Ancient ingredients with modern evidence

Academy of Scientifc Research and Technology
‫والتكنولوجيا‬ ‫العلمى‬ ‫البحث‬ ‫أكاديمية‬
Application Form
Ancient Ingredients with Modern Evidence
A Proposal on
Innovative Development of Egyptian Medicinal and Aromatic Plants and their Extracts
A new Approach for Medicinal Plants Sector Growth
BY Consortium Managed by
Faculty of Pharmacy Cairo University

Application Form: ASRT Initiatives 2015
-‫والعطرية‬ ‫الطبية‬ ‫النباتات‬ ‫تسىيق‬ ‫ودعم‬ ‫استغالل‬ ‫لحسن‬ ‫قىمية‬ ‫حملة‬ 5
Title oftheinitiative
(project):
Arabic/English
Ancient Ingredients with Modern Evidence
Innovative Development of Egyptian Medicinal and Aromatic Plants and
their Extracts
‫ببربب‬ ‫لذ٠ّت‬ ‫ِشوببث‬‫ػظش٠ت‬ ‫حبث‬
‫ٌٍٕببحبث‬ ‫ِبخىش‬ ‫حطٛ٠ش‬‫اٌطب١ت‬‫اٌؼطش٠ت‬ ٚ‫خالطبحٙب‬ ٚ ‫اٌّظش٠ت‬
Name of Applicant:
Arabic/English
Faculty of Pharmacy Cairo University
‫اٌظ١ذٌت‬ ‫وٍ١ت‬-‫اٌمب٘شة‬ ‫صبِؼت‬
Affiliation of the
applicant:
Governmental University
Name and contact
information of
Industrial
partner/End user
Dr. Amr Mohamed Helal (Industrial partner)
Mobil 01002100429 - Email dr.amrhelal@hotmail.com
Dr. Heba Labib
Mobil 01001607845 - Email hlabib@nu.edu.eg
Requested Budget
(LE):3500000
ASRT
Share:
74.5%
Industry/Private/
other partners
Sector Share:
1,200,000
Total:LE 4700000
Duration of the
project (months):
2 years
Type of the project:
(Please check one
only)
Manufacturin
g of
Functional
prototype □
Process
development/
Scaling Up □
Semi-industrial
Production/
Commercializatio
n□
Experimental
field □
Approvals
Principal
Investigator
Name:Prof. Dr. Essam
Abd El Hamid Abd El
Sattar
Signature:
Date:19.2.2015
Host Institution
Name:Faculty of Pharmacy Cairo University
Signature:
Date:19.2.2015
Seal:
Date of Submission 11.2.2015

Part A:Short CV of the applicant (One page maximum)
1. Basic Information
Full Name in Arabic:
Full name in English:
Essam Abdel-Sattar
Date of Birth: October 5, 1955
National ID: 25510051300974
Last University Degree
PH.D. Pharmaceutical Sciences
Faculty: Pharmacy, Cairo Univ,
Country: Egypt
PH.D. Graduation Date
1991
Title: Professor Field of specialization: Pharmacognosy
Affiliation: Faculty of Pharmacy, Cairo University, 11562 Cairo, Country:
Egypt
Current Position Professor
Contact Information:
Mobile Phone: 01065847211 Fax: 25321900 E-mail: abdelsattar@yahoo.com
2. Scientific Achievements
h index
14
Citations
277
Total no. of Int. publications in Scopus
48
Last three recent relevant publications
Authors (underline your name), year, title, Journal, vol. and pages
1 Hossam M. Abdallah, Abdel-Moneim M. Osman, Hussein Almehdar, Essam Abdel-Sattar*.
(2013). AcylatedPregnane glycosides from Carallumaqaudrangula. Phytochemistry: 88: 54-
60.
2 Essam Abdel-Sattar, Ashraf B. Abdel-Naim, Hossam M. Abdallah, Alaa Khedr (2012).
Chemical
and Biological Assessment of African Olive Leaf Extract. Research Journal of
Pharmaceutical,
Biological and Chemical Sciences 3: 155-172.
3 Essam Abdel-Sattar, Hossam M. Abdallah, Ashraf B. Abdel-Naim, Alaa Khedr (2011).
Mechanisms of the antihyperglycemic activity of Carallumatuberculata in streptozotocin-
induced diabetic rats (accepted to Food and chemical Toxicology).
Field editor for Journal of Functional Foods in Health and Disease (FFHD).
Granted projects: 18 (four are running)
Conferences: 27
Research of interests
- Isolation and purification of different natural compounds from their plant sources, viz.
sesquiterpene lactones, pregnane glycosides, saponin glycosides diterpenes, iridoids, etc.
- Search for Biologically active natural products through biologically guided fractionation (viz.
anticancer, antiviral, antimalarial, etc…)
- Quality control of herbal drugs.
Reviewers for several international journals
Previous or running projects with STDF
a. Running (ID no. & type of grant, role of applicant)
b. Previous (ID no., type, role of applicant and deliverables to be attached)

