My M Sc Thesis
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Title: New angular pyrroloquinolinones as potential photochemiotherapic agents: study of the mechanism of action.
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![Introduzione: Furocumarine 8-metossipsoralene (8-MOP) Angelicina Pirido[3,4-c]psoralene Benzo[4’,5’-d]psoralene Pirrolo[3,2,1-ij]chinolin-4-one 4,7-dimetilfuro[2,3-g]chinolin-2-one](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
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My M Sc Thesis
- 1. Nuovi pirrolochinolinoni angolari quali potenziali agenti fotochemioterapici: studio del meccanismo d’azione.
- 2. Introduzione: Furocumarine 8-metossipsoralene (8-MOP) Angelicina Pirido[3,4-c]psoralene Benzo[4’,5’-d]psoralene Pirrolo[3,2,1-ij]chinolin-4-one 4,7-dimetilfuro[2,3-g]chinolin-2-one
- 3. Pirrolo[2,3- h ]chinolin-2-oni B-86 B-87 B-88 B-89 B-94 B-95 B-96 B-120 (lead compound)
- 6. Solubilità e coefficienti di ripartizione
- 7. Rese quantiche di fluorescenza B-86
- 9. Determinazione dell’attività antiproliferativa (HT-1080)
- 12. Fotodegradazione dei composti (photobleaching)
- 14. Caratterizzazione dei fotoprodotti: LC/TOF-MS (B-86)
- 15. LC-TOF/MS (B-86)
- 16. Spettri di assorbimento dei fotoprodotti
- 18. Produzione di specie reattive dell’ossigeno Produzione di 1 O 2 mediante RNO bleaching. Produzione di O 2 -. attraverso il saggio dell’NBT.
- 19. Microscopia ad epifluorescenza * Per capire dove i pirrolochinolinoni agissero si è effettuata una localizzazione intracallulare tramite microsc. ad epifl. B-86 B-95 B-96 U.V. Campo chiaro
- 20. Localizzazione intramitocondriale tramite TMRM (B-88) B-88 TMRM B-88 + TMRM
- 21. Localizzazione intralisosomiale tramite acridina orange (B-88) B-88 AO B-88 + AO
- 24. Elettroforesi orizz. su gel di agarosio (plasmide pBR322) Controllo B-86 B-88
- 26. Elettroforesi verticale su gel di acrilammide (fotodanno alle proteine di membrana) In condizioni aerobiche avviene la polimerizzazione proteica In condizioni anaerobiche non si assiste alla formazione di legami crociati
- 28. Dicroismo circolare 0 20 Albumina RNAasi
- 35. *Caratterizzazione dei fotoprodotti2 Cinetiche di fotodegradazione di alcuni pirrolochinolinoni studiati.
- 36. Localizzazione cellulare dopo irradiazione U.V. B.F.