar disorder. Antipsychotics are a type of medication used to treat psychiatric conditions like psychosis, schizophrenia, and mania.
This document contains templates for PowerPoint presentations with various infographic styles. The templates include placeholder text that can be replaced and contain sections for titles, contents, images, and text. They provide a modern design with flexible colors, photos, and text that can be easily edited to create professional presentations.
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This template has a color theme and will automatically apply color when copied and pasted
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Industry 4.0 revolution-power point-templatesLatifaChannel
This document contains templates for PowerPoint presentations with various infographic styles. The templates include placeholders for images, text, charts and other content. They are designed to be easily customizable with different colors, photos and text. The templates allow users to create professionally designed presentations and impress audiences.
industry 4.0-Revolution-PowerPoint-Templates.pptxXavierdeSousa4
This document provides examples of free PowerPoint templates for presentations. It includes templates with different styles like agenda, timeline, infographic, portfolio and more. The templates can be easily customized by changing colors, photos and text. They are designed to impress audiences and add visual appeal to presentations.
industry 4.0-Revolution-PowerPoint-Templates.pptxaskme8539
The document contains templates for creating presentations using PowerPoint. It includes templates with different styles like agenda, timeline, teams, and infographics. The templates can be customized by changing colors, photos, and text. They are meant to help users create professionally designed presentations that will impress audiences.
The document describes a PowerPoint presentation template that allows users to easily create professional-looking presentations. The template contains various slide styles like timeline, infographic, world map and more. It states that the template can help save users' time and provides beautifully designed slides that are easy to customize.
The document contains templates for creating PowerPoint presentations using an infographic style. It includes templates for timeline slides, organizational charts, graphs, question and answer slides, and more. The templates are designed to be easily customizable by changing colors, photos, and text. The goal is to help users create beautifully designed modern presentations that impress audiences.
This document contains templates and slides for a PowerPoint presentation. The slides feature colorful, graphical designs and include text prompts like "get a modern PowerPoint presentation that is beautifully designed" and "you can simply impress your audience." Many of the slides are designed in an infographic style with icons, images, and charts. The templates allow for easy customization of colors, photos, and text. The overall document provides examples of professionally designed presentation templates that can be adapted for business presentations.
Breast Cancer Pink Ribbon PowerPoint Templates.pptxHassan Yousaf
The document provides examples of different styles and templates for PowerPoint presentations, including agenda, timeline, profile, infographic, and portfolio styles. The templates are designed to be easily customizable by changing colors, photos, and text. They can be used to create modern, professionally designed presentations that impress audiences.
The document appears to be a template for a PowerPoint presentation. It includes multiple slides with templates for different styles like timeline, infographic, portfolio. The slides can be customized with colors, photos, text. The overall message is that this template provides a modern, customizable presentation design to save time and impress audiences.
The document contains examples of different styles - including timeline, team, infographic, and arrow styles - that can be used for PowerPoint presentations. The styles demonstrate variations in layouts, formatting, and elements like progress bars, titles, text boxes, and examples of how customization of colors, photos and text is supported. The overall document serves as a reference guide for the different presentation styles available.
The document discusses having humility in service. It introduces the topics of having one love, one spirit, and one purpose in order to achieve unity in service. It provides examples of how to impress an audience and add uniqueness to presentations by using a modern, beautifully designed PowerPoint template that is easy to customize. The template includes various slide styles like infographics, timelines, teams, and portfolios that can simply presentations.
This document contains information about a group project. It includes:
1. The names of 5 group members: Alvin, Galang, Nisa, Ritha, and Linda.
2. Chapters that will be included in the project such as the introduction, literature review, implementation, results and discussion, and conclusion.
3. Key topics that will be discussed including entrepreneurship, hydroponics, and terrariums.
The document appears to be a template for creating PowerPoint presentations. It includes various slide layouts like agenda, infographic, timeline and team member slides. The slides can be customized with colors, photos and text. The template aims to help users create professionally designed presentations and impress audiences. It states the slides are easily customizable and can add uniqueness to presentations.
The document contains templates for infographic style PowerPoint presentations. The templates include slides with layouts for including text, images, and charts. The templates emphasize including modern designs, being easy to customize colors and content, and impressing audiences. The templates can be used to create presentations for topics like business, food, restaurants, and more.
