Chloroform was a popular anesthetic from the mid-1800s to around 1910 but was found to cause death in about one in 3,000 patients due to heart paralysis. Nitrous oxide, also known as laughing gas, was discovered as an anesthetic during a tooth removal in the 1800s. During World War I, the first anesthetic gas machines that produced nitrous oxide and oxygen mixtures were introduced by James Taylor Gwathmey and Geoffrey Marshall. Later, a portable machine was created by Edmund Boyle, which became more popular for its portability during the war. Early 1900s surgeons Harvey Cushing and George Crile contributed to anesthesia safety by promoting blood pressure monitoring during operations.