This document discusses using statistical process control (CUSUM) charts to monitor mortality rates at the level of individual general practitioners and health authorities. It describes how CUSUM charts could potentially have detected Harold Shipman, a GP who murdered over 200 patients, by spotting outliers in the routine mortality data. The document also discusses challenges in risk adjusting outcomes to account for differences in patient characteristics and casemix between providers. Accurately adjusting for factors like age, comorbidities, and emergency status is important for fair comparisons but difficult using only administrative data.
💸Cash Payment No Advance Call Girls Kanpur 🧿 9332606886 🧿 High Class Call Gir...
Applied use of CUSUMs in surveillance
1. Applied use of CUSUMs in surveillance
Paul Aylin, Co-Director of the Dr Foster Unit, Imperial College
London
Chair: Chris Sherlaw-Johnson, Senior Research Analyst,
Nuffield Trust
2. Applied use of CUSUMs in surveillance
Professor Paul Aylin
Dr Foster Unit at Imperial College London
p.aylin@imperial.ac.uk
3. Measuring Performance in Institutions
• Background
• Risk adjustment
• Analysis
• Alerting system
4. In an attempt to arrive at the truth, I
have applied everywhere for
information but in scarcely an
instance have I been able to obtain
hospital records fit for any purpose of
comparison. If they could be obtained
they would enable us to answer many
questions. They would show
subscribers how their money was
being spent, what amount of good
was really being done with it or
whether the money was not doing
mischief rather than good.
Florence Nightingale, 1863
Where healthcare measurement began
5. • Heart operations at
the Bristol Royal
Infirmary
“Inadequate care for one
third of children”
• Harold Shipman
Murdered more than 200
patients
Key events
10. Could we detect Shipman by looking at the data?
• Provided with data for over 1000 GPs in
five health authorities
• One GP was Shipman, but we were
blinded as to which one.
• Investigate methods for routine
surveillance of mortality data at the
level of General Practitioner (GP),
Practice and Health Authority (HA).
11. Prospective surveillance and multiple testing
• Different to Bristol
• No prior hypothesis
• Statistical process control charts (SPC) among
the most widely used methods for sequential
analysis
14. Key lessons
• Routine hospital admissions data are
good enough for performance
monitoring (Bristol)
• Statistical methods exist for spotting
outliers and detecting improvement
(Shipman)
• Make use of multiple data sources
• Risk adjustment important
15. Casemix
• Not all patients are alike: age, sex,
illness severity, comorbidity, frailty…
• Many of these factors affect your risk of
clinical events e.g. death, complications
• The distribution of these casemix
factors varies by hospital
• Comparing hospitals’ crude death rates
will therefore be misleading -> risk
adjust
16. Tricky. Why not compare processes of care instead?
• Patients care about outcomes
• Process measures describe what was
done to patient (drugs given, guidelines
followed, scans done, advice given)
• A large number of these comprise
quality of care, but which ones really
affect the outcome? Which ones should
we monitor?
• Less available in electronic data
17. Challenges - Case mix adjustment
Limited within administrative data?
• Age
• Sex
• Emergency/Elective
18. Data used in our UK risk modelling
• National routine hospital admissions
data (HES), updated monthly
• 15m records annually, 300+ fields
• Dx, ops, age, sex, emergency status,
area code, deaths. No lab or drugs
• ICD10 and OPCS coding systems
• Easy(ish) access, cheap, comp
• Quality much improved but varies
19. Casemix adjustment methods: evolving science/art
• Indirect standardisation by age and sex
-> SMR (19th Century to date)
• Computing and stats algorithms ->
regression methods (1970s onwards)
• Machine learning methods (1980s
onwards)
• We need i) right list of casemix factors
ii) defined and blended the best way…
20. How does risk adjustment work for mortality?
• For each hospital, get actual
(‘observed’) number of deaths and
divide by predicted (or ‘expected’)
number of deaths: this is the SMR
• Derive expected number from risk
model where each patient’s probability
of death is estimated depending on
their set of casemix factors: sum these
probabilities of death for each hospital
to give the expected number of deaths
21. What might go into these risk models?
• age
• sex
• elective status
• socio-economic deprivation
• diagnosis subgroups or procedure subgroups
• comorbidity – e.g. Charlson, Elixhauser, Holman, DRG…
• number of prior emergency admissions
• palliative care
• year
• month of admission
• ethnic group
• source of admission (own home, care home, other hospital)
22. Our approach to risk modelling
• Build one model per outcome and per patient
(dx/op) group
• This allows for e.g. age to affect post-op
mortality differently from readmission for
stroke
• Try all the candidate variables and key
interactions and drop the unimportant ones
• Automate age grouping and technical issues
to allow industrial scale
• Update models at least yearly: things change
23. Comorbidity adjustment
• MANY approaches tried: count ICD
codes; count ‘common’ or ‘impt’ ICD
codes; count comorbs; weight subset of
comorbs (which ones??? What
weights???)
• Common indices include Charlson
(1987), Elixhauser (1998). Which is
better? Depends on outcome, pt group
25. ROC curve areas comparing ‘simple’, ‘intermediate’ and ‘complex’ models
derived from HES with models derived from clinical databases
0.5
0.55
0.6
0.65
0.7
0.75
0.8
0.85
0.9
0.95
1
CABG AAA - unruptured AAA - ruptured Colorectal excision
for cancer
Index procedure
ROC
HES Simple model (Year, age, sex)
HES Intermediate model (including method of admission)
HES Full model
Best model derived from clinical dataset
Aylin P; Bottle A; Majeed A. Use of administrative data or clinical databases as predictors of risk of death in hospital:
comparison of models. BMJ 2007;334: 1044
26. Comparison of HES vs clinical databases
Vascular surgery
• HES = 32,242
• National Vascular Database = 8,462
Aylin P; Lees T; Baker S; Prytherch D; Ashley S. (2007) Descriptive study
comparing routine hospital administrative data with the Vascular Society of
Great Britain and Ireland's National Vascular Database. Eur J Vasc
Endovasc Surg 2007;33:461-465
Bowel resection for colorectal cancer
• HES 2001/2 = 16,346
• ACPGBI 2001/2 = 7,635
• ACPGBI database, 39% of patients had missing data for the risk factors
Garout M, Tilney H, Aylin, P. Comparison of administrative data with the
Association of Coloproctology of Great Britain and Ireland (ACPGBI)
colorectal cancer database. International Journal of Colorectal Disease
2008;23(2):155-63
27. How to identify outliers?
“Even if all surgeons are equally good, about half will
have below average results, one will have the worst
results, and the worst results will be a long way below
average”
• Poloniecki J. BMJ 1998;316:1734-1736
28.
29. Funnel plot for surgeon-level adjusted return to theatre (RTT)
rates for hip replacement.
30.
31.
32. Pyramid Model Of Investigation To Find Credible Cause
Lilford et al. Lancet 2004; 363: 1147-54
1st Step: Does the
coding reflect what
happened to the patient
4th Step: Examine when
other issues have occurred
2nd Step: Has
something occurred
locally to affect your
casemix
3rd Step: The Local Health
Economy may treat patients
differently than the rest of the
country/region e.g. provision of
hospices, etc
Finally: An individual is rarely the cause
of an alert. A Consultant name may be
coded against the primary diagnosis but
many individuals and teams are involved in
the patient’s care