Alzheimer's disease is a neurodegenerative disorder that affects the brain and results in losing the brain memory. The causative agents of this disease are different, it could be genetics, epigenetics, environmental, or change in the physiological function of the brain barrier. One of this causes is the mutation in the precursor of the protein beta-amyloid, that leads to accumulation of this protein in the brain and forms plaque. Thus, other protein is affected by this accumulation like Tau protein, increase the phosphorylation of this protein leads to losing the movement of protein like kinesin through the microtubules and then forms tangles. There are some advanced treatments like antibodies against this protein or deliver drugs-loaded nanoparticles to solve the aggregation and refold the proteins