CO PI
1. Basic Information
Full Name in Arabic:
‫هالل‬ ‫محمد‬ ‫عمرو‬
Full name in English: Amr M. Helal
Date of Birth: 20.2.1961
National ID 26102200102555
Last University Degree
PH.D Phytochemistry
Faculty, University, Country Cairo
University, Egypt
Graduation Date 1983
PH.D. 1996
Title: Dr. Field of specialization: Pharmacognosy and Phytochemistry
Affiliation: Health Tech for Integrated Health Solutions
Current Position: CEO
Contact Information:
Mobile Phone: 01002100429 Fax: 33477755 E-mail:
amr@itm.com.eg
2. Scientific Achievements
h index
4
Citations
62
Total no. of Int. publications in Scopus
7
Last three recent relevant publications
Authors (underline your name), year, title, Journal, vol. and pages
1 Ammar, H. O., Al-Okbi, S. Y., Mostafa, D. M., and Helal, A. M. (2012). Rice bran oil:
Preparation and evaluation of novel liquisolid and semisolid formulations. International
Journal of Pharmaceutical compounding, 16(6), 516-523 (USA).
2 Al-Okbi, S. Y., Mohamed, D. A., Hamed, I. M., Agoor, F. S., Ramadan, A. A. M., El-Saed,
S., Helal, A. M. (2013). Comparative Study on Egyptian Rice Bran Extracted by Solvents and
Supercritical CO2. Advances in Food Sciences, 35(1), 23-29. (Germany).
3 Hagl S, Grewal R, Ciobanu I, Helal A, Khayyal MT, Muller WE, Eckert GP
Rice Bran Extract compensates mitochondrial dysfunction in a cellular model of early
Alzheimer's disease
J Alz Dis 2015, 1;43(3):927-38.
If applicable, state other salient scientific achievements such as patents (granted only) and
scientific prizes
A- Winner of Green Apple Award, UK, Best Environmental Practice, Gold Winner, Africa 2005
for Environmental control of Black smog (Rice straw composting / AWARDS).
B- Innova award at 2011 from Heliopolis University (Rice Waste Management)
C- COMESA Gold Innovation AWARD 2013 (SME Catigory)

Part B: R&DProposal
The proposalshould provide a clear and concise definition of the R&D proposal, innovation or
invention, description of the target product, which will be developed through this fund and its
advantages in comparison with other existing technologies in the same field. Economic
feasibility and potential market of the product supported with verified statistics (with citation)
must be presented. The proposalshould not exceed 10pages(including all parts of the
proposal, i.e. part A, B, C and D) and can be written either in English or Arabic. The proposal
must include the following:

B.1. English Summary:
The Egyptian Folk medicine is a heritage of knowledge and experiences accumulated during
thousands of years from the Pharonic, Greek, Roman to the Arab era. These Egyptian medicinal and
aromatic plants (MAP) are used in a wide range for alleviation and/or treatment of many diseases as
well as national and international use as healthy ingredients. What enriched this field is the diversity in
the Egyptian climate from Sinai Mountains to Western Desert Oasis in Siwa, and from Nile Delta and
valley to Upper Egypt.
However our problem analysis clearly defines that the Egyptian exports market share of this
sectordid not exceed 3.2% in 2013 compared to China possessing more than 35 % of the sector market
share(1). Unfortunately, trade of Egyptian MAP, in the local market or for export; rely heavily on small
and medium producers who do not follow the appropriate standards (Good Agricultural Practices –
GAP or Good Manufacturing Practices - GMP) during the cultivation, harvesting, post harvest and
industrial processing. Thisresults into a low quality produce which does not match the exporting
standards, and hence cripples the export volume and value.This alarming scenario was exposed through
the report of Industrial Modernization Centre about herbs and spices sector in Egypt (2), published a
decade ago.
The problem is even intense in the medicinal plants extracts segment. The Egyptian
Pharmaceutical companies are importinggreat part of their requirements instead of producing them
locally. For instance, in 2013, Egypt imported Licorice extract for US$ 723000 (3) despite the
abundance of raw material in Egypt.
Due to the above we concluded that the supply chain of MAP needs serious reform. Starting with
production, farmers don’t observe good agricultural practices, especially in their usage of pesticides.
Postharvest processing is another concern especially that it doesn’t observe the necessary hygiene
practices required for food production. Finally, the export process itself has a huge space for
improvement, whether in applying quality measures in final processing and packaging, or in
establishing a collective brand or in terms of the value added and the final product form.
In this proposal, we try to tackle the aforementioned problem using two parallel alternatives, study
their feasibilities and compare their outcomes.
The First Alternative relies on acting upon the existing value chain and applying grass root reforms
along the chain to remedy the incompetence of that fragmented industry. The reform involves multiple
stages starting with awareness and capacity building to small farmers and processors, assisting small
exporters in the field in improving their processing and packaging techniques, and enforcing quality
control measures. At the same time, we will work on the scientific standardization of the targeted
products and avail a list of recommendations to regulators to ensure an end of process QC by the
authorities. Meanwhile, a “Seal of Quality” image and branding story is being built. The quality image
of “Seal of Quality” will be used for international industry branding (the outside image) and the success
stories associated with that Seal of Quality will be communicated to the inside beneficiaries as a
motivation to embrace higher quality standards.
The Second Alternative will take a disruptive approach; maximizing the value of existing products.
Instead of exporting bulk MAP (Low Value), we will develop the export chain of MAP extracts (High
Value).
The Main Objective of the proposal is toimprove and developMAP sectorthat will reflect on
the export value of this industry
The Specific Objectivesare to improve the competence of the industry through applying grass
root reforms to the classic MAP supply chain, supported by up-to-date monographs, to develop a
quality-approved plant materials and standardized extracts for a number of plants that is commonly
requested by the market, and to conduct a feasibility studyof the industrial extracts production asan
additional local market and export channel.

