BRAF
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. https://www.antibody-creativebiolabs.com/symbolsearch-braf.htm
Ctnnb1 antibody for hepatocellular carcinomaEchoHan4
CTNNB1
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. https://www.antibody-creativebiolabs.com/symbolsearch-ctnnb1.htm
Antibodies for commonly mutated targets
https://www.antibody-creativebiolabs.com/symbolsearch-tp53.htm
Innovative technologies and ideas
Numerous worldwide customers
High-level Ph.D. scientists and experienced technicians
High efficiency and short turnaround time
Close collaboration
Extensive forefront knowledge sharing
Advanced and one-stop platforms
CD96 antibody for t cell co signaling researchEchoHan4
This document from Creative Biolabs promotes their antibodies for research on T cell co-signaling. It provides an overview of T cell co-signaling and lists many antibodies they offer against co-stimulatory and co-inhibitory molecules from the Ig superfamily, TNF superfamily, and other families involved in T cell activation. The antibodies listed come from mouse, human and other species and are suitable for applications like flow cytometry, immunohistochemistry and western blotting to facilitate research on T cell co-signaling pathways.
Flt3 antibody antibodies for hematologic malignanciesCreative Biolabs
Hematologic malignancies, also known as cancer of the blood or lymph system, are classified as three main types including leukemia, lymphoma and myeloma. www.antibody-creativebiolabs.com
This document discusses the results of a BLASTx search of a DNA sequence from an operon gum between 21,000-23,000 base pairs. The top hit was to the GumC protein in Xanthomonas campestris with an E-value of 1.2e-116. Other significant hits included the GumD protein in X. campestris and proteins involved in exopolysaccharide biosynthesis and transport in organisms like Rhizobium meliloti. The BLASTx results indicate homology between the query sequence and proteins involved in gum biosynthesis.
In mammals, there are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in
various tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues. Elabscience provides 700+ antibodies for stem cells research. Worth to check!
More other antibodies:
http://www.elabscience.com/index.php/product/show/tid/73
The document provides a history of organ transplantation, beginning with early experiments in 1909 and the first successful human kidney transplant in 1954. It discusses general principles of immunosuppression and categories of immunosuppressive agents including induction agents, calcineurin inhibitors like cyclosporine and tacrolimus, antiproliferative agents, and protocols for withdrawal, avoidance and conversion. Specific agents, their mechanisms, dosing, monitoring, interactions and side effects are described in detail.
Ctnnb1 antibody for hepatocellular carcinomaEchoHan4
CTNNB1
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. https://www.antibody-creativebiolabs.com/symbolsearch-ctnnb1.htm
Antibodies for commonly mutated targets
https://www.antibody-creativebiolabs.com/symbolsearch-tp53.htm
Innovative technologies and ideas
Numerous worldwide customers
High-level Ph.D. scientists and experienced technicians
High efficiency and short turnaround time
Close collaboration
Extensive forefront knowledge sharing
Advanced and one-stop platforms
CD96 antibody for t cell co signaling researchEchoHan4
This document from Creative Biolabs promotes their antibodies for research on T cell co-signaling. It provides an overview of T cell co-signaling and lists many antibodies they offer against co-stimulatory and co-inhibitory molecules from the Ig superfamily, TNF superfamily, and other families involved in T cell activation. The antibodies listed come from mouse, human and other species and are suitable for applications like flow cytometry, immunohistochemistry and western blotting to facilitate research on T cell co-signaling pathways.
Flt3 antibody antibodies for hematologic malignanciesCreative Biolabs
Hematologic malignancies, also known as cancer of the blood or lymph system, are classified as three main types including leukemia, lymphoma and myeloma. www.antibody-creativebiolabs.com
This document discusses the results of a BLASTx search of a DNA sequence from an operon gum between 21,000-23,000 base pairs. The top hit was to the GumC protein in Xanthomonas campestris with an E-value of 1.2e-116. Other significant hits included the GumD protein in X. campestris and proteins involved in exopolysaccharide biosynthesis and transport in organisms like Rhizobium meliloti. The BLASTx results indicate homology between the query sequence and proteins involved in gum biosynthesis.
In mammals, there are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in
various tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues. Elabscience provides 700+ antibodies for stem cells research. Worth to check!
More other antibodies:
http://www.elabscience.com/index.php/product/show/tid/73
The document provides a history of organ transplantation, beginning with early experiments in 1909 and the first successful human kidney transplant in 1954. It discusses general principles of immunosuppression and categories of immunosuppressive agents including induction agents, calcineurin inhibitors like cyclosporine and tacrolimus, antiproliferative agents, and protocols for withdrawal, avoidance and conversion. Specific agents, their mechanisms, dosing, monitoring, interactions and side effects are described in detail.
This document discusses cancer at multiple levels. It begins by explaining that cancer starts when cells divide uncontrollably and spread into surrounding tissues. There are over 100 types of cancer named for the organs or tissues where they form. Later sections provide more details on genetic and molecular factors that drive cancer, including changes to proto-oncogenes, tumor suppressor genes, and DNA repair genes. The document also describes tumor markers and their role in cancer detection, diagnosis and prognosis. It concludes by listing ELISA kits from Elabscience focused on targets relevant to cancer research.
Elabscience Biotechnology Inc. specializes in immunodiagnostic technology for life science research. They have a complete R&D and manufacturing platform to produce proteins, antibodies, ELISA kits, and other reagents. Their products are used in applications like ELISA, western blot, immunohistochemistry, and they also offer custom services like protein expression and purification. The document then provides tables listing many of their angiogenesis-related products including various matrix metalloproteinases, integrins, laminins and their targets.
