The American Heart Association recommends a triglyceride level of 100 mg/dL or lower as optimal for heart health. While drug treatment is not usually recommended to reach this level, lifestyle changes such as diet, weight loss, and physical activity are encouraged to lower triglycerides through natural means, as triglycerides typically respond well to dietary and lifestyle modifications. High triglyceride levels are often caused by conditions like obesity, diabetes, thyroid issues, kidney disease, or excessive alcohol intake, and increasing physical activity, controlling weight and diet, limiting alcohol and sugars can help to reduce blood triglyceride levels.