The project aims to introduce to the sector the concepts of Exporting VALUE instead of VOLUME,
and "Forward Integration"to improve the competitiveness of Egyptian Herbs and aromatic plants
industry toward a better market share in the Export markets.
This project shall witness the establishment of a unique multidisciplinary team composed of
Private Sector; Health Tech for Integrated Health Solutions(HT), Nile’s Gift(NG),Research
Institutes; Faculty of Pharmacy Cairo University(FOPCU), Faculty of Agriculture Ain Shams
University(ASU), Faculty of Engineering Menia University(FEMU), Agriculture Research Center
(ARC) as well as NGO; Fayoum Agro Organic & Development Association (FAODA).
Also the participation of Bibliotheca Alexandrina represented by its consulting firm
Alexandrina for Technical Consultingin the consortium is a great edge in the direction of developing
draft for Egyptian MAP encyclopedia. The consortium members are cooperating together since more
than five years in different projects. The equipment purchased, the expertise generated, as well as the
international networking developed through these national and international projects are assets to the
project.
B.2. Arabic Summary: An understandable translation of the English summary.
ٌ ‫اٌذل١ك‬ ٍّٝ‫اٌؼ‬ ‫اٌفغض‬ ْ‫ا‬ِٓ ٓ١ٕ‫اٌس‬ ‫آالف‬ ‫خالي‬ ‫حشاوّج‬ ٝ‫ٚاٌخ‬ ٞ‫اٌّظش‬ ٟ‫اٌشؼب‬ ‫اٌطب‬ ٝ‫ف‬ ‫ٚاٌخبشاث‬ ‫اٌّؼبسف‬ ‫خشاد‬
ٟ‫ف‬ َ‫حسخخذ‬ ٝ‫اٌخ‬ ‫ٚاٌؼطش٠ت‬ ‫اٌطب١ت‬ ‫إٌببحبث‬ ِٓ ‫ٚاسؼت‬ ‫ِضّٛػت‬ ‫اوخشبف‬ ٝ‫ف‬ ‫سبػذ‬ ‫لذ‬ ‫اٌغذ٠ذ‬ ‫اٌؼظش‬ ٝ‫ٚعخ‬ ٟٔٛ‫اٌفشػ‬ ‫اٌؼظش‬
‫طغ١ت‬ ‫وأغز٠ت‬ ٚ‫أ‬ ،‫األِشاع‬ ِٓ ‫اٌؼذ٠ذ‬ ‫أٚػالس‬ /‫حخف١ف‬‫إٌببحبث‬ ٖ‫٘ز‬ ِٓ ‫اٌؼذ٠ذ‬ ‫الٔخبس‬ ُ‫ِالئ‬ ‫ِٕبػ‬ ‫ٚصٛد‬ ْ‫أ‬ ‫ببٌزوش‬ ‫صذ٠ش‬ .
‫٘زا‬ ٜ‫أرش‬ ‫لذ‬ ‫ِظش‬ ‫ٚطؼ١ذ‬ ، ‫اٌغشب١ت‬ ‫ٚاٌظغشاء‬ ‫س١ٕبء‬ ٝ‫ف‬ ‫اٌضذ٠ذة‬ ٟ‫ٚاألساض‬ ٞ‫اٌٛاد‬ ٝ‫ف‬ ‫اٌخشبت‬ ‫ٚحٕٛع‬ َ‫اٌؼب‬ ‫ِذاس‬ ٍٝ‫ػ‬
.ٌُ‫اٌؼب‬ ‫عٛي‬ ‫ٚاسغ‬ ‫بمبٛي‬ ٝ‫حغظ‬ ‫ِبصاٌج‬ ٝ‫اٌخ‬ ‫إٌببحبث‬ ِٓ ‫ببٌؼذ٠ذ‬ ‫اٌّضبي‬
١‫ٌٍب‬ ٟ‫إعظبئ‬ ً١ٍ‫حغ‬ ٝ‫ٚف‬ٓ‫ػ‬ ‫بٔبث‬‫اٌّظش٠ت‬ ‫اٌظبدساث‬‫ٚاٌؼطش٠ت‬ ‫اٌطب١ت‬ ‫إٌببحبث‬ ِٟٓ‫ف‬2013‫ٚصذ‬ٜ‫حخؼذ‬ ‫ال‬ ‫أٔٙب‬3.2%ٝ‫ف‬
‫اٌخظذ٠ش‬ ‫سٛق‬‫اٌّغذداث‬ ِٓ ‫ػذد‬ ‫ٚصٛد‬ ‫ٔخ١ضت‬ ‫٘زا‬ ْ‫ٚا‬‫حؼٛق‬ ٟ‫اٌخ‬‫أّ٘ٙب‬ ِٓ ‫اٌمطبع‬ ‫٘زا‬ ّٟٛٔ‫ف‬ ‫بذائ١ت‬ ‫حمٕ١بث‬ َ‫اسخخذا‬
ٚ ‫اٌخغٍ١ف‬ ٌٝ‫ا‬ ،‫ٚاٌخؼبئت‬ ‫ٚاٌخضف١ف‬ ‫اٌضّغ‬ ِٓ ،‫اٌغظبد‬ ‫بؼذ‬ ‫ِب‬ ‫ػٍّ١بث‬‫ِّب‬ ،‫اٌخسٛ٠ك‬ً١‫اٌّغبط‬ ٖ‫٘ز‬ َ‫أِب‬ ‫اٌخظذ٠ش‬ ‫فشص‬ ًٍ‫٠م‬
،،‫اٌذٌٚ١ت‬ ‫ٌٍّؼب٠١ش‬ ‫ٚفمب‬ ‫اٌّؼبٌضت‬ ‫ٚحمٕ١بث‬ ‫اٌضٛدة‬ ‫ِؼب٠١ش‬ ‫بخطٛ٠ش‬ ‫لبِج‬ ‫ٚإٌٙذ‬ ٓ١‫اٌظ‬ ً‫ِز‬ ‫بٍذأب‬ ٜ‫ٔش‬ ‫ا٢خش‬ ‫اٌضبٔب‬ ٍٝ‫ػ‬ ‫ب١ّٕب‬
ٌٝ‫(عٛا‬ ‫وب١شة‬ ‫عظت‬ ٍٝ‫ػ‬ ‫حسخغٛر‬ ْ‫أ‬ ‫ٚاسخطبػج‬35) %.‫اٌخظذ٠ش‬ ‫سٛق‬ ٝ‫ف‬
‫ِشوض‬ ‫حمش٠ش‬ ْ‫أ‬ ‫ببٌزوش‬ ‫صذ٠ش‬ِٓ ‫أوزش‬ ‫ِٕز‬ ٛ٠‫اٌس١ٕبس‬ ‫٘زا‬ ٌٝ‫ا‬ ‫أشبس‬ ‫لذ‬ ‫اٌظٕبػت‬ ‫حغذ٠ذ‬10َ‫ػب‬ ٖ‫احضب‬ ‫ٕ٘بن‬ ً‫ظ‬ ٓ‫ٚو‬ ‫سٕٛاث‬
،‫ِضبفت‬ ‫ل١ّت‬ ‫ٚصٛد‬ ْٚ‫ٚد‬ ٟٔ‫ِخذ‬ ٖ‫صٛد‬ ٜٛ‫بّسخ‬ "‫حضبس٠ت‬ ‫ػالِت‬ ‫راث‬ ‫"غ١ش‬ َ‫خب‬ ‫بظٛسة‬ ‫ٚاٌؼطش٠ت‬ ‫اٌطب١ت‬ ‫إٌببحبث‬ ‫ٌخظذ٠ش‬
‫ا‬ ِٓ ‫اعخ١بصبحٙب‬ ُ‫ِؼظ‬ ‫اسخ١شاد‬ ٍٝ‫ػ‬ ‫ِظش‬ ٟ‫ف‬ ‫اٌؼبٍِت‬ ‫اٌذٚاء‬ ‫ششوبث‬ ‫ٚاػخّذث‬‫ٌزٌه‬ ،‫ِسخخٍظبحٙب‬ ٚ‫أ‬ ‫اٌؼشب١ت‬ َ‫اٌخب‬ ‫ٌّٛاد‬
.‫إٌّبفست‬ ٍٝ‫ػ‬ ‫لبدس‬ ‫غ١ش‬ ‫ٚأطبظ‬ ًٍ‫ببٌش‬ ‫اٌمطبع‬ ‫٘زا‬ ‫أط١ب‬
ٓ٠‫ِسبس‬ ٟ‫ف‬ ‫بٙب‬ َ‫٠خمذ‬ ‫بّببدسة‬ ‫اٌّمخشط‬ ‫٘زا‬ ْ‫وب‬ ‫ٌٚزٌه‬ ،‫اٌّؼٛلبث‬ ‫حٍه‬ ٍٝ‫ػ‬ ‫ٌٍخغٍب‬ ‫ِبخىشة‬ ‫طش٠مت‬ ‫٠غخبس‬ ‫اٌمطبع‬ ‫٘زا‬ ْ‫فإ‬ ،‫ٌزٌه‬
ٓ١٠‫ِخٛاص‬.‫ٌّخشصبحّٙب‬ ‫ِٚمبسٔت‬ ٜٚ‫صذ‬ ‫دساست‬ ًّ‫ٚػ‬
ٟ‫ف‬:‫األول‬ ‫المسار‬ٟ‫ف‬ ‫ٚخالطبحٙب‬ ‫اٌطب١ت‬ ‫إٌببحبث‬ ‫حسٛ٠ك‬ ٌٝ‫ا‬ ‫ٚاٌخضف١ف‬ ‫اٌضّغ‬ ِٓ ‫اٌّخخٍفت‬ ً‫اٌّشاع‬ ٟ‫ف‬ ‫حطٛ٠ش‬ ًّ‫ٌؼ‬ ٝ‫ٔسؼ‬
‫اٌبشش٠ت‬ ‫ببٌخّٕ١ت‬ ‫اٌّسبس‬ ‫٘زا‬ ُ‫٠ٙخ‬ ‫وّب‬ ، ‫اٌضٛدة‬ ‫ػالِت‬ ًّ‫٠غ‬ ‫ِٕبفس‬ ‫ِٕخش‬ ٍٝ‫ػ‬ ‫اٌغظٛي‬ ْ‫ٌضّب‬ ‫ٚاٌخظذ٠ش‬ ٍٝ‫اٌّغ‬ ‫اٌسٛق‬
.‫ٚاٌخذس٠ب‬
‫الثانى‬ ‫المسار‬ٍٝ‫أػ‬ ‫ٌخغم١ك‬ ٝ‫ٔسؼ‬ :‫ٚحطٛ٠ش‬ ٜ‫اٌّظش‬ ‫ٌٍّٕخش‬ ‫اٌّضبفت‬ ‫اٌم١ّت‬ ‫ص٠بدة‬ ٍٝ‫ػ‬ ‫اٌخشو١ض‬ ‫خالي‬ ِٓ ‫اٌمطبع‬ ‫ٌٙزا‬ ‫اسخفبدة‬
‫ػالِت‬ ًّ‫حغ‬ ‫خالطبث‬ ‫حظذ٠ش‬ ٌٝ‫ا‬ ‫اٌضٛدة‬ ٟٔ‫ِخذ‬ ‫ٌّٕخش‬ ّٝ‫اٌى‬ ‫اٌخظذ٠ش‬ ِٓ ‫ٌٍخغٛي‬ ‫إٌببحبث‬ ِٓ ‫ٌؼذد‬ ‫خالطبث‬ ‫إٔخبس‬ ‫سٍسٍت‬
.‫اٌضٛدة‬
:‫االقتراح‬ ‫من‬ ‫األوسع‬ ‫الهدف‬‫ٌٍٕب‬ ‫ٚاٌخظذ٠ش‬ ‫اإلٔخبس‬ ‫لطبع‬ ‫حطٛ٠ش‬.‫ٚاٌؼطش٠ت‬ ‫اٌطب١ت‬ ‫بحبث‬
‫المحدد‬ ‫والهدف‬ً‫ٌّشاع‬ ً٠‫ٚحؼذ‬ ‫٘١ىٍت‬ ‫إػبدة‬ ‫خالي‬ ِٓ ‫ٚاٌؼطش٠ت‬ ‫اٌطب١ت‬ ‫إٌببحبث‬ ِٓ ‫اٌخظذ٠ش‬ ‫ٌمطبع‬ ‫اٌخٕبفس١ت‬ ‫اٌمذسة‬ ‫ص٠بدة‬ :
ٝ‫ِشصؼ‬ ‫حٛط١ف‬ ًّ‫ٚػ‬ ‫اٌؼبٌّ١ت‬ ‫اٌضٛدة‬ ‫ٌّؼب٠١ش‬ ‫ٚخالطبحٙبٚفمب‬ ‫إٌببحبث‬ ِٓ ‫ػذد‬ ‫ٚحظٕ١غ‬ ‫إٔخبس‬Monographs،‫ِٕٙب‬ ‫ٌؼذد‬
ٌٝ‫ا‬ ‫وزٌه‬ ٝ‫ٚٔسؼ‬.‫ٚدٌٚ١ب‬ ‫ِغٍ١ب‬ ٗ‫ٚحشٚ٠ض‬ ‫اٌّظش٠ت‬ ‫ٚاٌؼطش٠ت‬ ‫اٌطب١ت‬ ‫إٌببحبث‬ ِٓ ٜ‫اٌّظش‬ ‫إٌّخش‬ ‫ٌضٛدة‬ ‫ِؼخّذ‬ ‫شؼبس‬ ُ١ّ‫حظ‬
‫ل١ّت‬ ‫راث‬ ‫خالطبث‬ ‫حظذ٠ش‬ ٌٝ‫ا‬ ّٝ‫اٌى‬ ‫اٌخظذ٠ش‬ ِٓ ‫اٌخغٛي‬ ‫بضشٚسة‬ ‫صذ٠ذ‬ َٛٙ‫ِف‬ ُ٠‫حمذ‬ ٌٝ‫ا‬ ‫حٙذف‬ ‫اٌّببدسة‬ ٖ‫٘ز‬ ْ‫أ‬