Cancer Research Antibodies - ElabscienceElabscience
Cancer is a group of diseases involving abnormal cell growth with thepotential to invade or spread to other parts of the body. Not all tumorsare cancerous; benign tumors do not spread to other parts of the body.Possible signs and symptoms include a lump, abnormal bleeding,prolonged cough, unexplained weight loss and a change in bowelmovements. While these symptoms may indicate cancer, they mayhave other causes.Over 100 cancers affect humans. Elabsciece has 690+ antibodies for cancer research. Click to check!
More primary antibody please visit:
http://www.elabscience.com/index.php/product/show/tid/90
This document discusses several cases that presented with retinal pathologies that served as initial signs of underlying systemic diseases:
1) A woman with blurred vision was diagnosed with systemic lupus erythematosus based on anemia and autoantibodies.
2) A man with reading difficulty had Waldenstrom's macroglobulinemia indicated by increased serum viscosity and IgM levels.
3) A young woman with vision loss had acute myeloid leukemia shown by abnormal blood counts and blasts.
4) Retinal pathologies can indicate serious underlying conditions like cancer, requiring thorough workup.
Osteoporosis is a disease where decreased bone strength increases the risk of a broken bone. It is the most common reason for a broken bone among the elderly. Bones that commonly break include the back bones, the bones of the forearm, and the hip. More info visit: http://www.elabscience.com
34 elisa kits for breast cancer researchElabscience
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, or a red scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin.More info visit: http://www.elabscience.com
32 elisa kits for cervical cancer researchElabscience
Cervical cancer is a cancer arising from the cervix. It is due to the abnormal growth of cells that have the ability to invade or spread to other parts of the body. Early on, typically no symptoms are seen. Later symptoms may include abnormal vaginal bleeding, pelvic pain, or pain during sexual intercourse. While bleeding after sex may not be serious, it may also indicate the presence of cervical cancer.More info visit: http://www.elabscience.com
Lung cancer, characterized by uncontrolled cell growth in lung tissues, has been the most common cancer in the world for several decades. It's classified as small-cell lung carcinoma (SCLC) and non-smallcell lung carcinoma (NSCLC).https://www.antibody-creativebiolabs.com/anti-tp53-antibody-cf448-633983.htm
Antibody arrays are valuable for the parallel analysis of multiple proteins in small sample volumes. The earliest and most widely used application of antibody arrays has been to measure multiple protein abundances, using sandwich assays and label-based assays, for biomarker discovery and biological studies. Modifications to these assays have led to studies profiling specific protein post-translational modifications, such as protein phosphorylation that is a mechanism of regulation that is extremely important in most cellular processes.
https://www.antibody-creativebiolabs.com/category-introduction/antibody-array-analysis-132.htm
Lung cancer, characterized by uncontrolled cell
growth in lung tissues, has been the most common
cancer in the world for several decades. It's classified
as small-cell lung carcinoma (SCLC) and non-smallcell
lung carcinoma (NSCLC). www.antibody-creativebiolabs.com
Hepatocellular carcinoma (HCC), with a prevalence of around 600,000 people worldwide, is the sixth most common cancer globally. www.antibody-creativebiolabs.com
T cell activation requires two signals. One is recognition of the antigenic peptide/major histocompatibility complex (MHC) by the T cell receptor (TCR); another is antigen independent co-stimulation induced by interactions between co-signaling molecules expressed on antigen-presenting cells (APCs) and their T cell-expressed receptors. www.antibody-creativebiolabs.com
This document provides information on antibodies for breast cancer research from Creative Biolabs. It discusses the types and prevalence of breast cancer and key markers. It then provides a table listing antibodies for commonly mutated targets in breast cancer research, including targets, clone, applications and species reactivity. The document also discusses popular antibodies for other key markers and signaling factors involved in breast cancer.
Breast cancer is the principle cause of cancer-related mortality
among women worldwide. It's highly heterogeneous and can be
classified into 3 types - TNBC, HER2+ and Luminal (non-HER2+). www.antibody-creativebiolabs.com
Secondary antibodies bind to the primary antibody to assist in detection, classification and isolation of interest antigen. To ensure detection, the secondary antibody must be specific for the isotype and antibody species of the primary antibody in the application. Secondary antibodies are typically polyclonal.
Secondary antibody conjugates are important tools in biochemical and cell-based analysis. Enzyme-labeled secondary antibodies have high catalytic turnover rates and are routinely used in various assays for their robust and rapid signal generation. Secondary antibodies conjugated to fluorescent dyes offer brighter signals and multiplexing capabilities in cell analysis and protein analysis applications including immunofluorescence microscopy and cell imaging. For both enzyme-labeled and dye-labeled secondary antibodies, high sensitivity and signal amplification are two desirable qualities when detecting target antigens of low abundance.
