1. The document discusses trepanation, the ancient practice of drilling holes in the skull, which was commonly performed by cultures in the Andes region of South America.
2. Trepanation was a major surgical procedure, with around 13% of the population in the Andes having holes drilled in their skulls. In many cases, multiple trepanation procedures were performed on a single individual.
3. The reasons for trepanation included treating cranial fractures from injuries as well as unknown illnesses. Around 60% of trepanations were performed in areas of the skull that put the patient at high risk of complications.