The document discusses the shift in downstream processing from a bottleneck to a driver of biomanufacturing. It notes that while high titers can reduce costs, downstream processing costs still dominate and present challenges to handle increased volumes and contaminant loads from improved processes. New technologies in filtration and chromatography using single-use disposables aim to improve throughput and capacity while reducing costs. The future of downstream processing involves revisiting past approaches with a focus on continuous improvement rather than identifying any single best solution.
PPL Corporation's 2003 annual report discusses the company's operations and financial results. The report details how PPL works continuously to generate and deliver reliable power to customers in the US, UK, and Latin America. It highlights the company's focus on operational excellence, customer service, energy marketing, and growth. Financially, PPL grew revenues and earnings compared to 2002. Key metrics like return on equity and stock performance increased, demonstrating the company is producing strong results for shareholders.
The document summarizes a presentation on current best practices in biomanufacturing and the critical role of innovation. It discusses how high titers from upstream processing are challenging downstream processing, including increasing volumes and contaminant levels. Emerging technologies aim to address issues like large Protein A pool volumes, DNA and HCP levels after capture, and polishing load volumes. Alternative capture methods to Protein A are also discussed, though issues around selectivity, scale up, and comparability remain.
The document discusses design verification (DV) in the past, present, and future. In the past, DV techniques were basic like visual inspection and code coverage was in its infancy. Now, DV has evolved with more research, texts, and use of techniques like constrained random testing and static verification. The future of DV faces challenges of dealing with increasing capacity needs and being smarter about reaching verification goals. Formal verification and new algorithms are emerging to help address these challenges.
This document discusses severe sepsis and septic shock, which together affect over 500,000 Americans annually and have high mortality rates. Early Goal Directed Therapy (EGDT) following the 2001 Rivers trial has been shown to improve survival rates. While EGDT requires upfront resource utilization, this study from a community hospital found that after implementing an EGDT program, days on mechanical ventilation, ICU length of stay, and total hospital costs all decreased significantly. The cost per day was also lower for survivors versus non-survivors, suggesting EGDT can lower the overall cost of treating sepsis patients.
Martin Bardsley: New developments in resource allocationNuffield Trust
The document discusses the development of a person-based resource allocation (PBRA) formula in the English NHS. A team of experts worked from 2007 to develop budgets for practice-based commissioning based on individual patient data including secondary care, prescribing, and community health services. The PBRA aims to allocate resources based on individual patient characteristics rather than practice populations. It models hospital expenditure based on factors like age, sex, diagnoses, and needs and supply characteristics to predict costs. The results are applied to share out primary care trust budgets to individual practices according to their predicted needs.
After fermentation is completed, downstream processing (DSP) is used to harvest, separate, purify, and concentrate the product from the fermentation broth. DSP makes up a large portion of the workforce in biotechnology plants. It involves various separation, concentration, and purification operations like filtration, centrifugation, chromatography, and drying. The specific DSP operations used depend on factors like the type, size, and concentration of solids in the fermentation broth. Conditioning the broth is also an important initial step in DSP to facilitate easier separation of cells and products from the liquid.
The document discusses the downstream oil sector, which includes refining crude oil and distributing and selling the resulting products. It is divided into three segments: exploration and production (upstream), refining (downstream), and distribution and sales (downstream). The downstream sector refers specifically to refining crude oil into products like gasoline and diesel, and distributing those products through various wholesale and retail channels to consumers.
The document discusses the shift in downstream processing from a bottleneck to a driver of biomanufacturing. It notes that while high titers can reduce costs, downstream processing costs still dominate and present challenges to handle increased volumes and contaminant loads from improved processes. New technologies in filtration and chromatography using single-use disposables aim to improve throughput and capacity while reducing costs. The future of downstream processing involves revisiting past approaches with a focus on continuous improvement rather than identifying any single best solution.
PPL Corporation's 2003 annual report discusses the company's operations and financial results. The report details how PPL works continuously to generate and deliver reliable power to customers in the US, UK, and Latin America. It highlights the company's focus on operational excellence, customer service, energy marketing, and growth. Financially, PPL grew revenues and earnings compared to 2002. Key metrics like return on equity and stock performance increased, demonstrating the company is producing strong results for shareholders.
The document summarizes a presentation on current best practices in biomanufacturing and the critical role of innovation. It discusses how high titers from upstream processing are challenging downstream processing, including increasing volumes and contaminant levels. Emerging technologies aim to address issues like large Protein A pool volumes, DNA and HCP levels after capture, and polishing load volumes. Alternative capture methods to Protein A are also discussed, though issues around selectivity, scale up, and comparability remain.
The document discusses design verification (DV) in the past, present, and future. In the past, DV techniques were basic like visual inspection and code coverage was in its infancy. Now, DV has evolved with more research, texts, and use of techniques like constrained random testing and static verification. The future of DV faces challenges of dealing with increasing capacity needs and being smarter about reaching verification goals. Formal verification and new algorithms are emerging to help address these challenges.
This document discusses severe sepsis and septic shock, which together affect over 500,000 Americans annually and have high mortality rates. Early Goal Directed Therapy (EGDT) following the 2001 Rivers trial has been shown to improve survival rates. While EGDT requires upfront resource utilization, this study from a community hospital found that after implementing an EGDT program, days on mechanical ventilation, ICU length of stay, and total hospital costs all decreased significantly. The cost per day was also lower for survivors versus non-survivors, suggesting EGDT can lower the overall cost of treating sepsis patients.
Martin Bardsley: New developments in resource allocationNuffield Trust
The document discusses the development of a person-based resource allocation (PBRA) formula in the English NHS. A team of experts worked from 2007 to develop budgets for practice-based commissioning based on individual patient data including secondary care, prescribing, and community health services. The PBRA aims to allocate resources based on individual patient characteristics rather than practice populations. It models hospital expenditure based on factors like age, sex, diagnoses, and needs and supply characteristics to predict costs. The results are applied to share out primary care trust budgets to individual practices according to their predicted needs.