The document contains templates for infographic style PowerPoint presentations. The templates allow users to easily design modern presentations by changing colors, photos and text. The templates are meant to impress audiences and add unique appeal to presentations. The document provides numerous templates with different layouts that can be customized.
This document discusses various psychiatric conditions and their treatment with antipsychotics. Psychiatric conditions are divided into three main categories: psychosis, neurosis, and affective disorders. Neurosis includes conditions like anxiety, phobias, obsessive-compulsive disorder, hysteria, and reactive depression. Affective disorders, also called mood disorders, include endogenous depression, mania, bipolar disorder, and unipolar disorder. Antipsychotics are a type of medication used to treat psychiatric conditions like psychosis, schizophrenia, and mania.
This document contains templates for PowerPoint presentations with various infographic styles. The templates include placeholder text that can be replaced and contain sections for titles, contents, images, and text. They provide a modern design with flexible colors, photos, and text that can be easily edited to create professional presentations.
Fully and easily editable (shape color, size, and text)
This template has a color theme and will automatically apply color when copied and pasted
It includes a customizable icon family with 135 different icons(Fully editable)
Drag and drop image placeholder
Easy editable data-driven charts (Editable via Excel)
Industry 4.0 revolution-power point-templatesLatifaChannel
This document contains templates for PowerPoint presentations with various infographic styles. The templates include placeholders for images, text, charts and other content. They are designed to be easily customizable with different colors, photos and text. The templates allow users to create professionally designed presentations and impress audiences.
industry 4.0-Revolution-PowerPoint-Templates.pptxXavierdeSousa4
This document provides examples of free PowerPoint templates for presentations. It includes templates with different styles like agenda, timeline, infographic, portfolio and more. The templates can be easily customized by changing colors, photos and text. They are designed to impress audiences and add visual appeal to presentations.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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3. DEFINICIÓN
01
Hace referencia a la cantidad de fármaco que llega en
forma activa a la circulación sistémica y la velocidad a
la que accede a ésta.
02
Es decir, la fracción de medicamento capaz de llegar al lugar
de acción, dependerá de las características fisicoquímicas
del principio activo, de los excipientes del proceso de
fabricación y de la conservación de la forma farmacéutica
03
Y de la conservación de la forma farmacéutica, y
también de las características intrínsecas al individuo,
como la motilidad intestinal o el pH gástrico.
04
Cualquier modificación en alguno de estos factores
puede alterar tanto la cantidad total de principio activo
absorbido como la velocidad a la que se absorbe.
4. FACTORES QUE INFLUYEN LA BIODISPONIBILIDAD
Cuando se habla de biodisponibilidad se
supone que la concentración de un
fármaco en sangre como la cantidad de
fármaco excretada en la orina están
relacionadas.
No se puede orinar más de lo que se
absorbe, aquí es donde se observa la
eficacia clínica de un medicamento
Aquí entra el
principio activo y
la forma
farmacéutica:
manera de
preparación,
excipientes,etc.
Factores
Biológicos
Los más
importantes son
los factores
inherentes al
medicamento
Por ejemplo la
velocidad de
excreción de la
carboxitolbutamida
en la orina que por
tener el tamaño de
particular diferente a
la tolbutamida en la
forma farmaceutica
puede tener una
velocidad acelerada
de excreción
Factores
inherentes a
los
medicamentos Sexo, edad,
condiciones del
organismo, la
enfermedad en sí,
padecimientos,
factores
hormonales y
genéricos.
La
administración
de otros
medicamentos
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VALUE
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25. Infographic Style
STRENGTHS
OPPORTUNITIES
WEAKNESS
THREATS
SWOT
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UP
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DOWN
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TEXT
Add Your Text
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34. Infographic Style
Option A
Option B
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35. AWESOME
PRESENTATION
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POWERPOINT
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CONTENTS
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36. Infographic Style
Your Text Here
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01
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04
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02
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03
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06
37. Infographic Style
Text Here Text Here Text Here Text Here
Text Here Text Here Text Here Text Here
Add Text Add Text Add Text Add Text
Text Here Text Here Text Here Text Here
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38. Get a modern PowerPoint
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Portfolio
Presentation
39. Infographic Style
Add Text
Simple PowerPoint
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40. Infographic Style
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S
W O
T
OPPORTUNITI
ES
STRENGTH
S
WEAKNES
S
THREAT
S
41. Columns
Style PowerPoint Presentation
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01
PowerPoint Presentation
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02
42. Column
Style
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