B.3. Product Description:
On a pilot scale we will be applying modern postharvest techniques (collection, drying, packing
standardization and marketing support)for at least 15 plants and 7 extractsthe feasibility study of the
industrial extracts production will be reported as one of the main products of the project to address
the international importer and potential investor in this sector as well as the Sector stakeholders.
A number of Egyptian MAPare selected based on cultivation on large scale and big international
demands. These plants are currently exported as non-standardized, non-branded crude drugs and not
necessarily follow the required quality standards.These are: Chamomile, Basil, Marjoram, Spearmint,
Peppermint, Lemongrass, Calendula, Fennel, Caraway, Anise, Rosemary, Salvia, Nigella, Fenugreek,
Coriander, Cumin, Hibiscus, Parsley and Thyme. A number of products should be produced and
developed as an outcome of this fund as follow:
 Product
 Problem
 Impact
1- A Cultivation, Harvest, Post-Harvest Pilot Project with Process Manual.
a. Will solve the lack of quality standards.
This product will provide the sector with a demonstration pilot for GAP, GMP to improve
the quality of the MAP production to meet the export standards. Sufficient documentation
for this pilot will be done, and will act as an industry guideline, and can be employed
towards international branding.
2- Egypt MAP monographs Version 1
a. Lack of knowledge problem.
b. Absence of creative marketing tools.
This product will be a state of the art reference and marketing tool. To start with, it will
cover the selectedMAP, forming the nucleus of Egypt MAP Encyclopedia.
3- Standardized selected MAP extracts
a. Low value of exported raw material
b. Lack of local supply against MAP extract demands
This product will help changing the export trends from low value raw material to higher
value products. It will also increase the competitiveness of Egyptian pharmaceutical
industry through supplying it with high quality low cost ingredients.
4- Feasibility study with ROI indicators for the industrial extracts production.
a. Absence of clear vision on the potential industry growth.
The feasibility study will validate the Industrial Extracts as a profitable business.
5- An accredited Egyptian Medicinal and Aromatic Plants "Quality Excellency Seal".
a. Negative perception of Egyptian MAP quality in international market
This product will be a new accreditation produced by the project to be provided to
producers according to an NGO – Governmental Agreement to reflect Quality Excellency.
6- Branded Quality Excellency Seal on the national and internationallevels.
a. Lack of marketing tools
b. Absence of Egyptian produce competitive advantage
This is a new competitive advantage for quality producers to empower their production as
the best quality produce recognized by the Egyptian Government.