After fermentation is completed, downstream processing (DSP) is used to harvest, separate, purify, and concentrate the product from the fermentation broth. DSP makes up a large portion of the workforce in biotechnology plants. It involves various separation, concentration, and purification operations like filtration, centrifugation, chromatography, and drying. The specific DSP operations used depend on factors like the type, size, and concentration of solids in the fermentation broth. Conditioning the broth is also an important initial step in DSP to facilitate easier separation of cells and products from the liquid.
The document discusses the downstream oil sector, which includes refining crude oil and distributing and selling the resulting products. It is divided into three segments: exploration and production (upstream), refining (downstream), and distribution and sales (downstream). The downstream sector refers specifically to refining crude oil into products like gasoline and diesel, and distributing those products through various wholesale and retail channels to consumers.
This document discusses maximizing profitability of PET production lines through world-scale process design and operations. Some key points:
- PET line sizes have increased dramatically over the past decade from 200 tons/day to 800-1000 tons/day due to economies of scale lowering costs from $900/ton to $200/ton.
- Maximizing equipment utilization, minimizing downtime, maintaining product quality, and efficient grade changes are critical for reducing costs of production.
- Modern solid-state polymerization (SSP) lines are designed for continuous operation like melt plants through preventative maintenance, isolation capabilities, and high-purity nitrogen environments.
- Proper management of process bottlenecks and optimization of
1) The document describes an I-Corps team exploring the development of bio-based chemical intermediates for polymer, bio-surfactants, and bio-lubricants.
2) The value proposition is to provide sustainable, bio-based replacements for non-renewable petroleum-derived feedstocks used in surfactants and lubricants with improved performance features.
3) Interviews with potential customers revealed the largest market opportunity is in surfactants, so the team pivoted their focus to developing drop-in monomers for the $24 billion surfactant market.
Greening our Planet, our Industry, our Community and our Company – a goal we ...Rally Software
This is a presentation Ryan Martens presented at the Rockies Venture Club. The point of the talk was to encourage folks to get started on the curve toward greening and that strategic and tactical benefits would come as well as personal benefits. I left folks with the pointers, on the last slide, to a number of the sources that are helping us up the curve.
Achieving Market Dominance through Technology Leadership -Cascade Microtech, Inc. is the leading provider of advanced probing systems, non-memory probes and sockets, from design through production
This webinar discussed polysilicon supply, demand, and implications for the global PV industry from 2012-2016. It provided an overview of polysilicon production technologies and their costs, noting that Siemens hydrochlorination is currently the lowest cost and most profitable option. The webinar also showed that despite oversupply, lower polysilicon prices will reduce solar module costs, benefiting the industry. A Q&A session followed the presentation.
This document outlines 10 hot topics in biomanufacturing: 1) product mix and business models in biopharma, 2) high-titer processes in mammalian cell culture, 3) downstream processing being driven by mass rather than volume, 4) facility fit considerations, 5) cost of goods and price margin pressures, 6) biosimilars and biobetters, 7) offshore manufacturing, 8) technology platforms and implications of high titer, 9) emerging technologies for biomass removal and contaminant clearance, and 10) single-use technologies and integrated processing. The speaker concludes by emphasizing the need for new perspectives and solutions to address challenges in biomanufacturing.
Cutting-edge Technologies in the Water Industry (Jan 2011)venturecenter
The document discusses various technologies for treating and reusing water, as well as reducing water loss. It provides information on companies developing technologies in areas like biological treatment, waste-to-energy conversion, and generating electricity from wastewater using microbial fuel cells. Examples of technologies highlighted include the Cellruptor process for sludge treatment, the HYBACS process for industrial wastewater, and the MEGAWATTER system which uses a bioelectrochemical process. The goal is to purify water, treat and reuse wastewater, and reduce water loss using innovative solutions.
Patrick Costello Green Guide Presentation Final 032112wlambert_2001
This document discusses various options for reducing the carbon footprint of data center energy consumption, including establishing an emissions baseline, setting reduction targets, and investing in energy efficiency, clean energy, and carbon offsets. It outlines categories of emissions and compares the carbon intensity of different power grid regions. Key options presented for reducing energy consumption related emissions include onsite solar and fuel cell systems, offsite renewable energy projects, renewable energy certificates, and carbon offsets. The document provides an overview of benefits, costs, and considerations for each option and emphasizes the importance of strategic combinations of solutions to maximize value and alignment with organizational goals.
The document discusses clean technology research and development initiatives and implementation. It outlines the process of moving clean technologies from basic research through applied research, demonstration, commercialization, and market adoption. Barriers at each stage are identified. Priority clean technology areas are mapped based on their estimated impact and investment required. An action plan is proposed to increase investments in clean technology, shift subsidies to these areas, establish supportive policies, and promote education.
REAL OPTIONS ANALYSIS OF MARGINAL OILFIELD DEVELOPMENT PROJECTS: THE CASE OF ...Theo Acheampong
This document summarizes a thesis that analyzed the use of real options analysis to evaluate marginal oilfield development projects in the UK. It began with an overview of real options analysis and its ability to account for management flexibility. It then described the concepts and methodology of real options analysis. The case study examined a sample UK marginal oilfield, valuing it using traditional discounted cash flow analysis and real options analysis to determine the value of deferral, expansion, and abandonment options. The main results found that accounting for these options through real options analysis increased the net present value compared to only using discounted cash flow analysis.
This document provides guidance on developing key elements of an environmental project proposal, including the problem statement, scope of project, proposal title, objectives, and relationship between sections in an experimental chapter. It discusses how to write each element concisely and accurately to clearly define the research problem and planned methodology. Examples are given for objectives related to three sample project topics on leachate treatment, agricultural waste composites, and phytoremediation.
Making Sense of Cost and Performance Estimates for Thermochemical Biofuel PlantsIlkka Hannula
Achieving deep reductions in CO2 emissions from today’s transportation system presents major challenges, given the dominant role played by crude-oil derived fuels. Advanced biofuels, produced sustainably, provide one potential path for deep emissions reductions.
