Pharmacists around the world are playing immense roles in the growth of Clinical Research. Some does contribute as a part of their profession and a few are passionate about their behind the scenes role.
This document describes an encyclopedia called E-BABE that contains over 5,000 bioanalytical methods for studying the bioavailability and bioequivalence of pharmaceuticals. E-BABE allows searching by drug name, chemical formula, or structure to find relevant methods. It includes information from published studies and pharmacopeias to aid in method development and validation for bioavailability and bioequivalence studies. E-BABE is intended to help pharmaceutical companies and testing laboratories select appropriate analytical methods.
The document describes E-BABE, an encyclopedia of bioanalytical methods for studying the bioavailability and bioequivalence of pharmaceuticals. It contains over 5,000 thoroughly curated methods from literature and pharmacopeias. Each method includes details needed for development/validation, like chemical structure, analytical conditions, and pharmacokinetic parameters. Users can search by drug name, chemical formula, or structure to select appropriate quality control and bioequivalence study methods. E-BABE aims to support the pharmaceutical industry and testing laboratories in selecting bioanalytical methods.
The document describes E-BABE, an encyclopedia of bioanalytical methods for studying the bioavailability and bioequivalence of pharmaceuticals. It contains over 5,000 thoroughly curated methods from literature and pharmacopeias. Each method includes details needed for development/validation, like analytical parameters, sample preparation, and pharmacokinetic values. Users can search by drug name, chemical formula, or structure to select appropriate quality control and bioanalytical methods. E-BABE aims to support the pharmaceutical industry and testing laboratories in conducting bioavailability and bioequivalence studies.
In silico 360 Analysis for Drug DevelopmentChris Southan
Introduction:
Consequent to a memorandum of understanding between the Karolinska Institutet and the International Union of Basic and Clinical Pharmacology (IUPHAR) in 2018 a report on academic drug development, including guidelines (ADEV) has been drafted [1]. As part of this exercise, we conceived a triage for comprehensive informatics profiling around the compound, target, disease axis. We have termed this “in slico 360” (INS360) the aim of which was to support ADEV teams since they may lack either internal expertise or external support to do this on their own. Indeed, some past SciLifeLab Drug Discovery and Development Platform projects had been halted because of overlooked competitive impingements or insufficient target validation evidence.
Methods
We assessed the current database landscape, mostly public but including commercial, for potential utility for INS360. We were guided primarily by content coverage, usability, and reputation. We also explored some open property prediction resources for assay interference and toxicological inferences.
Results:
As a first-stop-shop, we selected the IUPHAR/BPS Guide to PHARMACOLOGY with ~900 ligand-target relationships captured via expert curation of journal papers Moving up in scale we evaluated ChEMBL at 1.8 million compounds with 1.1 million assay descriptions and 7,000 targets. With yet another jump we could search the patent corpus with 18 million extracted compounds in SureChEMBL. We explored PubChem that integrates these three with over 500 other sources linked to 96 million compounds, BioAssay results and connectivity into the NCBI Entrez system. The final jump in scale for document-to-chemistry navigation was represented by SciFinder with 155 million structures. On the target side, 360-exploration has the need to encompass literature, structure, genetic variation, splicing, interactions, and disease pathways. From their UniProt links, both GtoPdb and ChEMBL provide these entry points. Navigating genetic association data in support of target validation was enabled by the OpenTargets portal and the GWAS Catalog. We also fount servers that could produce prediction scores from chemical structures for a range of features important for de-risking development.
Conclusion:
This work scoped out initial resource choices for the INS360. We propose that not only ADEV operations but essentially any pharmacology research team has much to gain from this approach and many potential pitfalls can consequently be avoided when approaching key checkpoints, such as preparing a publication. However, support may be needed for both institutions and teams to get the best out of these complex and feature-rich databases.
[1] Southan C, (2019) Towards Academic Drug Development Guidelines, ChemRxiv pre-print no. 8869574
The U.S. Food and Drug Administration is offering another opportunity for stem cell clinics to work with the Agency and understand the regulatory framework. Will it work this time around? This blog article recaps how we got to this point...
Pharmaceutical companies use computers in many aspects of the drug discovery process. Computers allow researchers to analyze thousands of molecular structures and rapidly search databases to identify promising drug candidates that can bind to disease targets. They use computational modeling and simulations to predict how well a molecule will bind to and affect its target. This helps streamline the process of discovering and developing new drugs compared to traditional trial-and-error methods. Computers play a key role in expediting tasks from target identification to lead optimization and preclinical testing.
Guide to PHARMACOLOGY: a web-Based Compendium for Research and EducationChris Southan
This document summarizes a presentation about the IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) database. The following key points are made:
- GtoPdb is an online resource containing information on over 8,000 ligands and their interactions with around 1,500 human protein targets. It has been used widely by researchers and educators since 2009.
- The database contains detailed information on drug targets like GPCRs, ion channels, and enzymes. It also provides data on ligands, drugs, interactions between ligands and targets, and related clinical information.
- Users can browse targets and ligands or search the database. Detailed target pages contain pharmacology data, mechanisms, and links
The document summarizes a webinar presentation about accessing shelved pharmaceutical compounds through the CTSA Pharmaceutical Assets Portal. It provides background on the goals of the portal, which is to improve information exchange between pharmaceutical companies and academic researchers regarding drugs discontinued in clinical trials that could be candidates for drug repositioning. It describes some initial achievements and collaborations of the portal project. It also discusses the Clinical and Translational Science Awards program and how the portal was inspired by examples of drug repositioning.