B.4. State-of-the-Art
MAP market needs scientific evidence of authentication, proper and hygiene collection,
drying and packing processes for plants, proof of bioactives in both the crude drugs as well as
their extracts with validated methods of analysis, marketing and branding tools to promote the
sector. All these criteria and others are burdens for the development of this sector in Egypt. To
solve such problems a state of art technologies needs to be implemented to improve the
development process such as:
- State of art solar drying that improve the processing speed, product quality and hygiene
environment.
- State of the art Innovative extraction techniques such as ultrasonic extraction and
subcritical water extraction.
- The DNA profiling in monograph is an authentication tool to preserve the Egyptian MAP
products identity.
- Innovative analysis tools will be adopted to develop the state of art Fingerprint for the
plants and extracts.
- Using the state of art branding and Marketing tools and approaches to promote the
Egyptian MAP Export industry such as branding quality seals, Excellency accreditation,
etc.
In this regards, it has to be stated that, to the best of our knowledge, this might be the first time where a
number of funded projects (STDF- RDI- EU) will join their state of art results, equipment as well as
developed networking to serve the project tasks.(See Table below)
Ser.
Applicant /
Funding body
Project name
Project’s team / State-of-the-Art
experience
1
ITM (2014-15)
RDI/ EURO 100000
Innovation in Rice Bran extraction
Health tech Applicant - (ITM spin
off company) experienced in
extraction and Marketing.
2
FOPCU/ 2010-2012
RDI/ Euro 192,000
Rice Bran Nutraceuticals FOPCU –Partner 1 experienced in
extraction, standardization and
fingerprinting.3
FOPCU (2014-16)
STDF/LE 900,000
High value pharmaceutical materials from
food processing waste
4
FEMU (2014-2016)
STDF/ LE 1.2 M
Innovative Green Extraction Technology
for Medicinal Plants
FEMU –partner 2 experienced in
chemical engineering, green
extraction technology.
5
ARC (AEnRI)
STDF/ LE 1.35 M
Design and manufacture of mobile grapes
dryer
ARC- Partner 3, Agro- machinery
and solar drying.
6
NG / 2014
ILO/ LE 200,000
Solar dryer
Nile gift- partner 4 MAP drying,
Marketing, and Branding.
7
FAODA
EU
Agro Ecology Practices and Marketing for
Fayoum Small Growers project.
FAODA – Partner 5 Agro-
development implementation.
8
FAODA World
Bank
Enhance incomes for rural girls through
training them on Eco heritage hand craft
and marketing
9
BGED
MCIT /Bibliotheca
Alexandrina
2000,000 EGP
This project aims to document plants,
animals and history of 6 botanical gardens
beside the history of El-Zahraa stud. found
in Cairo under the authority of Ministry of
Agriculture
Alexandrina consulting- partner 6
(spin off Bibliotheca Alexandrina)
experienced in Documentation and
monographing,marketing and
branding development.

