This study evaluated the short-term clinical and radiographic outcomes of 64 patients who underwent biological resurfacing of the glenoid with a dermal graft and humeral head resurfacing. At a minimum of 2 years follow-up, patients demonstrated improvements in pain, range of motion, and function based on standardized scores. Radiographically, the procedure improved glenoid version and centering of the humeral head in patients with preoperative subluxation. One patient required revision to a polyethylene glenoid. The authors concluded that biological resurfacing may be a viable alternative to polyethylene resurfacing in young, active patients with glenohumeral osteoarthritis.