This document describes an encyclopedia called E-BABE that contains over 5,000 bioanalytical methods for studying the bioavailability and bioequivalence of pharmaceuticals. E-BABE allows searching by drug name, chemical formula, or structure to find relevant methods. It includes information from published studies and pharmacopeias to aid in method development and validation for bioavailability and bioequivalence studies. E-BABE is intended to help pharmaceutical companies and testing laboratories select appropriate analytical methods.
The document describes E-BABE, an encyclopedia of bioanalytical methods for studying the bioavailability and bioequivalence of pharmaceuticals. It contains over 5,000 thoroughly curated methods from literature and pharmacopeias. Each method includes details needed for development/validation, like chemical structure, analytical conditions, and pharmacokinetic parameters. Users can search by drug name, chemical formula, or structure to select appropriate quality control and bioequivalence study methods. E-BABE aims to support the pharmaceutical industry and testing laboratories in selecting bioanalytical methods.
The document describes E-BABE, an encyclopedia of bioanalytical methods for studying the bioavailability and bioequivalence of pharmaceuticals. It contains over 5,000 thoroughly curated methods from literature and pharmacopeias. Each method includes details needed for development/validation, like analytical parameters, sample preparation, and pharmacokinetic values. Users can search by drug name, chemical formula, or structure to select appropriate quality control and bioanalytical methods. E-BABE aims to support the pharmaceutical industry and testing laboratories in conducting bioavailability and bioequivalence studies.
In silico 360 Analysis for Drug DevelopmentChris Southan
Introduction:
Consequent to a memorandum of understanding between the Karolinska Institutet and the International Union of Basic and Clinical Pharmacology (IUPHAR) in 2018 a report on academic drug development, including guidelines (ADEV) has been drafted [1]. As part of this exercise, we conceived a triage for comprehensive informatics profiling around the compound, target, disease axis. We have termed this “in slico 360” (INS360) the aim of which was to support ADEV teams since they may lack either internal expertise or external support to do this on their own. Indeed, some past SciLifeLab Drug Discovery and Development Platform projects had been halted because of overlooked competitive impingements or insufficient target validation evidence.
Methods
We assessed the current database landscape, mostly public but including commercial, for potential utility for INS360. We were guided primarily by content coverage, usability, and reputation. We also explored some open property prediction resources for assay interference and toxicological inferences.
Results:
As a first-stop-shop, we selected the IUPHAR/BPS Guide to PHARMACOLOGY with ~900 ligand-target relationships captured via expert curation of journal papers Moving up in scale we evaluated ChEMBL at 1.8 million compounds with 1.1 million assay descriptions and 7,000 targets. With yet another jump we could search the patent corpus with 18 million extracted compounds in SureChEMBL. We explored PubChem that integrates these three with over 500 other sources linked to 96 million compounds, BioAssay results and connectivity into the NCBI Entrez system. The final jump in scale for document-to-chemistry navigation was represented by SciFinder with 155 million structures. On the target side, 360-exploration has the need to encompass literature, structure, genetic variation, splicing, interactions, and disease pathways. From their UniProt links, both GtoPdb and ChEMBL provide these entry points. Navigating genetic association data in support of target validation was enabled by the OpenTargets portal and the GWAS Catalog. We also fount servers that could produce prediction scores from chemical structures for a range of features important for de-risking development.
Conclusion:
This work scoped out initial resource choices for the INS360. We propose that not only ADEV operations but essentially any pharmacology research team has much to gain from this approach and many potential pitfalls can consequently be avoided when approaching key checkpoints, such as preparing a publication. However, support may be needed for both institutions and teams to get the best out of these complex and feature-rich databases.
[1] Southan C, (2019) Towards Academic Drug Development Guidelines, ChemRxiv pre-print no. 8869574
The U.S. Food and Drug Administration is offering another opportunity for stem cell clinics to work with the Agency and understand the regulatory framework. Will it work this time around? This blog article recaps how we got to this point...
Pharmaceutical companies use computers in many aspects of the drug discovery process. Computers allow researchers to analyze thousands of molecular structures and rapidly search databases to identify promising drug candidates that can bind to disease targets. They use computational modeling and simulations to predict how well a molecule will bind to and affect its target. This helps streamline the process of discovering and developing new drugs compared to traditional trial-and-error methods. Computers play a key role in expediting tasks from target identification to lead optimization and preclinical testing.
Guide to PHARMACOLOGY: a web-Based Compendium for Research and EducationChris Southan
This document summarizes a presentation about the IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) database. The following key points are made:
- GtoPdb is an online resource containing information on over 8,000 ligands and their interactions with around 1,500 human protein targets. It has been used widely by researchers and educators since 2009.
- The database contains detailed information on drug targets like GPCRs, ion channels, and enzymes. It also provides data on ligands, drugs, interactions between ligands and targets, and related clinical information.
- Users can browse targets and ligands or search the database. Detailed target pages contain pharmacology data, mechanisms, and links
The document summarizes a webinar presentation about accessing shelved pharmaceutical compounds through the CTSA Pharmaceutical Assets Portal. It provides background on the goals of the portal, which is to improve information exchange between pharmaceutical companies and academic researchers regarding drugs discontinued in clinical trials that could be candidates for drug repositioning. It describes some initial achievements and collaborations of the portal project. It also discusses the Clinical and Translational Science Awards program and how the portal was inspired by examples of drug repositioning.