B.5. Objectives: State briefly and concisely your project’s main and specific objectives.
The competitiveness and hence the export growth, of the medicinal plants and herbal sector are
low due to wrong pre- and postharvest practices as well as little added values in the value chain of
production
Main Objective
To improve and develop MAP cultivation and production that will reflect on the export value of this
industry and provide the market with new tools and product to enrich the industry.
Specific objectives
1- To apply a grass root reforms along the cultivation, Harvest,Post-harvest chain to remedy
the incompetence of the industry.
2- Preserving the Identity of the Egyptian MAPs with DNA fingerprint Identification.
3- Development of an Egyptian monographsfor Selected MAPs widely cultivated and
exported in large volumes.
4- Development of a quality-approved plant materials and standardized extracts for a number
of plants that is commonly requested by the market.
5- Develop a feasibility study with ROI indicators for the industrial extracts production as an
alternative product approach for export markets and investors.
6- Developing an accredited Egyptian MAP"Quality Excellency Seal".
7- Quality Excellency Seal branding nationally and internationally.
B.6. Outcomes and Impact:
This project is a continuation of collaboration of the consortium partners in related activities. The
synergistic cooperation in this project is expected to lead to the following
Outcomes:
1- The existence of Cultivation, Harvest, post Harvest process manual that will solve the lack of
quality standards that will upgrade the production capacity and quality to international export
level witch will have a great positive impact on the national income and export Market share.
2- An Egypt herbs and aromatic plants monographs in accordance with WHO requirementsthat
will be used as an educating tool to the benefit of the sector producers as well as a great
marketing tool to promote Egyptian herbs and Aroma plants.
3- A strategic Feasibility study to identify investment opportunity and a production alternative to
the row plants exporting industry.
4- Creation of a new Egyptian Herbs and aroma plant extracts product with an approved quality
for Export.
5- Identification of accredited Egyptian Medicinal and Aromatic Plants "Quality Excellency Seal"
to be Branded as a Quality Trademark for national producers and international importers.
6- Creation of a new trends in the herbal plant business; value rather than volume; business
consistency rather than random exportation.
7- Establishing a pilot village where the international standards of collection, drying, packing,
labeling are applied.