A clear understanding of the prospective economics of advanced biofuels is thus important to support analysis aimed at informing public- and private-sector decision making on biofuels.
Many techno-economic studies of advanced biofuels have been published, but individual studies are often difficult for decision makers to evaluate because of differences in analytical methodologies, input-data uncertainties, scope and battery limits of the analysis, and key assumptions.
Using both literature and data from demonstration projects, we address the following questions for advanced thermochemical cellulosic biofuels: What will first-of-a-kind (FOAK) cellulosic biofuels cost, and What cost levels can be expected in the near-term?
For more information, go to http://www.thinkdsi.com/grid/.
With the current focus on building a smart grid and investments being made on the technology side as well as the infrastructure side, energy is certainly getting much press! Uncertainty has never been higher.
This webinar aims to discuss this uncertainty. Based on field research and expert interviews, the recent comprehensive report "Future of the Energy Grid 2025" by Decision Strategies International presents views on everything from fuel mix to behind-the-meter innovation. What could the grid look like in 2025? How will different stakeholders be affected? Scott Snyder, President, and Stephan Hagelauer, Senior Consultant, will present the key findings of the report, and give you tools and tactics to help you develop resilient strategies and robust portfolio initiatives to succeed in the energy industry.
Three executives representing stakeholders in the energy industry will present how they have used the report to help “future proof” their own organizations and discuss some of the factors they find critical to success:
-Karl Pfirrman, Executive Vice President of PJM
-Rear Admiral Phil Cullom in charge of the US Navy Energy Strategy
-Govi Rao, CEO of Lighting Science
Qna L6 S Project Aa Cmp Oxide Range Reduction (Oct 08)Norbert Gloser
The document summarizes a Lean Six Sigma project to improve the uniformity of a CMP oxide film thickness process at a wafer fabrication plant. The project team used DMAIC methodology to define the problem, measure current performance, analyze causes of non-uniformity, improve the process, and establish controls. Specifically, the team defined a goal of reducing oxide thickness variation from 550 angstroms to 320 angstroms to close 70% of the gap with a benchmarking site. The project was expected to yield $4.1 million in annual savings through increased chip output and yield.
The document discusses the multiple benefits of energy efficiency policies in the EU. It argues that such policies could save the EU at least €50 billion per year in foreign energy expenditures, which could be invested domestically instead. Energy efficiency also improves competitiveness and reduces energy poverty. Examples from Germany show that co-financing energy efficiency triggers large private investments. The document outlines various other benefits of energy efficiency including reduced emissions, transmission and distribution capacity savings, and avoided costs of reserves, generation, and transmission and distribution infrastructure.
20111114 Iron Road Annual General Meeting 2011ajstocks
The document provides an overview of Iron Road Limited's Central Eyre Iron Project (CEIP) in South Australia. It summarizes the results of the CEIP Prefeasibility Study which outlined a 12.4 million tonne per annum magnetite concentrate operation. It also discusses Iron Road's 2011 achievements including resource upgrades and community engagement efforts. Looking ahead, it outlines plans for 2012 including further resource drilling, feasibility studies, and partnership discussions to advance the project.
Polypore International provides an investor presentation for April 2009. The presentation summarizes Polypore's business segments, including its leading positions in energy storage and separations media. It also discusses Polypore's global infrastructure, solid 2008 financial performance, and the current macroeconomic environment. Polypore serves attractive end markets and has grown its revenue and adjusted EBITDA in recent years.
Range Resources Corporation is at an inflection point, with 2012 expected to see a significant increase in organic growth rate of 30-35% compared to its historical rate of 10% or less. The company has improved its capital efficiency through higher quality and lower cost wells, with drill bit reserve replacement over 800% and finding and development costs under $1/mcfe in 2011. Range has a large inventory of unproved resource potential across its areas that could support double-digit per share growth in production and reserves for years to come.
This document summarizes a presentation given by Tom O'Neill of Exelon Generation on the potential for a nuclear renaissance in the United States. It notes that while cost estimates for new nuclear plants range from $2400/kw to $4500/kw, a study showed that the levelized cost of electricity from new nuclear could be competitive even against other low-carbon alternatives. However, it acknowledges there is significant uncertainty around construction costs and timelines for new plants. Exelon advocates for policies that can help reduce risks and support long-term planning for new nuclear as one strategy in the nation's energy portfolio.
This document discusses Molycorp's plans to build a rare earth supply chain from mine to magnets. It highlights Molycorp's successful IPO in 2010 that raised $378.6 million. Construction has started on a new facility and mining has restarted at their Mountain Pass, California site. Their goal is to produce a range of rare earth elements, including lanthanum, cerium, neodymium, and dysprosium, which are critical components in technologies like wind turbines, electric vehicles, and water treatment. Molycorp aims to ramp production to 40,000 metric tons per year of rare earth oxides by 2012 to meet growing demand and establish a domestic rare earth supply chain.
"Choosing proper type of scaling", Olena SyrotaFwdays
Imagine an IoT processing system that is already quite mature and production-ready and for which client coverage is growing and scaling and performance aspects are life and death questions. The system has Redis, MongoDB, and stream processing based on ksqldb. In this talk, firstly, we will analyze scaling approaches and then select the proper ones for our system.
This document discusses maximizing profitability of PET production lines through world-scale process design and operations. Some key points:
- PET line sizes have increased dramatically over the past decade from 200 tons/day to 800-1000 tons/day due to economies of scale lowering costs from $900/ton to $200/ton.
- Maximizing equipment utilization, minimizing downtime, maintaining product quality, and efficient grade changes are critical for reducing costs of production.
- Modern solid-state polymerization (SSP) lines are designed for continuous operation like melt plants through preventative maintenance, isolation capabilities, and high-purity nitrogen environments.
