This keynote lecture reviews the historical and ongoing investments in public-private partnerships related to precision medicine and the related technological infrastructures. It served as example to the Danish community how translational biomarkers in precision medicine can be organised, as basis for further collaboration between Denmark and Netherlands.

1. Developing a shared infrastructure for
personalised health and medicine research:
experience from the Netherlands
International Conference on
Perspectives in Precision
Medicine
Copenhagen, 1 March 2018
Prof Alain van Gool

2. The Dutch way of collaborating
2 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
Source: www.waterschappen.nl
Source: www.leestekensvanhetlandschap.nl
Source: http://www.deltawerken.com

3. 30 April 2009 A-STAR biomarker seminar, Singapore
The Dutch way of
collaborating

4. Collaboration is key to advance in health research
Dutch CC meeting ‘Personalized Health Care”
Ede, 2 October 2013
Alain van Gool
Lecture LKCH, UMC Utrecht
29 October 2013
Alain van Gool
Knowledge
validation &
application
Knowledge
translation
Knowledge
exploitation
Fundamental
knowledge
Universities IndustryUniversity medical
centers
Applied Research
Institutes
4 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

5. Collaboration is key to advance in health research
Dutch CC meeting ‘Personalized Health Care”
Ede, 2 October 2013
Alain van Gool
Lecture LKCH, UMC Utrecht
29 October 2013
Alain van Gool
Knowledge
validation &
application
Knowledge
translation
Knowledge
exploitation
Fundamental
knowledge
Universities IndustryUniversity medical
centers
Applied Research
Institutes
5 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

6. Money fuels collaboration
Dutch CC meeting ‘Personalized Health Care”
Ede, 2 October 2013
Alain van Gool
Lecture LKCH, UMC Utrecht
29 October 2013
Alain van Gool
6 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

7. Highlights discussed today
• Netherlands Genomics Initiative (NGI)
• Public Private Partnerships (TIP, CTMM, BMM)
• Topsector Life Science Health (Health~Holland)
• Dutch Techcenter for Life Sciences (DTL)
• Dutch National Research Agenda (NWA)
• Radboudumc Technology Centers (RTC)
• Large scale technology Infrastructures (X-omics)
• Dutch infrastructure for personalized
medicine and health research (Health-RI)
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8. Funding large scale Netherlands technological networks
2002-20103
8 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

9. Funding large public-private partnership programs
(Centre for Translational Molecular Medicine) (Top Institute Pharma)
(BioMolecular Materials)
2006-2015
9 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

10. Funding large public-private partnership programs
(Centre for Translational Molecular Medicine) (Top Institute Pharma)
(BioMolecular Materials)
2006-2015
Outcome:
1. Results (drugs, diagnostics, devices)
2. Culture change in Netherlands
10 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

11. 11 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
Redefine private interest in Public-Private Partnerships
{www.rijksoverheid.nl}
{http://www.zonmw.nl/nl/roadmaps-lsh/}
Roadmap Molecular Diagnostics:
• Build an efficient biomarker development pipeline in Netherlands
• Bring all stakeholders together in a functional open innovation
network based on public-private-partnerships
• Have end-users (patients) direct biomarker discovery in beginning
• Improve progress of biomarkers from discovery to clinical
implementation
9 TopSectors Multiple Roadmap teams per TopSector
2011-2012

12. Science for Science
Science for Industry
Science for Society
Strategy building
Nico van Meeteren
Email: meeteren@health-holland.com

13. Ambitions

14. Dutch Delta
Buck Consultatnts international, 2016

15. Growth
2017 2017

16. Growth

17. An ‘aligned’ cluster reaching out
37 applied universities
69 vocational education
institutes
“If ‘I’ is replaced by ‘we’,
even illness turns into wellness”

18. Redefine private interest in Public-Private Partnerships
{www.rijksoverheid.nl}
{http://www.zonmw.nl/nl/roadmaps-lsh/}
9 TopSectors Multiple Roadmap teams per TopSector
2011-2012
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19. DUTCH TECHCENTER FOR LIFE SCIENCES
NL platform enabling cross-disciplinary research