Computers play several important roles in the drug discovery process:
1) They analyze thousands of molecular structures and properties to identify candidate molecules that may bind to disease targets. This virtual screening allows faster evaluation of large libraries.
2) Databases organize data on chemical structures to facilitate computer-aided searches for promising drug candidates.
3) Software allows scientists to visualize and model molecular interactions, guiding the design of molecules that optimally bind to targets.
This document discusses the IUPHAR/BPS Guide to Pharmacology database and related resources. It provides open access information on pharmacological targets and the substances that act on them. It includes over 1,700 human drug targets, 9,700 ligands including 1,300 approved drugs. Related databases include the Guide to Immunopharmacology and Guide to Malaria Pharmacology. The databases are regularly updated and include links to other resources to enable interoperability.
Venipuncture needle and syringes marketAkshay Shinde
Venipuncture is a perforation on a vein as part of a medical practice, basically to draw a blood sample and or to inject a drug into the body. This is done by intravenous cannulation. The venipuncture blood collection is carried out with the help of needle and syringes.
Antimalarial drug dscovery data disclosureChris Southan
Dr. Christopher Southan presented on comparing open and closed antimalarial drug discovery approaches. He examined 32 recent antimalarial compounds and found major data connectivity issues, such as leads not being findable by code name or having publications not citing patents. In contrast, the open source Sydney University Malaria Project surfaces structures and shares data in near real-time through open lab books and crowdsourcing. Dr. Southan analyzed their collection of 411 molecules and found 250 matched in PubChem quickly. Open approaches can accelerate discovery by years by openly sharing data.
Discount discount.....research aarkstore enterprise companion diagnostics in ...Neel Terde
This document provides a summary of a report on companion diagnostics in personalized medicine and cancer therapy. It examines the use of companion diagnostics to personalize cancer treatment. The report provides qualitative and quantitative analysis of the industry, including profiles of leading companies developing companion diagnostic solutions. It also discusses regulatory trends around companion diagnostics and personalized medicine. Companion diagnostics are helping to personalize cancer care by linking diagnostic tests to specific drug therapies.
J & J Solutions has developed a closed system transfer device for safer handling of chemotherapy drugs. Their device eliminates risks of contamination, standardizes compounding to reduce errors, improves workflow efficiency, and reduces costs. They are seeking funding to complete product development including alpha and beta testing, obtain FDA approval, and launch the product to address a $1 billion market that is growing due to increasing cancer rates.
472_Strategies to Reduce Medication Errorssuneela amjad
The document discusses strategies to reduce medication errors in hospitals, including implementing barcode scanning and computerized physician order entry (CPOE) systems. Barcode scanning involves giving patients wristbands with unique IDs that are scanned before medication to ensure the right patient receives the right drug. CPOE allows doctors to directly enter medication orders into the computer system. Both aim to reduce errors from misread handwriting or similar drug names. While both systems have significantly reduced errors, CPOE may still require improvements to communication between staff. The document evaluates the effectiveness and disadvantages of these electronic systems in minimizing medication mistakes.
Computers as data analysis in preclinical developmentMegha Shah
The document discusses the use of computers for data analysis in preclinical drug development. It describes how computers are used for passive applications like data handling, processing, and storage of chromatography data from techniques like gas-liquid chromatography-mass spectrometry. It also discusses active applications like using computerized library systems to interpret mass spectra and diagnostic programs to help physicians make diagnoses based on patient information. The document focuses on the roles of chromatography data systems, laboratory information management systems, and text information management systems in processing and managing the large amounts of data and documents generated during preclinical drug development.
The document lists and describes various drug information resources available at hospitals and through library subscriptions, including Micromedex, Facts & Comparisons, MDConsult, AccessMedicine, DynaMed, StatRef, Goodman & Gilman’s Basic & Clinical Pharmacology, Poisoning and Drug Overdose, and AHFS DI Essentials. It also outlines free internet resources such as the NLM Drug Portal, RxList, Drugs.com, Epocrates Online, and the Johns Hopkins Antibiotic Guide. PDA resources mentioned include Epocrates, MicroMedex/Thomson Clinical Xpert, Tarascon, and Lexi-Drugs.
This document summarizes global initiatives to increase open access to clinical trial data. It discusses several key events and studies from 2000-2013 that highlighted issues of incomplete or suppressed trial results. Regulatory agencies like the EMA and FDA have since taken steps to increase reactive and proactive publication of trial data. However, pharmaceutical companies have argued against full data sharing due to concerns about misleading analyses, commercial confidentiality, and costs. Patient and advocacy groups are campaigning for all trial results to be reported. Regulators are now seeking public comments on policies to improve access to clinical trial data.
There are many career options available to pharmacists with a PharmD degree beyond just working in a retail pharmacy setting. Some of the major options include working in hospital pharmacies providing medication management services; industrial pharmacy roles in research, development, production, and quality control; government agency roles ensuring safety standards; roles in pharmaceutical education and research; nuclear pharmacy preparing radioactive materials; clinical research associate roles overseeing trials; and roles in sales, marketing, and community pharmacy patient services. Compensation remains relatively consistent across these varied practice settings.