- Proper management of process bottlenecks and optimization of
1) The document describes an I-Corps team exploring the development of bio-based chemical intermediates for polymer, bio-surfactants, and bio-lubricants.
2) The value proposition is to provide sustainable, bio-based replacements for non-renewable petroleum-derived feedstocks used in surfactants and lubricants with improved performance features.
3) Interviews with potential customers revealed the largest market opportunity is in surfactants, so the team pivoted their focus to developing drop-in monomers for the $24 billion surfactant market.
Greening our Planet, our Industry, our Community and our Company – a goal we ...Rally Software
This is a presentation Ryan Martens presented at the Rockies Venture Club. The point of the talk was to encourage folks to get started on the curve toward greening and that strategic and tactical benefits would come as well as personal benefits. I left folks with the pointers, on the last slide, to a number of the sources that are helping us up the curve.
Achieving Market Dominance through Technology Leadership -Cascade Microtech, Inc. is the leading provider of advanced probing systems, non-memory probes and sockets, from design through production
This webinar discussed polysilicon supply, demand, and implications for the global PV industry from 2012-2016. It provided an overview of polysilicon production technologies and their costs, noting that Siemens hydrochlorination is currently the lowest cost and most profitable option. The webinar also showed that despite oversupply, lower polysilicon prices will reduce solar module costs, benefiting the industry. A Q&A session followed the presentation.
This document outlines 10 hot topics in biomanufacturing: 1) product mix and business models in biopharma, 2) high-titer processes in mammalian cell culture, 3) downstream processing being driven by mass rather than volume, 4) facility fit considerations, 5) cost of goods and price margin pressures, 6) biosimilars and biobetters, 7) offshore manufacturing, 8) technology platforms and implications of high titer, 9) emerging technologies for biomass removal and contaminant clearance, and 10) single-use technologies and integrated processing. The speaker concludes by emphasizing the need for new perspectives and solutions to address challenges in biomanufacturing.
Cutting-edge Technologies in the Water Industry (Jan 2011)venturecenter
The document discusses various technologies for treating and reusing water, as well as reducing water loss. It provides information on companies developing technologies in areas like biological treatment, waste-to-energy conversion, and generating electricity from wastewater using microbial fuel cells. Examples of technologies highlighted include the Cellruptor process for sludge treatment, the HYBACS process for industrial wastewater, and the MEGAWATTER system which uses a bioelectrochemical process. The goal is to purify water, treat and reuse wastewater, and reduce water loss using innovative solutions.
Patrick Costello Green Guide Presentation Final 032112wlambert_2001
This document discusses various options for reducing the carbon footprint of data center energy consumption, including establishing an emissions baseline, setting reduction targets, and investing in energy efficiency, clean energy, and carbon offsets. It outlines categories of emissions and compares the carbon intensity of different power grid regions. Key options presented for reducing energy consumption related emissions include onsite solar and fuel cell systems, offsite renewable energy projects, renewable energy certificates, and carbon offsets. The document provides an overview of benefits, costs, and considerations for each option and emphasizes the importance of strategic combinations of solutions to maximize value and alignment with organizational goals.
The document discusses clean technology research and development initiatives and implementation. It outlines the process of moving clean technologies from basic research through applied research, demonstration, commercialization, and market adoption. Barriers at each stage are identified. Priority clean technology areas are mapped based on their estimated impact and investment required. An action plan is proposed to increase investments in clean technology, shift subsidies to these areas, establish supportive policies, and promote education.
REAL OPTIONS ANALYSIS OF MARGINAL OILFIELD DEVELOPMENT PROJECTS: THE CASE OF ...Theo Acheampong
This document summarizes a thesis that analyzed the use of real options analysis to evaluate marginal oilfield development projects in the UK. It began with an overview of real options analysis and its ability to account for management flexibility. It then described the concepts and methodology of real options analysis. The case study examined a sample UK marginal oilfield, valuing it using traditional discounted cash flow analysis and real options analysis to determine the value of deferral, expansion, and abandonment options. The main results found that accounting for these options through real options analysis increased the net present value compared to only using discounted cash flow analysis.
This document provides guidance on developing key elements of an environmental project proposal, including the problem statement, scope of project, proposal title, objectives, and relationship between sections in an experimental chapter. It discusses how to write each element concisely and accurately to clearly define the research problem and planned methodology. Examples are given for objectives related to three sample project topics on leachate treatment, agricultural waste composites, and phytoremediation.
Making Sense of Cost and Performance Estimates for Thermochemical Biofuel PlantsIlkka Hannula
Achieving deep reductions in CO2 emissions from today’s transportation system presents major challenges, given the dominant role played by crude-oil derived fuels. Advanced biofuels, produced sustainably, provide one potential path for deep emissions reductions.
A clear understanding of the prospective economics of advanced biofuels is thus important to support analysis aimed at informing public- and private-sector decision making on biofuels.
Many techno-economic studies of advanced biofuels have been published, but individual studies are often difficult for decision makers to evaluate because of differences in analytical methodologies, input-data uncertainties, scope and battery limits of the analysis, and key assumptions.
Using both literature and data from demonstration projects, we address the following questions for advanced thermochemical cellulosic biofuels: What will first-of-a-kind (FOAK) cellulosic biofuels cost, and What cost levels can be expected in the near-term?
For more information, go to http://www.thinkdsi.com/grid/.
With the current focus on building a smart grid and investments being made on the technology side as well as the infrastructure side, energy is certainly getting much press! Uncertainty has never been higher.
This webinar aims to discuss this uncertainty. Based on field research and expert interviews, the recent comprehensive report "Future of the Energy Grid 2025" by Decision Strategies International presents views on everything from fuel mix to behind-the-meter innovation. What could the grid look like in 2025? How will different stakeholders be affected? Scott Snyder, President, and Stephan Hagelauer, Senior Consultant, will present the key findings of the report, and give you tools and tactics to help you develop resilient strategies and robust portfolio initiatives to succeed in the energy industry.
