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Wise Innovations for a
     Better Care
Better Care Origins



   ●   Company born at Corporació Sanitària Parc Taulí, promoted by
       professionals from differents fields from Corporació Sanitaria
       Parc Taulí and Fundació Parc Taulí




   ●   Target’s Company: Create, maintain, improve and innovate tools
       for patient care in critical and semi-critical environment


Better Care               Better Patient              Optimization of
Patient                   Life's Quality             Health Resources
Chronology (I)




●   2004: Starts as a Final Career Project "System to aid the
    creation of medical records" from Bernat Sales computer engineer
    and led by Enric Laporte PhD MD and orchestrated by Fundació
    Parc Taulí


●   2006: Rethinking of the project: “Integral and universal system
    for data collection, integrated with Electronic Medical Record" Led
    by Lluis Blanch PhD MD
Chronology (& II)



●   2008: Search for company to register Intellectual Property and patents
●   2010: Constitution of the company under Fundació Parc Taulí regulatory framework
●   2008-2010: Agreements with:
     ○   GMV as a technological partner
     ○   Catalonia Department of Health
     ○   Ministry of Defence
●   2011: First licenses sold to Spanish Ministry of Defence
Awards



    ●    2009:"Bioemprenedors XXI" (Bioentrepreneurs) finalist award, organized by BioCat(1),
         Barcelona Activa(2), La Caixa(3) , Barcelona city council, Genoma España(4) and Barcelona
         Chamber of Commerce.
    ●    2012: "Fem Industria" finalist award, organized by College of Industrial Engineers of
         Catalonia, La Salle Technova Barcelona(5) and Leitat Technological Center(6).




(1) Organization that coordinates and promotes the biotechnology, biomedicine and medical technology sector in Catalonia
(2) Barcelona Activa, a Development Agency
(3) La Caixa
(4) Public foundation devoted to promoting technology development, knowledge transfer and innovative practices, chiefly in the biotechnology sector.
(5) La Salle Technova Barcelona
(6) Leitat Technological Center
Better Care
                                    The Team

                                                     Bernat Sales
                                                     Founding Partner
                                                     Technical Director
                                                     Computer Engineer
                                                     Specialized in mathematical
                                                     analysis and signal processing

                                                     Jaume Montanyà
                                                     Integration Engineering
                                                     Computer Engineer
                                                     Specialized in medical devices
                                                     integration and statistical
                                                     analysis




Daniel Alomar                                        The Founders
Director                                             Bernat Sales
Background in Technical Engineering degree in        Gastón Murias MD PhD
Telecommunications and Industrial Engineering        Lluís Blanch MD PhD
Broad experience in leading companies in the field   Glòria Palomar
of telemedicine with high technological component    Oscar Esquirol MD
What is Better Care? (I)
                               Knowledge Fusion


Integration of biomedical signals from a wide range of medical devices
incorporating medical knowledge




                Monitorization          Interface and
                  systems                  reports



                  Decision             Advanced alarms
               support systems


                                       Synchronization
                 Integration                 and
                   systems             HIS integration
What is Better Care? (II)
                                Devices Integrated
Some Medical Devices Integrated by Better Care:

 ●   Dräger: Evita2, Evita2 Dura, Evita4, EvitaXL, Infinity,
     Savina, Oxylog 3000+
 ●   Marquette: Solar 7000,8000, Eagle, Centralscope,
 ●   Philips: Agilent M1165/66/67/75/76/77A CMS,
     M1205A V24 y V26, Intellivue MP20/40/60/70/90.
 ●   Siemens: Servo-i, Servo-s
 ●   Viasys: All devices with comm capabilities
 ●   General Electric: Engstrom CE, Centiva, Aisys,
     Avance, Aestiva, Aespire, 7100, 7900
 ●   RGB: Omicrom FT Plus/Surveyor
 ●   Respironics: NICO, NM3
 ●   Puritan Bennett 840
 ●   …
What is Better Care? (II)
   Knowledge Fusion
What is Better Care? (IV)
                                                        Advanced Alarms

Some advanced alarms recorded and analyzed breath-by-breath
 ECG
  1.     Lead quality
  2.     HR (tachycardia - bradycardia)
  3.     Extrasystole index
  4.     Pause