Impacts:
1- MAP Value chain Process development.
2- Improving the pharmaceutical sector competitiveness by supplying high quality ingredients at
reasonable cost.
3- The empowerment of women (usual labor force in this sector) in the pilot village through
training and awareness will have its socioeconomic impacts.
4- Raised awareness among the Herbs and Aroma producers Where Value is more important than
Volume
The overall impact of this development is increasing the competiveness of the MAP sector with
more jobs creation, exports volume and value as well as lowering to some extent importation of herbal
extracts. The feasibility studies within this project are expected to attract more investors (Local and
foreign) to this field of promising growth and profits.
B.7. Approach and Methodology:
Project implementation:
The project will be based on a pilot implementation that will take place in one of the least
developed areas in Egypt at Fayoum Governoratethat will roll out the cultivation , collection , drying ,
packing , Process mapping and Manual development. Extraction and standardization will take place in
the partner’s facilities (HealthTech, FOPCU and ARC) in a collaboration between owned resources and
other funded resources with over than 6M value equipment and facilities.
Final Monograph will be developed for all the outputs in a joint effort lead by Bibliotheca
Alexandrina in cooperation with FOPCU and ASU.
Approach
Two parallel (classical and non-classical) approaches will be adopted. In the former the classical
way of cultivation and production processed will be innovatively developed, while value added MAP
extracts will be developed in the second approach.

