The document discusses the challenges and innovations in using clinical decision support systems (CDSS) for managing chronic diseases, which affect 90 million Americans and consume a significant portion of healthcare expenditures. Key lessons include the importance of project management, the risks of alert fatigue, and the critical role of human factors in the successful implementation of CDSS. Future directions involve expanding the focus of CDSS beyond a few diseases to a wider range, alongside fostering public-private partnerships.