The document provides a program guide for integrating gender-based violence (GBV) prevention and response within PEPFAR (U.S. President's Emergency Plan for AIDS Relief) programs. It emphasizes the interconnectedness of GBV and HIV, highlighting the need for coordinated responses that address both issues simultaneously to improve health outcomes, particularly for women and vulnerable populations. The guide offers strategies and recommendations for program managers to enhance the integration of GBV services within existing HIV frameworks, promoting a multi-sectoral approach to addressing these public health challenges.