 ICU Ventilator
  1. Trapped gas at end-expiration
  2. Presence of secretions in airways (1)
  3. Double-cycling
  4. Asynchronies during expiration (experts + EADi validation -ATS 2011)
  5. Pulse Pressure Variation > 13% in non-triggered breaths (2)
  6. Tidal overinflation (stress index b>1.2 in VCV square flow and non-triggered breaths) (3)
  7. Tidal recruitment & collapse (stress index b<0.8 in VCV square flow and non-triggered breaths) (3)

 (1) Jubran A et al. Am J Respir Crit Care Med. 1994;150:766-9.
 (2) Michard F et al. Am J Respir Crit Care Med. 1999;159:935-9.
 (3) Ranieri VM, et al.Anesthesiology. 2000;93:1320-8.
What is Better Care? (V)
                        Platform Layout




                                    Server Directory
    Client


                                                                Net Server
                       LAN, gprs, ISDN,
                     Internet (xDSL, 3G),
    Client
                           Satellite
                                                                 Net Server




Review (off-line)
                                                       Mobile
What is Better Care? (VI)
             Information System Integration


                            HL7

                                                                   HIS
                                                      HL7 CDA
                             BB.DD.      HL7




               DICOM vwf
Net Server
                                  PACS    DICOM vwf       Client

                                          DICOM img    Plugin
                                                       UDIAT



                            Server                      HL7
                           Directory
What is Better Care? (VII)
                  Better Care Client



Integrated Monitoring System Server (bedside monitoring)



                    Synchronized and
                     high resolution
                         signals
                                                  Video
                                               integration



                  Homogeneous, intuitive and
   Multiple        completely customizable
   patients               interface
  managemet
What is Better Care? (VIII)
                     Better Care Client

Integrated Monitoring System Client (remote monitoring)




  Algorithms to detect clinical events not included in any monitoring
     device, designed and developed together with clinical staff.
        Contextual alarms will give additional information and
         recomendations on patient evolution and treatment.
What is Better Care? (IX)
                       Better Care Client

Integrated Monitoring System Client Quickreview (remote monitoring)




                       Quick review of last clinical
                            events detected
What is Better Care? (& X)
               Better Care Review



Integrated Monitoring System Study revision (off-line)




                  Review of stored data
Better Care platform description (I)
                         Main Functionalities



●   Simple and intuitive interface, easily customizable
●   Single and homogeneous interface for a wide range of
    heterogeneous devices
●   Cost savings in the integration of medical devices
●   Visualization of biomedical signals from anywhere in the world
    with simple Internet connection
Better Care platform description (& II)
                         Main Functionalities



●   Configurable alarms as required by the professional.
●   Analysis of biomedical signals in offline mode, allowing review of
    past events (with Better Care Review software).
●   Can be used in teaching environment (with Better Care Review
    software)
●   Digitization of biomedical signals and integration into the Hospital
    Information Systems HIS and PACS through DICOM and HL7
Where we come?
                             Current Projects

●   Licenses acquired by the Ministry of Defence of Spain
●   Installed on beds in 5 ICU (Intensive Care Units) from 5 Hospitals in a
    Spanish Research multicentric project
●   Installed in the Simulation Lab and ICUs of Hospital Clínic de Barcelona
●   Installed in 8 beds for semi-critical patient care in Parc Taulí de
    Sabadell.
●   Collaboration with medical professionals to adapt the platform to
    different specialties (cardiology, respiratory medicine, neuropsychology,
    ...)
●   Participation in Marató TV3: Neurostimulation in ICU (Research project)
Added Value
                            Scientific Evidence

●   Citation in scientific papers:
     1. Correger E, Murias G, Chacon E, Estruga A, Sales B, López-
         Aguilar J, Montanya J, Lucangelo U, García-Esquirol O, Villagrá A,
         Villar J, Kacmarek RM, Burgueño MJ, Blanch L. Interpretación de
         las curvas del respirador en pacientes con insuficiencia
         respiratoria aguda. Medicina Intensiva 2011;doi:10.1016 /j.
         medin.2011.08.005.
    2.    Blanch L, Sales B, Montanya J et al . Validation of the Better
          Care© system to detect ineffective efforts during expiration in
          mechanically ventilated patients. A pilot study. Intensive Care
          Med doi: 10.1007/s00134-012-2493-4
●   Additional papers pending to review.
IP and Regulations




