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Benchmarks in Thought Leader Management
          Manufacturer Survey
           December 31,2007
Study Objectives
               Provide participating companies with a competitive
               benchmark related to their management &
               compensation practices with contracted Thought
               Leaders (aka Key Opinion Leaders).

               Provide a method of data collection within Anti-Trust
               Safe Harbors to assist companies in meeting
               regulatory statutes
                 • Companies required to ensure compensation for
                   contracted Thought Leaders meets “Fair Market Values”
                   of “legitimate consulting services.”

               Begin to identify industry trends and best practices
               that allow for more efficient operation of this business
               process.

©BioPharma Advisors LLC            www.BioPharmaAdvisors.net
12 Studies over 4 years
                             Thought Leader           Manufacturer   Vendor Segment
                             Segment                  Segment


        Year 1-2006                 1                           2          3


        Year 2-2007                 4                           5          6


        Year 3-2008                 7                           8          9



        Year 4-2009                10                           11         12



©BioPharma Advisors LLC             www.BioPharmaAdvisors.net
Study Objectives

                            Thought Leader
                                                                Determine
                                                                Objective
                                          *                     Data Points
                                   *

                                   * * *
                                     *
                            *                               *
     Vendor               * *                               *   Manufacturer



©BioPharma Advisors LLC         www.BioPharmaAdvisors.net
Manufacturer Study Background
               6 Sections form 71 questions
                 • Section 1-Demographics    Section 4- Medical Content
                 • Section 2-Advisory Boards Section 5-Lead Author
                 • Section 3-Promotional Prgm Section 6-Clinical Trial
               15 companies participated
                 • 10 Pharmaceutical Companies
                       10 Big Pharma
                 • 4 Biotech Companies
                 • 1 Medical Device Company
                       A second medical device company participated, but could not
                       answer the questions-No policy in place
               Fielded from July – December 2007 via phone interview


©BioPharma Advisors LLC            www.BioPharmaAdvisors.net
What are these payments called


              S2.Q1. What term below, in your opinion, best describes the payment for the
               services these Thought Leaders provide? (choose only a single answer)

                                                                                         Cumulative
                                            Frequency       Percent      Valid Percent    Percent
             Valid        consulting fees           8           53.3              53.3         53.3
                          Fee for svcs              4           26.7              26.7         80.0
                          Advisor fees              3           20.0              20.0        100.0
                          Total                    15          100.0            100.0



               Notice that no one called these fees Honoraria!
               Last year 18% responded with that answer.


©BioPharma Advisors LLC                      www.BioPharmaAdvisors.net
Most Common Payment
                                          2007 Survey
               S2.Q3. When remitting fees to Thought Leaders for services provided,
                which of the following is the most common increment of payment?

                                                                                        Cumulative
                                       Frequency       Percent          Valid Percent    Percent
             Valid        Per Hour             1            6.7                   6.7           6.7
                          Per Day              3           20.0                  20.0         26.7
                          Per Event           11           73.3                  73.3        100.0
                          Total               15          100.0                100.0

                                           2006 Survey
                   Q7. When paying to the TL, which is the most common increment of
                                      payment in your company?

                                                                                        Cumulative
                                       Frequency        Percent         Valid Percent    Percent
                Valid      Per Day             7            43.8                 43.8         43.8
                           Per Event           8            50.0                 50.0         93.8
                           Other               1             6.3                  6.3        100.0
                           Total              16           100.0               100.0
©BioPharma Advisors LLC                     www.BioPharmaAdvisors.net
Range for All Specialties
           0-500              0%

           501-750            2%

           751-1250           5%

           1251-1750          10%

           1751-2250          7%
                                                            69 specialties were measured
           2251-2750          6%

           2751-3250          3%                            Only 34% of the time did a
           3251-3750          0%
                                                            company report having a set fee
                                                            for a specific specialty.
           3751-4250          0%

           4251-4750          0%

           4751 or more       0%

           No Set Fee         60%

           Do Not Know        6%


©BioPharma Advisors LLC             www.BioPharmaAdvisors.net
Payment for Travel
             S2.Q5.Does your company pay for your travel time of the thought
           leader(the time spent in actual travel to and from the actual meeting)?

                                                                                      Cumulative
                                   Frequency      Percent             Valid Percent    Percent
            Valid         No              13          86.7                     86.7         86.7
                          Yes              2          13.3                     13.3        100.0
                          Total           15         100.0                   100.0



               S2.Q6.Do you believe your company will consider compensating
             Thought Leaders for their travel time (the time spent in actual travel to
                       and from the meeting) at some point this year?

                                                                                      Cumulative
                                   Frequency      Percent             Valid Percent    Percent
               Valid       No              9          60.0                     60.0         60.0
                           Yes             6          40.0                     40.0        100.0
                           Total          15         100.0                   100.0
©BioPharma Advisors LLC                   www.BioPharmaAdvisors.net
Ad Board Compensation Limit

           S2.Q14. Does your organization have some type of compensation limit
         regarding the amount of money they pay an individual Thought Leader as
                                       an advisor?