The human brain remains a great mystery in science and current research strives to understand molecular and cellular processes of the nervous system.https://www.antibody-creativebiolabs.com/search.aspx?key=neuroscience&ty=tag
Antibody arrays have emerged as an important tool, which enable multiplexed protein expression profiling such as cytokines, chemokines and growth factors, which may be involved in diseases. To design high-performing antibody arrays, it is necessary to develop an integrated technology platform, where the interplay between the surfaces and the antibody is anticipated to play an important role.
https://www.antibody-creativebiolabs.com/category/glass-slide-antibody-arrays-126.htm
Anti gfap antibodies for neuroscience research creative biolabsCreative Biolabs
The human brain remains a great mystery in science and current research
strives to understand molecular and cellular processes of the nervous
system. The prevention and effective treatment of neurological disorders
like Alzheimer's and Parkinson's diseases has been a major medical
challenge. Creative Biolabs offers a broad range of antibodies to help you
win the race in your discovery of the nervous system. www.antibody-creativebiolabs.com
The document discusses immunotherapy and immunological checkpoint treatment. It provides background on how immunotherapy works to activate the immune system against tumors. Immunological checkpoint treatment in particular has shown promise, with FDA approval of antibodies against CTLA-4 and PD-1. Ongoing research is exploring additional immunosuppressive targets like LAG-3, TIM-3, and TIGIT. The document also lists antibodies available from Creative Biolabs that target checkpoints like CTLA-4, PD-1, and IL-17A for research purposes.
Creative Biolabs offers a comprehensive range of quality recombinant antibodies for cell & organelle imaging. These antibodies are covering significant research areas such as cancer research, cell signaling, cell morphology and organelle detection.
Live cell imaging is the study of living cells using time-lapse microscopy. Scientists use it to better understand and validate the biological function through the study of cellular dynamics. Organelles are specialized and well-defined parts of the cell which are usually separately enclosed within their own lipid bilayers. Very often organelles have to be stained to follow cellular processes and the effects of changing parameters on these processes. Thus, there is a great significance and strong need for tools to stain and follow specific organelles in living cells.
https://www.antibody-creativebiolabs.com/category-introduction/cell-organelle-imaging-3.htm
This document discusses cancer at multiple levels. It begins by explaining that cancer starts when cells divide uncontrollably and spread into surrounding tissues. There are over 100 types of cancer named for the organs or tissues where they form. Later sections provide more details on genetic and molecular factors that drive cancer, including changes to proto-oncogenes, tumor suppressor genes, and DNA repair genes. The document also describes tumor markers and their role in cancer detection, diagnosis and prognosis. It concludes by listing ELISA kits from Elabscience focused on targets relevant to cancer research.
Elabscience Biotechnology Inc. specializes in immunodiagnostic technology for life science research. They have a complete R&D and manufacturing platform to produce proteins, antibodies, ELISA kits, and other reagents. Their products are used in applications like ELISA, western blot, immunohistochemistry, and they also offer custom services like protein expression and purification. The document then provides tables listing many of their angiogenesis-related products including various matrix metalloproteinases, integrins, laminins and their targets.
Cancer Research Antibodies - ElabscienceElabscience
Cancer is a group of diseases involving abnormal cell growth with thepotential to invade or spread to other parts of the body. Not all tumorsare cancerous; benign tumors do not spread to other parts of the body.Possible signs and symptoms include a lump, abnormal bleeding,prolonged cough, unexplained weight loss and a change in bowelmovements. While these symptoms may indicate cancer, they mayhave other causes.Over 100 cancers affect humans. Elabsciece has 690+ antibodies for cancer research. Click to check!
More primary antibody please visit:
http://www.elabscience.com/index.php/product/show/tid/90
This document discusses several cases that presented with retinal pathologies that served as initial signs of underlying systemic diseases:
1) A woman with blurred vision was diagnosed with systemic lupus erythematosus based on anemia and autoantibodies.
2) A man with reading difficulty had Waldenstrom's macroglobulinemia indicated by increased serum viscosity and IgM levels.
3) A young woman with vision loss had acute myeloid leukemia shown by abnormal blood counts and blasts.
4) Retinal pathologies can indicate serious underlying conditions like cancer, requiring thorough workup.
Osteoporosis is a disease where decreased bone strength increases the risk of a broken bone. It is the most common reason for a broken bone among the elderly. Bones that commonly break include the back bones, the bones of the forearm, and the hip. More info visit: http://www.elabscience.com
34 elisa kits for breast cancer researchElabscience
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, or a red scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin.More info visit: http://www.elabscience.com
32 elisa kits for cervical cancer researchElabscience
Cervical cancer is a cancer arising from the cervix. It is due to the abnormal growth of cells that have the ability to invade or spread to other parts of the body. Early on, typically no symptoms are seen. Later symptoms may include abnormal vaginal bleeding, pelvic pain, or pain during sexual intercourse. While bleeding after sex may not be serious, it may also indicate the presence of cervical cancer.More info visit: http://www.elabscience.com
Lung cancer, characterized by uncontrolled cell growth in lung tissues, has been the most common cancer in the world for several decades. It's classified as small-cell lung carcinoma (SCLC) and non-smallcell lung carcinoma (NSCLC).https://www.antibody-creativebiolabs.com/anti-tp53-antibody-cf448-633983.htm
Antibody arrays are valuable for the parallel analysis of multiple proteins in small sample volumes. The earliest and most widely used application of antibody arrays has been to measure multiple protein abundances, using sandwich assays and label-based assays, for biomarker discovery and biological studies. Modifications to these assays have led to studies profiling specific protein post-translational modifications, such as protein phosphorylation that is a mechanism of regulation that is extremely important in most cellular processes.
