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Anti-Rheumatic Effect of Langhan In Aamvata.
Case study
 Patient name – XYZ
 Age – 60 Sex - M
 Desha – Aanup to saadharan Kaala –Visarga
 Rutu – Varsha to Sharad
 K/C/O – None
 H/0 – Liver cirrhosis 10 yrs back
Malaria , Typhoid , MI ( 2 episodes)
 S/H - haemorrhoidectomy & Appendisectomy 25 yrs back
 D/H – Took Ayurvedic Rx For liver illness & Naturopathy Rx for Arthritis
 A/H - none
Saamanya Parikshana
Naadi - 86/ min Kshudha - Mandya
Mala – Asamyak (saamta) Nidra –
Mutra - Samyak Khandit ( Pain) Urah -
Prakrut
Jivha - Saam Udara – Non tender.
BP – 130/80 mm of Hg BSL – 102mg/dl
RR - 19/min
RS - AEBE
CVS – S1 S2 Normal
CNS – conscious and well oriented
Treatment Followed
Langhan Paachan Snehapaan
Virechan
Jalaukaavcharan
Intermediate
Rx Results
After Treatment
Introduction
 लघुत्रयी
 First explained in the माधव निदाि
 Later in the books like योगरत्िाकर, भैषज्य रत्िावली .
 सामान्यज व्याधी
References of word आम
1. अपक्वम् (सु.सू 46/209)
2. अश्रुतम अक्वथीतं (च नि 2/4)
3. उष्माणोऽल्प बलत्वेि धातूमाद्यमपाचचतम् |
दुष्टमामाशायगतं रसमांम प्रचक्षते || अ .हृ. सू 13/25
हेमाद्री - उष्मणो as रसाग्नि.
4. आचायय सुश्रूत. सू .१५/३७
अव्यायाममिो ददवास्वप्िस्यतस्य च आम .............|
डल्हण – धात्वाग्निमभरपाकादाम् इत्युच्यते |
आमस्वरुप
 गुरु
 अनेकवर्ण
 स्स्नग्ध
 बहुपपस्चिल
 तंतुमय
 दुगणन्ध
 द्रवरूप
आम वात
जलरुपप लघु
स्स्नग्ध रुक्ष
स्थूल सूक्ष्म
स्स्थर िल
शीत (common)
पृथ्वी + आप महाभूत ववकृ त वृद्चध व तेज महाभूत क्षय
Defination of आमवात
 आमवात is a condition where stabdhata of the body
parts occurs due to lodging of vitiated आम and वात
in the त्रत्रकसंधध.
 आम and वात both are held responsible for the
pathogenesis.
Types of आमवात
A ] According to माधव निदाि
1) क
े वल वातज
2) पपत्तानुबंधध
3) कफानुबंधध
B] According to HARITA
 पवष्टम्भी - गात्र-गौरवता , आध्माि and बग्स्तशूल.
 गुल्मी - जठरगजयिा ,गुल्मवत पीडा and कदटजडता.
 स्नेही - गात्रग्स्िनधता,जाड्य , मंदानिी .
 सवाांगी - Excreation of वपत,ववजल and पक्व आम,
श्रम and क्लम.
According to Severity
सामान्य आमवात
प्रवृद्ध आमवात
Hetu of आमवात
 पवरुद्धाहारिेष्टस्य मंदॆग्नौर्नणचिलस्य ि |
स्स्नग्धं भुक्तवतो ह्यन्नं व्यायामं क
ु वणतस्तथा ||
मा.र्न./आमवात/१
1. पवरुध्द आहार
2. पवरुध्द िेष्टा
3. मन्दास्ग्न
4. र्नचिलत्व(sedentary life)
5. व्यायाम Immediatedy after taking स्स्नग्ध आहार.
 पवरुध्द आहार
यद्ककस्चित दोशमुत्क्लेचय न
हरेत्त्तत्समासतः |
पवरुद्धं शुद्धधरत्रेष्टा शमो वा तद्पवरोधधभभः
||
अ हृ सु ७ / ४५
संस्कार पवरुध्द or मात्रा पवरुध्द etc.
Eg: मत्स्य + दुनध
fruit salad , preservatives etc.
पवरुध्द आहार - गुरू , शीत ,मृत्स्ि ,and ग्स्िनध गुण of कफ
दोष
and शीतगुण of वात.
