Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.
Curare and Related Compounds George Hsiao 2008
<ul><li>Hans Zatzka, Austrian painter (1859-1945) </li></ul>
北城醫院事件(atracurium) Mistake of Hepatitis vaccination, 2002
I: Neuromuscular Junction (NMJ)
NMJ
(a) Muscular site
 
 
(b) Motor neuron Site Motor neuron axon innervation
Nicotinic receptor Local events
Neuromuscular Junction & Neurotransmission
Whole Story
II. Muscular Nicotinic Receptor
 
 
Nicotinic-Nn and Nm
 
 
 
 
 
 
III. NMJ Blockers
 
 
 
 
The therapeutic uses of NMJ blocking are as follows:      To serve as  an adjunct to general anesthetics  during surgery,...
IV. Acetylcholinesterase and its Inhibitor
 
 
 
 
 
 
AChE reactivator: Pralidoxime (PAM)
Upcoming SlideShare
Loading in …5
×

Nmj Nov08

519 views

Published on

Published in: Health & Medicine
  • Be the first to comment

  • Be the first to like this

Nmj Nov08

  1. 1. Curare and Related Compounds George Hsiao 2008
  2. 2. <ul><li>Hans Zatzka, Austrian painter (1859-1945) </li></ul>
  3. 3. 北城醫院事件(atracurium) Mistake of Hepatitis vaccination, 2002
  4. 4. I: Neuromuscular Junction (NMJ)
  5. 5. NMJ
  6. 6. (a) Muscular site
  7. 9. (b) Motor neuron Site Motor neuron axon innervation
  8. 10. Nicotinic receptor Local events
  9. 11. Neuromuscular Junction & Neurotransmission
  10. 12. Whole Story
  11. 13. II. Muscular Nicotinic Receptor
  12. 16. Nicotinic-Nn and Nm
  13. 23. III. NMJ Blockers
  14. 28. The therapeutic uses of NMJ blocking are as follows:      To serve as an adjunct to general anesthetics during surgery, when reflex muscle movement could interfere with the surgical procedure or the delivery of gas anesthesia.  To facilitate mechanical intubation by preventing resistance to passing the endotracheal tube and in situation in which patients “fight” or resist the respirator.      To facilitate electroconvulsive therapy when intense skeletal muscle contractions as a result of electric shock could cause the patient broken bones or other injury.
  15. 29. IV. Acetylcholinesterase and its Inhibitor
  16. 36. AChE reactivator: Pralidoxime (PAM)

×