Three executives representing stakeholders in the energy industry will present how they have used the report to help “future proof” their own organizations and discuss some of the factors they find critical to success:
-Karl Pfirrman, Executive Vice President of PJM
-Rear Admiral Phil Cullom in charge of the US Navy Energy Strategy
-Govi Rao, CEO of Lighting Science
Qna L6 S Project Aa Cmp Oxide Range Reduction (Oct 08)Norbert Gloser
The document summarizes a Lean Six Sigma project to improve the uniformity of a CMP oxide film thickness process at a wafer fabrication plant. The project team used DMAIC methodology to define the problem, measure current performance, analyze causes of non-uniformity, improve the process, and establish controls. Specifically, the team defined a goal of reducing oxide thickness variation from 550 angstroms to 320 angstroms to close 70% of the gap with a benchmarking site. The project was expected to yield $4.1 million in annual savings through increased chip output and yield.
The document discusses the multiple benefits of energy efficiency policies in the EU. It argues that such policies could save the EU at least €50 billion per year in foreign energy expenditures, which could be invested domestically instead. Energy efficiency also improves competitiveness and reduces energy poverty. Examples from Germany show that co-financing energy efficiency triggers large private investments. The document outlines various other benefits of energy efficiency including reduced emissions, transmission and distribution capacity savings, and avoided costs of reserves, generation, and transmission and distribution infrastructure.
20111114 Iron Road Annual General Meeting 2011ajstocks
The document provides an overview of Iron Road Limited's Central Eyre Iron Project (CEIP) in South Australia. It summarizes the results of the CEIP Prefeasibility Study which outlined a 12.4 million tonne per annum magnetite concentrate operation. It also discusses Iron Road's 2011 achievements including resource upgrades and community engagement efforts. Looking ahead, it outlines plans for 2012 including further resource drilling, feasibility studies, and partnership discussions to advance the project.
Polypore International provides an investor presentation for April 2009. The presentation summarizes Polypore's business segments, including its leading positions in energy storage and separations media. It also discusses Polypore's global infrastructure, solid 2008 financial performance, and the current macroeconomic environment. Polypore serves attractive end markets and has grown its revenue and adjusted EBITDA in recent years.
Range Resources Corporation is at an inflection point, with 2012 expected to see a significant increase in organic growth rate of 30-35% compared to its historical rate of 10% or less. The company has improved its capital efficiency through higher quality and lower cost wells, with drill bit reserve replacement over 800% and finding and development costs under $1/mcfe in 2011. Range has a large inventory of unproved resource potential across its areas that could support double-digit per share growth in production and reserves for years to come.
This document summarizes a presentation given by Tom O'Neill of Exelon Generation on the potential for a nuclear renaissance in the United States. It notes that while cost estimates for new nuclear plants range from $2400/kw to $4500/kw, a study showed that the levelized cost of electricity from new nuclear could be competitive even against other low-carbon alternatives. However, it acknowledges there is significant uncertainty around construction costs and timelines for new plants. Exelon advocates for policies that can help reduce risks and support long-term planning for new nuclear as one strategy in the nation's energy portfolio.
This document discusses Molycorp's plans to build a rare earth supply chain from mine to magnets. It highlights Molycorp's successful IPO in 2010 that raised $378.6 million. Construction has started on a new facility and mining has restarted at their Mountain Pass, California site. Their goal is to produce a range of rare earth elements, including lanthanum, cerium, neodymium, and dysprosium, which are critical components in technologies like wind turbines, electric vehicles, and water treatment. Molycorp aims to ramp production to 40,000 metric tons per year of rare earth oxides by 2012 to meet growing demand and establish a domestic rare earth supply chain.
"Choosing proper type of scaling", Olena SyrotaFwdays
Imagine an IoT processing system that is already quite mature and production-ready and for which client coverage is growing and scaling and performance aspects are life and death questions. The system has Redis, MongoDB, and stream processing based on ksqldb. In this talk, firstly, we will analyze scaling approaches and then select the proper ones for our system.
LF Energy Webinar: Carbon Data Specifications: Mechanisms to Improve Data Acc...DanBrown980551
This LF Energy webinar took place June 20, 2024. It featured:
-Alex Thornton, LF Energy
-Hallie Cramer, Google
-Daniel Roesler, UtilityAPI
-Henry Richardson, WattTime
In response to the urgency and scale required to effectively address climate change, open source solutions offer significant potential for driving innovation and progress. Currently, there is a growing demand for standardization and interoperability in energy data and modeling. Open source standards and specifications within the energy sector can also alleviate challenges associated with data fragmentation, transparency, and accessibility. At the same time, it is crucial to consider privacy and security concerns throughout the development of open source platforms.
This webinar will delve into the motivations behind establishing LF Energy’s Carbon Data Specification Consortium. It will provide an overview of the draft specifications and the ongoing progress made by the respective working groups.
Three primary specifications will be discussed:
-Discovery and client registration, emphasizing transparent processes and secure and private access
-Customer data, centering around customer tariffs, bills, energy usage, and full consumption disclosure
-Power systems data, focusing on grid data, inclusive of transmission and distribution networks, generation, intergrid power flows, and market settlement data
The Department of Veteran Affairs (VA) invited Taylor Paschal, Knowledge & Information Management Consultant at Enterprise Knowledge, to speak at a Knowledge Management Lunch and Learn hosted on June 12, 2024. All Office of Administration staff were invited to attend and received professional development credit for participating in the voluntary event.
The objectives of the Lunch and Learn presentation were to:
- Review what KM ‘is’ and ‘isn’t’
- Understand the value of KM and the benefits of engaging
- Define and reflect on your “what’s in it for me?”