पवरुध्द िेष्टा -
eg: वेगपवधारर् , अर्तव्यायाम ,
पवषमशयाशयात्वं, अर्तव्यवाय ,
वेग उददरर् , ददवास्वाप
रात्रीजागरर्
मंदाग्नी
रोगाः सवेऽपप मन्देग्नौ || अ हृ र्न १२
र्नचिलत्व - sedentary lifestyle
स्स्नग्धं भुक्तवतो ह्यन्नं व्यायाम
Samprapti
वायुना प्रेररतो ह्यामः चलेष्मस्थानं प्रधावर्त।
तेनात्यथां पवदग्धोऽसौ धमनीः प्रर्तपद्यते।।
वातपपत्तकफ़
ै भुणयो दूपषतः सोऽन्नजो रसः।
स्रोतांस्यभभष्यन्दयर्त नानावर्ोऽर्तपपस्छिलः।।
जनयत्याशु दौबणल्यं गौरवं हृदयस्य ि।
व्याधधनामाश्रयो येष आमसंज्ञोऽर्तदारुर्ः।।
'युगपत्क
ु पपतावन्तसत्रत्रकसस्न्धप्रवेशकौ।
स्तब्धं ि क
ु रुतो गात्रमामवातः स उछयते।। मा.र्न./आमवात/ २ - ५
Samprapti of आमवात
PHASE 1( sanchaya avastha )
आहारज पवहारज
पवरुध्द आहार ददवास्वाप ्,व्यायामादद,
स्स्नग्ध आहार and र्नस्िलत्व
गुरू आहार
कफ दुस्ष्ट कफ़ , वात-प्रकोप (िलगुर् )
(गुरू ,स्स्नग्ध, मृत्स्न ,
शीत गुर् वृद्धध)
दुस्ष्ट of अस्ग्न
Phase 2 : Prakopa avastha
अस्ग्नमांद्य (पवशेषतः रसास्ग्न)
आम formation
(due to vitiated वात दोष it goes into प्रसर अवस्था
PHASE 3 -Prasara avastha
आम goes through the धमनी into whole body(साम
वायु)
More vitiation of आम by स्थार्नक दोष s
नानावर्ण & अर्त पपस्स्िलत्व to आम
PHASE 4 – स्थािसंश्रय
प्रक
ु पीत वात & आम along with दुष्यादद does स्थािसंश्रय in श्लेष्म
स्थाि & त्रत्रकसंचध.
PHASE 5 – व्यग्क्तअवस्था
symptoms produced like दौबयल्य,हृद-गौरव
,गात्रस्तब्धता,
संचध-शूल, संचध-शोथ ,संचध-ग्रह & स्पशायसहत्व.
Phase ६ - भेद अवस्था
दोष भेदेि लक्षण
वात प्राधान्य पपत्त प्राधान्य कफ प्राधान्य
तीव्रसंधध शूल स दाह् स्स्तभमत
र्नद्रानाश सराग गुरुता
पवबन्ध
पपपासाधधक्य कण्डु
उत्साह हार्न मृदुज्वर अस्ग्नमांद्य
भ्रम मूिाण बहुमूत्रता
पूवयरूप of आमवात
 When प्रक
ु पपत आम via रसवह स्रोतस endures स्थानसंश्रय in हृदय ,संधध etc. before
getting fully menefestated as a disease आमवात, in the early stage produces
mild symptoms like अपाक,अरुधि etc which can be considered as पूवणरूप of
आमवात.
 वङ्गसेन has given भशरोरुजा & गात्ररुजा as पूवणरूप of आमवात.
 अस्ग्नमांद्य
 अपाक
 दौबणल्य
 अङ्गमदण
 अरुधि
 गात्रस्तब्धता
 गौरव.
