Trustwave has seen an increase in PHP-based e-commerce sites being exploited through remote file inclusion vulnerabilities. These vulnerabilities allow attackers to execute malicious code on vulnerable systems by configuring PHP to include files from remote sites. Attackers often use this to install backdoors like r57shell that give them continued access. E-commerce sites can prevent this by disabling the PHP register_globals and allow_url_open settings in php.ini, as well as keeping applications like osCommerce and X-Cart up to date with the latest security patches.