20. PARTNERSHIP FOR DATA, TECHNOLOGIES & LEARNING

21. >100 EXPERT GROUPS INVOLVED SO FAR
Nijmegen
Amsterdam
Wageningen
Utrecht
Rotterdam
Eindhoven
Maastricht
Groningen
Leiden
Delft
Enschede
Zeist
Hanze University
University Groningen
UMCG
Hubrecht Institute
UMCU
Utrecht University
Wageningen UR
PRI
TU Twente
Radboudumc
Radboud University
Maastricht Univ.
MUMC+
CTMM
TUe
ErasmusMC
Generade
LUMC
Leiden University
Naturalis
TUDelft
AMC
AMOLF
CWI
NLeSC
NKI
SURFSARA
University of Amsterdam
VU University Amsterdam
VUMC
TNO
20
17
44
13 1
15
6
4
5
1
9
Technology & data
hotels
 Access to high-tech
expertise & facilities
 Wetlab & data facilities
 Collections of
biosamples/cohorts
 Public and private labs
 Training & education
High-quality
 experimental design
 measuring
 data stewardship
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22. Enabling Technology Hotels
program
www.dtls.nl
www.zonmw.nl
• Explore and use the DTL network
• 4 rounds of funding 30k projects
• Total 4,2M euro
• 5 page proposals
• 50% success rate
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23. FOCUS ON CRITICAL COMPONENT: THE DATA
{Wilkinson et al, Nature Scientific Data, 2016}
 Data capture
 Data stewardship (FAIR)
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24. FAIR EVOLVING RAPIDLY INTO A GLOBAL MOVEMENT
Rapid acceptance and endorsement process
✓ The conference
✓ The Website
✓ Research Data Alliance endorsement
✓ DTL flagship project
✓ FORCE11 international partner
✓ Articles accepted in NATURE
✓ NIH accepts FAIR compliance in Life Sciences Commons
✓ DTL Data lead Prof. Barend Mons Chair High Level Expert Group EC
✓ The Personal Health Train Initiative started
✓ EC announces European Open Science Cloud with FAIR as leading principle
World 2017
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25. ALSO THE G20 HAS RECENTLY ADOPTED FAIR!
“We support appropriate efforts to promote open science and facilitate
appropriate access to publicly funded research results on findable, accessible,
interoperable and reusable (FAIR) principles.” (Statement 12)
http://europa.eu/rapid/press-release_STATEMENT-16-2967_en.htm
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26. Personal Health Train
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27. 27 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018
Redefine public needs: Dutch National Research Agenda
2ND intl Pharma-Nutrition Conference
Singapore, 17 April 2013
Alain van Gool
Lecture LKCH, UMC Utrecht
29 October 2013
Alain van Gool
https://wetenschapsagenda.nl/?lang=en
2016

28. • 12.000 questions from citizens
• Summarized in 140 cluster questions
• Addressed in 16 routes
• Translated into National Research Agenda
• Presented to government

29. Highlights discussed today
• Netherlands Genomics Initiative (NGI)
• Public Private Partnerships (TIP, CTMM, BMM)
• Topsector Life Science Health (Health~Holland)
• Dutch Techcenter for Life Sciences (DTL)
• Dutch National Research Agenda (NWA)
• Radboudumc Technology Centers (RTC)
• Large scale technology Infrastructures (X-omics)
• Dutch infrastructure for personalized
medicine and health research (Health-RI)
29 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

30. www.radboudumc.nl
30 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

31. Genomics
Bioinformatics
Animal
Research
Facility
Stem
cells
Translational
neuroscience
Image-guided
treatment
Imaging
Microscopy
Biobank
Health
economics
Mass
Spectrometry
Radboudumc
Technology
Centers
Investigational
products
Clinical
studies
Health Data
Biostatistics
Human
performance
Data
stewardship
Molecule
Flow
cytometry
3D lab
100+ technology experts working in 19 Technology Centers, ~1800 users (internal, external), ~150 consortia
www.radboudumc.nl/research/technologycenters
31

32. Build biomarker validation pipelines
Standardisation, harmonisation,
knowledge sharing in:
1. Assay development
2. Clinical validation
www.biomarkerdevelopmentcenter.nl
Rainer Bischoff
Theo Luider,
Alain van Gool and
32 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