Pharmacy orientation Gp A Evening Batch 2021Tehmina Adnan
a. Introduction and orientation to the Profession of Pharmacy in relation to Hospital Pharmacy, Retail Pharmacy, Industrial Pharmacy, Forensic Pharmacy, Pharmaceutical education and research etc
Prateesh Varughese is a highly experienced healthcare professional with over eight years of experience in patient care, management, operations, and clinical sales strategy. He holds a PharmD and MBA and is currently a Senior Director at CompanionDx Reference Labs where he oversees clinical affairs and biopharma solutions. Previously he has held roles managing clinical and medical science liaison teams, launching education programs, and developing clinical trials. He has a strong background in precision medicine, pharmacogenomics, and oncology.
This document discusses patient-centered drug development and clinical trials. It defines patient centricity as meaningfully including patients, particularly in trial protocol design, and linking clinical trial goals with patients' needs and experiences. It emphasizes measuring what matters to patients. While patient centricity is seen as important, there is no consensus on how to measure it. The document explores definitions of patient centricity, challenges in measuring it, examples of companies working to include the patient voice, and the need for new approaches to drug development that place greater focus on the patient experience.
This document discusses patient-centered drug development and clinical trials. It defines patient centricity as meaningfully including patients, particularly in designing trial protocols, and linking clinical trial goals with patients' needs and experiences. It emphasizes measuring what matters to patients. While patient centricity is seen as important, there is no consensus on how to measure it. The document explores how companies are working to include the patient voice, such as through patient advisory boards and surveys to capture patient perceptions and experiences in clinical trials. It argues that simply talking about patient centricity is not enough, and that meaningful action is needed to achieve it.
Unethical Practices in Pharma - Interesting Study from Pakistan Anup Soans
This study clarifies the current pharmaceutical drug promotion and prescribing practices in Pakistan. The majority of prescribers and national pharmaceutical firms and to some extent the multinational pharmaceuticals are involved in unethical practices in drug promotion and prescribing. Alarming policies governing the drug promotion and prescribing are required to be implemented by the concerned regulatory authorities to avoid unnecessary harm to the patient’s life and pocket through the unethical drug promotion. The prescribers should not accept any incentives, gifts of financial value from any pharmaceutical companies in return for an increase in prescribing selected brand. On the other hand, pharmaceutical companies must compete in the market on the basis of the drug quality and do not offer any valuable gift and incentives to the prescribers. The interaction between doctors and phar- maceutical firms should be restricted within acceptable boundaries and the authorities must be prepared to play an active role. Strengthening the regulatory machinery and formulating policies in this regard in neces- sary. It is essential that a health care professional such as a pharmacist can play an important role in this process since he/she is an expert in the pharmaceutical field as well as more aware of the outcomes of unethical drug prescribing practices such as polypharmacy and adverse drug reactions.
This document summarizes the role of clinical pharmacists in diagnostic imaging procedures that utilize contrast agents or radiopharmaceuticals. It discusses how clinical pharmacists are experts in drug management and can help ensure proper use and monitoring of contrast agents and radiopharmaceuticals. The document also reviews literature showing that involvement of clinical pharmacists in imaging procedures can improve patient outcomes and safety while reducing costs.
A pharmacologist has several key roles:
1. Medical education - Teaching undergraduate and postgraduate students about rational drug use, effects, toxicity, and interactions.
2. Research - Conducting both basic and clinical research, ensuring adherence to guidelines for clinical trials and ethical reviews.
3. Regulatory affairs - Involved in essential drug lists, national drug policy, and regulatory bodies like drug authorities.
Quintiles is a leading clinical research organization that acquired Expression Analysis (EA) in 2013 to gain expertise in genomics and precision medicine. EA's VP of Genomic Operations Kellie Yarnell discusses how integrating genomics into clinical trials can help identify responsive patient populations, reduce costs and timelines, and improve drug efficacy and safety. The combination of EA's genomics expertise and Quintiles' clinical trial experience helps sponsors achieve precision medicine goals like identifying genomic biomarkers. EA has been involved in standardization initiatives and has success stories in using genomic testing to match cancer patients to effective therapies.
Reverse pharmacology is an approach to drug discovery that begins with clinical observations of traditional medicines and then uses exploratory and experimental studies to validate efficacy and safety. It reverses the conventional path of discovery from the laboratory to clinics. Key advantages include starting with clinically tested botanicals, reducing costs and time, and leveraging an experiential database of traditional medicines. Challenges include few success stories adopted by industry. Increased awareness and innovative solutions inspired by traditional knowledge may help accelerate discovery through the reverse pharmacology approach.
Computers play several important roles in the drug discovery process:
1) They analyze thousands of molecular structures and properties to identify candidate molecules that may bind to disease targets. This virtual screening allows faster evaluation of large libraries.
2) Databases organize data on chemical structures to facilitate computer-aided searches for promising drug candidates.
3) Software allows scientists to visualize and model molecular interactions, guiding the design of molecules that optimally bind to targets.
This document discusses the IUPHAR/BPS Guide to Pharmacology database and related resources. It provides open access information on pharmacological targets and the substances that act on them. It includes over 1,700 human drug targets, 9,700 ligands including 1,300 approved drugs. Related databases include the Guide to Immunopharmacology and Guide to Malaria Pharmacology. The databases are regularly updated and include links to other resources to enable interoperability.