●   "Method and System for Managing related Patient Parameters
    provided by a Monitoring Device” (PCT/EP2008/052458)
    Status: Pending


●   Finalising the approval of CE mark Class IIb
●   FDA on the roadmap
Thank you for your time




Wise Innovations for a   Daniel Alomar Claramonte
     Better Care                  Director



http://www.bettercare.es

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Better Care Corporate Presentation

  • 1. Wise Innovations for a Better Care
  • 2. Better Care Origins ● Company born at Corporació Sanitària Parc Taulí, promoted by professionals from differents fields from Corporació Sanitaria Parc Taulí and Fundació Parc Taulí ● Target’s Company: Create, maintain, improve and innovate tools for patient care in critical and semi-critical environment Better Care Better Patient Optimization of Patient Life's Quality Health Resources
  • 3. Chronology (I) ● 2004: Starts as a Final Career Project "System to aid the creation of medical records" from Bernat Sales computer engineer and led by Enric Laporte PhD MD and orchestrated by Fundació Parc Taulí ● 2006: Rethinking of the project: “Integral and universal system for data collection, integrated with Electronic Medical Record" Led by Lluis Blanch PhD MD
  • 4. Chronology (& II) ● 2008: Search for company to register Intellectual Property and patents ● 2010: Constitution of the company under Fundació Parc Taulí regulatory framework ● 2008-2010: Agreements with: ○ GMV as a technological partner ○ Catalonia Department of Health ○ Ministry of Defence ● 2011: First licenses sold to Spanish Ministry of Defence
  • 5. Awards ● 2009:"Bioemprenedors XXI" (Bioentrepreneurs) finalist award, organized by BioCat(1), Barcelona Activa(2), La Caixa(3) , Barcelona city council, Genoma España(4) and Barcelona Chamber of Commerce. ● 2012: "Fem Industria" finalist award, organized by College of Industrial Engineers of Catalonia, La Salle Technova Barcelona(5) and Leitat Technological Center(6). (1) Organization that coordinates and promotes the biotechnology, biomedicine and medical technology sector in Catalonia (2) Barcelona Activa, a Development Agency (3) La Caixa (4) Public foundation devoted to promoting technology development, knowledge transfer and innovative practices, chiefly in the biotechnology sector. (5) La Salle Technova Barcelona (6) Leitat Technological Center
  • 6. Better Care The Team Bernat Sales Founding Partner Technical Director Computer Engineer Specialized in mathematical analysis and signal processing Jaume Montanyà Integration Engineering Computer Engineer Specialized in medical devices integration and statistical analysis Daniel Alomar The Founders Director Bernat Sales Background in Technical Engineering degree in Gastón Murias MD PhD Telecommunications and Industrial Engineering Lluís Blanch MD PhD Broad experience in leading companies in the field Glòria Palomar of telemedicine with high technological component Oscar Esquirol MD
  • 7. What is Better Care? (I) Knowledge Fusion Integration of biomedical signals from a wide range of medical devices incorporating medical knowledge Monitorization Interface and systems reports Decision Advanced alarms support systems Synchronization Integration and systems HIS integration
  • 8. What is Better Care? (II) Devices Integrated Some Medical Devices Integrated by Better Care: ● Dräger: Evita2, Evita2 Dura, Evita4, EvitaXL, Infinity, Savina, Oxylog 3000+ ● Marquette: Solar 7000,8000, Eagle, Centralscope, ● Philips: Agilent M1165/66/67/75/76/77A CMS, M1205A V24 y V26, Intellivue MP20/40/60/70/90. ● Siemens: Servo-i, Servo-s ● Viasys: All devices with comm capabilities ● General Electric: Engstrom CE, Centiva, Aisys, Avance, Aestiva, Aespire, 7100, 7900 ● RGB: Omicrom FT Plus/Surveyor ● Respironics: NICO, NM3 ● Puritan Bennett 840 ● …
  • 9. What is Better Care? (II) Knowledge Fusion