- Share actionable ways you can participate in Knowledge - - Capture & Transfer
Must Know Postgres Extension for DBA and Developer during MigrationMydbops
Mydbops Opensource Database Meetup 16
Topic: Must-Know PostgreSQL Extensions for Developers and DBAs During Migration
Speaker: Deepak Mahto, Founder of DataCloudGaze Consulting
Date & Time: 8th June | 10 AM - 1 PM IST
Venue: Bangalore International Centre, Bangalore
Abstract: Discover how PostgreSQL extensions can be your secret weapon! This talk explores how key extensions enhance database capabilities and streamline the migration process for users moving from other relational databases like Oracle.
Key Takeaways:
* Learn about crucial extensions like oracle_fdw, pgtt, and pg_audit that ease migration complexities.
* Gain valuable strategies for implementing these extensions in PostgreSQL to achieve license freedom.
* Discover how these key extensions can empower both developers and DBAs during the migration process.
* Don't miss this chance to gain practical knowledge from an industry expert and stay updated on the latest open-source database trends.
Mydbops Managed Services specializes in taking the pain out of database management while optimizing performance. Since 2015, we have been providing top-notch support and assistance for the top three open-source databases: MySQL, MongoDB, and PostgreSQL.
Our team offers a wide range of services, including assistance, support, consulting, 24/7 operations, and expertise in all relevant technologies. We help organizations improve their database's performance, scalability, efficiency, and availability.
Contact us: info@mydbops.com
Visit: https://www.mydbops.com/
Follow us on LinkedIn: https://in.linkedin.com/company/mydbops
For more details and updates, please follow up the below links.
Meetup Page : https://www.meetup.com/mydbops-databa...
Twitter: https://twitter.com/mydbopsofficial
Blogs: https://www.mydbops.com/blog/
Facebook(Meta): https://www.facebook.com/mydbops/
"NATO Hackathon Winner: AI-Powered Drug Search", Taras KlobaFwdays
This is a session that details how PostgreSQL's features and Azure AI Services can be effectively used to significantly enhance the search functionality in any application.
In this session, we'll share insights on how we used PostgreSQL to facilitate precise searches across multiple fields in our mobile application. The techniques include using LIKE and ILIKE operators and integrating a trigram-based search to handle potential misspellings, thereby increasing the search accuracy.
We'll also discuss how the azure_ai extension on PostgreSQL databases in Azure and Azure AI Services were utilized to create vectors from user input, a feature beneficial when users wish to find specific items based on text prompts. While our application's case study involves a drug search, the techniques and principles shared in this session can be adapted to improve search functionality in a wide range of applications. Join us to learn how PostgreSQL and Azure AI can be harnessed to enhance your application's search capability.
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...Alex Pruden
Folding is a recent technique for building efficient recursive SNARKs. Several elegant folding protocols have been proposed, such as Nova, Supernova, Hypernova, Protostar, and others. However, all of them rely on an additively homomorphic commitment scheme based on discrete log, and are therefore not post-quantum secure. In this work we present LatticeFold, the first lattice-based folding protocol based on the Module SIS problem. This folding protocol naturally leads to an efficient recursive lattice-based SNARK and an efficient PCD scheme. LatticeFold supports folding low-degree relations, such as R1CS, as well as high-degree relations, such as CCS. The key challenge is to construct a secure folding protocol that works with the Ajtai commitment scheme. The difficulty, is ensuring that extracted witnesses are low norm through many rounds of folding. We present a novel technique using the sumcheck protocol to ensure that extracted witnesses are always low norm no matter how many rounds of folding are used. Our evaluation of the final proof system suggests that it is as performant as Hypernova, while providing post-quantum security.
Paper Link: https://eprint.iacr.org/2024/257
Northern Engraving | Nameplate Manufacturing Process - 2024Northern Engraving
Manufacturing custom quality metal nameplates and badges involves several standard operations. Processes include sheet prep, lithography, screening, coating, punch press and inspection. All decoration is completed in the flat sheet with adhesive and tooling operations following. The possibilities for creating unique durable nameplates are endless. How will you create your brand identity? We can help!
From Natural Language to Structured Solr Queries using LLMsSease
This talk draws on experimentation to enable AI applications with Solr. One important use case is to use AI for better accessibility and discoverability of the data: while User eXperience techniques, lexical search improvements, and data harmonization can take organizations to a good level of accessibility, a structural (or “cognitive” gap) remains between the data user needs and the data producer constraints.
That is where AI – and most importantly, Natural Language Processing and Large Language Model techniques – could make a difference. This natural language, conversational engine could facilitate access and usage of the data leveraging the semantics of any data source.
The objective of the presentation is to propose a technical approach and a way forward to achieve this goal.
The key concept is to enable users to express their search queries in natural language, which the LLM then enriches, interprets, and translates into structured queries based on the Solr index’s metadata.
This approach leverages the LLM’s ability to understand the nuances of natural language and the structure of documents within Apache Solr.
The LLM acts as an intermediary agent, offering a transparent experience to users automatically and potentially uncovering relevant documents that conventional search methods might overlook. The presentation will include the results of this experimental work, lessons learned, best practices, and the scope of future work that should improve the approach and make it production-ready.
Northern Engraving | Modern Metal Trim, Nameplates and Appliance PanelsNorthern Engraving
What began over 115 years ago as a supplier of precision gauges to the automotive industry has evolved into being an industry leader in the manufacture of product branding, automotive cockpit trim and decorative appliance trim. Value-added services include in-house Design, Engineering, Program Management, Test Lab and Tool Shops.
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectorsDianaGray10
Join us to learn how UiPath Apps can directly and easily interact with prebuilt connectors via Integration Service--including Salesforce, ServiceNow, Open GenAI, and more.
The best part is you can achieve this without building a custom workflow! Say goodbye to the hassle of using separate automations to call APIs. By seamlessly integrating within App Studio, you can now easily streamline your workflow, while gaining direct access to our Connector Catalog of popular applications.
We’ll discuss and demo the benefits of UiPath Apps and connectors including:
Creating a compelling user experience for any software, without the limitations of APIs.
Accelerating the app creation process, saving time and effort
Enjoying high-performance CRUD (create, read, update, delete) operations, for
seamless data management.