Venipuncture needle and syringes marketAkshay Shinde
Venipuncture is a perforation on a vein as part of a medical practice, basically to draw a blood sample and or to inject a drug into the body. This is done by intravenous cannulation. The venipuncture blood collection is carried out with the help of needle and syringes.
Antimalarial drug dscovery data disclosureChris Southan
Dr. Christopher Southan presented on comparing open and closed antimalarial drug discovery approaches. He examined 32 recent antimalarial compounds and found major data connectivity issues, such as leads not being findable by code name or having publications not citing patents. In contrast, the open source Sydney University Malaria Project surfaces structures and shares data in near real-time through open lab books and crowdsourcing. Dr. Southan analyzed their collection of 411 molecules and found 250 matched in PubChem quickly. Open approaches can accelerate discovery by years by openly sharing data.
Discount discount.....research aarkstore enterprise companion diagnostics in ...Neel Terde
This document provides a summary of a report on companion diagnostics in personalized medicine and cancer therapy. It examines the use of companion diagnostics to personalize cancer treatment. The report provides qualitative and quantitative analysis of the industry, including profiles of leading companies developing companion diagnostic solutions. It also discusses regulatory trends around companion diagnostics and personalized medicine. Companion diagnostics are helping to personalize cancer care by linking diagnostic tests to specific drug therapies.
J & J Solutions has developed a closed system transfer device for safer handling of chemotherapy drugs. Their device eliminates risks of contamination, standardizes compounding to reduce errors, improves workflow efficiency, and reduces costs. They are seeking funding to complete product development including alpha and beta testing, obtain FDA approval, and launch the product to address a $1 billion market that is growing due to increasing cancer rates.
472_Strategies to Reduce Medication Errorssuneela amjad
The document discusses strategies to reduce medication errors in hospitals, including implementing barcode scanning and computerized physician order entry (CPOE) systems. Barcode scanning involves giving patients wristbands with unique IDs that are scanned before medication to ensure the right patient receives the right drug. CPOE allows doctors to directly enter medication orders into the computer system. Both aim to reduce errors from misread handwriting or similar drug names. While both systems have significantly reduced errors, CPOE may still require improvements to communication between staff. The document evaluates the effectiveness and disadvantages of these electronic systems in minimizing medication mistakes.
Computers as data analysis in preclinical developmentMegha Shah
The document discusses the use of computers for data analysis in preclinical drug development. It describes how computers are used for passive applications like data handling, processing, and storage of chromatography data from techniques like gas-liquid chromatography-mass spectrometry. It also discusses active applications like using computerized library systems to interpret mass spectra and diagnostic programs to help physicians make diagnoses based on patient information. The document focuses on the roles of chromatography data systems, laboratory information management systems, and text information management systems in processing and managing the large amounts of data and documents generated during preclinical drug development.
The document lists and describes various drug information resources available at hospitals and through library subscriptions, including Micromedex, Facts & Comparisons, MDConsult, AccessMedicine, DynaMed, StatRef, Goodman & Gilman’s Basic & Clinical Pharmacology, Poisoning and Drug Overdose, and AHFS DI Essentials. It also outlines free internet resources such as the NLM Drug Portal, RxList, Drugs.com, Epocrates Online, and the Johns Hopkins Antibiotic Guide. PDA resources mentioned include Epocrates, MicroMedex/Thomson Clinical Xpert, Tarascon, and Lexi-Drugs.
This document summarizes global initiatives to increase open access to clinical trial data. It discusses several key events and studies from 2000-2013 that highlighted issues of incomplete or suppressed trial results. Regulatory agencies like the EMA and FDA have since taken steps to increase reactive and proactive publication of trial data. However, pharmaceutical companies have argued against full data sharing due to concerns about misleading analyses, commercial confidentiality, and costs. Patient and advocacy groups are campaigning for all trial results to be reported. Regulators are now seeking public comments on policies to improve access to clinical trial data.
There are many career options available to pharmacists with a PharmD degree beyond just working in a retail pharmacy setting. Some of the major options include working in hospital pharmacies providing medication management services; industrial pharmacy roles in research, development, production, and quality control; government agency roles ensuring safety standards; roles in pharmaceutical education and research; nuclear pharmacy preparing radioactive materials; clinical research associate roles overseeing trials; and roles in sales, marketing, and community pharmacy patient services. Compensation remains relatively consistent across these varied practice settings.
Pharmacy orientation Gp A Evening Batch 2021Tehmina Adnan
a. Introduction and orientation to the Profession of Pharmacy in relation to Hospital Pharmacy, Retail Pharmacy, Industrial Pharmacy, Forensic Pharmacy, Pharmaceutical education and research etc
Prateesh Varughese is a highly experienced healthcare professional with over eight years of experience in patient care, management, operations, and clinical sales strategy. He holds a PharmD and MBA and is currently a Senior Director at CompanionDx Reference Labs where he oversees clinical affairs and biopharma solutions. Previously he has held roles managing clinical and medical science liaison teams, launching education programs, and developing clinical trials. He has a strong background in precision medicine, pharmacogenomics, and oncology.
This document discusses patient-centered drug development and clinical trials. It defines patient centricity as meaningfully including patients, particularly in trial protocol design, and linking clinical trial goals with patients' needs and experiences. It emphasizes measuring what matters to patients. While patient centricity is seen as important, there is no consensus on how to measure it. The document explores definitions of patient centricity, challenges in measuring it, examples of companies working to include the patient voice, and the need for new approaches to drug development that place greater focus on the patient experience.