प्रत्यत्म लक्षण(cardinal signs & symptoms)
 संचधशूल
 संचधशोथ
 स्तब्धता
 स्पशायसहत्व
आमवात
सामान्य
लक्षर्
अङ्गमदय
अरुचच
तृष्णा
आलस्य
ज्वर
शुिता
अङ्गािां
सामान्य लक्षण ( general/Associated
features)
•उत्साहहार्न
•भ्रम
•मूिाण
•र्नद्रपवपयणय
• संधधरुजा
• संधधशोथ
• संधध स्तब्धता
• वृस्चिक दंशवत
वेदना
• ज्वर
• गौरव
• दाह
• शूल
• अरुधि
• प्रसेक
• अस्ग्नमांद्य
• िददण
• तृष्र्ा
कोष्ठाचश्रत सावयदेदहक
मािमसक
स्थानिक
Joints which are affected
 जानुसंधध
 त्रत्रक संधध
 मन्यासंधध
 कदटसंधध
 पृष्ठसंधध
प्रवृद्धआमवात लक्षण
स कष्टः सवणरोगार्ां यदा प्रक
ु पपतो भवेत्।
हस्तपादभशरोगुल्फत्रत्रकजानूरुसस्न्धषु।।
करोर्त सरुजं शोथं यत्र दोषः प्रपद्यते।
स देशो रुज्यतेऽत्यथां व्यापवद्ध इव वृस्चिक
ै ः।।
जनयेत्सोऽस्ग्नदौबणल्यं प्रसेकारुधिगौरवम ्।।
उत्साहहार्न वैरस्य दाहं ि बहुमूत्रताम ्।।
क
ु क्षौ कदठनतां शूलं तथा र्नद्रापवपयणम ्।।
तृट्िददणभ्रममूिाणचि हृद्रहं पवपवबद्धताम ्।।
जाड्यान्नक
ू जनमानाहं कष्टांचिान्यानुपद्रवान्।।‘
- मा.र्न./आमवात ६ - १०
आमवात उपद्रव
 योगरत्नाकर– रहर्ी
 माधव र्नदान – प्रवृद्धमान लक्षर् ,अन्य उपद्रवार्न
 पवजयरक्षक्षत – संकोि & खचज
 हारीत - अङ्गवैकल्य
व्याधध घटकार्न
दोष - वात कफ प्रधान त्रत्रदोष ,आमदोष
दूष्य - रस ,रक्त ,मांस ,स्नायु ,अस्स्थ ,संधध,कन्दरा
स्रोतस - रसवह स्रोतस , मांसवह स्रोतस , अस्स्थवह , मज्जावह
अधधष्ठान - सवण संधध.
उद्भव स्थान - आमाशयोत्थ.
व्यस्क्त स्थान - सवण शरीर पवशेषतः संधध
रोग मागण - मध्यम
व्याधध अवस्था - आशुकारी
अस्ग्न - जठरास्ग्न ,धात्वास्ग्न
साध्यासाध्यत्व
 नवीन रोग - साध्य
 द्पवदोषज – याप्य
 त्रत्रदोषज - असाध्य
लङ्घि
स्वेदि
नतक्त
ददपिानि कटु
ववरेचि
स्िेहपाि
बग्स्त
सामान्य चचककत्सा सूत्र
Drugs and kalpas used in आमवात
Drug kalpa
एरण्डमूल भसंहनाद गुग्गुलु
अजमोदा गोधूम भल्लातक
शुण्ठी रास्ना पचिक क्वाथ
लशुन आमवातारी कषाय
रास्ना आमवातरर गुदटका
गुडुधि वैचवानर िूर्ण
देवदारु अजमोदादद िूर्ण
गुग्गुलु योगराज गुग्गुलु
पुननणवा
conclusion
 आमवात is a condition where stabdhata of body parts occurs
due to lodging of vitiated आम & वात in त्रत्रक संधध.
 आमवात is आमाशयोत्थ व्याधध so treatment given in आमवात is
1 st langhana then swedana,tikta katu dipana dravyas ,
virechan, snehapaana & basti.
 Which has ultimate goal to achieve आमपािन ,वातशमन ,&
स्रोतोशोधन , स्थानबल्य धिककत्सा.
Rheumatoid Arthritis
 Chronic
 Inflamatory
 Multi system
 Autoimmune Dissorder of Joints
 Affects Synovial & Peripheral Joints.
 Symmetrical – Destructive – Deforming.
Pathophysiology
 Presentation of antigen to T cells
 T- and B-cells Proliferation Angiogenesis in the Synovial
lining causes more cells to arrive at the site.
 Neutrophils accumulation in synovial fluid.
 Synovitis
 Early Pannus Formation
 Subchondral Bone erosion
 Pannus invasion of Cartilage Chondrocyte Proliferation.
 Laxity of ligaments.
 Joints instability, contractures, decrease ROM, Systemic
complications
Signs and symptoms of Rheumatoid
Arthritis
 Joint tenderness, swelling, redness, warmth, stiffness.
 Fatigue
 Joint pain
 Loss of ROM( Range of Motion)
 Limping
 Joint Deformity
 Early morning Stiffness( lasting more than 30mins)
 Low grade fever
Blood investigations in Rheumatoid
Arthritis
 Blood Count - ESR and CRP are raised.
 Serum autoantibodies - Anti-CCP has high Specificity
 Anti-nuclear antibody(ANA) - Commonly found in the
blood of people who are having auto immune disease.
This test can be used to confirm the diagnosis of
Rheumatoid Arthritis.