Speakers:
Russell Alfeche, Technology Leader, RPA at qBotic and UiPath MVP
Charlie Greenberg, host
How information systems are built or acquired puts information, which is what they should be about, in a secondary place. Our language adapted accordingly, and we no longer talk about information systems but applications. Applications evolved in a way to break data into diverse fragments, tightly coupled with applications and expensive to integrate. The result is technical debt, which is re-paid by taking even bigger "loans", resulting in an ever-increasing technical debt. Software engineering and procurement practices work in sync with market forces to maintain this trend. This talk demonstrates how natural this situation is. The question is: can something be done to reverse the trend?
This talk will cover ScyllaDB Architecture from the cluster-level view and zoom in on data distribution and internal node architecture. In the process, we will learn the secret sauce used to get ScyllaDB's high availability and superior performance. We will also touch on the upcoming changes to ScyllaDB architecture, moving to strongly consistent metadata and tablets.
[OReilly Superstream] Occupy the Space: A grassroots guide to engineering (an...Jason Yip
The typical problem in product engineering is not bad strategy, so much as “no strategy”. This leads to confusion, lack of motivation, and incoherent action. The next time you look for a strategy and find an empty space, instead of waiting for it to be filled, I will show you how to fill it in yourself. If you’re wrong, it forces a correction. If you’re right, it helps create focus. I’ll share how I’ve approached this in the past, both what works and lessons for what didn’t work so well.
[OReilly Superstream] Occupy the Space: A grassroots guide to engineering (an...
Acs 2010 Handout
1. “Downstream Processing 2.0:
From a Bottleneck to a Pacemaker”
Platzhalter Bild
ACS Biot 2010
Dr. Uwe Gottschalk, VP Purification
Technologies, Sartorius Stedim Biotech
2. What are the hot Topics?
6th Annual Survey of Biopharmaceutical Manufacturing.
Eric S. Langer, BioPlan Associates Inc.
3. Finally there seems to be a Bottleneck ...
6th Annual Survey of Biopharmaceutical Manufacturing.
Eric S. Langer, BioPlan Associates Inc.
5. Who is facing Limitations?
“Obviously there is no downstream bottleneck
if you have unlimited cash”
– K. John Morrow, Jr., PhD., 2009
6. Agenda
1.Improving throughput –
1.Improving throughput –
The Capacity Disconnect
The Capacity Disconnect
2.Process Economy – Cost
2.Process Economy – Cost
of Goods matter
of Goods matter
3.Discovering new Shores -
3.Discovering new Shores -
Fortune favors the Brave
Fortune favors the Brave
4.Benchmarks of the Future
4.Benchmarks of the Future
– No best, just better
– No best, just better
5.The Future of DSP –
5.The Future of DSP –
Revisiting the Past
Revisiting the Past
Data adapted from: F. Wurm Production of recombinant Protein Therapeutics
in Cultivated Mammalian Cells. Nature Biotechnology 22, 1-6 (2004)
7. Hot Topic: High Titer Processes
Improving Titres – MAbs (Bulk API)
Titre Improvements 4 Bioreactors
800
Important cost benefits as
titres go beyond 1g/L 700 Estimate of CoG based on
These diminish as we go 600
standard MAb process for
beyond 5g/L bulk drug substance
500
COG ($/g)
400
Beyond 5g/L 300
Downstream cost dominates
In this example the plateau 200
is just under $100/g 100
0
Challenge in DSP 0 2 4 6 8 10 12
Bioreactors decrease in size? Titre (g/L)
Cope with increased titres
2000L 5000L
Need to drive out costs
Implications for facility
design Results from Biopharm Services Generic MAb cost model
Bulk API Direct manufacturing costs
A universal cost model for single use systems in biomanufacturing.
Andrew Sinclair, BioPharm Services; Berlin Oct. 2007
8. DSP is Mass not Volume driven
Jim Davis, Lonza Economics of Monoclonal Antibody Production: The relationship between upstream titer and
downstream costs; IBC San Diego March 2008
11. Agenda
1.Improving throughput –
1.Improving throughput –
The Capacity Disconnect
The Capacity Disconnect
2.Process Economy – Cost of
2.Process Economy – Cost of
Goods matter
Goods matter
3.Discovering new Shores -
3.Discovering new Shores -
Fortune favors the Brave
Fortune favors the Brave
4. Benchmarks of the Future
4. Benchmarks of the Future
– No best, just better
– No best, just better
5.The Future of DSP –
5.The Future of DSP –
Revisiting the Past
Revisiting the Past
12. Challenges of a Modern Downstream Process
Technical challenge
Sensitive and technically demanding products require processes with inherent
complexity and expensive infrastructure
Need for robust & scalable processes for the entire DSP
Increasing regulatory scrutiny (Comparability!)
Financial challenge
Processes are fixed-cost driven (Investment vs Consumables)
Manufacturing costs 15 - 25% of sales price
Costs for DSP up to 75% of manufacturing costs
Cost Balance Benefit for innovative treatments
Biosimilars
18. Agenda
1.Improving throughput –
1.Improving throughput –
The Capacity Disconnect
The Capacity Disconnect
2.Process Economy – Cost
2.Process Economy – Cost
of Goods matter
of Goods matter
3.Discovering new Shores -
3.Discovering new Shores -
Fortune favors the Brave
Fortune favors the Brave
4.Benchmarks of the Future
4.Benchmarks of the Future
– No best, just better
– No best, just better
5.The Future of DSP –
5.The Future of DSP –
Revisiting the Past
Revisiting the Past
20. Downstream Processing 2010
“Le mieux est l’ennemi du bien”
(better is the enemy of good)
– Voltaire, 1772
“没有最好,只有更好”
(No best – only better)
– Chinese Movie Cliche
21. Companies are questioning current Standards
6th Annual Survey of Biopharmaceutical Manufacturing.
Eric S. Langer, BioPlan Associates Inc.