33. Collaboration towards Good Biomarker Practices
{van Gool et al, Nature Reviews Drug Discovery, Apr 2017}
COST action CA16113
http://clinimark.eu
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34. Fund large scale scientific infrastructures
www.nwo.nl
2016:
• Inventory
• Clustering
• Communicating
2017:
• 1st call for proposals
(100M)
2018:
• Funding
2019:
• 2nd call for proposals
(100M)
34 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

35. The Netherlands X-omics Initiative
www.x-omics.nl
2018-2023 ?
35 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

36. Further joining forces in Netherlands
To drive personalized medicine & health research
2015
36 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

37. Organize a scattered landscape …
Knowledge institutes
VSNU
Beta
NFU projects
Topinstitutes
CTMM / TraIT
TI Pharma /
Mondriaan
NL Roadmap largescale research
infrastructure/ ESFRI
EATRIS-
NL/EATRIS
DTL/ELIXIR-
NL/ELIXIR
BBMRI-NL /
BBMRI
- /ECRIN
NeCEN/
INSTRUCT
PSI/Life Lines
Funding other than ESFRI
ZonMW
Various charities
BioImagingNL/Bioi
maging
IMI
RIVM
private
institutes
NKI
Sanquin
Top-sectors
Ministeries
OC&W
International community
Many different parties
BMM
Sector/cross-sector platforms
Health~Holland
NGI/NBIC
Registratie aan
de Bron
Platform Clinical Research
Horizon 2020
NWO
eScience
Center
NFU
UU LU VU UvA
3TU RUG UM
VWS
DTLBMS.NL
Partners in PPP
CRO’s
Standardisation institutes
NEN NICTIZ
Pharma
MKB / Spin off
Patient organisations
Various patient organisations
Hospitals
Diverse andere ziekenhuizen
Suppliers
EPD’s suppliers
IT companies (IBM, Oracle,
SAS etc.)
Largescale devices (Philips
e.a.)
SURF/VANCIS
TNO
EZ
Hubrecht
Institute
UMC Utrecht LUMC VUmc AMC
RadboudMC ErasmusMC UMCG MUMC
Radboud
KNAW
(overig)
CBS
37 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

38. Bring together relevant initiatives …
2014
2016
- 2009 200 biobanks
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39. Nationwide community in personalized healthcare
www.health-ri.org
39 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

40. 1-3-2018 40

41. Towards life-spanning personalized health and medicine
research
Source: Nico van Meeteren, Health~Holland
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42. The ‘funhouse mirror’ effect in Precision Medicine
• Multiple sources of
your data
• EPD
• Diagnostics
• Wearables
• Health apps
• Commercial health
tests
• Social media
• Surrounding
• Each give an
(incomplete) image of
you
• Some you want to see,
some you don’t
• Not technical issue
• Ethical, philosophical
42 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018

43. Acknowledgements
Hans Wessels Jolein Gloerich
Roel Tans Esther Willems
Maurice van Dael Jenneke Keizer
Dirk Lefeber Monique van
Scherpenzeel
Leo Kluijtmans Ron Wevers
Marcel Verbeek Karlien Coene
Jan Kremer Bas Bloem
Lucien Engelen Paul Smits
the Radboudumc Technology Centers
and many others
Jan van der Greef Ben van Ommen
Ivana Bobeldijk Hans Princen
Lars Verschuren Marjan van Erk
Suzan Wopereis Heleen Wortelboer
Wessel Kraaij Jildau Bouwman
Peter van Dijken and many others
Ruben Kok Barend Mons
Jaap Heringa Merlijn van Rijswijk
and many others
Anton Ussi Florence Bietrix
Laura Bermejo Andreas Scherer
Sulev Koks Marian Hajduch
Toni Andreu
and many others
Collaborators/funders
CarTarDis
alain.vangool@radboudumc.nl
www.linkedIn.com
www.slideshare.net/alainvangool
43 Alain van Gool, Int Conf on Perspectives in Precision Medicine, Copenhagen, 1 March 2018