3. A Peace Corps physician is stationed in a small area of the Carpathian Mountains. A few of her patients have hemolytic ancmia- -inemia that results from fragile red blood cell membranes that rupture easily. These patieats have a mutation in the gene A K l (adenylate kinase). A K l is on chromosome 9 and is linked to the gene encoding the ABO blood group (locus h ). Here are the genotypes and phenotypes for different blood types (we are not considering the Bombay phenotype): Both I A and I l alleles are dominant over i . The I A and I B alleles are co-dominant. Here is a pedigree with affected individuals indicated in black. The two alleles at the AKl locus are A (dominant, wild type) and a (recessive, mutant). The blood types for this family are also noted on this pedigree. A. What are the two possible ways to write the genotype of individual I-3 at the A K I and I loci with phase information? Remember to use horizontal parallel lines or a " p " 6 indicate the orientation of the pairs of alleles on different bomologs (phase). B. What is the genotype of individual 1.4 at the AKI and I loci? Is there any ambiguity as to the phase of I 4 ? C. What is the genotype of individual II-I at the A K l and / loci? Which alleles of each gene are carried on the chromosome he inherited from his father, and which alleles are carried on the chromosome he inberited from his mother? D. Individuals If-1 and I1-2 just had a baby boy who has blood type B and hemolytic anemia. (Put him on the pedigree above.) Explain how this could happen by drawing a diagram of meiosis in individual II-1. Include drawings of boch chromosome 9 and the sex chromosomes ( X and Y ) .
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3- A Peace Corps physician is stationed in a small area of the Carpath.docx
1. 3. A Peace Corps physician is stationed in a small area of the Carpathian Mountains. A few of
her patients have hemolytic ancmia- -inemia that results from fragile red blood cell membranes
that rupture easily. These patieats have a mutation in the gene A K l (adenylate kinase). A K l is
on chromosome 9 and is linked to the gene encoding the ABO blood group (locus h ). Here are
the genotypes and phenotypes for different blood types (we are not considering the Bombay
phenotype): Both I A and I l alleles are dominant over i . The I A and I B alleles are co-
dominant. Here is a pedigree with affected individuals indicated in black. The two alleles at the
AKl locus are A (dominant, wild type) and a (recessive, mutant). The blood types for this family
are also noted on this pedigree. A. What are the two possible ways to write the genotype of
individual I-3 at the A K I and I loci with phase information? Remember to use horizontal
parallel lines or a " p " 6 indicate the orientation of the pairs of alleles on different bomologs
(phase). B. What is the genotype of individual 1.4 at the AKI and I loci? Is there any ambiguity
as to the phase of I 4 ? C. What is the genotype of individual II-I at the A K l and / loci? Which
alleles of each gene are carried on the chromosome he inherited from his father, and which
alleles are carried on the chromosome he inberited from his mother? D. Individuals If-1 and I1-2
just had a baby boy who has blood type B and hemolytic anemia. (Put him on the pedigree
above.) Explain how this could happen by drawing a diagram of meiosis in individual II-1.
Include drawings of boch chromosome 9 and the sex chromosomes ( X and Y ) .