Activities
Ser. Activity Task/(methods) Input/provided by
1
Products selection and
Mapping
- Selecting the MAPs ( Statistical )
- Authentication ( Taxonomy)
- Standardization ( HPLC )
- Advanced monograph editing (
DNA)
Collective experience and facilities that will
do the market studies, Technical and
scientific support, Documentation &
publishing experience.BA- FOPCU – ASU
2
Pilot project
implementation
- Cultivation Selected MAPs (
GAP )
- Harvest Selected MAPs (GAP)
- Post-Harvest ( Solar Drying –
Hygiene Auto- packing )
- Process Documentation and
Manual Development.
Land cultivation and labor management, Women
capacity building, Training, Business
Commercial experience.Utilization of thePartners
assets(Industrial and pilot SolarDryer).Packing
machine purchased by the project. Training
material. workshops
facilities.FAODA – NG – ASU – ARC- AC
3
Pilot MAP extraction
& feasibility study
- Extraction of the selected
plants(subcritical &ultrasonic)
- Analyze the plants bioactive(s).
(HPLC- LC/MS/MS)
- Feasibility studies for the
industrial scale extraction process.
Utilizing Health Tech resources and ARC to
extract the selected plants .FOPCU will analyze
and standardize the outputs of the extraction
process.Alexandrina for Tech. consulting will
utilize its resources to develop a feasibility study
for industrial implementation. HT-FOPCU-
ARC- AC
4
Branding and
Marketing
- Creatingquality Excellency seal
for the Egyptian MAP.
- Branding Quality Seal Locally
and internationally
- International Marketing for the
outputs.
Quality process accreditation system will be the
input of the ARC in this phase.
Utilizing the international Branding experts of
AC and business operation experience of NG
Brand the quality Excellency seal.Utilizing the
International Network of HT will be the main
input for the international marketing task in this
activity.ARC -AC-NG- HT
B.8. Key References:List outstanding, recent and relevant literature cited in the proposal and
source of given statistics.
References
1- List of exporters for the selected product in 2013 - Product : 1211 Medicinal plants
- http://www.trademap.org/Country_SelProduct.aspx.
2- http://www.imc- egypt.org/studies/Full Report/Herbs%20&%20Spices%20
Survey_Part%203_EN.pdf)
3- http://www.trademap.org/Index.aspx
4- Reducing risks and preventing disease:population-wide interventions
http://www.who.int/nmh/publications/ncd_report_chapter4.pdf
5- http://apps.who.int/medicinedocs/index/assoc/s14213e/s14213e.pdf

Part C: Gantt chart and Logical Framework Matrix (LFM)
# Task Title StartDate
EndDate
Duration
(Months)
M1-M2
M3-M4
M5-M6
M7-M8
M9-M10
M11-M12
M13-M14
M15-M16
M17-M18
M19-M20
M21-M22
M23-M24
Expected measurable
outcomes of successful
implementation of the task
1
Selecting the
MAPs(Statistical)
X List of 15 plant
2
Authentication (
Taxonomy)
X X 15 certificate of authenticity
3
Standardization (
HPLC )
X X X 15 HPLC chromatograms
4
Advanced
monograph
editing ( DNA)
X X X
X
15 Monograph
15 DNA Fingerprint
5
Cultivation
Selected MAPs (
GAP )
X
X X X X X X X X 15 planted acers
6
Harvest Selected
MAPs (GAP)
X X X X X X X X X X 15 harvested plant.
7
Post-Harvest (
Solar Drying –
Hygiene Auto-
packing )
X X X X X X X X X
15 dried and packed plant.
8
Process
Documentation
and Manual
Development.
X X X X X X X X X X
Production Chain manual .
9
Extraction of the
selected
plants(subcritical
&ultrasonic)
X X X X X X X
7 Extracts at the pilot scale.
10
Analyze the
plants
bioactive(s).
X X X X X X X 7 Certificates for Extracts
ingredients.
11
(HPLC-
LC/MS/MS)
X X X X 7 chromatograms
12
Feasibility studies
for the industrial
scale extraction
process.
X X X X
Feasibility study document.
13
Creating quality
Excellency seal
for the Egyptian
MAP.
X X X Excellency seal Pre-requisites
manual.
Excellency seal design and
model.
14
Branding Quality
Seal Locally and
internationally
X X X X Recognition certificate by
Local and International
agencies.
15
International
Marketing for the
outputs.
X X X X Certificate of attendance for
Marketing exhibitions.

Part: D Budget Distribution
IPR: all issues related to IPR, royalty and revenue/profit must be discussed case by case and
accepted by all parties in the light of governing rules and laws (law no. 82/2002).
Item
Cost in LE
ASRT share Others
Incentives and labor 875000
Supplies and Materials 800000
Equipment and parts 650000 1200000 *
Certified analysis and tests 200000
Costs of feasibility study/ business
plan/Startups/ Visibility/
Registration
250000
Exhibitions, national and
international, seminars,
conferences, travel
550000
Overhead 175000
Subtotal 3500000 1200000
Grand Total : LE 4 700 000
 Purchases by the partners through other projects and will be supplied to serve this project

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