 Rheumatoid factor - Detects and measures the level of
an antibody, positive in people with Rheumatoid arthritis.
Radiology Investigations
X-rays :- X-rays of hands and feet are generally
performed in people with Rheumatoid Arthritis.
Magnetic resonance Imaging(MRI)
X ray of Rheumatoid Arthritis hands
• Physical Examinations in Rheumatoid Arthritis
It is important to assess the following:
- Stiffness
- Tenderness
- Pain on movements
- Swelling
- Deformity
- Limitation of motions
- Extra-articular Manifestations
- Rheumatoid Nodules
Treatment
Long Term
A] DMARD
Methotrexate ,Hydroxychloroquine , Sulfasalazine
Supress Inflamation
B] Biological Response Modifier ( Biologics)
Abatacept (Supress T-cell)
Rituximab ( Supress B-cell)
Adalimumab, Etanercept, Infliximab ( Block Chemicals Like Tumor Necrosis
Factors)
Anakinra ( Block IL- 1)
Tocilizimab ( Block IL- 6 )
 Short Term
C ] Acute Flares ( Anti- Inflamatories)
NSAID’S
Glucocorticosteroids
Complications of Rheumatoid Arthritis
• Ruptured tendons
• Ruptured joints
• Joint infection
Langhan Chikitsa
 "यत् ककस्न्ित लाघवकर देहे तत् लंघनं स्मृतम ् " ि.सू. २२/९
 "लंघन लाघवाय यत् ।“
 "तदेवास्यतपणर्म ् !" अ.सं.सू. २४
 महाभूत संघटन - तेज + वायु + आकाश
 लंघन गुर् –
“लघूष्र्तीक्ष्र् पवशदं रूक्षं सूक्ष्मं खरं
सरं कदठर् यद् द्रव्य प्रायस्तल्लघनं स्मृतम ् ।" ि.सू. २२/१२
Types of langhan –
िरक – द्रव्यरूप - वमन, पवरेिन, भशरोपवरेिन, र्नरुह.
अद्रव्यरूप - पपपासा , मारुत, आतप, पािन, उपवास, व्यायाम.
वाग्भट - शोधन , शमन .
 How does langhan works
"अनवस्स्थ दोषार्ां पािनमग्ने दीपनं ज्वरस्य
नाशनमाहारेछिाकरं रुधिकरं लाघवकरं ि ।" सु.उ. ३९/१०३
Digestion of food takes place by जाठराग्नि, if not food then it
digest ववकृ त दोष
and if duration increased then it digest normal धातु.
Fasting
 Willfull refrainment from eating & sometimes drinking( water fasting or juice
fasting).
 Starting after digestion of last meal.
TYPES
1. Water fasting – Only water or zero calory beverage.
2. Intermittant – 1-2 days weekly
3. Alternate day
4. Calorie restriction – reduce daily calorie intake by 10-45%
5. Fasting mimicking diet – for 5 days a month drastically limit their calorie diet.
6. Prolonged fasting – > 2 days.
Phases of Fasting
1. Gastro intestinal phase
2. Glycogenolysis
3. Gluconeogenesis
4. Ketosis
Autophagy / Auto-phagocytosis
 Self digesting mechanism responsible for removal of damaged orgenelles,
malformed proteins & long lived proteins by lysosomes.
 By influeincing lymphocyte development, survival And proliferation.
 Autophagy regulates the immune response against self and non self antigens.
 De-regulation of autophagic pathway has been implicated in several
autoimmune diseases eg: RA, cancer.
 Autophagy seems to be involved in generation of cittrullinated peptides.
 Autophagy reduces with age (protein involved in autophagy are reduced).
 Regulators of autophagy control regulator of inflammation & vice versae.
 Autophagy is avtivated in response to diverse the stress & physiological
condition Eg:- food deprevation.
Mechanism
Formation of double membrane vesicle
around the protein
Which encapsulates the cytoplasm &
malformed proteins.
Fuses with lysosomes
Degradation
Role of Autophagy in RA
(Frontiers in immunology, July 2018 | vol 9 | Article
1577)
 In RA, Autophagy activation was found to be essential for the survival
of inflammatory cells Eg synoviocytes & lymphocytes
 Imp role in cittrullination & osteoclastogenesis.
 Repression of autophagy could expose patients to premature ageing,
infections & development of malignancy.
Anti-Rheumatic effect on of fasting
(Rheumatic disease clinics of north America, 01, May 1991,
17(2):351-362.)