  • 10. What is Better Care? (IV) Advanced Alarms Some advanced alarms recorded and analyzed breath-by-breath ECG 1. Lead quality 2. HR (tachycardia - bradycardia) 3. Extrasystole index 4. Pause ICU Ventilator 1. Trapped gas at end-expiration 2. Presence of secretions in airways (1) 3. Double-cycling 4. Asynchronies during expiration (experts + EADi validation -ATS 2011) 5. Pulse Pressure Variation > 13% in non-triggered breaths (2) 6. Tidal overinflation (stress index b>1.2 in VCV square flow and non-triggered breaths) (3) 7. Tidal recruitment & collapse (stress index b<0.8 in VCV square flow and non-triggered breaths) (3) (1) Jubran A et al. Am J Respir Crit Care Med. 1994;150:766-9. (2) Michard F et al. Am J Respir Crit Care Med. 1999;159:935-9. (3) Ranieri VM, et al.Anesthesiology. 2000;93:1320-8.
  • 11. What is Better Care? (V) Platform Layout Server Directory Client Net Server LAN, gprs, ISDN, Internet (xDSL, 3G), Client Satellite Net Server Review (off-line) Mobile
  • 12. What is Better Care? (VI) Information System Integration HL7 HIS HL7 CDA BB.DD. HL7 DICOM vwf Net Server PACS DICOM vwf Client DICOM img Plugin UDIAT Server HL7 Directory
  • 13. What is Better Care? (VII) Better Care Client Integrated Monitoring System Server (bedside monitoring) Synchronized and high resolution signals Video integration Homogeneous, intuitive and Multiple completely customizable patients interface managemet
  • 14. What is Better Care? (VIII) Better Care Client Integrated Monitoring System Client (remote monitoring) Algorithms to detect clinical events not included in any monitoring device, designed and developed together with clinical staff. Contextual alarms will give additional information and recomendations on patient evolution and treatment.
  • 15. What is Better Care? (IX) Better Care Client Integrated Monitoring System Client Quickreview (remote monitoring) Quick review of last clinical events detected
  • 16. What is Better Care? (& X) Better Care Review Integrated Monitoring System Study revision (off-line) Review of stored data
  • 17. Better Care platform description (I) Main Functionalities ● Simple and intuitive interface, easily customizable ● Single and homogeneous interface for a wide range of heterogeneous devices ● Cost savings in the integration of medical devices ● Visualization of biomedical signals from anywhere in the world with simple Internet connection
  • 18. Better Care platform description (& II) Main Functionalities ● Configurable alarms as required by the professional. ● Analysis of biomedical signals in offline mode, allowing review of past events (with Better Care Review software). ● Can be used in teaching environment (with Better Care Review software) ● Digitization of biomedical signals and integration into the Hospital Information Systems HIS and PACS through DICOM and HL7
  • 19. Where we come? Current Projects ● Licenses acquired by the Ministry of Defence of Spain ● Installed on beds in 5 ICU (Intensive Care Units) from 5 Hospitals in a Spanish Research multicentric project ● Installed in the Simulation Lab and ICUs of Hospital Clínic de Barcelona ● Installed in 8 beds for semi-critical patient care in Parc Taulí de Sabadell. ● Collaboration with medical professionals to adapt the platform to different specialties (cardiology, respiratory medicine, neuropsychology, ...) ● Participation in Marató TV3: Neurostimulation in ICU (Research project)
  • 20. Added Value Scientific Evidence ● Citation in scientific papers: 1. Correger E, Murias G, Chacon E, Estruga A, Sales B, López- Aguilar J, Montanya J, Lucangelo U, García-Esquirol O, Villagrá A, Villar J, Kacmarek RM, Burgueño MJ, Blanch L. Interpretación de las curvas del respirador en pacientes con insuficiencia respiratoria aguda. Medicina Intensiva 2011;doi:10.1016 /j. medin.2011.08.005. 2. Blanch L, Sales B, Montanya J et al . Validation of the Better Care© system to detect ineffective efforts during expiration in mechanically ventilated patients. A pilot study. Intensive Care Med doi: 10.1007/s00134-012-2493-4 ● Additional papers pending to review.
  • 21. IP and Regulations ● "Method and System for Managing related Patient Parameters provided by a Monitoring Device” (PCT/EP2008/052458) Status: Pending ● Finalising the approval of CE mark Class IIb ● FDA on the roadmap
  • 22. Thank you for your time Wise Innovations for a Daniel Alomar Claramonte Better Care Director http://www.bettercare.es