Dental implants have been used for thousands of years to stabilize or replace missing teeth. The Egyptians began using gold wire to stabilize teeth as early as 2500 BC. The Mayans in 600 AD used pieces of shell in the lower jaw as some of the first true implants. In the 16th century, European doctors implanted human teeth sourced from cadavers into patients, gaining understanding of how blood vessels can grow into teeth. Modern dental implant technology builds on this long history of using implant-like structures to replace missing teeth.