1. This document discusses the treatment and management of hepatitis B in Taiwan. It provides guidelines for the treatment of hepatitis B based on disease severity and stage. 2. The guidelines outline 9 treatment criteria based on factors like HBeAg status, ALT levels, liver stiffness measurements, and genotype. First-line treatments recommended are pegylated interferon-alfa or nucleoside analogues like entecavir and tenofovir. 3. The guidelines aim to help eradicate hepatitis B in Taiwan through effective disease management and treatment according to the criteria provided. Regular monitoring of disease markers and liver function is important to determine treatment response and progression.

1. B
B
21.8%
14.2%
B
1997
(Lamivudine) B
2015 B
( Entecavir,
Tenofovir )
(Pegylated-IFN- alfa) B
( )
HBsAg ( 3-5%)
(<1%)
HBeAg
HBeAg
HBeAg ALT
genotype A

2. ( )
B :
(Pegylated-IFN-
alfa)
(Entecavir
Tenofovir)
( <2000 IU/ml)
ALT
(undetectable)
ALT
48
B
: ( )
( ) ALT
( )
1.
2.
>2000 IU/ml .
3.
( prothrombin
time prolonged by more than 3seconds)
INR 1.5
4.
ALT > 2 X upper limt of normal
(ULN) ( )
HBeAg
>20,000 IU/ml HBeAg
>2000 IU/ml
5. (HBeAg
>20,000 IU/ml
HBeAg
>2000 IU/ml) ALT
< 2 X upper limt of normal (ULN)
Fibroscan
APRI
35
;

3. 6. HBeAg
< 20,000 IU/ml
35 ;
7. HBeAg
< 2000 IU/ml
35
;
8.
Fibroscan
Mean liver stiffness 8 kPa
APRI 1.5
9.
( Tenofovor or Enteca-
vir)
Tenofovir
Tenofovir
Entecavir
Entecavir
1.2%
Tenofovir Entecavir
(<
1%)
1%
Hypophosphatemia ( < 2g/ml )
Entecavir Class
C
Tenofovir
Class B
B

4. 1.Towards the eradication of hepatitis B in
Taiwan.
Suzanne Wait a, Ding-Shinn Chen b,
a SHW Health Ltd, London, United Kingdom
b Department of Internal Medicine, Hepatitis
Research Center and Graduate Institute of
Clinical Medicine,
National Taiwan University College of
Medicine and National Taiwan University
Hospital, Taipei, Taiwan
Kaohsiung Journal of Medical Sciences (2012)
28, 1-9.
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management of hepatitis B: a 2015 update.
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Hepatol Int (2016) 10:1–98