This document discusses patient-centered drug development and clinical trials. It defines patient centricity as meaningfully including patients, particularly in designing trial protocols, and linking clinical trial goals with patients' needs and experiences. It emphasizes measuring what matters to patients. While patient centricity is seen as important, there is no consensus on how to measure it. The document explores how companies are working to include the patient voice, such as through patient advisory boards and surveys to capture patient perceptions and experiences in clinical trials. It argues that simply talking about patient centricity is not enough, and that meaningful action is needed to achieve it.
Unethical Practices in Pharma - Interesting Study from Pakistan Anup Soans
This study clarifies the current pharmaceutical drug promotion and prescribing practices in Pakistan. The majority of prescribers and national pharmaceutical firms and to some extent the multinational pharmaceuticals are involved in unethical practices in drug promotion and prescribing. Alarming policies governing the drug promotion and prescribing are required to be implemented by the concerned regulatory authorities to avoid unnecessary harm to the patient’s life and pocket through the unethical drug promotion. The prescribers should not accept any incentives, gifts of financial value from any pharmaceutical companies in return for an increase in prescribing selected brand. On the other hand, pharmaceutical companies must compete in the market on the basis of the drug quality and do not offer any valuable gift and incentives to the prescribers. The interaction between doctors and phar- maceutical firms should be restricted within acceptable boundaries and the authorities must be prepared to play an active role. Strengthening the regulatory machinery and formulating policies in this regard in neces- sary. It is essential that a health care professional such as a pharmacist can play an important role in this process since he/she is an expert in the pharmaceutical field as well as more aware of the outcomes of unethical drug prescribing practices such as polypharmacy and adverse drug reactions.
This document summarizes the role of clinical pharmacists in diagnostic imaging procedures that utilize contrast agents or radiopharmaceuticals. It discusses how clinical pharmacists are experts in drug management and can help ensure proper use and monitoring of contrast agents and radiopharmaceuticals. The document also reviews literature showing that involvement of clinical pharmacists in imaging procedures can improve patient outcomes and safety while reducing costs.
A pharmacologist has several key roles:
1. Medical education - Teaching undergraduate and postgraduate students about rational drug use, effects, toxicity, and interactions.
2. Research - Conducting both basic and clinical research, ensuring adherence to guidelines for clinical trials and ethical reviews.
3. Regulatory affairs - Involved in essential drug lists, national drug policy, and regulatory bodies like drug authorities.
Quintiles is a leading clinical research organization that acquired Expression Analysis (EA) in 2013 to gain expertise in genomics and precision medicine. EA's VP of Genomic Operations Kellie Yarnell discusses how integrating genomics into clinical trials can help identify responsive patient populations, reduce costs and timelines, and improve drug efficacy and safety. The combination of EA's genomics expertise and Quintiles' clinical trial experience helps sponsors achieve precision medicine goals like identifying genomic biomarkers. EA has been involved in standardization initiatives and has success stories in using genomic testing to match cancer patients to effective therapies.
Reverse pharmacology is an approach to drug discovery that begins with clinical observations of traditional medicines and then uses exploratory and experimental studies to validate efficacy and safety. It reverses the conventional path of discovery from the laboratory to clinics. Key advantages include starting with clinically tested botanicals, reducing costs and time, and leveraging an experiential database of traditional medicines. Challenges include few success stories adopted by industry. Increased awareness and innovative solutions inspired by traditional knowledge may help accelerate discovery through the reverse pharmacology approach.
The document provides an overview of careers in the biopharmaceutical industry. It describes the long process of developing new drugs, which involves identifying drug targets, designing and testing compounds, conducting preclinical and clinical trials, gaining regulatory approval, and post-launch monitoring. Many roles are needed across research, development, manufacturing, regulatory affairs, sales, and other functions. The average time to get a new drug to market is 14 years and over $1 billion.
An introduction for those who may be interested in a career in clinical research, but need to understand the industry and their potential for a role in it.
Provides an overview of the later stages of drug development, explaining the phases of drug studies and explores in brief the key roles for those participating.
A hospital staff pharmacist provides pharmacy services to both inpatients and outpatients at a hospital. They work closely with doctors and nurses to administer medications to patients and may prepare specialized medications. Hospital pharmacists are experts in medications and work to ensure patients receive the best treatment. Key responsibilities include dispensing prescriptions accurately, advising medical staff on drug selection and dosage, and educating patients. A degree in pharmacy is required to become a licensed hospital pharmacist.
Clinical pharmacist Managed Oncology Clinic In University Hospitalfathy alazhary
The document discusses the role and history of clinical pharmacists in managing oncology clinics. It describes how clinical pharmacists began in the 1960s and their role has expanded over the years. The main goals of clinical pharmacists are to assist physicians in prescribing and monitoring drug therapy, assist medical staff, and maximize patient compliance. Oncology pharmacists play a vital role on the healthcare team by ensuring optimal medication regimens for cancer patients, educating patients, and monitoring patients for side effects during chemotherapy treatment.
Career in pharmacy and scope of pharmacy. Pharma industry, Hospital pharmacy , Community Pharmacy, Teaching in Pharmacy, Sales & Marketing , Clinical research , Career in Regulatory Body, Biotechnology, Cosmetic, Food Industry etc.