https://www.antibody-creativebiolabs.com/category-introduction/antibody-array-analysis-132.htm
Lung cancer, characterized by uncontrolled cell
growth in lung tissues, has been the most common
cancer in the world for several decades. It's classified
as small-cell lung carcinoma (SCLC) and non-smallcell
lung carcinoma (NSCLC). www.antibody-creativebiolabs.com
Hepatocellular carcinoma (HCC), with a prevalence of around 600,000 people worldwide, is the sixth most common cancer globally. www.antibody-creativebiolabs.com
T cell activation requires two signals. One is recognition of the antigenic peptide/major histocompatibility complex (MHC) by the T cell receptor (TCR); another is antigen independent co-stimulation induced by interactions between co-signaling molecules expressed on antigen-presenting cells (APCs) and their T cell-expressed receptors. www.antibody-creativebiolabs.com
This document provides information on antibodies for breast cancer research from Creative Biolabs. It discusses the types and prevalence of breast cancer and key markers. It then provides a table listing antibodies for commonly mutated targets in breast cancer research, including targets, clone, applications and species reactivity. The document also discusses popular antibodies for other key markers and signaling factors involved in breast cancer.
Breast cancer is the principle cause of cancer-related mortality
among women worldwide. It's highly heterogeneous and can be
classified into 3 types - TNBC, HER2+ and Luminal (non-HER2+). www.antibody-creativebiolabs.com
Secondary antibodies bind to the primary antibody to assist in detection, classification and isolation of interest antigen. To ensure detection, the secondary antibody must be specific for the isotype and antibody species of the primary antibody in the application. Secondary antibodies are typically polyclonal.
Secondary antibody conjugates are important tools in biochemical and cell-based analysis. Enzyme-labeled secondary antibodies have high catalytic turnover rates and are routinely used in various assays for their robust and rapid signal generation. Secondary antibodies conjugated to fluorescent dyes offer brighter signals and multiplexing capabilities in cell analysis and protein analysis applications including immunofluorescence microscopy and cell imaging. For both enzyme-labeled and dye-labeled secondary antibodies, high sensitivity and signal amplification are two desirable qualities when detecting target antigens of low abundance.
The human brain remains a great mystery in science and current research strives to understand molecular and cellular processes of the nervous system.https://www.antibody-creativebiolabs.com/search.aspx?key=neuroscience&ty=tag
Antibody arrays have emerged as an important tool, which enable multiplexed protein expression profiling such as cytokines, chemokines and growth factors, which may be involved in diseases. To design high-performing antibody arrays, it is necessary to develop an integrated technology platform, where the interplay between the surfaces and the antibody is anticipated to play an important role.
https://www.antibody-creativebiolabs.com/category/glass-slide-antibody-arrays-126.htm
Anti gfap antibodies for neuroscience research creative biolabsCreative Biolabs
The human brain remains a great mystery in science and current research
strives to understand molecular and cellular processes of the nervous
system. The prevention and effective treatment of neurological disorders
like Alzheimer's and Parkinson's diseases has been a major medical
challenge. Creative Biolabs offers a broad range of antibodies to help you
win the race in your discovery of the nervous system. www.antibody-creativebiolabs.com
The document discusses immunotherapy and immunological checkpoint treatment. It provides background on how immunotherapy works to activate the immune system against tumors. Immunological checkpoint treatment in particular has shown promise, with FDA approval of antibodies against CTLA-4 and PD-1. Ongoing research is exploring additional immunosuppressive targets like LAG-3, TIM-3, and TIGIT. The document also lists antibodies available from Creative Biolabs that target checkpoints like CTLA-4, PD-1, and IL-17A for research purposes.
Creative Biolabs offers a comprehensive range of quality recombinant antibodies for cell & organelle imaging. These antibodies are covering significant research areas such as cancer research, cell signaling, cell morphology and organelle detection.
Live cell imaging is the study of living cells using time-lapse microscopy. Scientists use it to better understand and validate the biological function through the study of cellular dynamics. Organelles are specialized and well-defined parts of the cell which are usually separately enclosed within their own lipid bilayers. Very often organelles have to be stained to follow cellular processes and the effects of changing parameters on these processes. Thus, there is a great significance and strong need for tools to stain and follow specific organelles in living cells.
https://www.antibody-creativebiolabs.com/category-introduction/cell-organelle-imaging-3.htm
Neuroscience is the scientific study of the nervous system. The scope of neuroscience has broadened to include different approaches used to study the molecular, cellular, developmental, structural, functional, evolutionary, computational, and medical aspects of the nervous system. Elabscience offers 380+ antibodies for your neuroscience research.
Click for more antibodies:
http://www.elabscience.com/index.php/product/show/tid/90
Traditional polyclonal antibody preparations are derived from antisera or immunoglobulin preparations from immunized animals. Monoclonal antibodies are produced from immortalized B cells that secrete antibodies against a single epitope. Antibody screening uses phage display technology to identify antibodies that bind to a unique cell surface antigen. Vaccines work by stimulating either active or passive immunity. Active immunity is stimulated through attenuated live vaccines, killed vaccines, or purified vaccine components that trigger an immune response through antigen presentation without causing disease.
Neutralizing antibodies for infectious diseases.pdfthomasm2014
Creative Diagnostics offers a wide selection of neutralizing antibodies that can be used for applications like ELISA assays, neutralization experiments, and more. They provide monoclonal antibodies for pathogens like adenovirus, alphaviruses, astrovirus, and others. Their proprietary cloning platform allows them to produce recombinant versions of these antibodies, which are valuable for vaccine development and diagnostic research.