 Total fasting induces within few days shows substantial reduce in
Joint pain, swelling, morning stiffness & other rheumatic symptoms.
Remission.
Diminished activation of neutrophils & lymphocytes & Decreased
generaton of leukotrienes & other pro-inflammatory factors.
ANTI - RHEUMATIC EFFECT OF LANGHAN IN AAMVATA

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ANTI - RHEUMATIC EFFECT OF LANGHAN IN AAMVATA

  • 1. Anti-Rheumatic Effect of Langhan In Aamvata.
  • 2. Case study  Patient name – XYZ  Age – 60 Sex - M  Desha – Aanup to saadharan Kaala –Visarga  Rutu – Varsha to Sharad  K/C/O – None  H/0 – Liver cirrhosis 10 yrs back Malaria , Typhoid , MI ( 2 episodes)  S/H - haemorrhoidectomy & Appendisectomy 25 yrs back  D/H – Took Ayurvedic Rx For liver illness & Naturopathy Rx for Arthritis  A/H - none
  • 3. Saamanya Parikshana Naadi - 86/ min Kshudha - Mandya Mala – Asamyak (saamta) Nidra – Mutra - Samyak Khandit ( Pain) Urah - Prakrut Jivha - Saam Udara – Non tender. BP – 130/80 mm of Hg BSL – 102mg/dl RR - 19/min RS - AEBE CVS – S1 S2 Normal CNS – conscious and well oriented
  • 4. Treatment Followed Langhan Paachan Snehapaan Virechan Jalaukaavcharan
  • 7. Introduction  लघुत्रयी  First explained in the माधव निदाि  Later in the books like योगरत्िाकर, भैषज्य रत्िावली .  सामान्यज व्याधी
  • 8. References of word आम 1. अपक्वम् (सु.सू 46/209) 2. अश्रुतम अक्वथीतं (च नि 2/4) 3. उष्माणोऽल्प बलत्वेि धातूमाद्यमपाचचतम् | दुष्टमामाशायगतं रसमांम प्रचक्षते || अ .हृ. सू 13/25 हेमाद्री - उष्मणो as रसाग्नि. 4. आचायय सुश्रूत. सू .१५/३७ अव्यायाममिो ददवास्वप्िस्यतस्य च आम .............| डल्हण – धात्वाग्निमभरपाकादाम् इत्युच्यते |
  • 9. आमस्वरुप  गुरु  अनेकवर्ण  स्स्नग्ध  बहुपपस्चिल  तंतुमय  दुगणन्ध  द्रवरूप
  • 10. आम वात जलरुपप लघु स्स्नग्ध रुक्ष स्थूल सूक्ष्म स्स्थर िल शीत (common) पृथ्वी + आप महाभूत ववकृ त वृद्चध व तेज महाभूत क्षय
  • 11. Defination of आमवात  आमवात is a condition where stabdhata of the body parts occurs due to lodging of vitiated आम and वात in the त्रत्रकसंधध.  आम and वात both are held responsible for the pathogenesis.
  • 12. Types of आमवात A ] According to माधव निदाि 1) क े वल वातज 2) पपत्तानुबंधध 3) कफानुबंधध
  • 13. B] According to HARITA  पवष्टम्भी - गात्र-गौरवता , आध्माि and बग्स्तशूल.  गुल्मी - जठरगजयिा ,गुल्मवत पीडा and कदटजडता.  स्नेही - गात्रग्स्िनधता,जाड्य , मंदानिी .  सवाांगी - Excreation of वपत,ववजल and पक्व आम, श्रम and क्लम.
  • 14. According to Severity सामान्य आमवात प्रवृद्ध आमवात
  • 15. Hetu of आमवात  पवरुद्धाहारिेष्टस्य मंदॆग्नौर्नणचिलस्य ि | स्स्नग्धं भुक्तवतो ह्यन्नं व्यायामं क ु वणतस्तथा || मा.र्न./आमवात/१ 1. पवरुध्द आहार 2. पवरुध्द िेष्टा 3. मन्दास्ग्न 4. र्नचिलत्व(sedentary life) 5. व्यायाम Immediatedy after taking स्स्नग्ध आहार.
  • 16.  पवरुध्द आहार यद्ककस्चित दोशमुत्क्लेचय न हरेत्त्तत्समासतः | पवरुद्धं शुद्धधरत्रेष्टा शमो वा तद्पवरोधधभभः || अ हृ सु ७ / ४५ संस्कार पवरुध्द or मात्रा पवरुध्द etc. Eg: मत्स्य + दुनध fruit salad , preservatives etc. पवरुध्द आहार - गुरू , शीत ,मृत्स्ि ,and ग्स्िनध गुण of कफ दोष and शीतगुण of वात.
