Addison disease power point presentation is here. Thanks me later. I created this for my friend assignment submission.

1. (general elective)

3.  Addison's disease (also known as primary adrenal insufficiency or
hypoadrenalism) is a rare disorder of the adrenal glands. It affects the
production of two hormones - cortisol and aldosterone.
 Cortisol is released in stressful situations and helps to maintain your
energy levels, your blood sugar levels and carbohydrate metabolism.
 Aldosterone maintains the balance of salt and water in your body, which
helps to control blood pressure.
Introduction

6.  Addison’s disease is an autoimmune inflammation of
adrenal glands, resulting in their gradual destruction
and inability to make sufficient amounts of adrenal
hormones.
 Life threatening emergency.
 No Cortisol & Aldosterone.
 Addison's can afflict persons of any age, gender, or
ethnicity, but it typically presents in adults between 30
and 50 years of age

7.  SST
– 250mcg synacthen test
– 1mcg synacthen test
 ITT
– More laborious and potentially dangerous
– Gold standard

8.  TUBERCULOSIS-
It was a leading cause of addison’s disease until the
antibiotics were introduced that successfully treated T.B.
Autoimmune disorders-Here the body’s immune system
makes antibiotics which cells of the adrenal cortex and
slowly destroys them.
 Adrenocortical destruction-
Bilateral adrenocortical destruction after T.B or
fungal infection and an idiopathic atrophy are the most
frequent causes .

10.  Extreme fatigue
 Weight loss and decreased appetite
 Darkening of your skin (hyperpigmentation)
 Low blood pressure, even fainting
 Salt craving
 Low blood sugar (hypoglycemia)
 Nausea, diarrhea or vomiting (gastrointestinal symptoms)
 Abdominal pain
 Muscle or joint pains
 Irritability
 Depression or other behavioral symptoms
 Body hair loss or sexual dysfunction in women
SYMPTOMS

11. • darkening of gums due to increased pigment
as seen in Addison's disease

12. • Darkening of the skin seen on the
legs of a white person with
Addison's disease

13. CAUSES
 •In an autoimmune disease, your body’s immune system
mistakes any organ or area of the body for a virus,
bacteria, or another outside invader.
 • Other causes of primary adrenal insufficiency include:
 • prolonged administration of glucocorticoids (e.g.
prednisone)
 • infections in your body
 • cancer and abnormal growths (tumors)
 • certain blood thinners used to control clotting in the
blood

14. There are also many other causes of secondary
adrenal insufficiency, including:
 tumors
 medications
 genetics
 traumatic brain injury

15. • Hydrocortisone pills to replace cortisol.
• If patient also lacking aldosterone, fludrocortisones
acetate pills will be provided.
• If patient are taking fludrocortisones, need to increase
salt intake, especially in hot and humid weather and after
exercise.
• In emergencies and during surgery, the medicine is
given intravenously (directly into a vein).
It is done by adequate corticosteroid maintenance
therapy provided by an average daily dose of 25-40 mg
cortisone.
TREATMENT