10. आम वात
जलरुपप लघु
स्स्नग्ध रुक्ष
स्थूल सूक्ष्म
स्स्थर िल
शीत (common)
पृथ्वी + आप महाभूत ववकृ त वृद्चध व तेज महाभूत क्षय
11. Defination of आमवात
आमवात is a condition where stabdhata of the body
parts occurs due to lodging of vitiated आम and वात
in the त्रत्रकसंधध.
आम and वात both are held responsible for the
pathogenesis.
12. Types of आमवात
A ] According to माधव निदाि
1) क
े वल वातज
2) पपत्तानुबंधध
3) कफानुबंधध
13. B] According to HARITA
पवष्टम्भी - गात्र-गौरवता , आध्माि and बग्स्तशूल.
गुल्मी - जठरगजयिा ,गुल्मवत पीडा and कदटजडता.
स्नेही - गात्रग्स्िनधता,जाड्य , मंदानिी .
सवाांगी - Excreation of वपत,ववजल and पक्व आम,
श्रम and क्लम.
16. पवरुध्द आहार
यद्ककस्चित दोशमुत्क्लेचय न
हरेत्त्तत्समासतः |
पवरुद्धं शुद्धधरत्रेष्टा शमो वा तद्पवरोधधभभः
||
अ हृ सु ७ / ४५
संस्कार पवरुध्द or मात्रा पवरुध्द etc.
Eg: मत्स्य + दुनध
fruit salad , preservatives etc.
पवरुध्द आहार - गुरू , शीत ,मृत्स्ि ,and ग्स्िनध गुण of कफ
दोष
and शीतगुण of वात.
19. Samprapti of आमवात
PHASE 1( sanchaya avastha )
आहारज पवहारज
पवरुध्द आहार ददवास्वाप ्,व्यायामादद,
स्स्नग्ध आहार and र्नस्िलत्व
गुरू आहार
कफ दुस्ष्ट कफ़ , वात-प्रकोप (िलगुर् )
(गुरू ,स्स्नग्ध, मृत्स्न ,
शीत गुर् वृद्धध)
दुस्ष्ट of अस्ग्न
20. Phase 2 : Prakopa avastha
अस्ग्नमांद्य (पवशेषतः रसास्ग्न)
आम formation
(due to vitiated वात दोष it goes into प्रसर अवस्था
21. PHASE 3 -Prasara avastha
आम goes through the धमनी into whole body(साम
वायु)
More vitiation of आम by स्थार्नक दोष s
नानावर्ण & अर्त पपस्स्िलत्व to आम
22. PHASE 4 – स्थािसंश्रय
प्रक
ु पीत वात & आम along with दुष्यादद does स्थािसंश्रय in श्लेष्म
स्थाि & त्रत्रकसंचध.
PHASE 5 – व्यग्क्तअवस्था
symptoms produced like दौबयल्य,हृद-गौरव
,गात्रस्तब्धता,
संचध-शूल, संचध-शोथ ,संचध-ग्रह & स्पशायसहत्व.
23. Phase ६ - भेद अवस्था
दोष भेदेि लक्षण
वात प्राधान्य पपत्त प्राधान्य कफ प्राधान्य
तीव्रसंधध शूल स दाह् स्स्तभमत
र्नद्रानाश सराग गुरुता
पवबन्ध
पपपासाधधक्य कण्डु
उत्साह हार्न मृदुज्वर अस्ग्नमांद्य
भ्रम मूिाण बहुमूत्रता
24. पूवयरूप of आमवात
When प्रक
ु पपत आम via रसवह स्रोतस endures स्थानसंश्रय in हृदय ,संधध etc. before
getting fully menefestated as a disease आमवात, in the early stage produces
mild symptoms like अपाक,अरुधि etc which can be considered as पूवणरूप of
आमवात.
वङ्गसेन has given भशरोरुजा & गात्ररुजा as पूवणरूप of आमवात.
अस्ग्नमांद्य
अपाक
दौबणल्य
अङ्गमदण
अरुधि
गात्रस्तब्धता
गौरव.
34. Drugs and kalpas used in आमवात
Drug kalpa
एरण्डमूल भसंहनाद गुग्गुलु
अजमोदा गोधूम भल्लातक
शुण्ठी रास्ना पचिक क्वाथ
लशुन आमवातारी कषाय
रास्ना आमवातरर गुदटका
गुडुधि वैचवानर िूर्ण
देवदारु अजमोदादद िूर्ण
गुग्गुलु योगराज गुग्गुलु
पुननणवा
35. conclusion
आमवात is a condition where stabdhata of body parts occurs
due to lodging of vitiated आम & वात in त्रत्रक संधध.