  • 17. पवरुध्द िेष्टा - eg: वेगपवधारर् , अर्तव्यायाम , पवषमशयाशयात्वं, अर्तव्यवाय , वेग उददरर् , ददवास्वाप रात्रीजागरर् मंदाग्नी रोगाः सवेऽपप मन्देग्नौ || अ हृ र्न १२ र्नचिलत्व - sedentary lifestyle स्स्नग्धं भुक्तवतो ह्यन्नं व्यायाम
  • 18. Samprapti वायुना प्रेररतो ह्यामः चलेष्मस्थानं प्रधावर्त। तेनात्यथां पवदग्धोऽसौ धमनीः प्रर्तपद्यते।। वातपपत्तकफ़ ै भुणयो दूपषतः सोऽन्नजो रसः। स्रोतांस्यभभष्यन्दयर्त नानावर्ोऽर्तपपस्छिलः।। जनयत्याशु दौबणल्यं गौरवं हृदयस्य ि। व्याधधनामाश्रयो येष आमसंज्ञोऽर्तदारुर्ः।। 'युगपत्क ु पपतावन्तसत्रत्रकसस्न्धप्रवेशकौ। स्तब्धं ि क ु रुतो गात्रमामवातः स उछयते।। मा.र्न./आमवात/ २ - ५
  • 19. Samprapti of आमवात PHASE 1( sanchaya avastha ) आहारज पवहारज पवरुध्द आहार ददवास्वाप ्,व्यायामादद, स्स्नग्ध आहार and र्नस्िलत्व गुरू आहार कफ दुस्ष्ट कफ़ , वात-प्रकोप (िलगुर् ) (गुरू ,स्स्नग्ध, मृत्स्न , शीत गुर् वृद्धध) दुस्ष्ट of अस्ग्न
  • 20. Phase 2 : Prakopa avastha अस्ग्नमांद्य (पवशेषतः रसास्ग्न) आम formation (due to vitiated वात दोष it goes into प्रसर अवस्था
  • 21. PHASE 3 -Prasara avastha आम goes through the धमनी into whole body(साम वायु) More vitiation of आम by स्थार्नक दोष s नानावर्ण & अर्त पपस्स्िलत्व to आम
  • 22. PHASE 4 – स्थािसंश्रय प्रक ु पीत वात & आम along with दुष्यादद does स्थािसंश्रय in श्लेष्म स्थाि & त्रत्रकसंचध. PHASE 5 – व्यग्क्तअवस्था symptoms produced like दौबयल्य,हृद-गौरव ,गात्रस्तब्धता, संचध-शूल, संचध-शोथ ,संचध-ग्रह & स्पशायसहत्व.
  • 23. Phase ६ - भेद अवस्था दोष भेदेि लक्षण वात प्राधान्य पपत्त प्राधान्य कफ प्राधान्य तीव्रसंधध शूल स दाह् स्स्तभमत र्नद्रानाश सराग गुरुता पवबन्ध पपपासाधधक्य कण्डु उत्साह हार्न मृदुज्वर अस्ग्नमांद्य भ्रम मूिाण बहुमूत्रता
  • 24. पूवयरूप of आमवात  When प्रक ु पपत आम via रसवह स्रोतस endures स्थानसंश्रय in हृदय ,संधध etc. before getting fully menefestated as a disease आमवात, in the early stage produces mild symptoms like अपाक,अरुधि etc which can be considered as पूवणरूप of आमवात.  वङ्गसेन has given भशरोरुजा & गात्ररुजा as पूवणरूप of आमवात.  अस्ग्नमांद्य  अपाक  दौबणल्य  अङ्गमदण  अरुधि  गात्रस्तब्धता  गौरव.
