blood cancer be cured from brewers yeast

1. PROTEIN ISOLATED FROM
BAKERS YEAST HAS POTENTIAL
TO CURE LEUKEMIA CANCER
SHREYA MANEK
DEPARTMENT OF BIOTECHNOLOGY
TY B.SC
CHRIST COLLEGE RAJKOT

2. Can leukemia be cured ?
“YES”

3. HOW ?
An enzyme isolated identifies in Sacchromyces
cerevisiae, commonly known as brewers yeast or
bakers yeast has passed in vitro trials, demonstrating its
capacity to kill acute lymphoblastic leukemia cells.

4. Leukemia cancer
 Leukemia is the cancer of the blood
 It begins in the bone marrow, where blood cells are
produced
 Bone marrow is found in the soft, spongy centers of
the long bones of arms and legs
 Bone marrow makes three types of blood cells -:
1)White blood cells which fight against infection
2)Red blood cells which carries oxygen
3)Platelets which makes the blood clot and stop
bleeding

5. FACTS
 There are about 54,000 new cases of leukemia each
year and about 24,000 deaths due to leukemia.
 It’s the most common childhood cancer .
 It is slightly more common in men than women.
 While the exact cause of leukemia is not known, but
risk factors have been identified, including exposure to
radiation and benzene.
 People with leukemia are at significantly increased risk
for developing infections, anemia and bleeding.

6. TREATMENT
 Chemotherapy
 Radiation therapy
 Stem cell transplantation
 Surgery
 Targeted drugs

7. Identifying a safer treatment for all
 According to the “GISELE MONTERIO” an enzyme
isolated from the bacteria Escherichia coli and Erwinia
chrysynthemi has been used for the treatment for all
decades
 But treatment with this bacterial enzyme can lead to
high remission rate, he noted that it can trigger mild to
severe immune response around 25% of the patient. As
such, a less toxic biopharmaceutical for the treatment of
all is required
 Monterio and his team isolated an enzyme from non
bacterial source sacchromyces cerevisiae

8.  Monterio aim of his project was not to isolate enzyme
but rather to find a new source of biodrug in
microorganism for use in patients who develop
resistance to the bacterial enzyme
 He and his team identified a gene in S. cerevisiae
called ASP1 that encodes an enzyme similar to
l.asparginase

9.  The researchers tested both purified L.asparginase from
yeast cell and L.asparginase from E.coli in three group
of human leukemia cell.
 One group was unable to produce normal amount of
L.asparginase, one group produced L.asparginase at
normal level and normal group was non-malignant.
yeast derived from L.asparginase killed approximately
70-80% comparatively.
 However purified l.asparginase from yeast found to be
less toxic.
.

10.  The researchers tested both purified l.asparginase
from yeast cell and L.asparginase from E.coli in three
groups of human leukemia cell.
 One group was unable to produce normal amount of
asparagines, one group produced L.asparginase at
normal level and normal group was non-malignant. Yeast
derived from L.asparginase killed approximately 70-80%
comparatively.
 However purified l.asparginase from yeast found to be
less toxic

11. Future aspects
 Researchers are now planning to conduct in vitro
studies of l.asparginase from yeast in order to gain a
better understanding of toxicity in various types of
cells as well as the immune response to the enzyme.
 If studies shows promising result then its easy to
cure leukemia and we will be at the top of the world.

12. THANK YOU