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Curare and Related Compounds George Hsiao 2008
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北城醫院事件(atracurium) Mistake of Hepatitis vaccination, 2002
I: Neuromuscular Junction (NMJ)
NMJ
(a) Muscular site
 
 
(b) Motor neuron Site Motor neuron axon innervation
Nicotinic receptor Local events
Neuromuscular Junction & Neurotransmission
Whole Story
II. Muscular Nicotinic Receptor
 
 
Nicotinic-Nn and Nm
 
 
 
 
 
 
III. NMJ Blockers
 
 
 
 
The therapeutic uses of NMJ blocking are as follows:      To serve as  an adjunct to general anesthetics  during surgery, when reflex muscle movement could interfere with the surgical procedure or the delivery of gas anesthesia.    To facilitate  mechanical intubation  by preventing resistance to passing the endotracheal tube and in situation in which patients “fight” or resist the respirator.      To facilitate  electroconvulsive therapy  when intense skeletal muscle contractions as a result of electric shock could cause the patient broken bones or other injury.
IV. Acetylcholinesterase and its Inhibitor
 
 
 
 
 
 
AChE reactivator: Pralidoxime (PAM)

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