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Practical Hematology
By
ALI TH. Khalifa Tamimi
Leukemia
Part ( 2 )
Acute leukemia
2-Acute leukemia can be divided into :
A - Acute Lymphoblastic leukemia ( ALL ):-
Acute lymphoblastic leukemia is a type of cancer
that affects white blood cells. is a cancer of the
lymphoid line of blood cells characterized by the
development of large numbers of immature
lymphocytes. It progresses quickly and
aggressively and requires immediate treatment.
Both adults and children can be affected.
classification of ALL
can be classification may be on the basis of
morphological and immunological markers
Morphological classification : the French – American –
British ( FAB ) group sub classification ALL into three
types :
Type 1 / which shows uniform , small blast with scanty cytoplasm .
Type 2 / large blast cells with prominent nucleoli and cytoplasm .
Type 3/ the blasts are larger with prominent nucleoli , strongly
basophilic cytoplasm .
Diagnosis of ALL
▪ CBC and blood smears . the WBC count ↑ increase
▪ WBC total may be increased to 200 × 10 9 L or more .
▪ Normochromic Normocytic anemia with
thrombocytopenia in most cases
▪ Blast cells are seen on blood smears in 90 % of cases .
▪ Bone marrow is hyper cellular with > 20 % leukemic
blast .
B- Acute myeloblastic Leukemia ( AML ) .
is the cancer of myeloid line of blood cell, characterized
by the rapid growth of abnormal white blood cell that
accumulation in the bone marrow .withe production of
normal blood cell , AML affects adult and its incidence
increase with age .
Diagnosis of AML .
▪ CBC and blood smears . the WBC count ↑ increase
▪ Normochromic Normocytic anemia
▪ Blood film examination ( leukocytosis ) anemia and
thrombocytopenia and decrease in red blood cell count
▪ Erythroblast may be found
▪ Presence of red Aure rods in the cytoplasm of Myeloblast
▪ Auer rods (or Auer bodies) are large, crystalline cytoplasmic
inclusion bodies sometimes observed in myeloid blast cells
during acute myeloid leukemia,
ACUTE LEUKEMIA.pdf
ACUTE LEUKEMIA.pdf

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ACUTE LEUKEMIA.pdf

  • 1. Practical Hematology By ALI TH. Khalifa Tamimi Leukemia Part ( 2 )
  • 2. Acute leukemia 2-Acute leukemia can be divided into : A - Acute Lymphoblastic leukemia ( ALL ):- Acute lymphoblastic leukemia is a type of cancer that affects white blood cells. is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. It progresses quickly and aggressively and requires immediate treatment. Both adults and children can be affected.
  • 3. classification of ALL can be classification may be on the basis of morphological and immunological markers Morphological classification : the French – American – British ( FAB ) group sub classification ALL into three types : Type 1 / which shows uniform , small blast with scanty cytoplasm . Type 2 / large blast cells with prominent nucleoli and cytoplasm . Type 3/ the blasts are larger with prominent nucleoli , strongly basophilic cytoplasm .
  • 4. Diagnosis of ALL ▪ CBC and blood smears . the WBC count ↑ increase ▪ WBC total may be increased to 200 × 10 9 L or more . ▪ Normochromic Normocytic anemia with thrombocytopenia in most cases ▪ Blast cells are seen on blood smears in 90 % of cases . ▪ Bone marrow is hyper cellular with > 20 % leukemic blast .
  • 5.
  • 6.
  • 7. B- Acute myeloblastic Leukemia ( AML ) . is the cancer of myeloid line of blood cell, characterized by the rapid growth of abnormal white blood cell that accumulation in the bone marrow .withe production of normal blood cell , AML affects adult and its incidence increase with age .
  • 8. Diagnosis of AML . ▪ CBC and blood smears . the WBC count ↑ increase ▪ Normochromic Normocytic anemia ▪ Blood film examination ( leukocytosis ) anemia and thrombocytopenia and decrease in red blood cell count ▪ Erythroblast may be found ▪ Presence of red Aure rods in the cytoplasm of Myeloblast ▪ Auer rods (or Auer bodies) are large, crystalline cytoplasmic inclusion bodies sometimes observed in myeloid blast cells during acute myeloid leukemia,