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Presentation made by Aagami at Lifesciences Summit at CGI - 18 MayAagami, Inc.
The Consulate General India - Chicago organized a Life Science Summit on May 18, 2015 at Chicago
Mr. Dinesh Jain, Founder CEO, Aagami Inc. and Mr. Michael Rosen, Managing Director, Rosen Bioscience Strategies (also partner consultant at Aagami) attended the event as speakers and made a presentation on “Life Science Connections between the Midwest and India” as well as some of the life science M&A and FDI activity going on between the U.S. and India”
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. • Avanafil is an oral phosphodiesterase type 5 (PDE5)
inhibitor indicated for the treatment of erectile
dysfunction.
• It relaxes muscles and increases blood flow. The
product received U.S. Food and Drug Administration
approval for the treatment of erectile dysfunction in April
2012 under the approved trade name STENDRA.
• In June 2013, the European countries adopted a
decision granting marketing authorization for SPEDRA.
4. 1. Akhil Healthcare Pvt Ltd.:
• Akhil Healthcare Pvt Ltd. is one of the leading suppliers
of Pharmaceutical raw materials, cosmetics raw
materials and packing materials in India since last more
than 2 decades.
• They thrive to provide their customers with the highest
quality material and is now one of the most eminent and
trustworthy suppliers of High-Grade APIs, Excipients and
Packing materials.
5. 2. Aarambh Life Science:
• Aarambh Life Science established in the year 2009 and
is one of the leading Avanafil API Manufacturer in India.
• The company consists of Five Manufacturing units.
Each located at the best of locations in India – Gujarat
and Andhra Pradesh, which are Pharma Manufacturing
hub of India.
• The company has a world-class Unit with GMP facility.
6. 3. Manus Aktteva Biopharma LLP:
• Manus Aktteva Biopharma LLP, a global supplier of
Avanafil, 330784-47-9 offers for your requirements of
RND / Development quantities or commercials, based
on the status of the product.
• They can also offer its intermediates with supportive
technical package require for evaluation. Avanafil is
certified by GMP, Factory GMP, cGMP, EUGMP, WHO
GMP, ISO Certified, USFDA norms. Export worthy
packing for their client's satisfaction.
7. 4. Merix Laboratories Pvt. Ltd.:
• Merix Laboratories Pvt. Ltd. is one of the
leading Avanafil API Manufacturer in India.
• The company always stick to high standards of quality
in all areas of operations especially in the manufacturing
of Avanafil.
• With commitment and responsibility as an integral part
of their business, they always practice strong corporate
ethics.
8. 5. Hermes Chemical Company Private
Limited:
• Hermes aims to apply science and their resources to
improve global health and well-being through affordable
API’s which in turn can lower the cost of medicines.
• The company believes in providing quality healthcare,
hence at every step of the manufacturing process, they
test and produce goods only to standards that are
approve by major regulatory bodies.
9. 6. Ultratech India Limited:
• Ultratech India Limited is a WHO-GMP and ISO
certified Pharmaceutical company that manufactures
and markets a wide range of Pharmaceutical
Formulations in various dosage forms (Tablets,
Capsules, Syrups, Gels, Injections, Nasal Sprays,
Metered Dose Inhalers), advanced Drug Intermediates
and Active Pharmaceutical Ingredients.
• They are one of the leading Avanafil API Manufacturer
in India.
10. 7. Honour Lab Limited:
• Honour Lab Limited established in the year 2012. The
company is involves in the manufacturing of Bulk Drug
Intermediates and Active Pharmaceutical Ingredients
(APIs) mainly Avanafil.
• However, the company's major thrust area remains
developing high-quality Avanafil that meets the
competitive demands of the rapidly growing global drug
markets.
11. 8. MSN Laboratories:
• MSN Laboratories established in the year 2003 and
is one of the leading Avanafil API Manufacturer in India.
• The company has a diverse product portfolio, with
multiple products in the market and in the pipeline, MSN
has nine API (including Avanafil) and five finished
dosage facilities (including one for oncology) and an
integrated R&D Center for Contract Research And
Manufacturing Services (CRAMS) located in Hyderabad.
12. 9. Salvavidas Pharmaceutical Pvt. Ltd.:
• Salvavidas Pharmaceutical Pvt. Ltd. established in the
year 2015.
• Their Avanafil is highly effective and appreciated by the
consumers for its effectiveness, purity, safety, innovative
composition and potency.
• Its customer-support oriented approach fosters the
company to get a sizable client base across the country.
13. Conclusion:
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