This PPT covers Drug therapy for Viral Infection or disease. It includes Viral replication cycle, classification of antiviral drugs, Anti-Herpes drug, Anti Influenza drugs, Anti hepatitis drugs and anti retroviral drugs
This PPT covers Drug therapy for Viral Infection or disease. It includes Viral replication cycle, classification of antiviral drugs, Anti-Herpes drug, Anti Influenza drugs, Anti hepatitis drugs and anti retroviral drugs
medicinal chemistry of Antiviral drugsFatenAlsadek
medicinal chemistry of antiviral drugs with its chemical structures and how they chemically work
Done by: Faten Al-Sadek , Pharmacy student at Mohammed Al-Mana college for Health Sciences -MACHS
Antiviral drugs are a class of medication used specifically for treating viral infections rather than bacterial ones. Most antivirals are used for specific viral infections, while a broad-spectrum antiviral is effective against a wide range of viruses.
TREATMENT OF RESPIRATORY VIRUS INFECTIONS
A.Neuraminidase inhibitors
NAIs block the release of the influenza virus from infected host cells and thus reduce the spread of infection in the respiratory tract.
B.Inhibitors of viral uncoating
amantadine and rimantad are example of drug for viral uncoating inhibitors
the drugs effective in both treatment and prevention
Ribavirin
Ribavirin is a synthetic guanosine analog.
It is effective against a broad spectrum of RNA and DNA viruses.
. Lamivudine This cytosine analog
is an inhibitor of both hepatitis B virus (HBV) DNA polymerase and human immunodeficiency virus (HIV) reverse transcriptase.
. Adefovir dipivoxil is a nucleotide analog that is phosphorylated to adefovir diphosphate , which is
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medicinal chemistry of Antiviral drugsFatenAlsadek
medicinal chemistry of antiviral drugs with its chemical structures and how they chemically work
Done by: Faten Al-Sadek , Pharmacy student at Mohammed Al-Mana college for Health Sciences -MACHS
Antiviral drugs are a class of medication used specifically for treating viral infections rather than bacterial ones. Most antivirals are used for specific viral infections, while a broad-spectrum antiviral is effective against a wide range of viruses.
TREATMENT OF RESPIRATORY VIRUS INFECTIONS
A.Neuraminidase inhibitors
NAIs block the release of the influenza virus from infected host cells and thus reduce the spread of infection in the respiratory tract.
B.Inhibitors of viral uncoating
amantadine and rimantad are example of drug for viral uncoating inhibitors
the drugs effective in both treatment and prevention
Ribavirin
Ribavirin is a synthetic guanosine analog.
It is effective against a broad spectrum of RNA and DNA viruses.
. Lamivudine This cytosine analog
is an inhibitor of both hepatitis B virus (HBV) DNA polymerase and human immunodeficiency virus (HIV) reverse transcriptase.
. Adefovir dipivoxil is a nucleotide analog that is phosphorylated to adefovir diphosphate , which is
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
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International FDP on Fundamentals of Research in Social Sciences
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Introduction to AI for Nonprofits with Tapp NetworkTechSoup
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Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
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2. TREATMENT FOR HERPES VIRUS INFECTIONS
• Herpes viruses are associated with a broad spectrum of diseases, for example,
cold sores, viral encephalitis, and genital infections. The drugs that are effective
against these viruses exert their actions during the acute phase of viral infections
and are without effect during the latent phase.
• A. Acyclovir
• Acyclovir [ay-SYE-kloe-veer] (acycloguanosine) is the prototypic antiherpetic
therapeutic agent. Herpes simplex virus (HSV) types 1 and 2, varicella-zoster virus
(VZV), and some Epstein-Barr virus–mediated infections are sensitive to acyclovir.
It is the treatment of choice in HSV encephalitis.
3. M. O. A
• Acyclovir, a guanosine analog, is monophosphorylated in the cell by the
herpesvirus-encoded enzyme thymidine kinase (Figure 45.8). Therefore, virus-
infected cells are most susceptible. The monophosphate analog is converted to
the di- and triphosphate forms by the host cell kinases. Acyclovir triphosphate
competes with deoxyguanosine triphosphate as a substrate for viral DNA
polymerase and is itself incorporated into the viral DNA, causing premature DNA
chain termination.