  • 25. प्रत्यत्म लक्षण(cardinal signs & symptoms)  संचधशूल  संचधशोथ  स्तब्धता  स्पशायसहत्व
  • 27. •उत्साहहार्न •भ्रम •मूिाण •र्नद्रपवपयणय • संधधरुजा • संधधशोथ • संधध स्तब्धता • वृस्चिक दंशवत वेदना • ज्वर • गौरव • दाह • शूल • अरुधि • प्रसेक • अस्ग्नमांद्य • िददण • तृष्र्ा कोष्ठाचश्रत सावयदेदहक मािमसक स्थानिक
  • 28. Joints which are affected  जानुसंधध  त्रत्रक संधध  मन्यासंधध  कदटसंधध  पृष्ठसंधध
  • 29. प्रवृद्धआमवात लक्षण स कष्टः सवणरोगार्ां यदा प्रक ु पपतो भवेत्। हस्तपादभशरोगुल्फत्रत्रकजानूरुसस्न्धषु।। करोर्त सरुजं शोथं यत्र दोषः प्रपद्यते। स देशो रुज्यतेऽत्यथां व्यापवद्ध इव वृस्चिक ै ः।। जनयेत्सोऽस्ग्नदौबणल्यं प्रसेकारुधिगौरवम ्।। उत्साहहार्न वैरस्य दाहं ि बहुमूत्रताम ्।। क ु क्षौ कदठनतां शूलं तथा र्नद्रापवपयणम ्।। तृट्िददणभ्रममूिाणचि हृद्रहं पवपवबद्धताम ्।। जाड्यान्नक ू जनमानाहं कष्टांचिान्यानुपद्रवान्।।‘ - मा.र्न./आमवात ६ - १०
  • 30. आमवात उपद्रव  योगरत्नाकर– रहर्ी  माधव र्नदान – प्रवृद्धमान लक्षर् ,अन्य उपद्रवार्न  पवजयरक्षक्षत – संकोि & खचज  हारीत - अङ्गवैकल्य
  • 31. व्याधध घटकार्न दोष - वात कफ प्रधान त्रत्रदोष ,आमदोष दूष्य - रस ,रक्त ,मांस ,स्नायु ,अस्स्थ ,संधध,कन्दरा स्रोतस - रसवह स्रोतस , मांसवह स्रोतस , अस्स्थवह , मज्जावह अधधष्ठान - सवण संधध. उद्भव स्थान - आमाशयोत्थ. व्यस्क्त स्थान - सवण शरीर पवशेषतः संधध रोग मागण - मध्यम व्याधध अवस्था - आशुकारी अस्ग्न - जठरास्ग्न ,धात्वास्ग्न
  • 32. साध्यासाध्यत्व  नवीन रोग - साध्य  द्पवदोषज – याप्य  त्रत्रदोषज - असाध्य
  • 34. Drugs and kalpas used in आमवात Drug kalpa एरण्डमूल भसंहनाद गुग्गुलु अजमोदा गोधूम भल्लातक शुण्ठी रास्ना पचिक क्वाथ लशुन आमवातारी कषाय रास्ना आमवातरर गुदटका गुडुधि वैचवानर िूर्ण देवदारु अजमोदादद िूर्ण गुग्गुलु योगराज गुग्गुलु पुननणवा
  • 35. conclusion  आमवात is a condition where stabdhata of body parts occurs due to lodging of vitiated आम & वात in त्रत्रक संधध.  आमवात is आमाशयोत्थ व्याधध so treatment given in आमवात is 1 st langhana then swedana,tikta katu dipana dravyas , virechan, snehapaana & basti.  Which has ultimate goal to achieve आमपािन ,वातशमन ,& स्रोतोशोधन , स्थानबल्य धिककत्सा.
  • 36. Rheumatoid Arthritis  Chronic  Inflamatory  Multi system  Autoimmune Dissorder of Joints  Affects Synovial & Peripheral Joints.  Symmetrical – Destructive – Deforming.
  • 37.
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  • 39. Pathophysiology  Presentation of antigen to T cells  T- and B-cells Proliferation Angiogenesis in the Synovial lining causes more cells to arrive at the site.  Neutrophils accumulation in synovial fluid.  Synovitis  Early Pannus Formation  Subchondral Bone erosion  Pannus invasion of Cartilage Chondrocyte Proliferation.  Laxity of ligaments.  Joints instability, contractures, decrease ROM, Systemic complications
  • 40. Signs and symptoms of Rheumatoid Arthritis  Joint tenderness, swelling, redness, warmth, stiffness.  Fatigue  Joint pain  Loss of ROM( Range of Motion)  Limping  Joint Deformity  Early morning Stiffness( lasting more than 30mins)  Low grade fever
  • 41. Blood investigations in Rheumatoid Arthritis  Blood Count - ESR and CRP are raised.  Serum autoantibodies - Anti-CCP has high Specificity  Anti-nuclear antibody(ANA) - Commonly found in the blood of people who are having auto immune disease. This test can be used to confirm the diagnosis of Rheumatoid Arthritis.  Rheumatoid factor - Detects and measures the level of an antibody, positive in people with Rheumatoid arthritis.