The document provides an introduction to the clinical laboratory for pharmacists, explaining that as clinical pharmacy services expand, interactions between pharmacists and laboratories will increase. It notes that laboratory results are essential for pharmacists to monitor drug therapy and adjust dosing regimens. However, the field of laboratory medicine is complex and constantly evolving, so methodologies and tests may vary between laboratories and over time. Quality control is necessary to ensure accurate results. The document recommends that pharmacists utilize medical technologists as consultants for test interpretation and consult the pharmacist in areas like therapeutic drug monitoring.
Wearable Cardioverter Defibrillators Market forecast to witness phenomenal gr...sushant deshmukh
Wearable cardioverter defibrillators industry is slated to witness a strong growth owing to rapidly growing geriatric population. As per United Nations statistics, 2015, the number of people over 60 years of age has increased significantly over the past few years in most of regions, United Nations further projected that between 2015 and 2030, the number of people over 60 years of age will grow by more than 55% from 901 million to 1.4 billion in 2030 globally.
Clinical research is quite vital in the field of physiotherapy. Physiotherapists depends on information from researches to enhance the knowledge they have already gained through their university education and with continuous education courses.
Clinical research is quite vital in the field of physiotherapy. Physiotherapists depends on information from researches to enhance the knowledge they have already gained through their university education and with continuous education courses.
Problems in using_spreadsheets_to_collect_clinicalsushant deshmukh
Microsoft Excel is a free and a very familiar tool for all of us. Spreadsheets are used for a wide range of projects, but they are far from ideal when it comes to data capture in clinical trials. Excel wasn’t created to build case report forms (CRFs) or to compare and verify patient's data that’s collected in clinical research. Despite technological advances,many organizations still cling to spreadsheets.
The clinical trial industry is gaining continuously a positive metamorphosis in India. Now the clinical trial processes are being viewed as drug discovery rather than drug development destination only. At present, several companies are looking at the innovation. And rise of these companies have led to many more openings for clinical research job in Pune and India as a whole.
The CRB Tech Institute of Clinical Research is a unique year-long education, learning and guidance system for fellows with biology background. It provides a broad education and learning on clinical research methods, research partnerships and managing the demands of family and profession. The goal of CRB Tech Institution is to produce a team of researchers armed with suggestions for clinical research carrying out innovative clinical trials and access to sources to make their concepts a reality.
studies involving people. They are divided into different stages, called phases. The earliest phase trials might focus at whether a drug is safe or the side effects it causes. A later phase trial aims to test and compare whether a new treatment is better than existing ones.also checkwhy clinical trials are important in clinical research.
Types of Classifi
Types Of Clinical Trials And Its Significance Clinical trials means medical research studies involving people. They are divided into different stages, called phases. The earliest phase trials might focus at whether a drug is safe or the side effects it causes. A later phase trial aims to test and compare whether a new treatment is better than existing ones.also checkwhy clinical trials are important in clinical research.
ere we continue with the remaining concept of crowdfunding. As stated crowd-funding is gearing significance in the field of clinical research or medical research in general.
Pharmacists around the world are playing immense roles in the growth of Clinical Research. Some does contribute as a part of their profession and a few are passionate about their behind the scenes role.
Such passionate pharm
Pharmacists around the world are playing immense roles in the growth of Clinical Research. Some does contribute as a part of their profession and a few are passionate about their behind the scenes role.
Keeping with its promises, Association of the British Pharmaceutical Industry has launched a clinical-trial disclosure toolkit to help its member businesses observe with transparency needs for information from or about clinical trials.
Keeping with its promises, Association of the British Pharmaceutical Industry has launched a clinical-trial disclosure toolkit to help its member businesses observe with transparency needs for information from or about clinical trials.
Role responsibilities of_a_clinical_research_coordsushant deshmukh
Clinical Research Coordinator (CRC) is a specialized research person working with and under the direction of the Principal Investigator .While the Principal Investigator(PI) is primarily responsible for the overall designing, conducting, and management of the clinical trial, the CRC supports, and coordinates the regular clinical trial activities and plays a crucial role in the conduct of the study. By doing these duties, the CRC works with the PI, sponsor ,department, and institution to support and provide guidance on every related aspects of the study.
Every clinical research project may have one or more study coordinators depending on the workload at the trial site. Clinical trials at site level can be roughly divided into 3 stages. The three stages and the role of the coordinators at these stages are:
1) Before starting the clinical trial
2) During the conduct of the clinical trial
3) After finishing the clinical trial
1) Before starting the clinical trial:
Clinical Research Coordinator (CRC) is a specialized research person working with and under the direction of the Principal Investigator .While the Principal Investigator(PI) is primarily responsible for the overall designing, conducting, and management of the clinical trial, the CRC supports, and coordinates the regular clinical trial activities and plays a crucial role in the conduct of the study. By doing these duties, the CRC works with the PI, sponsor ,department, and institution to support and provide guidance on every related aspects of the study.
Pharmacovigilance is the approach related to making an assessment, detection, understanding and prevention of inappropriate effects or any other problems to drug-related . So those working in the field of pharmacovigilance must have a good working knowledge of the principles of drug safety, regulations and proactive strategies for risk management. So people who want to pursue a clinical research career, can take up Pharmacovigilance training for adding value to their qualification.
Pharmacovigilance is the approach related to making an assessment, detection, understanding and prevention of inappropriate effects or any other problems to drug-related . So those working in the field of pharmacovigilance must have a good working knowledge of the principles of drug safety, regulations and proactive strategies for risk management. So people who want to pursue a clinical research career, can take up Pharmacovigilance training for adding value to their qualification.