Robert Soler and Lluis Orozco. Regenerative Tissue Therapy Institute at the T...MuscleTech Network
This document discusses research on stem cell therapy. It references animal models using cartilage from sheep and horses, as well as tendons from horses. Clinical trials are mentioned for using stem cells to treat pseudoarthrosis, bone injuries, osteonecrosis, and cartilage defects of varying severity. Regulations and guidelines from the EMA, PEI, and Spanish laws are covered. Applications discussed include muscle repair timing, stem cell differentiation potential, and clinical trials for rotator cuff injuries and epicondylitis using doses of MSCs ranging from 1-40 million. The conclusion emphasizes that stem cell therapy with MSCs is a viable, safe option showing efficacy indications but currently only available under clinical trials or compassionate use.
Similar to BRAF antibody for melanoma research (19)
Antibody-drug conjugates employ the specific monoclonal antibodies (mAbs) to achieve targeted delivery of the conjugated cytotoxic molecules to tumor cells.
https://www.creative-biolabs.com/adc/conjugate-sites-analysis.htm
As one major component of an antibody-drug conjugate (ADC), the antibody is the key for target specificity and serves as the cargo to deliver the cytotoxic drug (payload).
https://www.creative-biolabs.com/adc/antibody-design-and-conjugation.htm
To retain antibody bioactivity, mild, near-physiological conditions are often used for conjugation reactions. Under these conditions, endogenous amino acids such as Lys and Cys are chemically reactive and can be used as conjugation sites.https://www.creative-biolabs.com/adc/antibody-design-and-conjugation.htm
As one major component of an antibody-drug conjugate (ADC), the antibody is the key for target specificity and serves as the cargo to deliver the cytotoxic drug (payload). A payload drug can be attached to different sites on an antibody using diverse conjugation chemistry. Multiple endogenous amino acids can serve as potential conjugation sites. However, to achieve more precisely controlled site-directed conjugations and subsequently a narrower distribution of drug-to-antibody ratio (DAR), special moieties with unique conjugation chemistries are engineered into antibody sequences in our antibody design services.
https://www.creative-biolabs.com/adc/antibody-design-and-conjugation.htm
CD40, also known as TNFRSF5, is a type I transmembrane protein. The molecular weight of CD40 is 48-kDa and it consists of a 193 amino acid (aa) extracellular domain, 21 aa leader sequence, 22 aa transmembrane domain, and a 62 aa intracellular domain in human (90 aa in mouse).https://www.creative-biolabs.com/adc/target-cd40-122.htm
CD30 (also known as TNFRSF8) was first identified as an antigen expressed on Hodgkin and Reed-Sternberg cells of Hodgkin's disease in 1992.https://www.creative-biolabs.com/adc/adc-development-services-targeting-cd30.htm
ADC preparation involves the chemical conjugation of the three components and depending on the conjugation strategy used, this process often yields complex and heterogeneous products.https://www.creative-biolabs.com/adc/adc-biochemical-analysis.htm
While conventional cancer therapies (surgery, chemo therapy, and radiation therapy) have shown some success in the battle again cancer, they are often accompanied by complex and sometimes, severe side-effects due to the lack of target specificity. To circumvent this flaw and improve the efficacy and safety of cancer treatment, targeted cancer therapies, especially antibody-drug conjugates (ADCs), have been actively exploited and they are gaining a significant amount of attention during the recent years.https://www.creative-biolabs.com/adc/adc-antibody-screening.htm
The elegant design of an antibody-drug conjugate is designated to achieve targeted delivery of the conjugated cytotoxic agents to tumor cells and drug release upon antigen binding and internalization, thus maximizing the antitumor effects while minimizing cytotoxicity to normal tissues. The efficacy of an ADC greatly depends on the specific antigen binding activities of the monoclonal antibody (mAb) portion of the molecule.https://www.creative-biolabs.com/adc/adc-affinity-measurement.htm
Antibody-drug conjugates (ADCs) are a unique class of novel anti-tumor agents produced by the conjugation of highly cytotoxic drug payloads with tumor specific monoclonal antibodies via elaborate chemical linkers.https://www.creative-biolabs.com/adc/adc-fc-cytotoxicity.htm
Development of 5T4-based Bispecific ADCs
A bispecific antibody can bind two different targets or two distinct epitopes on the same target. 5T4, specifically overexpressed on the cell surface of various tumors and internalized rapidly when bound to antibody, may be used as an attractive target to develop effective immunotherapy such as bispecific antibody-drug conjugate (ADC).
https://www.creative-biolabs.com/adc/development-of-5t4-based-bispecific-adcs.htm
Cancer immunotherapy is a therapy used to treat cancer patients that involves components of the immune system, commonly consisting of antibodies, vaccines, T cell infusions, and so like. https://www.creative-biolabs.com/immuno-oncology/modality.htm
✔ Registration with CTSC
✔ Preparing IND package including Cover letter, IND, 1571, 1572 form and certification form 3674.
