This slide is useful for students who have been studying in d.pharm 2nd year from BTE, Lucknow.

1. S N A INSTITUTE OF PHARMACY
HAIDERGARH, BARABANKI
SUBJECT – PHARMACEUICAL CHEMISTRY – II
TOPIC
ANTISEPTICS AND DISINFECTANTS

2. DEFINATION
Antiseptics: Antiseptics are the agents that destroy
or prevent the growth of micro organisms when
applied to living tissues.
Disinfectants: Disinfectants are chemical agents
designed to inactivate or destroy microorganisms on
inert surfaces Disinfection does not necessarily kill all
microorganisms, especially resistant bacterial spores;

3. Bactericides: The agents which kill the bacteria are
called bactericides.
Bacteriostatics: The agents which prevent the
growth of bacteria are called bacteriostatics.
Preservatives: Preservatives are the agents that
prevent the microbial growth or biological
destruction of the pharmaceutical preparations.

4. CLASSIFICATION
Phenols and related compounds: Liquified phenol,
Cresol, Chlorocresol, Chloroxylenol,
Hexachlorophene.
Alcohols and related compounds: Ethanol,
Isopropyl.
Aldehydes: Formaldehyde.
Carboxylic acid: Benzoic Acid.
 Halophors: Iodoform, Povidone-iodine.

5. Heavy Metal Compounds: Thiomersal, Silver Protein
Dyes: Proflavine, Brilliant green
Quaternary ammonium compounds (cationic
surface active agents): Benzalkonium chloride,
Cetrimide.
Miscellaneous: Nitrofurantoin, Nitrofurazone.

6. PROFLAVIN
Structure:
IUPAC Name:
3,6 –diamino acridine, sulphate dihydrate

7. 3,6-diamino acridine

8. Physical Properties:
• It occurs as an orange red crystalline hygroscopic
powder.
• It is odourless.
• It is sparingly soluble in water.
• It is insoluble in chloroform and ether.

9. Storage:
• It is affected by light and is hygroscopic. Hence it is
stored in a tightly closed light resistant containers.

10. Uses:
• It is used in the treatment of infected wounds.
• It is used for dressing of wounds and burns.
• For the treatment of local infections of external ear,
mouth, throat and skin.
• It is effective against many gram +ve and gram –ve
bacteria.
Preparation:
• Proflavine cream BP.