                                                                                     Cumulative
                                  Frequency      Percent             Valid Percent    Percent
           Valid          No              9          60.0                     60.0         60.0
                          Yes             4          26.7                     26.7         86.7
                          DK/NA           2          13.3                     13.3        100.0
                          Total          15         100.0                    100.0


            Of the 4 who responded the range was $30,000
              to $65,000 annually. One suggested their
              rate would be in place by 1/1/08.

©BioPharma Advisors LLC                  www.BioPharmaAdvisors.net

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Benchmarks in Thought Leader Management

  • 1. Benchmarks in Thought Leader Management Manufacturer Survey December 31,2007
  • 2. Study Objectives Provide participating companies with a competitive benchmark related to their management & compensation practices with contracted Thought Leaders (aka Key Opinion Leaders). Provide a method of data collection within Anti-Trust Safe Harbors to assist companies in meeting regulatory statutes • Companies required to ensure compensation for contracted Thought Leaders meets “Fair Market Values” of “legitimate consulting services.” Begin to identify industry trends and best practices that allow for more efficient operation of this business process. ©BioPharma Advisors LLC www.BioPharmaAdvisors.net
  • 3. 12 Studies over 4 years Thought Leader Manufacturer Vendor Segment Segment Segment Year 1-2006 1 2 3 Year 2-2007 4 5 6 Year 3-2008 7 8 9 Year 4-2009 10 11 12 ©BioPharma Advisors LLC www.BioPharmaAdvisors.net
  • 4. Study Objectives Thought Leader Determine Objective * Data Points * * * * * * * Vendor * * * Manufacturer ©BioPharma Advisors LLC www.BioPharmaAdvisors.net
  • 5. Manufacturer Study Background 6 Sections form 71 questions • Section 1-Demographics Section 4- Medical Content • Section 2-Advisory Boards Section 5-Lead Author • Section 3-Promotional Prgm Section 6-Clinical Trial 15 companies participated • 10 Pharmaceutical Companies 10 Big Pharma • 4 Biotech Companies • 1 Medical Device Company A second medical device company participated, but could not answer the questions-No policy in place Fielded from July – December 2007 via phone interview ©BioPharma Advisors LLC www.BioPharmaAdvisors.net
  • 6. What are these payments called S2.Q1. What term below, in your opinion, best describes the payment for the services these Thought Leaders provide? (choose only a single answer) Cumulative Frequency Percent Valid Percent Percent Valid consulting fees 8 53.3 53.3 53.3 Fee for svcs 4 26.7 26.7 80.0 Advisor fees 3 20.0 20.0 100.0 Total 15 100.0 100.0 Notice that no one called these fees Honoraria! Last year 18% responded with that answer. ©BioPharma Advisors LLC www.BioPharmaAdvisors.net
  • 7. Most Common Payment 2007 Survey S2.Q3. When remitting fees to Thought Leaders for services provided, which of the following is the most common increment of payment? Cumulative Frequency Percent Valid Percent Percent Valid Per Hour 1 6.7 6.7 6.7 Per Day 3 20.0 20.0 26.7 Per Event 11 73.3 73.3 100.0 Total 15 100.0 100.0 2006 Survey Q7. When paying to the TL, which is the most common increment of payment in your company? Cumulative Frequency Percent Valid Percent Percent Valid Per Day 7 43.8 43.8 43.8 Per Event 8 50.0 50.0 93.8 Other 1 6.3 6.3 100.0 Total 16 100.0 100.0 ©BioPharma Advisors LLC www.BioPharmaAdvisors.net
  • 8. Range for All Specialties 0-500 0% 501-750 2% 751-1250 5% 1251-1750 10% 1751-2250 7% 69 specialties were measured 2251-2750 6% 2751-3250 3% Only 34% of the time did a 3251-3750 0% company report having a set fee for a specific specialty. 3751-4250 0% 4251-4750 0% 4751 or more 0% No Set Fee 60% Do Not Know 6% ©BioPharma Advisors LLC www.BioPharmaAdvisors.net
  • 9. Payment for Travel S2.Q5.Does your company pay for your travel time of the thought leader(the time spent in actual travel to and from the actual meeting)? Cumulative Frequency Percent Valid Percent Percent Valid No 13 86.7 86.7 86.7 Yes 2 13.3 13.3 100.0 Total 15 100.0 100.0 S2.Q6.Do you believe your company will consider compensating Thought Leaders for their travel time (the time spent in actual travel to and from the meeting) at some point this year? Cumulative Frequency Percent Valid Percent Percent Valid No 9 60.0 60.0 60.0 Yes 6 40.0 40.0 100.0 Total 15 100.0 100.0 ©BioPharma Advisors LLC www.BioPharmaAdvisors.net
  • 10. Ad Board Compensation Limit S2.Q14. Does your organization have some type of compensation limit regarding the amount of money they pay an individual Thought Leader as an advisor? Cumulative Frequency Percent Valid Percent Percent Valid No 9 60.0 60.0 60.0 Yes 4 26.7 26.7 86.7 DK/NA 2 13.3 13.3 100.0 Total 15 100.0 100.0 Of the 4 who responded the range was $30,000 to $65,000 annually. One suggested their rate would be in place by 1/1/08. ©BioPharma Advisors LLC www.BioPharmaAdvisors.net