✔ Assembling and binding volumes
✔ Submission
https://www.creative-biolabs.com/immuno-oncology/ind-publishing-and-submission.htm
For the drug development, pre-IND meeting is a critical tool to discuss the needs and challenges specific to the general product development, nonclinical testing, manufacturing information, protocol design or other regulatory questions defined in the Code of Federal Regulations (21 CFR 312.82). https://www.creative-biolabs.com/immuno-oncology/pre-ind-meeting.htm
✔ Clinical overviews (eCTD Module 2.5) including literature review and references
✔ Clinical summaries (eCTD Module 2.7) including clinical pharmacology, efficacy, and safety
✔ Clinical study report preparation and review (eCTD Module 5)
✔ Clinical justification documents for EU, US and other emerging Regulatory markets
✔ Gap analysis for dossiers in clinical module
✔ Clinical and nonclinical document support, handling queries during HA meetings and responding to them
✔ Technical review dossiers
✔ Biowaiver support and justification document services
https://www.creative-biolabs.com/immuno-oncology/medical-writing-and-translation.htm
To gain approval for clinical testing after finalizing the pre-clinical testing of innovative new therapies, it is a key milestone for pharmaceutical companies to apply for approval of Investigational New Drug (IND) with FDA or other agencies.https://www.creative-biolabs.com/immuno-oncology/regulatory-strategy-consulting.htm
Navigating the drug development process from early stage discovery to clinical stage is complex and expensive. https://www.creative-biolabs.com/immuno-oncology/ind-regulatory-services.htm
In the United States, the Current Good Manufacturing Practice (cGMP) is the Food and Drug Administration (FDA) 's formal regulations on the design, monitoring, control and maintenance of manufacturing processes and facilities.https://www.creative-biolabs.com/immuno-oncology/cgmp-manufacturing.htm
Pre-clinical toxicology is a study of the toxic effects of drugs in development based on statistical and quantitative analysis. https://www.creative-biolabs.com/immuno-oncology/antibody-and-protein-toxicology.htm
Pharmacology is a key component concerned with the study of drug action in animal models which is essential and determinant to IND approval and ultimate NDA approval for a drug candidate. https://www.creative-biolabs.com/immuno-oncology/antibody-and-protein-pharmacology.htm
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
How to Control Your Asthma Tips by gokuldas hospital.
BRAF antibody for melanoma research
1. Antibodies for Melanoma
Research
Antibodies: detection, imaging, diagnostic, etc.
Increase Your Efficiency and Value with
Consistent Performance
info@creative-biolabs.com
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2. Antibodies
for Melanoma Research
Creative Biolabs is the leading antibody service
provider with extensive experience in a variety of
antibody production and engineering field for
both basic science research and pharmaceutic
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01
3. Types Cutaneous Acral Mucosal Ocular/Uveal
Chronic sun
damage
Non-chronic sun damage
Incident 91.2% 2.3% 1.3% 5.2%
Mutated genes KIT, BRAF, NRAS BRAF, NRAS
KIT, BRAF,
NRAS
KIT, NRAS GNAQ, GNA11
Mutated targets
• BRAF
• NRAS
• TP53
• PTEN
• p16INK4a
• p14ARF
• PPP6C
• RAC1
Amplified/deleted targets
• CDKN2A
• PTEN
• TERT
• CCND1
• KIT
• MITF
• CDK4
• MAP2K1
• SNX31
• TACC1
• STK19
• ARID2
• CTNNB1
• PIK3CA
• EZH2
• IDH1
• FBXW7
• KIT
• HRAS
• GNA11
• WT1
A Quick Glance at Key Targets in Melanoma
Kind reminder: If you are interested in any other targets, please visit our website or contact us.
• p75NGFR
• CD133
• CSPG
• ALDH1
• CD20
• JARID1A
• ABCB5
Markers
Signaling pathway targets
• PI3K
• PTEN
• RAC
• AKT
• NF-kB
• mTOR
• MDM2
• p53
• CDKs
• ERK
• MEK
• BRARAS
• MC1R
• IGF1-R
• EGFR
• PDGFRβ
• FGFR
• HGFR
Melanoma
Melanoma, the deadliest skin cancers, is caused by
the transformation of melanocytes which
accumulate genetic alterations, leading to abnormal
proliferation and dissemination.
Incidence, types, and associated mutant genes
Melanoma
02 info@creative-biolabs.com www.antibody-creativebiolabs.com
Antibodies
for Melanoma Research
4. Popular Creative Biolabs’ antibodies for melanoma key factors
Creative Biolabs’ antibodies help meet your melanoma cancer research needs and budget requirements, increasing
efficiency and offering the best value for a wide range of applications and specific assays.
Targets Clone Applications Species reactivity Cat.No.
