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Need Drugs?
Normal State
Monoamine theory   (iproniazid, 1950-irreversible MAO I) [NE] low Depressive State
Biosynthesis of  Neurotransmitters  (acetylcholine and monoamines)
Projections of Norepinephrine Containing Neurons in the  Locus Coeruleus
[NE] Treatment State (I)
[NE] Treatment State (II) *Increase [NE],  [5-HT] or [DA]
Monoamine transporter NE
Serotonin (5-HT) Transporter Polymorphism Missense mutation Obsessive-compulsive disorder (Molecular Psychiatry 2003: 8, 933-936)
Autoreceptor Desensitization
 
3 5 4 1 2 R S R N R D
 

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