आमवात is आमाशयोत्थ व्याधध so treatment given in आमवात is
1 st langhana then swedana,tikta katu dipana dravyas ,
virechan, snehapaana & basti.
Which has ultimate goal to achieve आमपािन ,वातशमन ,&
स्रोतोशोधन , स्थानबल्य धिककत्सा.
36. Rheumatoid Arthritis
Chronic
Inflamatory
Multi system
Autoimmune Dissorder of Joints
Affects Synovial & Peripheral Joints.
Symmetrical – Destructive – Deforming.
37.
38.
39. Pathophysiology
Presentation of antigen to T cells
T- and B-cells Proliferation Angiogenesis in the Synovial
lining causes more cells to arrive at the site.
Neutrophils accumulation in synovial fluid.
Synovitis
Early Pannus Formation
Subchondral Bone erosion
Pannus invasion of Cartilage Chondrocyte Proliferation.
Laxity of ligaments.
Joints instability, contractures, decrease ROM, Systemic
complications
40. Signs and symptoms of Rheumatoid
Arthritis
Joint tenderness, swelling, redness, warmth, stiffness.
Fatigue
Joint pain
Loss of ROM( Range of Motion)
Limping
Joint Deformity
Early morning Stiffness( lasting more than 30mins)
Low grade fever
41. Blood investigations in Rheumatoid
Arthritis
Blood Count - ESR and CRP are raised.
Serum autoantibodies - Anti-CCP has high Specificity
Anti-nuclear antibody(ANA) - Commonly found in the
blood of people who are having auto immune disease.
This test can be used to confirm the diagnosis of
Rheumatoid Arthritis.
Rheumatoid factor - Detects and measures the level of
an antibody, positive in people with Rheumatoid arthritis.
42. Radiology Investigations
X-rays :- X-rays of hands and feet are generally
performed in people with Rheumatoid Arthritis.
Magnetic resonance Imaging(MRI)
45. • Physical Examinations in Rheumatoid Arthritis
It is important to assess the following:
- Stiffness
- Tenderness
- Pain on movements
- Swelling
- Deformity
- Limitation of motions
- Extra-articular Manifestations
- Rheumatoid Nodules
51. How does langhan works
"अनवस्स्थ दोषार्ां पािनमग्ने दीपनं ज्वरस्य
नाशनमाहारेछिाकरं रुधिकरं लाघवकरं ि ।" सु.उ. ३९/१०३
Digestion of food takes place by जाठराग्नि, if not food then it
digest ववकृ त दोष
and if duration increased then it digest normal धातु.
52. Fasting
Willfull refrainment from eating & sometimes drinking( water fasting or juice
fasting).
Starting after digestion of last meal.
TYPES
1. Water fasting – Only water or zero calory beverage.
2. Intermittant – 1-2 days weekly
3. Alternate day
4. Calorie restriction – reduce daily calorie intake by 10-45%
5. Fasting mimicking diet – for 5 days a month drastically limit their calorie diet.
6. Prolonged fasting – > 2 days.
54. Autophagy / Auto-phagocytosis
Self digesting mechanism responsible for removal of damaged orgenelles,
malformed proteins & long lived proteins by lysosomes.
By influeincing lymphocyte development, survival And proliferation.
Autophagy regulates the immune response against self and non self antigens.
De-regulation of autophagic pathway has been implicated in several
autoimmune diseases eg: RA, cancer.
Autophagy seems to be involved in generation of cittrullinated peptides.
Autophagy reduces with age (protein involved in autophagy are reduced).
Regulators of autophagy control regulator of inflammation & vice versae.
Autophagy is avtivated in response to diverse the stress & physiological
condition Eg:- food deprevation.
55. Mechanism
Formation of double membrane vesicle
around the protein
Which encapsulates the cytoplasm &
malformed proteins.
Fuses with lysosomes
Degradation
56. Role of Autophagy in RA
(Frontiers in immunology, July 2018 | vol 9 | Article
1577)
In RA, Autophagy activation was found to be essential for the survival
of inflammatory cells Eg synoviocytes & lymphocytes
Imp role in cittrullination & osteoclastogenesis.
Repression of autophagy could expose patients to premature ageing,
infections & development of malignancy.
57. Anti-Rheumatic effect on of fasting
(Rheumatic disease clinics of north America, 01, May 1991,
17(2):351-362.)
Total fasting induces within few days shows substantial reduce in
Joint pain, swelling, morning stiffness & other rheumatic symptoms.
Remission.
Diminished activation of neutrophils & lymphocytes & Decreased
generaton of leukotrienes & other pro-inflammatory factors.