BRAF
CBYY-2108 IHC, IPS, WB Human, Monkey CBMAB-2457-YY
CBYY-2024 IC, IHC, IPS, WB Human, Dog, Monkey, Rat CBMAB-2373-YY
EP152Y WB, IPS, FC, IP Mouse, Rat, Human CBMAB-1219-CN
NRAS
RBT-NRAS IFS, IPS Human CBMAB-N0518-WJ
2G9 WB, FC, E, IF Human CBMAB-N0517-WJ
CBWJN-0812 WB, FC, IP Mouse, Rat, Human CBMAB-N3523-WJ
TP53
1285C WB, IHC, IF, IPS, FC Human, Mouse CBMAB-1838CQ
CBWJW-083 WB, IPS, PE Human, Mouse, Rat CBMAB-T0002-WJ
1F7 IP, M, WB Human CBMAB-0266-LY
PTEN
10BA32 IF, WB Human CBMAB-1515CQ
10BA33 IF, WB Human CBMAB-1516CQ
10BA34 WB Human CBMAB-1517CQ
p16INK4a
1E12E10 WB, P Human, Mouse, Rat CBMAB-C3919-LY
5-C3 WB, IP, C, IC/IF Mouse CBMAB-C7384-LY
3F3 E, WB Human CBMAB-C6031-LY
RAC1
4A4B11 E, IF, IH, IP, WB Human, Mouse, Rat CBMAB-R0993-CN
2180C3a DB, IC Human CBMAB-C0644-LY
0.T.127
WB, IP, E, P, C, F, P,
IF
Mouse, Rat, Rabbit, Human CBMAB-R0988-CN
MAP2K1
CBFYM-1440 F, IC, IF, P, WB
Human, Mouse, Non-human
primate, Rat
CBMAB-M1600-FY
25/MEK1 F Human, Chicken, Dog, Mouse, Rat CBMAB-M0108-FY
CBFYM-0552 IC, IF, IH, IP, WB Human CBMAB-M0681-FY
ARID2
CBYC-A766 DB, IC, WB Human, Mouse, Rat CBMAB-A3547-YC
1A1 IP, M Human CBMAB-0127-YC
13HCLC F, IC, IF, WB Human, Mouse CBMAB-0051-WJ
CTNNB1
8E4 E, IC/IF, WB, P Human, Mouse, Rat CBMAB-C9162-LY
7A7 IA, IF, P, WB Human, Mouse, Rat CBMAB-C8567-LY
6B3 WB, IP, P, C
Human, Mouse, Rat, Monkey,
Xenopus, Cattle, Dog, Pig
CBMAB-C8091-LY
EZH2
6G4F4 WB, F, E, IH, IC, MC Human CBMAB-E0234-FY
1B3 CI, IP, M Human CBMAB-0366-YC
CBFYE-1433 IF, IH, IP, WB Human, Monkey, Mouse, Rat CBMAB-E2059-FY
IDH1
1D1 P, WB Human CBMAB-I0237-YY
IDH1/1152 C, WB, F, P, IF, MC Human CBMAB-I0238-YY
CBYY-I0585 WB, IH, E Human, Dog, Rat, Monkey, Mouse CBMAB-I1288-YY
FBXW7
SP237 P, F Human, Mouse, Rat CBMAB-F0223-CQ
3D1 WB, E, P, SE Human CBMAB-F0835-CQ
FBOX 3a9/1 WB, F, IH, IF, IP, MC Human, Mouse CBMAB-F0065-CQ
Antibodies for mutated targets in Melanoma
03
Antibodies
for Melanoma Research
info@creative-biolabs.com
To be continued.
www.antibody-creativebiolabs.com
5. Targets Clone Applications Species reactivity Cat.No.
KIT
5C8D4 WB, E, IH, P Human CBMAB-C7434-LY
3A8 E, WB Human CBMAB-K0974-LY
104D2 F Cattle, Human, Monkey CBMAB-K0116-LY
HRAS
1C8 WB Human, Monkey CBMAB-G6073-LY
1A1 WB Mouse, Rat, Dog, Human, Monkey CBMAB-G6072-LY
CBFYH-1956 IF, C, P, IP, N, WB Human CBMAB-H2967-FY
GNA11 CBLG1-3194 WB Mouse, Rat, Human CBMAB-G4050-LY
WT1
6F-H2 WB, P, C, IP Human, Mouse, Rat CBMAB-W0142-WJ
WT1/857 F, IF, IH Human, Mouse, Rat CBMAB-W0384-WJ
RMWT1-1 IF, P Human CBMAB-W0376-WJ
Antibodies for mutated targets in Melanoma
Targets Clone Applications Species reactivity Cat.No.
CDKN2A
1E12E10 WB, P Human, Mouse, Rat CBMAB-C3919-LY
5-C3 WB, IP, C, IC/IF Mouse CBMAB-C7384-LY
3F3 E, WB Human CBMAB-C6031-LY
PTEN
10BA32 IF, WB Human CBMAB-1515CQ
10BA33 IF, WB Human CBMAB-1516CQ
10BA34 WB Human CBMAB-1517CQ
TERT CBFYE-1667 WB, IC, P, C, E Human CBMAB-E2336-FY
CCND1
1F7 WB Human CBMAB-C4075-LY
2G3G5 E, C, WB Human, Mouse, Rat, Zebrafish CBMAB-C5177-LY
17H3L3 F, IC, IF, WB Human CBMAB-C3434-LY
KIT
5C8D4 WB, E, IH, P Human CBMAB-C7434-LY
3A8 E, WB Human CBMAB-K0974-LY
104D2 F Cattle, Human, Monkey CBMAB-K0116-LY
MITF
1D9 IP, WB, M Human CBMAB-0676-YC
CBFYM-0644 E, IH, WB Human CBMAB-M0780-FY
CBFYM-2242 WB Dog, Horse, Human, Mouse, Rat CBMAB-M2426-FY
CDK4
4F11 E, IF, WB Human CBMAB-C6910-LY
2G7 E, IF, WB Human CBMAB-C5208-LY
0.N.199 IF, IP, WB Human, Mouse, Pig, Rat CBMAB-C1404-LY
Antibodies for amplified/deleted targets in Melanoma
To be continued.
04
Antibodies
for Melanoma Research
info@creative-biolabs.com www.antibody-creativebiolabs.com
6. To be continued.
Targets Clone Applications Species reactivity Cat.No.