  • 42. Radiology Investigations X-rays :- X-rays of hands and feet are generally performed in people with Rheumatoid Arthritis. Magnetic resonance Imaging(MRI)
  • 43. X ray of Rheumatoid Arthritis hands
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  • 45. • Physical Examinations in Rheumatoid Arthritis It is important to assess the following: - Stiffness - Tenderness - Pain on movements - Swelling - Deformity - Limitation of motions - Extra-articular Manifestations - Rheumatoid Nodules
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  • 47. Treatment Long Term A] DMARD Methotrexate ,Hydroxychloroquine , Sulfasalazine Supress Inflamation B] Biological Response Modifier ( Biologics) Abatacept (Supress T-cell) Rituximab ( Supress B-cell) Adalimumab, Etanercept, Infliximab ( Block Chemicals Like Tumor Necrosis Factors) Anakinra ( Block IL- 1) Tocilizimab ( Block IL- 6 )
  • 48.  Short Term C ] Acute Flares ( Anti- Inflamatories) NSAID’S Glucocorticosteroids
  • 49. Complications of Rheumatoid Arthritis • Ruptured tendons • Ruptured joints • Joint infection
  • 50. Langhan Chikitsa  "यत् ककस्न्ित लाघवकर देहे तत् लंघनं स्मृतम ् " ि.सू. २२/९  "लंघन लाघवाय यत् ।“  "तदेवास्यतपणर्म ् !" अ.सं.सू. २४  महाभूत संघटन - तेज + वायु + आकाश  लंघन गुर् – “लघूष्र्तीक्ष्र् पवशदं रूक्षं सूक्ष्मं खरं सरं कदठर् यद् द्रव्य प्रायस्तल्लघनं स्मृतम ् ।" ि.सू. २२/१२ Types of langhan – िरक – द्रव्यरूप - वमन, पवरेिन, भशरोपवरेिन, र्नरुह. अद्रव्यरूप - पपपासा , मारुत, आतप, पािन, उपवास, व्यायाम. वाग्भट - शोधन , शमन .
  • 51.  How does langhan works "अनवस्स्थ दोषार्ां पािनमग्ने दीपनं ज्वरस्य नाशनमाहारेछिाकरं रुधिकरं लाघवकरं ि ।" सु.उ. ३९/१०३ Digestion of food takes place by जाठराग्नि, if not food then it digest ववकृ त दोष and if duration increased then it digest normal धातु.
  • 52. Fasting  Willfull refrainment from eating & sometimes drinking( water fasting or juice fasting).  Starting after digestion of last meal. TYPES 1. Water fasting – Only water or zero calory beverage. 2. Intermittant – 1-2 days weekly 3. Alternate day 4. Calorie restriction – reduce daily calorie intake by 10-45% 5. Fasting mimicking diet – for 5 days a month drastically limit their calorie diet. 6. Prolonged fasting – > 2 days.
  • 53. Phases of Fasting 1. Gastro intestinal phase 2. Glycogenolysis 3. Gluconeogenesis 4. Ketosis
  • 54. Autophagy / Auto-phagocytosis  Self digesting mechanism responsible for removal of damaged orgenelles, malformed proteins & long lived proteins by lysosomes.  By influeincing lymphocyte development, survival And proliferation.  Autophagy regulates the immune response against self and non self antigens.  De-regulation of autophagic pathway has been implicated in several autoimmune diseases eg: RA, cancer.  Autophagy seems to be involved in generation of cittrullinated peptides.  Autophagy reduces with age (protein involved in autophagy are reduced).  Regulators of autophagy control regulator of inflammation & vice versae.  Autophagy is avtivated in response to diverse the stress & physiological condition Eg:- food deprevation.
  • 55. Mechanism Formation of double membrane vesicle around the protein Which encapsulates the cytoplasm & malformed proteins. Fuses with lysosomes Degradation
  • 56. Role of Autophagy in RA (Frontiers in immunology, July 2018 | vol 9 | Article 1577)  In RA, Autophagy activation was found to be essential for the survival of inflammatory cells Eg synoviocytes & lymphocytes  Imp role in cittrullination & osteoclastogenesis.  Repression of autophagy could expose patients to premature ageing, infections & development of malignancy.
  • 57. Anti-Rheumatic effect on of fasting (Rheumatic disease clinics of north America, 01, May 1991, 17(2):351-362.)  Total fasting induces within few days shows substantial reduce in Joint pain, swelling, morning stiffness & other rheumatic symptoms. Remission. Diminished activation of neutrophils & lymphocytes & Decreased generaton of leukotrienes & other pro-inflammatory factors.