autonomic receptors

1. AUTONOMIC RECEPTORS
PHARMACOLOGY
Dr Reham ellisy
Assistant lecturer

2. AUTONOMIC NERVOUS SYSTEM RECEPTORS

4. CHOLINERGIC
(PARASYMPATHETIC)
RECEPTORS

5. MUSCARINIC RECEPTORS
 Related to muscarine plant.
 M1,M3.M5(Gq)
 M2,M4(Gi)

6. MUSCARINIC RECEPTORS
• Gq coupled receptor
• GIT-pareital cell-CNS
M1
• Gi coupled receptor
• Heart -CNS
M2
• Gq coupled receptor
• Smooth muscles
M3
M4,5
CNS

7. MUSCARINIC RECEPTORS
 M1 →parietal cell→increase GIT secretion.
 M2 → Heart →↓HR →↓A-V conduction →↓contractility.
 presynaptic →↓ach release.
 CNS.

8. MUSCARINIC RECEPTORS
 M3 receptors:smooth muscles:
1-Eye:M3 ciliary muscle (contraction)-iris CPM(miosis)
2-Bronchi:

9. MUSCARINIC RECEPTORS
3-GIT:M3 present in wall ↑motility & secretion.
4-Bladder wall : contraction & relax sphincter.
5-Exocrine gland: ↑secretion of all glands.
6-Vascular endothelium: vasodilatation
7-♂sex organ :erection.

10. NICOTINIC
RECEPTORS
Nicotinic
receptors
NmorN1
Neuromuscular
junction
Nn orN2
Autonomic ganglia
Adrenal medulla
CNS

11. NICOTINIC
RECEPTORS
 Nm receptors: skeletal

12. NICOTINIC RECEPTORS

13. ADRENERGIC RECEPTORS
Adrenergic
receptors
α receptors
1α α2
Β-
receptors
Β1 Β2 Β3

14. ADRENERGIC RECEPTORS(GPCR)
 (α1) receptors:
 Gq receptors:
1-Smooth muscles
A-Vascular SM
Contraction→VC
→↑TPR→↑BP.
B-Eye:
Dilator Pupillae
muscle→mydriasis

15. ADRENERGIC RECEPTORS
 (α1) receptors: Gq receptors:
C-GIT
relax wall&
Contract sphincter.
D-Urinary bladder
Relax wall
contraction of
sphincter.
E-♂sex organ :
Ejaculation.
F-uterus:contraction.

16. ADRENERGIC RECEPTORS
 (α1) receptors:
 Gq receptors:
F-pilomotor sm muscle: Contraction→ erection of hair.
2-Skeletal muscles : facilitate neuro muscular transmission.
3-Sweat gland: apocrine gland in sole & palm (non-thermoregulatory).

17. ADRENERGIC RECEPTORS
 (α2) receptors: Gi↓→adenylcyclase→↓cAMP.
(α2) receptors
CNS
↓symp discharge
Presynaptic
Receptors
↓adrenaline release
Pancrease
↓insulin release
Platelet
↑aggregatione

18. ADRENERGIC RECEPTORS
 Alpha 2 receptors:
 Gi coupled receptors
5-Kidney : juxta-glomerular apparatus :decrease
renin release.
6-Eye :ciliary epithelium decrease aqueus humor
formation.
7-Adipose tissue:decrease lipolysis.

19. ADRENERGIC RECEPTORS
BETA 1 RECEPTORS
 Beta 1 receptors: Gs→ ↑adenylcyclase →↑cAMP
 Heart &kidney.
 CNS:
↑sympathetic
discharge→
Anxiety.

20. ADRENERGIC RECEPTORS
BETA 2 RECEPTORS
 Beta 2 receptors:Gs→↑adenylcyclase →↑cAMP
1-Smooth muscles:
 relaxation: bronchi-BVS-intestine- urinary bladder-uterus.

21. ADRENERGIC RECEPTORS
BETA 2 RECEPTORS
2-Skeletal muscles: ↑skeletal twitches.
 ↑ k uptake by muscle.
3-Liver:↑glycogenolysis.
4-Pancrese:↑insulin release.
5-Eye:in ciliary epithelium.
↑in aqueous humor formation.

23. ISOLATED ORGAN AUTONOMIC SUPPLY
 Blood vessels:
 Coronary& skeletal
blood vessels
 B.V of skeletal ms has
sympathetic cholinergic
supply.
 Blood vessels:
 Skin & mucous
memberane.
α1˃β2
M3
α1˂β2
M3

24. INTESTINE
 Wall:M3 &α1 &β2
 Sphincter: α1 &M3
 Urinary bladder:

25. SWEAT GLAND