• ADVERSE EFFECTS: headache, diarrhea, nausea, and vomiting
4. B. CIDOFOVIR
• Cidofovir [si-DOE-foe-veer] is approved for the treatment of cytomegalovirus (CMV)
retinitis in patients with AIDS. [Note: CMV is a member of the herpesvirus family.]
Cidofovir is a nucleotide analog of cytosine, the phosphorylation of which is not
dependent on viral or cellular enzymes. It inhibits viral DNA synthesis
C. Foscarnet
foscarnet [fos-KAR-net] is not a purine or pyrimidine analog. Instead, it is a
phosphonoformate (a pyrophosphate derivative) and does not require activation by viral
(or cellular) kinases. Foscarnet is approved for CMV retinitis in immunocompromised
hosts and for acyclovir-resistant HSV infections. Foscarnet works by reversibly inhibiting
viral DNA and RNA polymerases, thereby interfering with viral DNA and RNA synthesis.
5. D. GANCICLOVIR
• Ganciclovir [gan-SYE-kloe-veer] is an analog of acyclovir that has greater activity
against CMV. It is used for the treatment of CMV retinitis in immunocompromised
patients and for CMV prophylaxis in transplant patients.
• Mechanism of action: Like acyclovir, ganciclovir is activated through conversion to
the nucleoside triphosphate by viral and cellular enzymes. The nucleotide inhibits
viral DNA polymerase and can be incorporated into the DNA resulting in chain
termination
• Adverse effects: Adverse effects include severe, dose- dependent neutropenia.
Ganciclovir is carcinogenic as well as embryotoxic and teratogenic in
experimental animals.
6. E. PENCICLOVIR AND FAMCICLOVIR
• Penciclovir pen-SYE-kloe-veer is an acyclic guanosine nucleoside derivative that is
active against HSV-1, HSV-2, and VZV. Penciclovir is only administered topically. It
is monophosphorylated by viral thymidine kinase, and cellular enzymes form the
nucleoside triphosphate, which inhibits HSV DNA polymerase. Penciclovir
triphosphate has an intracellular half-life much longer than acyclovir
triphosphate. Penciclovir is negligibly absorbed upon topical application and is
well tolerated. Famciclovir fam-SYE-kloe-veer, another acyclic analog of 2′-
deoxyguanosine, is a prodrug that is metabolized to the active penciclovir. The
antiviral spectrum is similar to that of ganciclovir, and it is approved for treatment
of acute herpes zoster, genital HSV infection, and recurrent herpes labialis. The
drug is effective orally. Adverse effects include headache and nausea.
7. F. TRIFLURIDINE
• Trifluridine [trye-FLURE-i-deen] is a fluorinated pyrimidine nucleoside analog that
is structurally similar to thymidine. Once converted to the triphosphate, the agent
is believed to inhibit the incorporation of thymidine triphosphate into viral DNA
and, to a lesser extent, lead to the synthesis of defective DNA that renders the
virus unable to replicate. Trifluridine is active against HSV-1, HSV-2, and vaccinia
virus. It is indicated for treatment of HSV keratoconjunctivitis and recurrent
epithelial keratitis. Because the triphosphate form of trifluridine can also
incorporate to some degree into cellular DNA, the drug is considered to be too
toxic for systemic use. Therefore, the use of trifluridine is restricted to a topical
ophthalmic preparation. A short half-life necessitates that the drug be applied
frequently. Adverse effects include a transient irritation of the eye and palpebral
(eyelid) edema.
8. OVERVIEW OF THE TREATMENT
FOR HIV INFECTION
• treatment of HIV infections
• focused on decreasing the occurrence of opportunistic infections that
• caused a high degree of morbidity and mortality in AIDS patients. Today,
• the viral life cycle is understood and a combination of
• drugs is used to suppress replication of HIV and restore the number of CD4 cells
and immunocompetence to the host.
9. CONT….
• This multidrug regimen is
• commonly referred to as “highly active antiretroviral therapy,” or HAART
• There are five classes of antiretroviral drugs, each of which targets one of the
four viral processes. These classes of drugs are :
• nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs),
nonnucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors
• (PIs), entry inhibitors, and the integrase inhibitors.