The clinical trial industry is gaining continuously a positive metamorphosis in India. Now the clinical trial processes are being viewed as drug discovery rather than drug development destination only. At present, several companies are looking at the innovation. And rise of these companies have led to many more openings for clinical research job in Pune and India as a whole.
Medical Research: Rebuilt, Retooled and Rebooted An early stage mobile medical device company developing a human-centered suite of consumer products using science and technology to empower everyday people to monitor and better understand their own health—anytime, anywhere.
A workshop hosted by the South African Journal of Science aimed at postgraduate students and early career researchers with little or no experience in writing and publishing journal articles.
How to Add Chatter in the odoo 17 ERP ModuleCeline George
In Odoo, the chatter is like a chat tool that helps you work together on records. You can leave notes and track things, making it easier to talk with your team and partners. Inside chatter, all communication history, activity, and changes will be displayed.
বাংলাদেশের অর্থনৈতিক সমীক্ষা ২০২৪ [Bangladesh Economic Review 2024 Bangla.pdf] কম্পিউটার , ট্যাব ও স্মার্ট ফোন ভার্সন সহ সম্পূর্ণ বাংলা ই-বুক বা pdf বই " সুচিপত্র ...বুকমার্ক মেনু 🔖 ও হাইপার লিংক মেনু 📝👆 যুক্ত ..
আমাদের সবার জন্য খুব খুব গুরুত্বপূর্ণ একটি বই ..বিসিএস, ব্যাংক, ইউনিভার্সিটি ভর্তি ও যে কোন প্রতিযোগিতা মূলক পরীক্ষার জন্য এর খুব ইম্পরট্যান্ট একটি বিষয় ...তাছাড়া বাংলাদেশের সাম্প্রতিক যে কোন ডাটা বা তথ্য এই বইতে পাবেন ...
তাই একজন নাগরিক হিসাবে এই তথ্য গুলো আপনার জানা প্রয়োজন ...।
বিসিএস ও ব্যাংক এর লিখিত পরীক্ষা ...+এছাড়া মাধ্যমিক ও উচ্চমাধ্যমিকের স্টুডেন্টদের জন্য অনেক কাজে আসবে ...
This presentation includes basic of PCOS their pathology and treatment and also Ayurveda correlation of PCOS and Ayurvedic line of treatment mentioned in classics.
A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
1. Behind the Scenes, Role Of Pharmacists In Clinical Research
Pharmacists around the world are playing immense roles in the growth of Clinical Research. Some
does contribute as a part of their profession and a few are passionate about their behind the scenes
role.
Such passionate pharmacist is Michelle Foust ; she doesn't dispense pills at the corner pharmacy but
she distributes them worldwide. Foust is the director of new product development at Almac Group,
a multinational company that packages and distributes experimental drugs for clinical trials.
Behind the scenes, Foust and other pharmacists help coordinate the research and development
process that brings new medication from the laboratory to the road corner pharmacy.
Foust in her career is most of pharmacists fill in a research setting instead of in the much more
familiar retail setting. Although pharmacists who pursue research careers are still a minority, their
ranks are expanding quickly within the pharmaceutical industry and the multitude of organizations
developing and testing novel compounds.
Opportunities are Abound
Pharmacists occupy a variety of roles within Clinical Research Organizations and Labs; some
designing phase I trials, others occupying executive-level management positions. Still other
pharmacists work as clinical research associates in late-phase clinical trials, traveling to investigator
sites to oversee compliance with research protocols and investigating adverse drug events and
safety concerns.
2. Some pharmacists and their companies give presentations at pharmacy schools to raise awareness of
the growing career opportunities for pharmacists in clinical research. Often clinical research officers
or project managers typically write protocols, choose investigators and study sites. They also
monitor clinical trials, collect and analyze trial data, report adverse events, and write and publish
clinical-study reports. Within the clinical research enterprise, pharmacists often move into
leadership positions in drug-development studies. But because the work is behind the scenes, few
pharmacists hear about these job opportunities.
In addition, a number of pharmacists are working as consultants to biotechnology or small
pharmaceutical companies that have a promising compound and are trying to design the first
clinical protocol to test the compound's safety in human subjects.
Bridging the gap in drug information
Individuals trained in the field of pharmacy are in the exact position to bridge the gap between the
pool of gnomic informations becoming available and the goal of personalized medications.
On taking a look at the pharmagnetic information there is a tremendous need for clinical
pharmacologists, and the only group that will be able to fill that gap is pharmacists. Pharmacy has
to meet that challenge. They have to be better trained in general science in order to do the
pharmagenetics that is out there.
Douglas Figg, a pharmacist points out that his laboratory recently completed a study using a DNA
chip that can rapidly profile 1243 single-nucleotide polymorphisms in 163 genes involved in drug
metabolism and transport using a single DNA sample. This vast amount of data is soon going to be
available on each patient who would interpret and modify therapies based on this information?
In words of Figg, it won't be physicians. Fewer than a dozen physicians train to become clinical
pharmacologists each year. However, pharmacists are perfectly poised to bridge the knowledge gap
between laboratory data, and opportunities for them in clinical practice are only going to expand.
The profession of pharmacy has a lot to offer!
In the race of many institutes and organizations CRB Tech Solutions has created a niche in
conferring Clinical Research Training.