2018 Next Generation Biopharmaceutical Downstream Processing Symposium

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Are you ready to take your bioprocessing strategy to the next level? Register now for the Next Generation Biopharmaceutical Downstream Processing Symposium: http://bit.ly/2C0xFF6 Date: Tuesday, March 27th, 2018 Location: NIBRT, Fosters Avenue, Mount Merrion, Blackrock, Co. Dublin, IRELAND

Healthcare

Join us to learn more about the project objectives:
• Implement a fully integrated manufacturing platform based on continuous chromatography
• Learn single-use disposable techniques for all unit operations of DSP sequence for mAbs at
pilot or small production scale
• Incorporate advanced analytical tools into your process
Presentation Topics
• Primary separation: substitution of the standard process for primary separation with the utilization of
flocculants and Tangential Flow Filtration (TFF).
• Continuous capture step: integration of continuous chromatography in the capture step and development
of novel disposable equipment for larger scale. Additionally non-chromatographic capture step alternatives,
such as continuous precipitation.
• Disposable DSP: evaluation of single-use disposable solutions for flow-through polishing steps for efficient
removal of impurities and single pass TFF (SPTFF) as continuous product concentration approach.
• Advanced analytical tools: different tools for measuring impurities, product content and other parameters
in real time or close to real time.
To register for the event, please contact Alison Quinn: alison.quinn@nibrt.ie
Learn more about the nextBioPharmDSP project: http://nextbiopharmdsp.eu
Register Now
Next Generation Biopharmaceutical Downstream
Process (nextBioPharmDSP) Symposium
Date: Tuesday, March 27th, 2018
Location: NIBRT, Fosters Avenue, Mount Merrion, Blackrock, Co. Dublin, IRELAND
Primary separation Capture VF UF/DFIntermediate / polishingBioreactor
Bioreactor
Bioreactor
with
Flocculation
Filtration
Continuous Chrom
Carbon f/t
device
AEX f/t
device
CEX f/t
device
PrecipitationTFF
Centrifuge Filtration Protein A
Cation
Exchange
Bind/Elute
Cation
Exchange
Bind/Elute
Anion Exchange
Traditional Approach
Flow-through
Anion Exchange
Traditional
Approach
Flow-through
The life science business of Merck operates as
MilliporeSigma in the U.S. and Canada.
© 2018 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved. Merck and
the vibrant M are trademarks of Merck KGaA, Darmstadt, Germany. All other trademarks are the
property of their respective owners. Detailed information on trademarks is available via publicly
accessible resources.
This project has received funding from the European Union's Horizon 2020 research and
innovation program under grant agreement No 635557.

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