22. Off the Shelf Platform for Rapid Process Train Assembly
Cell Removal/
Cell Removal/ Intermediate
Intermediate Virus
Virus
Fermentation
Fermentation Capturing
Capturing Polishing
Polishing
Clarification
Clarification Purification
Purification Clearance
Clearance
Microorg. CEX HIC Size-Exclusion
Size-Exclusion
BHK X-FLow Mixed-Mode Ceramic HA AEX (B/E)
CHO
CHO Centrifuge
Centrifuge CEX Inactivation
Human Depthfilter
Depthfilter Protein A
Protein A Gelfiltration AEX (FT)
Hybridoma EBA AEX-Membrane
AEX-M Adsorption
CHO Centr./DF New Aprocess CEX
Protein AEX (FT) Orthogonal
New process train
train
New process train ready K. Konstantinov
Bayer Corp, USA
25. A Consensus – Value Chain in Bioseparation
High Titer Implications:
Increasing biomass and
contaminant levels
Protein A pool volumes
and step cost
DNA & HCP levels post
Capturing
Polishing load volumes
and conductivity
Pathogen clearance as a
moving target
26. Agenda
1.Improving throughput –
1.Improving throughput –
The Capacity Disconnect
The Capacity Disconnect
2.Process Economy – Cost
2.Process Economy – Cost
of Goods matter
of Goods matter
3.Discovering new Shores -
3.Discovering new Shores -
Fortune favors the Brave
Fortune favors the Brave
4.Benchmarks of the Future
4.Benchmarks of the Future
– No best, just better
– No best, just better
5.The Future of DSP –
5.The Future of DSP –
Revisiting the Past
Revisiting the Past
27. Biomass Removal and Early Contaminant Clearance
addresses:
Increasing biomass and
contaminant levels
DNA & HCP levels post
Capturing
• New generation of lenticular
filtration media
• No Diatomeaceous Earth;
Synthetic
• Cell removal, clarification &
early on contaminant removal
28. The Focus on Column Chromatography is increasing
6th Annual Survey of Biopharmaceutical Manufacturing.
Eric S. Langer, BioPlan Associates Inc.
29. Packed Bed Chromatography: The Good The Bad and The Ugly
John Curling and Uwe Gottschalk
BioPharm Intl. October 2007
U. Gottschalk. Bioseparation in antibody manufacturing:
The good, the bad and the ugly.
Biotechnol Prog. 2008 May-Jun;24(3):496-503.
32. Hot Topic: Cost of Capturing
6th Annual Survey of Biopharmaceutical Manufacturing.
Eric S. Langer, BioPlan Associates Inc.
33. addresses:
Protein A pool volumes
and step cost
D. Low BioManufacturing Paris 2007
34. Two Birds –one Stone: Contaminant Precipitation
at Pfizer addresses:
Protein A pool volumes
and step cost
DNA & HCP levels post
Capturing
35. Three Birds – one Stone: Contaminant Precipitation at Medarex
addresses:
Fig 7a. precipitation based process Fig 7b. TFF based process
Contaminant Protein A pool volumes
TFF
precipitation and step cost
DNA & HCP levels post
CEX HCP < 10ng/mg Capturing < 1000 ng/mg
CEX HCP
Dilution Polishing load volumes
Dilution
and conductivity
Q Membrane Q Membrane HCP < 1000 ng/mg
HCP BDL 2 g/ml
20 g/ml
Dilution
VF
Mix Mode
Precipitation of Process-Derived Impurities in Non-Protein A VF
Purification Schemes for MAb; J. Wang et al. BioPharm Intl. 10/2009, 2-9
36. Hot Topic: Polishing load volume/conductivity
addresses:
Polishing load volumes
and conductivity
• Salt Tolerant Interaction
Chromatography (STIC)
• New cellulose-based
membrane structure
• Primary instead of
quartenary amine ligand
37. Results so far achieved:
No CHOP-breakthrough at 10 kg MAb/ L of membrane
> 4.96 LRV for MMV at 150m mM NaCl.
38. Downstream Costs: Why bother?
Jim Davis, Lonza Economics of Monoclonal Antibody Production: The relationship between upstream titer and
downstream costs; IBC San Diego March 2008
39. Will Protein A Capturing ever be Single-Use?
2000: Oleosin Platform 2005: TMV Nanoparticles 2010: Bio Polyester Platform
Polyester
Synthase
Polyester Granule
Immunoabsorbent nanoparticles based on a 100-300 nm
tobacco mosaic virus displaying protein A
Limitation: Oleosin yields < 1kg/ha S. Werner et al. PNAS 103, 17678 - 17683
Grage, K. and Rehm, B.H.A. (2008)
Bioconj. Chemistry, 19(1):254-62.
43. The problem: Virus filters shows low Vmax and Flow Rate for blocking Feed Streams
Vmax 200 – 1000 L/m²
50 -100 L/m2.h.bar
low or moderatly blocking
e.g. MAb
Vmax <100 L/m²
Vmax2
5 - 30 L/m2.h.bar
highly blocking
e.g. IVIG, Enbrel
44. Agenda
1.Improving throughput –
1.Improving throughput –
The Capacity Disconnect
The Capacity Disconnect
2.Process Economy – Cost
2.Process Economy – Cost
of Goods matter
of Goods matter
3.Discovering new Shores -
3.Discovering new Shores -
Fortune favors the Brave
Fortune favors the Brave
4.Benchmarks of the Future
4.Benchmarks of the Future
– No best, just better
– No best, just better
5.The Future of DSP –
5.The Future of DSP –
Revisiting the Past
Revisiting the Past
45. The Renaissance of Protein Purification
Michelangelo de Lodovico Buonarotti
46. Old Enabling Technology: Boring but Reliable
• Centrifugation
• Extraction
• Precipitation
• Filtration
• Crystallization
• UV-Inactivation
47. Downstream Processing 2010+
“The real voyage of discovery consists not
in seeking new landscapes
but in having new eyes.”
Marcel Proust.