10. CONT….
• The preferred initial therapy is a combination of two NRTIs with a PI, an NNRTI,
or an integrase inhibitor. Selection of the appropriate combination is based on 1)
avoiding the use of two agents of the same nucleoside analog; 2) avoiding
overlapping toxicities and genotypic and phenotypic characteristics of the virus
3) patient factors,
• 4) impact of drug interactions; and 5) ease of adherence to the
• regimen.
11. NRTIS USED TO TREAT HIV INFECTION
• Mechanism of action: NRTIs are analogs of native ribosides (nucleosides or
nucleotides containing ribose), which all lack a 3′-hydroxyl group. Once they
enter cells, they are phosphorylated by
• cellular enzymes to the corresponding triphosphate analog, which
• is preferentially incorporated into the viral DNA by RNA.
12. CONT…
• Pharmacokinetics: The NRTIs are primarily renally excreted,
• and all require dosage adjustment in renal insufficiency except
• abacavir, which is metabolized by alcohol dehydrogenase and
• glucuronyl transferase.
• Adverse effects: Many of the toxicities of the NRTIs are believed
• to be due to inhibition of the mitochondrial DNA polymerase in
• certain tissues.
13. ZIDOVUDINE (AZT)
• Zidovudine (AZT)
• Zidovudine [zye-DOE-vyoo-deen], the pyrimidine analog, 3′-azido-
• 3′-deoxythymidine (AZT), was the first agent available for the treatment of HIV infection. AZT is
approved for the treatment of HIV in
• children and adults and to prevent perinatal transmission of HIV
• . Stavudine (d4T)
• Stavudine [STAV-yoo-deen] is an analog of thymidine approved for
• the treatment of HIV. The drug is well absorbed after oral administration, and it penetrates the blood–
brain barrier. The majority of the
• drug is excreted unchanged in the urine
14. CONT…
• Didanosine (ddI)
• Upon entry of didanosine
• into the host cell, ddI is biotransformed into dideoxyadenosine triphosphate (ddATP) through a series of reactions that involve
phosphorylations and aminations.
• The drug penetrates into the CSf
• Pancreatitis, which may be fatal,
• . Tenofovir (TDF)
• Tenofovir is a nucleotide analog, namely, an acyclic
• nucleoside phosphonate analog of adenosine 5′-monophosphate. It
• is converted by cellular enzymes to the diphosphate, which is the
• inhibitor of HIV RT
15. CONT…
• Lamivudine (3TC)
• Lamivudine [la-MI-vyoo-deen] (2′-deoxy-3′-thiacytidine, 3TC) inhibits
• the RT of both HIV and HBV it does not affect mitochondrial DNA synthesis or bone
marrow precursor cells, resulting in less
• toxicity.
• Emtricitabine (FTC)
• Emtricitabine [em-tri-SIGH-ta-been], a fluoro derivative of lamivudine,
• inhibits both HIV and HBV RTalso cause hyperpigmentation of the soles and palms.
16. NNRTIS USED TO TREAT HIV INFECTION
• NNRTIs are highly selective, noncompetitive inhibitors of HIV-1 RT.
They bind to HIV RT at an allosteric hydrophobic site adjacent to
the active site,
• Nevirapine (NVP)
• Nevirapine [ne-VYE-ra-peen] is used in combination with other
antiretroviral drugs for the treatment of HIV infections in adults and
children.
17. DELAVIRDINE (DLV)
• Delavirdine [de-LA-vir-deen] is not recommended as a preferred or
• alternate NNRTI in the current HIV guidelines due to its inferior antiviral efficacy and
inconvenient (three times daily) dosing.
• Efavirenz (EFV)
• Efavirenz [e-FA-veer-enz] is the preferred NNRTI. Following oral
• administration, efavirenz is well distributed, including to the CNS
• It should be administered on an empty stomach to
• reduce adverse CNS effects.
18. ETRAVIRINE (ETR)
• Etravirine [et-ra-VYE-rine] is a second-generation NNRTI active
• against many HIV strains that are resistant to the first-generation NNRTIs.
• Rilpivirine (RPV)
• Rilpivirine [ril-pi-VIR-een] is approved for HIV treatment-naïve patients
• in combination with other antiretroviral agents. It is administered orally
• once daily with meals and has pH-dependent absorption .