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Open Platforms Drive Collaborative Discovery
- 1. Open Platforms for Collaborative Discovery richard j. bookman rbookman@miami.edu 2012 AAHC ELG Meeting Washington, DC 6 December 2012
- 3. NIH Purchasing Power – 2003-2013 NIH Purchasing Power – 2003-2013 $32 $31.0 $30.5 $30.7 $30.6 $30.7 $30 $29.3 $29.0 $27.9 $28.5 $28.5 $27.1 $28 $26.9 $26.4 Billions $25.3 $26 $24.8 $23.9 $24.2 $23.9 $24 $23.0 $22.4 $21.9 $22 $20 $18 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 Current Constant (BRDPI) Senate Labor-HHS BA only Labor-HHS NIHonly Sources: BA Budget Office; House and Senate Appropriations Committees Sources: NIH Budget Office; House and Senate Appropriations Committees
- 6. Over the past decade, before pursuing a particular line of research, scientists (including C.G.B.) in the haematology and oncology department at the biotechnology firm Amgen in Thousand Oaks, California, tried to confirm published findings related to that work. Fifty- three papers were deemed 'landmark' studies. It was acknowledged from the outset that some of the data might not hold up, because papers were deliberately selected that described something completely new, such as fresh approaches to targeting cancers or alternative clinical uses for existing therapeutics. Nevertheless, scientific findings were confirmed in only 6 (11%) cases. Even knowing the limitations of preclinical research, this was a shocking result.
- 7. you may ask yourself… …how did we get here?
- 8. research 1.0 who’s doing research? who’s paying for research? how is research organized? how is research communicated?
- 9. Newton Darwin Einstein
- 10. research 1.0 who’s doing research? who’s paying for research? how is research organized? how is research communicated?
- 11. research 2.0 who’s doing research? who’s paying for research? how is research organized? how is research communicated?
- 13. research 2.0 who’s doing research? who’s paying for research? how is research organized? how is research communicated?
- 15. research 2.0 who’s doing research? who’s paying for research? how is research organized? how is research communicated?
- 17. 2012: a tipping point year? Majority of computers sold are smartphones 50% of all US book* sales are e-books Online movie views surpass in-theatre views 3-D printers fall below $1000 & self-replicate! * non-textbook sales
- 18. research 3.0 ?
- 19. Our challenge
- 20. “Institutions seek to preserve the problem for which they are the solution.” - Clay Shirky
- 21. Research 3.0 who’s doing research? who’s paying for research? how is research organized? how is research communicated?
- 24. Research 3.0 who’s doing research? who’s paying for research? how is research organized? how is research communicated?
- 28. Research 3.0 who’s doing research? who’s paying for research? how is research organized? how is research communicated?
- 31. Research 3.0 who’s doing research? who’s paying for research? how is research organized? how is research communicated?
- 32. 3 = 1+2
- 33. 3 > 1+2
- 34. platforms: weather GPS google maps
- 35. re-useful is the new useful
- 37. open platforms for collaborative discovery
- 39. end
- 40. Some emerging trends in research communications http://altmetrics.org http://force11.org http://www.executablepapers.com/
- 41. orphans
- 42. ”…a new platform can be said to succeed when your customers and partners build new features before you do.” Tim O’Reilly
- 48. Vannevar Bush
- 50. NIH Grant Success Rates FY 1978-2012
- 51. 2012: 1.0 megapub per year… …and that’s just medline.
- 52. source: David Browdy, Northwestern
Editor's Notes
- Goal of talk – stimulate thinking about how we need to evolve the research enterpriseRichter image is a hint that I’ll often be using a VERY broad brush!This is a talk about the research enterprise.Numerous reports out in the last year or so, but few have the focus of my remarks today.Image is Gerhard Richter painting.http://www.gerhardrichterpainting.com/wp-content/uploads/2012/01/gerhardrichter_photo3.jpg
- http://4.bp.blogspot.com/-flNnHy6l9Nc/T-nt716AI4I/AAAAAAAAGxQ/QWTLtCfUNsE/s1600/alltheyear3.jpg
- http://blogs-images.forbes.com/matthewherper/files/2011/06/BCG-bernstein-drug-approvals-per-dollar.jpg
- Nature 483 531-533 (29 March 2012) doi:10.1038/48351ainteresting comment in May, 2012….can’t disclose which papers bec/ of confidentiality agreements between Amgen and authors of the original papers.
- David Byrne, Talking Heads, “Stop Making Sense”
- 1643-1727
- Watson & Crick at Cavendish Lab at CambridgeThomson & Ritchie at Bell Labs LHC @ Cern
- Big bang of the digital universe as described by George Dyson…..Turing’s Cathedral1953: the total global inventory of RAM was 53 kb…..about 3.2 seconds of an mp3 music file.Today, global DRAM production is ~3*10**8kB/sec
- What is the impact of the internet on the research enterprise??What are some of the key processes that are unleashed?
- Also, 2012 is the year when PubMed indexes more than 1 million pubs/year
- Clay Shirky is at NYU.
- …within 24 hours of launch we were stunned to be receiving almost 70,000 classifications an hour. In the end, more than 50 million classifications were received by the project during its first year, contributed by more than 150,000 people.from: http://www.galaxyzoo.org/#/story
- http://patientslikeme.com
- http://medstartr.com
- http://www.kaggle.com/16 July 2012
- Summmarize hints of 3.0 for each area…
- they call it re-search for a reason…
- https://synapse.sagebase.org/
- http://www.ebay.com/itm/Change-Good-You-go-First-Funny-Sarcasm-Button-/160554822338?pt=LH_DefaultDomain_0&var=&hash=item6b1b442394
- Comment at GE Industrial Internet conference. November, 2012.
- Translation is supposed to get us across the valley of death…
- But something Is amiss….
- This course will probably not turn you all into riders of death valley…