CD20
4A4 P, WB Human CBMAB-C6595-LY
B9E9 E, F, C, IP Human CBMAB-M0301-FY
2H7 D, CI, IP Human, Monkey CBMAB-0947-LY
ABCB5
13B6 E, F, IC, IH, WB Human CBMAB-A0214-YC
5H3C6 E, F, IC, IF, IH, P, WB Human CBMAB-A0215-YC
CBYC-A135 WB, IC, P, C, E Human CBMAB-A0216-YC
Antibodies for markers of Melanoma
05
Targets Clone Applications Species reactivity Cat.No.
CD133
13A4 F, C, IP, WB Dog, Mouse CBMAB-C0309-LY
13B112 E, F, IH Human CBMAB-C2770-LY
170411 F, MC Human CBMAB-C0422-LY
CSPG
9.9.27 F, IF, IP Human CBMAB-C9303-LY
132.38 WB, IP, E, C, P, IC Mouse, Rat CBMAB-N0688-WJ
7G4E5 WB, E, F Human CBMAB-1458-CN
ALDH1
5A11 E, IH, P, WB Human CBMAB-A2246-YC
1G6 E, P, IP, WB Human CBMAB-A2245-YC
1A10A2 E, IF, IH, WB Human, Mouse, Pig, Rat CBMAB-A2243-YC
Antibodies for markers of Melanoma
Antibodies
for Melanoma Research
info@creative-biolabs.com www.antibody-creativebiolabs.com
7. Targets Clone Applications Species reactivity Cat.No.
PTEN
10BA32 IF, WB Human CBMAB-1515CQ
10BA33 IF, WB Human CBMAB-1516CQ
10BA34 WB Human CBMAB-1517CQ
RAC1
4A4B11 E, IF, IH, IP, WB Human, Mouse, Rat CBMAB-R0993-CN
2180C3a DB, IC Human CBMAB-C0644-LY
0.T.127 WB, IP, E, P, C, F, P, IF Mouse, Rat, Rabbit, Human CBMAB-R0988-CN
AKT1
9Q7 P, WB Human, Mouse, Rat CBMAB-A2060-YC
18F10.E5 E, WB, IH Human, Mouse, Rat, Chimpanzee CBMAB-A2022-YC
3B4 IF, F, IH, WB Human, Dog, Rat, Monkey, Mouse CBMAB-A2043-YC
mTOR
12F10-5F11 IF, IH, IP Common fruit fly CBMAB-0019-CN
CBFYM-1208 WB, IP, P, IC Mouse, Human CBMAB-M1365-FY
CBYJL-1176 WB, IP, P, IF Human, Mouse, Rat, Monkey CBMAB-L0675-YJ
MDM2
CBFYM-0419 WB, IP, E, P, C, F Mouse, Rat, Human CBMAB-M0532-FY
CBFYM-0613 IF, IH, IP, WB Human CBMAB-M0746-FY
CBFYM-1962 C, P, IP, WB Human, Mouse CBMAB-M2137-FY
p53
CBWJW-083 WB, P, PE Human, Mouse, Rat CBMAB-T0002-WJ
CBLG1-2390 IF, SE, E, WB Human CBMAB-G6398-LY
25F4 IF, IH, IP, WB Common fruit fly CBMAB-0432-LY
CDK1
26E11 WB, E, IP, P Human, Mouse, Rat CBMAB-C4505-LY
3G92 E, IH, IP, WB Chicken, Human, Rd CBMAB-C6197-LY
1A6 E, F, IC, IF, C, WB Human CBMAB-C3564-LY
ERK1
1D1 E, IP, WB Human CBMAB-0633-YC
4C11 E, IC, IF, IH, C, P, WB Human, Mouse, Monkey CBMAB-1201-YC
5AD13MA IC, IF, P, WB Human, Mouse, Rat CBMAB-E0215-FY
MEK1
25/MEK1 F Human, Chicken, Dog, Mouse, Rat CBMAB-M0108-FY
CBFYM-1441 WB, P, IF, IP Human, Mouse, Rat, Zebrafish CBMAB-M1601-FY
CBFYM-1437 WB, IP, IF, E Mouse, Rat, Human CBMAB-M1597-FY
MC1R
CBFYM-1849 WB Human, Mouse, Rat CBMAB-M2017-FY
CBFYM-1848 E, WB Human CBMAB-M2016-FY
CBFYM-1847 IH, WB Human CBMAB-M2015-FY
EGFR
111.6 F, IC, IF, P, IP, WB Human, Mouse CBMAB-E0954-FY
Matuzumab F Human CBMAB-E0089-FY
GFR450 F, IP, N, MC Human CBMAB-E0086-FY
PDGFRβ
42G12 P, WB Human, Mouse, Rat CBMAB-C6479-LY
21/72 IC/IF, IP, WB, P Human, Monkey CBMAB-C4362-LY
28D4 F Human CBMAB-C0790-LY
Antibodies for signaling pathway related targets in Melanoma
To be continued.
06
Antibodies
for Melanoma Research
info@creative-biolabs.com www.antibody-creativebiolabs.com
8. Antibodies for signaling pathway related targets in Melanoma
Targets Clone Applications Species reactivity Cat.No.
FGFR
BA0345 IF, WB Human CBMAB-0295CQ
CBXF-0601 WB, IP, P, IF, F Human, Mouse, Rat, Monkey CBMAB-F1391-CQ
CBXF-1878 E, ED Mouse CBMAB-F3412-CQ
HGFR
3D4 E, IH, IP, WB Human CBMAB-C1095-LY
1G7NB IH, IF, P, F Human CBMAB-H0399-FY
4AT259 WB, IF Human, Mouse CBMAB-H3681-FY
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